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1 Kestle, John R. W.Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshopObject. Treatment for hydrocephalus has not advanced appreciably since the advent of cerebrospinal fluid (CSF) shunts more than 50 years ago. Many questions remain that clinical and basic research could address, which in turn could improve therapeutic options. To clarify the main issues facing hydr...Biomedical research2007
2 Couldwell, William T.Conflict and opportunity: neurosurgery and industryThe relationship between neurosurgery and industry is multifaceted. Most aspects of this relationship promote the advancement of a highly technical field such as neurosurgery, helping neurosurgeons bring ever more effective therapies to their patients. However, serious ethical and legal concerns a...2007-01-01
3 Couldwell, William T.Pituitary modelsPituitary tumor animal models provide researchers a microenvironment that simulates the clinical situation; however, in comparison with astrocytoma and meningioma tumor research where intracranial xenograft transplantations are increasingly being used to test various therapeutic modalities, in vivo ...2013-01-01
4 Kestle, John R. W.Potentially useful outcome measures for clinical research in pediatric neurosurgeryThe choice of outcome (or outcomes) and their measurement are critical for a sound clinical trial. Surgeons have traditionally measured simple outcomes such as death, duration of survival, or tumor recurrence but have recently developed more sophisticated measures of the effect of an intervention. M...Pediatric neurosurgery2005
5 Dailey, Andrew T.Lateral mass screw fixation in the cervical spineTo The Editor: We read with interest the article by Kawabata et al.15 (Kawabata S, Watanabe K, Hosogane N, et al: Surgical correction of severe cervical kyphosis in patients with neurofibromatosis Type 1. Report of 3 cases. J Neurosurg Spine 18:274-279, March 2013). Reconstructive spinal surgery has...2014-01-01
6 Couldwell, William T.; Nelson, Don HarryNelson syndrome: historical perspectives and current conceptsThe appearance of an adrenocorticotropic hormone (ACTH)-producing tumor after bilateral adrenalectomy for Cushing disease was first described by Nelson in 1958. The syndrome that now bears his name was characterized by hyperpigmentation, a sellar mass, and increased plasma ACTH levels. The treatment...2007-01-01
7 Couldwell, William T.Development of neurosurgery in Southern California and the Los Angeles County/University of Southern California Medical CenterThe Los Angeles County General Hospital has played an integral role in the development of medicine and neurosurgery in Southern California. From its fledgling beginnings, the University of Southern California School of Medicine has been closely affiliated with the hospital, providing the predomina...Historical vignette; Los Angeles County General Hospital; University of Southern California School of Medicine; Neurosurgical history1993
8 Couldwell, William T.Personal perspective: AANS Bulletin's momentum continues: new editor considers peer review, practice survey impactWith this issue, I assume the reins as editor of the AANS Bulletin. I am indebted to James Bean, MD, for his extraordinary efforts in this capacity, as witnessed by review of the recent issues published under his leadership. An important initiative put forth by Dr. Bean and the Bulletin Advisory Boa...2005
9 Dailey, Andrew T.Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 2: Assessment of functional outcome following lumbar fusionAssessment of functional patient-reported outcome following lumbar spinal fusion continues to be essential for comparing the effectiveness of different treatments for patients presenting with degenerative disease of the lumbar spine. When assessing functional outcome in patients being treated with l...2014-01-01
10 Couldwell, William T.OR noise: the potential for hearing lossWith the use of the electric or air-powered drill in cranial or spinal procedures comes the potential for hearing loss among operating team members. Exposure to loud noise can result in sensorineural hearing loss, and this loss is a function of sound pressure levels and duration of exposure. Much r...2008-01-01
11 Kestle, John R. W.Work hour restrictions: impact on neurosurgical resident training at the University of UtahResident work hour restrictions imposed by the Accreditation Council for Graduate Medical Education became effective on July 1, 2003. To evaluate the effect of these regulations on resident operative experience, we reviewed and compared the surgical experience of junior and senior neurosurgical res...Neurosurgical resident training; Work hour restrictions2006
12 Dailey, Andrew T.Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 9: Lumbar fusion for stenosis with spondylolisthesisPatients presenting with stenosis associated with a spondylolisthesis will often describe signs and symptoms consistent with neurogenic claudication, radiculopathy, and/or low-back pain. The primary objective of surgery, when deemed appropriate, is to decompress the neural elements. As a result of t...2014-01-01
13 Couldwell, William T.Glioma invasionA characteristic pathological feature of malignant glioma cells is their ability to extensively invade surrounding brain parenchyma-particularly along white matter tracts- thus rendering focal therapies incapable of controlling tumor growth and resulting in inevitable recurrence. In this regard, ...2001
