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Creator | Title | Description | Subject | Date |
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Couldwell, William T.; Gillespie, David L.; Jensen, Randy L. | Comparison of the cell lines used in meningoma research | Background: Immortal cell lines and cell lines derived from operative specimens transplanted into animal models are used in meningioma research. We address two criticisms of the mouse xenograft flank tumor model: Why are tumor induction rates derived from operative specimens low and inconsistent? Ar... | CH-157 MN; IOMM-Lee; Meningioma; Xenograft Mouse Model; Flank tumors | 2008 |
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Kestle, John R. W. | Potentially useful outcome measures for clinical research in pediatric neurosurgery | The choice of outcome (or outcomes) and their measurement are critical for a sound clinical trial. Surgeons have traditionally measured simple outcomes such as death, duration of survival, or tumor recurrence but have recently developed more sophisticated measures of the effect of an intervention. M... | Pediatric neurosurgery | 2005 |
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Kestle, John R. W. | Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshop | Object. Treatment for hydrocephalus has not advanced appreciably since the advent of cerebrospinal fluid (CSF) shunts more than 50 years ago. Many questions remain that clinical and basic research could address, which in turn could improve therapeutic options. To clarify the main issues facing hydr... | Biomedical research | 2007 |
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Jensen, Randy Lynn | Treatment-related brain tumor imaging changes: so-called "pseudoprogression" vs. tumor progression: Review and future research opportunities | Background: Glioblastoma multiforme (GBM) has a dismal prognosis despite aggressive therapy. Initial diagnosis and measurement of response to treatment is usually determined by measurement of gadolinium-enhanced tumor volume with magnetic resonance imaging (MRI). Unfortunately, many GBM treatment mo... | | 2013-01-01 |