Creator | Title | Description | Subject | Date | ||
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1 | Capecchi, Mario R. | Selective degradation of abnormal proteins in mammalian tissue culture cells. | The degradation rates of several missense mutants of hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) in mouse L cells are compared to those of the wild-type enzyme. Although the rates of total protein breakdown in the mutant cell lines are identical to that of the parental L cell line, ... | Gene Expression Regulation; Mice, Transgenic; Microscopy, Fluorescence | 1974-12-01 |