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Symons, John David | Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia | Elevation of plasma total homocysteine (tHcy) is associated with an increased risk of cardiovascular disease, but the underlying mechanisms are not well understood.1 Worldwide, the most common cause of mild hyperhomocysteinemia (HHcy) is deficiency of folate.2,3 Some4-8 but not all9,10 studies sugg... | Cystathionine B-synthase; Carotid artery; Aorta; Cardiovascular risk factors; Folate; Hyperhomocysteinemia; Arterial permeability; Arterial stiffness | 2006 |
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Symons, John David | Hyperhomocysteinemia evoked by folate depletion: effects on coronary and carotid arterial function | High circulating concentrations of homocysteine (ie, hyperhomocysteinemia [Hhcy]) impair the vascular function of peripheral conduit arteries and arterioles perfusing splanchnic and skeletal muscle regions. The effects of HHcy on coronary resistance vessel function and other indexes of vascular func... | Hyperhomocysteinemia; Coronary resistance artery; Arterial stiffness; Arterial permeability; Vascular reactivity; Folate depletion; Rat | 2002 |