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Creator | Title | Description | Subject | Date |
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| AAMC Award for Distinguished Research presentation for 1998 | This is a 3 minutes, 51 seconds video of the presentation of the American Association of Medical Colleges' Award for Distinguished Research to Mario Capecchi and Oliver Smithies for their independent work as pioneers in gene targeting. | Transgenic mice; Gene targeting; Genetic engineering; Mutagenesis; Capecchi, Mario R.; Science - Awards - United States; Smithies, Oliver; Awards presentations | 1998 |
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| KUTV news featurette on cloning, molecular genetics, and disease aired November 9, 1997 | This 3 minutes, 1 second video clip from Salt Lake City's KUTV, Channel 2 features a short interview with Mario Capecchi concerning cloning and its use in molecular genetics and the study of human diseases. | Gene targeting; Genetic engineering; Molecular genetics; Cancer Research; Capecchi, Mario R.; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis; Television feature stories | 1997-11-09 |
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| KSL News clip of Mario Capecchi receiving the National Medal of Science for 1991 | This 1 minute, 44 seconds news clip from Salt Lake City's KSLTV, Channel 5 shows Mario Capecchi receiving the National Medal of Science for 1991 from President George W. Bush at the June 13, 2002 awards ceremony. The medal was presented for Capecchi's work in genetics and his development of the pro... | Transgenic mice; Gene targeting; Capecchi, Mario R.; Science - Awards - United States; Television broadcasting of news | 1992-06 |
| 4 |
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Capecchi, Mario R. | Role of Hox genes in mediating the mammalian body plan | This is a 1 hour, 5 minutes, 28 seconds video of a lecture given by Mario Capecchi on the genetic analysis of the Hox complex, or Hox cluster and their role in embryogenesis. Using examples such as the development of the hindbrain (rhombencephalon), facial nerves, and hands Capecchi outlines the re... | Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype | |
| 5 |
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| Genetics in Utah : NPR talk of the nation, science Friday for May 15, 1998 | This is a 1 hour, 9 seconds audio transcript of National Public Radio's Science Friday that was taped at Westminster College of Salt Lake on 1998/05/15. The host, Ira Flatow, leads a panel composed of University of Utah scientists and researchers, Jeffrey Bodkin, Mario Capecchi, Ray Gesteland, Mark... | Genetic engineering; Molecular genetics; Capecchi, Mario R.; Homeobox genes; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis | 1998 |
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| Local television news clips for June 14, 1994 featuring Mario Capecchi | This is a compilation of news clips from Salt Lake City's four major commercial television stations (Channels 2, 4, 5, and 13) lasting a total of 2 minutes, 59 seconds. The topic is Capecchi's winning of the General Motors Corporation's Alfred P. Sloan Jr. Prize for Outstanding Basic Science Contrib... | Transgenic mice; Gene targeting; Cancer - Research - Awards; Capecchi, Mario R.; Science - Awards - United States; Television broadcasting of news | 1994-06-14 |
| 7 |
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Capecchi, Mario R. | Creating mice with targeted disruptions in protooncogenes and homeobox genes, NIH Director's Lecture given May 21, 1992 | This is an audio transcript of a 1 hour, 2 minutes and 12 seconds lecture given at the National Institutes of Health by Mario Capecchi on 1992/05/21. Beginning with a short summary of the mechanics of gene transfer and the ability to create germline chimera with mutations that become hereditary wit... | Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Mutagenesis; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype | 1992 |
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| Secret of life module: on the brink, four profiles in groundbreaking science | This is a 15 minutes, 12 seconds segment of the WGBH series, Secret of life. Profiles include Dennis Slamon of UCLA and his work on the oncagenes and the creation of excess receptors that play a significant role in breast cancer; Patricia Steeg of the National Cancer Institute (NCI) and her work on... | Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Cancer - Research; Capecchi, Mario R.; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis; Gene expression; Gene regulation | |
| 9 |
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| Albert Lasker Awards Ceremony, 2001 | This is the 1 hour, 45 minutes, and 41 seconds video of the Lasker Awards Ceremony and Banquet held in September, 2001. The Albert Lasker Award for Basic Medical Research was given to Mario R. Capecchi, Oliver Smithies, and Martin Evans for their work in genetic research. Martin Evans discovered h... | Capecchi, Mario R.; Gene targeting; Embryonic stem cells; Transgenic mice; Genetic engineering; Science - Awards - United States; Smithies, Oliver; Evans, Martin J.; Awards presentations | 2001 |
| 10 |
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Huang, Lin Eric | HIF-1? mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression | Although tumor progression involves genetic and epigenetic alterations to normal cellular biology, the underlying mechanisms of these changes remain obscure. Numerous studies have shown that hypoxia-inducible factor 1? (HIF-1?) is overexpressed in many human cancers and up-regulates a host of hypoxi... | | |
| 11 |
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| Franklin Institute award dinner and ceremony held May 1, 1997 | This is a 1 hour, 42 minutes, 53 seconds video of the 1997 Franklin Institute Awards Banquet and Ceremony. The awards included a summary of each winner's achievements, the presentation of the award, and an acceptance speech. The award winners included Ralph L. Brinster, the Bower Award and Prize f... | Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Mutagenesis; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype | 1997 |
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| National Medals of Science and Technology Awards (2001) Ceremony and Banquet, held June 13, 2002 | This 51 minutes, 5 seconds video is divided into two parts: the first part is a film introducing the award winners and their achievements; the second is the presentation of the actual awards by George W. Bush, President of the United States. Medal winners were: Mario R. Capecchi for his pioneering... | Molecular genetics; Gene targeting; Transgenic mice; Gene expression; Genetic engineering; Capecchi, Mario R.; Science - Awards - United States; Awards presentations | 2002 |
