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1 Couldwell, William T.Man for all seasons: W.W. KeenWILLIAM WILLIAMS KEEN was the catalyst for the advent of neurosurgery in the United States. He served in the Civil War and collaborated with Silas Weir Mitchell in studying injuries sustained to the nervous system. These studies culminated in the publication in 1864 of Gunshot Wounds and Other Inj...Brain tumor2002
2 Kestle, John R. W.Late rapid deterioration after endoscopic third ventriculostomy: additional cases and review of the literatureObject. Late rapid deterioration after endoscopic third ventriculostomy (ETV) is a rare complication. The authors previously reported three deaths from three centers. Three other deaths and a patient who experienced rapid deterioration have also been reported. Following the death at the University ...Endoscopic third ventriculostomy; ETV; Pediatric neurosurgery; Adverse outcome2006
3 Kestle, John R. W.Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalusOBJECTIVE: Forty percent of standard cerebrospinal fluid shunts implanted for the treatment of pediatric hydrocephalus fail within the first year. Two new shunt valves designed to limit excess flow, particularly in upright positions, were studied to compare treatment failure rates with those for st...Shunt failure; Valve design; Orbis-Sigma valve; Delta valve1998
4 Jaeckle, Kurt A.; Digre, Kathleen B.; Jones, Christopher R.; Bailey, Peter L.Central neurogenic hyperventilation: pharmacologic intervention with morphine sulfate and correlative analysis of respiratory, sleep, and ocular motor dysfunction.Central neurogenic hyperventilation (CNH), for which there is no effective therapy, can eventually result in respiratory fatigue and death. This report describes a patient with CNH due to a brainstem anaplastic astrocytoma who also exhibited disturbances of sleep and ocular motor function. The CNH r...Central Neurogenic H yperventilation; Ocular Motor Dysfunction1990-11
5 Couldwell, William T.William Osler at McGill University: the baby professor and his early contributions to neurosurgeryBetween 1870 and 1884, as both a medical student and a member of the faculty, Sir William Osler performed approximately 1000 postmortem examinations at McGill University in Montreal. He conducted 786 of these examinations during his 7 years (1877-1884) of service as a pathologist at the M were caref...2004-10
6 Kestle, John R. W.Change in ventricular size and effect of ventricular catheter placement in pediatric patients with shunted hydrocephalusOBJECTIVE: The multicenter, randomized pediatric cerebrospinal fluid shunt valve design trial found no difference in the rate of shunt failure between a standard valve, a siphon-reducing valve (Delta; Medtronic PS Medical, Goleta, CA), and a flow-limiting valve (Orbis Sigma; Cordis, Miami, FL); ho...Shunt failure; Valve design; Ventricular size; Ventricular catheter placement1999
7 Couldwell, William T.; Nelson, Don HarryNelson syndrome: historical perspectives and current conceptsThe appearance of an adrenocorticotropic hormone (ACTH)-producing tumor after bilateral adrenalectomy for Cushing disease was first described by Nelson in 1958. The syndrome that now bears his name was characterized by hyperpigmentation, a sellar mass, and increased plasma ACTH levels. The treatment...2007-01-01
8 Kestle, John R. W.Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshopObject. Treatment for hydrocephalus has not advanced appreciably since the advent of cerebrospinal fluid (CSF) shunts more than 50 years ago. Many questions remain that clinical and basic research could address, which in turn could improve therapeutic options. To clarify the main issues facing hydr...Biomedical research2007
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