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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
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Capecchi, Mario R. | Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes. | We describe the generation of mammalian cell lines carrying amber suppressor genes. Nonsense mutants in the herpes simplex virus thymidine kinase (HSV tk) gene, the Escherichia coli xanthine-guanine phosphoribosyl transferase (Eco-gpt) gene and the aminoglycoside 3' phosphotransferase gene of the Tn... | Cercopithecus aethiops; Escherichia coli; Xenopus | 1982-11-30 |
| 2 |
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Gussin, Gary N.; Capecchi, Mario R. | Protein synthesis directed by DNA phage messengers. | Even through the amino acids corresponding to most of the 64 nucleotide triplets are now known, several important aspects of the genetic code are not yet fully understood. In particular we need more knowledge about the "punctuation marks" of the code-for example, the signals necessary for the initia... | Carbon Isotopes; Escherichia coli; Genetic Code; Methionine | 1967-09-01 |
| 3 |
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Capecchi, Mario R. | Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro. | tRNA isolated from two different yeast super-suppressor strains translates a known nonsense mutation in vitro, whereas tRNA from a closely related nonsuppressing strain does not. Suppression was assayed by translation of RNA isolated from an amber coat mutant of bacteriophage Qbeta (GB11) in a prote... | Codon; Escherichia coli; Protein Biosynthesis | 1975-11 |
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