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Thomas, Kirk R.; Capecchi, Mario R. | High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. | Mutations were targeted to the Hprt locus in murine embryonic stem cells by using sequence replacement vectors. When the vector was designed such that the mutated sequences were flanked on both sides by several kilobases of DNA homologous to the target locus, replacement of chromosomal sequences wit... | Drug Resistance; Gene Rearrangement; Gentamicins | 1992-07 |
| 14 |
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Capecchi, Mario R. | Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. | Mice with targeted disruptions in Hox genes have been generated to evaluate the role of the Hox complex in determining the mammalian body plan. This complex of 38 genes encodes transcription factors that specify regional information along the embryonic axes. Early in vertebrate evolution an ancestra... | Alleles; Animals; Bone and Bones; Carpal Bones | 2003-09-02 |
| 15 |
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Capecchi, Mario R. | Polypeptide chain termination in vitro: isolation of a release factor. | The growing polypeptide chain remains bound to the ribosome-messenger RNA complex through the sRNA carrying the last amino acid incorporated into the polypeptide chain.' On completion of the polypeptide chain a mechanism must exist for releasing it from the protein-synthesizing machinery. To date, m... | Carbon Isotopes; Phenylalanine; Proteins | 1967-09-01 |
| 16 |
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Capecchi, Mario R. | Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells. | We have used site-specific mutagenesis to change the anticodon of a Xenopus laevis tyrosine tRNA gene so that it would recognize ochre codons. This tRNA gene is expressed when amplified in monkey cells as part of a SV40 recombinant and efficiently suppresses termination at both the ochre codon separ... | Xenopus; Nucleic Acid Conformation; Kidney; DNA Restriction Enzymes | 1984-11 |
| 17 |
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Capecchi, Mario R. | Male fertility is dependent on dipeptidase activity of testis ACE. | Testis angiotensin-converting enzyme (ACE) is an isozyme exclusively expressed by developing sperm. This protein has only a single catalytic domain containing the HEXXH consensus-site motif typical of zinc metallopeptidases. The exact role of testis ACE is unknown, but male mice lacking the protein ... | Amino Acid Motifs; Blotting, Western; Catalytic Domain; Comparative Study; Isoenzymes; Protein Structure, Tertiary | 2005-11-11 |
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Capecchi, Mario R. | High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. | Direct microinjection of DNA by glass micropipettes was used to introduce the Herpes simplex virus thymidine kinase gene into cultured mammalian cells. When DNA was delivered directly into the nuclei of LMTK-, a mouse cell line deficient in thymidine kinase activity, 50--100% of the cells expressed ... | Cell Nucleus; Cytoplasm; DNA, Viral; Microinjections; Recombination, Genetic | 1980-11-22 |
| 19 |
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Capecchi, Mario R. | Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. | Implantation within the mammalian uterus elicits dramatic changes in the growth, differentiation, and morphogenesis of the conceptus. This process is interrupted in mice carrying a targeted disruption of the murine evx1 gene, a homolog of the Drosophila even-skipped (eve) gene. Upon implantation, pr... | Extraembryonic; Homozygotes; Drosophila | 1994-08-15 |
| 20 |
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Capecchi, Mario R. | Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. | A porcine class I major histocompatibility complex (SLA) gene has been introduced into the genome of a C57BL/10 mouse. This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were... | Genetic Engineering; Graft Rejection; Mice, Inbred C57BL | 1985-05-03 |
| 21 |
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Capecchi, Mario R. | Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune system | Mammalian TBP consists of a 180 amino acid core that is common to all eukaryotes, fused to a vertebrate-specific N-terminal domain. We generated mice having a modified tbp allele, tbp(DeltaN), that produces a version of TBP lacking 111 of the 135 vertebrate-specific amino acids. Most tbp(DeltaN/Delt... | Alleles; Animals, Genetically Modified; Binding Sites; Embryonic and Fetal Development; Evolution, Molecular; Female; Fetus; Immune Tolerance; Male; Mice; Mutation; ATA-Box Binding Protein | 2002-07-12 |
| 22 |
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Moon, Ann M.; Capecchi, Mario R. | Fgf8 is required for outgrowth and patterning of the limbs. | The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of mice has prevented direct assessment of these roles. Here we rep... | Animals; Body Patterning; Bone Morphogenetic Proteins; Ectoderm | 2000-12-26 |
| 23 |
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Thomas, Kirk R.; Capecchi, Mario R. | Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. | The int-1 proto-oncogene was first identified as a gene activated in virally induced mouse mammary tumours. Expression studies, however, suggest that the normal function of this gene may be in spermatogenesis and in the development of the central nervous system. Genes sharing sequence similarity wit... | Animals; Blastocyst; Cell Line; Chimera; DNA; Female; Genotype; Heterozygote; Homozygote; Male; Mice, Inbred C57BL; Motor Activity | 1990-08-30 |
| 24 |
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Capecchi, Mario R.; Tvrdik, Petr | Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. | Formation of neuronal circuits in the head requires the coordinated development of neurons within the central nervous system (CNS) and neural crest-derived peripheral target tissues. Hoxb1, which is expressed throughout rhombomere 4 (r4), has been shown to be required for the specification of facial... | Rhombomere 4; Branchiomotor; Cranial Nerve | 2004-07-04 |
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Hansen, Mark S.; Coffin, Cheryl M.; Capecchi, Mario R. | Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. | To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do... | Neuroprogenitor; Embryogenesis | 2004-11-01 |
