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Creator | Title | Description | Subject | Date |
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| AAMC Award for Distinguished Research presentation for 1998 | This is a 3 minutes, 51 seconds video of the presentation of the American Association of Medical Colleges' Award for Distinguished Research to Mario Capecchi and Oliver Smithies for their independent work as pioneers in gene targeting. | Transgenic mice; Gene targeting; Genetic engineering; Mutagenesis; Capecchi, Mario R.; Science - Awards - United States; Smithies, Oliver; Awards presentations | 1998 |
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| KUTV news featurette on cloning, molecular genetics, and disease aired November 9, 1997 | This 3 minutes, 1 second video clip from Salt Lake City's KUTV, Channel 2 features a short interview with Mario Capecchi concerning cloning and its use in molecular genetics and the study of human diseases. | Gene targeting; Genetic engineering; Molecular genetics; Cancer Research; Capecchi, Mario R.; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis; Television feature stories | 1997-11-09 |
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| KSL News clip of Mario Capecchi receiving the National Medal of Science for 1991 | This 1 minute, 44 seconds news clip from Salt Lake City's KSLTV, Channel 5 shows Mario Capecchi receiving the National Medal of Science for 1991 from President George W. Bush at the June 13, 2002 awards ceremony. The medal was presented for Capecchi's work in genetics and his development of the pro... | Transgenic mice; Gene targeting; Capecchi, Mario R.; Science - Awards - United States; Television broadcasting of news | 1992-06 |
| 4 |
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Capecchi, Mario R. | Role of Hox genes in mediating the mammalian body plan | This is a 1 hour, 5 minutes, 28 seconds video of a lecture given by Mario Capecchi on the genetic analysis of the Hox complex, or Hox cluster and their role in embryogenesis. Using examples such as the development of the hindbrain (rhombencephalon), facial nerves, and hands Capecchi outlines the re... | Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype | |
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| Genetics in Utah : NPR talk of the nation, science Friday for May 15, 1998 | This is a 1 hour, 9 seconds audio transcript of National Public Radio's Science Friday that was taped at Westminster College of Salt Lake on 1998/05/15. The host, Ira Flatow, leads a panel composed of University of Utah scientists and researchers, Jeffrey Bodkin, Mario Capecchi, Ray Gesteland, Mark... | Genetic engineering; Molecular genetics; Capecchi, Mario R.; Homeobox genes; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis | 1998 |
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| Local television news clips for June 14, 1994 featuring Mario Capecchi | This is a compilation of news clips from Salt Lake City's four major commercial television stations (Channels 2, 4, 5, and 13) lasting a total of 2 minutes, 59 seconds. The topic is Capecchi's winning of the General Motors Corporation's Alfred P. Sloan Jr. Prize for Outstanding Basic Science Contrib... | Transgenic mice; Gene targeting; Cancer - Research - Awards; Capecchi, Mario R.; Science - Awards - United States; Television broadcasting of news | 1994-06-14 |
| 7 |
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Capecchi, Mario R. | Creating mice with targeted disruptions in protooncogenes and homeobox genes, NIH Director's Lecture given May 21, 1992 | This is an audio transcript of a 1 hour, 2 minutes and 12 seconds lecture given at the National Institutes of Health by Mario Capecchi on 1992/05/21. Beginning with a short summary of the mechanics of gene transfer and the ability to create germline chimera with mutations that become hereditary wit... | Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Mutagenesis; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype | 1992 |
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| Secret of life module: on the brink, four profiles in groundbreaking science | This is a 15 minutes, 12 seconds segment of the WGBH series, Secret of life. Profiles include Dennis Slamon of UCLA and his work on the oncagenes and the creation of excess receptors that play a significant role in breast cancer; Patricia Steeg of the National Cancer Institute (NCI) and her work on... | Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Cancer - Research; Capecchi, Mario R.; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis; Gene expression; Gene regulation | |
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| Albert Lasker Awards Ceremony, 2001 | This is the 1 hour, 45 minutes, and 41 seconds video of the Lasker Awards Ceremony and Banquet held in September, 2001. The Albert Lasker Award for Basic Medical Research was given to Mario R. Capecchi, Oliver Smithies, and Martin Evans for their work in genetic research. Martin Evans discovered h... | Capecchi, Mario R.; Gene targeting; Embryonic stem cells; Transgenic mice; Genetic engineering; Science - Awards - United States; Smithies, Oliver; Evans, Martin J.; Awards presentations | 2001 |
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Huang, Lin Eric | HIF-1? mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression | Although tumor progression involves genetic and epigenetic alterations to normal cellular biology, the underlying mechanisms of these changes remain obscure. Numerous studies have shown that hypoxia-inducible factor 1? (HIF-1?) is overexpressed in many human cancers and up-regulates a host of hypoxi... | | |
| 11 |
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| Franklin Institute award dinner and ceremony held May 1, 1997 | This is a 1 hour, 42 minutes, 53 seconds video of the 1997 Franklin Institute Awards Banquet and Ceremony. The awards included a summary of each winner's achievements, the presentation of the award, and an acceptance speech. The award winners included Ralph L. Brinster, the Bower Award and Prize f... | Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Mutagenesis; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype | 1997 |
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| National Medals of Science and Technology Awards (2001) Ceremony and Banquet, held June 13, 2002 | This 51 minutes, 5 seconds video is divided into two parts: the first part is a film introducing the award winners and their achievements; the second is the presentation of the actual awards by George W. Bush, President of the United States. Medal winners were: Mario R. Capecchi for his pioneering... | Molecular genetics; Gene targeting; Transgenic mice; Gene expression; Genetic engineering; Capecchi, Mario R.; Science - Awards - United States; Awards presentations | 2002 |