14 Dailey, Andrew T.Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 8: Lumbar fusion for disc herniation and radiculopathyPatients suffering from a lumbar herniated disc will typically present with signs and symptoms consistent with radiculopathy. They may also have low-back pain, however, and the source of this pain is less certain, as it may be from the degenerative process that led to the herniation. The surgical al...2014-01-01
15 Schmidt, Meic H.Light-emitting diodes as a light source for intraoperative photodynamic therapyTHE DEVELOPMENT OF more cost-effective light sources for photodynamic therapy of brain tumors would be of benefit for both research and clinical applications. In this study, the use of light-emitting diode arrays for photodynamic therapy of brain tumors with Pholofrin porfimer sodium was investiga...Photodynamic therapy; Brain tumors; Brain tumor therapy; Photofrin; LED1996
16 Dailey, Andrew T.Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 3: Assessment of economic outcomeA comprehensive economic analysis generally involves the calculation of indirect and direct health costs from a societal perspective as opposed to simply reporting costs from a hospital or payer perspective. Hospital charges for a surgical procedure must be converted to cost data when performing a c...2014-01-01
17 Couldwell, William T.Expanding neurosurgeryThe history of medicine is replete with innovations in neurosurgery that have spurred further developments across the medical spectrum. Surgeons treating pathologies in the head and spine have broken ground with new approaches, techniques, and technologies since ancient times. Neurosurgeons occupy a...2014-01-01
18 Schmidt, Meic H.Role of light-emitting diodes for photodynamic therapy of brain tumorsThe development of more effective light sources for Photodynamic Therapy (PDT) of brain tumors would be of benefit for both research and clinical application. In this study, the use of light-emitting diode arrays for PDT of brain tumors with Photofrin® porfimer sodium was investigated. An inflatabl...Aluminum Gallium Arsenide; Photodynamic therapy; Brain tumors; Photofrin1996
19 Dailey, Andrew T.Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 1: Introduction and methodologyFusion procedures are an accepted and successful management strategy to alleviate pain and/or neurological symptoms associated with degenerative disease of the lumbar spine. In 2005, the first version of the "Guidelines for the performance of fusion procedures for degenerative disease of the lumbar ...2014-01-01
20 Couldwell, William T.Stress and burnout: insidious influencesA career in neurosurgery may take a substantial toll on an individual?s body and mind. From the ?baptism by fire? experienced by a brand-new junior resident, to keeping one?s head above water as the residency proceeds, to the realization shortly after graduation of being responsible for the health a...2008-01-01
21 Dailey, Andrew T.; Brodke, Darrel S.Differences between neurosurgeons and orthopaedic surgeons in classifying cervical dislocation injuries and making assessment and treatment decisions: a multicenter reliability studyVariability exists in the management of cervical spinal injuries. The goal of this study was to assess the effect of training specialty (orthopedic surgery vs neurosurgery) on management of cervical dislocations.Cervical dislocation injuries; Classification; Orthopedic surgeons; Orthopaedic surgeons; Assessment decisions; Treatment decisions2008
22 Couldwell, William T.; Gillespie, David L.; Jensen, Randy L.Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysisOvercoming the metabolic restrictions of hypoxia may allow the progression of lower-grade tumors to glioblastoma multiforme. Our findings of up-regulation of HIF-1α and its downstream targets VEGF, GLUT-1, and CAIX in higher-grade gliomas support this hypothesis. We compared the gene expression pro...Glioblastoma multiforme; U-251; Hypoxia; Microarray analysis; Brain tumor; Depp; Astrocytoma2007
23 Dailey, Andrew T.Risk factors for respiratory failure following operative stabilization of thoracic and lumbar spine fracturesBackground: Respiratory failure is a serious complication that can adversely affect the hospital course and survival of multiply injured patients. Some studies have suggested that delayed surgical stabilization of spine fractures may increase the incidence of respiratory complications. However, the...Respiratory failure; Operative stabilization; Thoracic spine; Lumbar spine2006
24 Dailey, Andrew T.; Brodke, Darrel S.; Bachus, Kent N.Anterior cervical fixation: analysis of load-sharing and stability with use of static and dynamic platesBackground: Anterior plates provide stability following decompression and fusion of the cervical spine. Various plate designs have emerged, and they include static plates with fixed-angle screws, rotationally dynamic plates that allow the screws to toggle in the plate, and translationally dynamic pl...Anterior cervical fixation; Load-sharing; Stability; Static plates; Dynamic plates2006
25 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 1: introduction and methodologyAs scientific understanding of the pathophysiology of degenerative disease of the lumbar spine has increased, the possibilities for correcting the underlying problem and the resulting improvement in clinical function have expanded exponentially. Fueled by advances in material technology and surgica...Lumbar fusion; Lumbar spine; Degenerative disease; Practice guidelines2005
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