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Capecchi, Mario R. | Male fertility is dependent on dipeptidase activity of testis ACE. | Testis angiotensin-converting enzyme (ACE) is an isozyme exclusively expressed by developing sperm. This protein has only a single catalytic domain containing the HEXXH consensus-site motif typical of zinc metallopeptidases. The exact role of testis ACE is unknown, but male mice lacking the protein ... | Amino Acid Motifs; Blotting, Western; Catalytic Domain; Comparative Study; Isoenzymes; Protein Structure, Tertiary | 2005-11-11 |
| 14 |
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Capecchi, Mario R. | How close are we to implementing gene targeting in animals other than the mouse? | Describes several significant contributions that bring us much closer to extending ‘‘gene targeting'' to mammalian species other than the mouse. Gene targeting now provides the means for creating new strains of mice with mutations in virtually any gene. First, the desired mutation is introduced ... | Cattle; Mutagenesis; Mice; Humans; Ethics, Medical | 2000-02-01 |
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Capecchi, Mario R. | Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. | The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA rec... | Animals, Newborn; Crosses, Genetic | 1997-10-14 |
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Capecchi, Mario R. | Measurement of suppressor transfer RNA activity. | Transfer RNA (tRNA) suppression of nonsense mutations in prokaryotic systems has been widely used to study the structure and function of different prokaryotic genes. Through genetic engineering techniques, it is now possible to introduce suppressor (Su+) tRNA molecules into mammalian cells. A quanti... | Animals; Cells, Cultured; Eukaryotic Cells; Genes, Viral; Mice; Orthomyxoviridae; Peptide Chain Termination, Translational; Protein Biosynthesis | 1983-08-26 |
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Capecchi, Mario R. | Gene targeting. How efficient can you get? | With targeting in Leishmania and Trypanosoma, there are now greater incentives to develop the technology in organisms of intermediate complexity such as Caenorhabditis elegans and Drosophila. The ratio of homologous to nonhomologus recombination in these organisms might prove to be greater than in m... | Animals; DNA Mutational Analysis; Recombination, Genetic | 1990-11-08 |
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Capecchi, Mario R. | Gene targeting: tapping the cellular telephone. | Gene targeting means that we now have the potential to generate mice of virtually any desired genotype. In the first instance, standards recombinant DNA technology is used to alter a cloned DNA sequence of a chosen locus; the modified potent stem cell derived from a mouse embryo, and homologous reco... | Animals; Blotting, Southern; Bone and Bones; Gene Targeting; Genotype; Immunochemistry; In Situ Hybridization; Mice | 1990-03-08 |
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Capecchi, Mario R. | Choose your target. | The technology of modifying endogenous genes has recently been extended from mice to Drosophila and sheep. Concurrently, genomic sequencing is uncovering thousands of previously uncharacterized genes. Armed with today's technologies, what are our best options for delineating the functions of these n... | Animals; Mice; Sheep | 2000-09-13 |
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Moon, Ann M.; Capecchi, Mario R. | Roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. | Although numerous molecules required for limb bud formation have recently been identified, the molecular pathways that initiate this process and ensure that limb formation occurs at specific axial positions have yet to be fully elucidated. Based on experiments in the chick, Fgf8 expression in the in... | Animals; Apoptosis; Forelimb; Gene Expression Regulation, Developmental; High Mobility Group Proteins; Hindlimb; In Situ Hybridization; Mesoderm; Mice, Mutant Strains; Trans-Activators | 2004-09 |
| 21 |
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Capecchi, Mario R. | Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase. | We have examined the effect of cell cycle position on homologous recombination between plasmid molecules coinjected into synchronized rat fibroblasts. Recombination activity was found to be low in G1 and to rise 10- to 15-fold, peaking in early to mid-S phase. | Cell Line; Kinetics; Plasmids | 1986-06 |
| 22 |
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Capecchi, Mario R. | In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells. | Embryonic stem cells (ES) are pluripotent and may therefore serve as a source for the generation of specific cell types required for future therapies based on cell replacement. The isolation of defined cell populations from a certain lineage or tissue is a prerequisite for the analysis of the potent... | Animals; Cell Differentiation; Cells, Cultured; Gene Transfer Techniques; Mice, Transgenic | 2005-10-23 |
| 23 |
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Capecchi, Mario R. | Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. | The Hox genes encode transcription factors which mediate the formation of the mammalian body plan along the anteroposterior and appendicular axes. Paralogous Hox genes within the separate linkage groups are closely related with respect to DNA sequence and expression, suggesting that they could have ... | Animals; Atlas; Homozygote; Mice; Models, Genetic | 1994-07-28 |
| 24 |
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Capecchi, Mario R.; Bernstein, Kenneth E.; Thomas, Kirk R. | Targeting genes for self-excision in the germ line | A procedure is described that directs the self-induced deletion of DNA sequences as they pass through the male germ line of mice. The testes-specific promoter from the angiotensin-converting enzyme gene was used to drive expression of the Cre-recombinase gene. Cre was linked to the selectable marker... | Cre-recombinase; Hoxa3; Chimeric mice | 1999-06-15 |
| 25 |
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Capecchi, Mario R. | Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. | Mice with targeted disruptions in Hox genes have been generated to evaluate the role of the Hox complex in determining the mammalian body plan. This complex of 38 genes encodes transcription factors that specify regional information along the embryonic axes. Early in vertebrate evolution an ancestra... | Alleles; Animals; Bone and Bones; Carpal Bones | 2003-09-02 |
