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1 Dailey, Andrew T.Magnetic resonance neurography for cervical radiculopathy: a preliminary reportMAGNETIC RESONANCE NEUROGRAPHY was used to directly image cervical spinal nerves in patients with clinical and radiographic evidence of cervical radiculopathy. A magnetic resonance imaging phased-array coil system was used to obtain high-resolution coronal T1-weighted spin echo, coronal/axial T2-wei...1996
2 Couldwell, William T.Immunology and immunotherapy of intrinsic glial tumorsImmunological aspects of glial neoplasms have been actively investigated for the past several years with particular focus on academic, diagnostic, and therapeutic objectives. As more knowledge is acquired about the cellular events relating to tumor behavior the more it appears that the immune system...Immunology; Glial tumors1990
3 Couldwell, William T.Malignant glioma-derived soluble factors regulate proliferation of normal adult human astrocytesMalignant gliomas are characteristically surrounded by marked gliosis. To assess whether glioma-derived products contribute to the proliferation of astrocytes, a feature of the gliosis response, we evaluated the influence of culture supernatants from malignant human glioma lines and tumor cyst fluid...Astrocyte; Glioma; Gliosis; Proliferation; Soluble factors1992
4 Couldwell, William T.Transmaxillary approach to the anterior cavernous sinus: a microanatomic studyOBJECTIVE: Several approaches to expose the anterior cavernous sinus have been used, such as frontotemporal, orbitofrontal, anterior subtemporal, and various transfacial approaches. In an effort to gain exposure to the anterior cavernous sinus without necessitating a craniotomy or wide transfacial ...Anterior cavernous sinus; Clivus; Cranial base; Maxillary sinus1997
5 Dailey, Andrew T.Resolution of an actinomycotic abscess with nonsurgical treatment: case reportA CASE OF actinomycotic brain abscess is presented. Conservative treatment by prolonged administration of antibiotics after needle biopsy showed complete resolution of the abscess. Previously reported cases suggest that definitive treatment requires excision or open surgical drainage of the abscess...Actinomycotic abscess; Brain abscess; Actinomyces israelii; Nonsurgical treatment1993
6 Couldwell, William T.Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic applicationProtein kinase C (PKC) is an enzyme involved in the regulation of cellular growth, proliferation, and differentiation in a number of tissues including the anterior pituitary, in which it is also believed to play a role in hormone secretion. Protein kinase C activity and expression have been found to...Apoptosis; Hypericin; Pituitary adenoma; Protein kinase C1996
7 Schmidt, Meic H.Repeated operations for infiltrative low-grade gliomas without intervening therapyProgression of infiltrative low-grade gliomas (LGGs) has been reported previously. The limitations of such studies include diverse histological grading systems, intervening therapy, and the lack of histological confirmation of malignant tumor progression. The aim of this study was to determine tumo...Infiltrative low-grade gliomas; LGG; Tumor progression; Repeated operations; Tumor recurrence2003
8 Couldwell, William T.Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifenPREVIOUS WORK HAS demonstrated the importance of the Protein Kinase C (PKC) signal transduction system in regulating the growth rate of malignant gliomas in vitro. Tamoxifen inhibits PKC in a minority of malignant gliomas within the micromolar concentration range in vitro, a property distinct from...Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Chemotherapy; Glioma1993
9 House, Paul A.; Couldwell, William T.De novo fenestration of the optic nerve case illustration.Fenestration of the optic nerve or chiasm due to the presence of aneurismal dilation of the internal carotid artery (ICA) has been described. In three out of five cases reviewed recently, the optic nerve was penetrated by an ICAΓÇôophthalmic artery aneurysm.3 Penetration of the optic nerve was du...Aneurysm; Congenital Optic Nerve2005-02-01
10 Couldwell, William T.Photophobia in a blind patient: an alternate visual pathwayPhotophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from mult...2006-11
11 Digre, Kathleen B.; Couldwell, William T.; Amini, AminPhotophobia in a blind patient: An alternate visual pathway. Case report.Photophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from multi...Photophobia, Blindness, Signaling Pathway, Pretectal Nuclei, Trigeminal Pathway2006-12-14
12 Couldwell, William T.Intracranial hypotension as a complication of lumbar puncture prior to elective aneurysm clippingBackground: Lumbar dural defects are an uncommon but important cause of persistent intracranial hypotension in the neurosurgical population. We present a case of intracranial hypotension after elective craniotomy due to a lumbar puncture performed 3 weeks earlier. Case Description: A 55‑year‑old...2014-01-01
13 Couldwell, William T.Far-lateral transcondylar approach: surgical technique and its application in neurenteric cysts of the cervicomedullary junctionNeurenteric cysts are rare benign lesions of the central nervous system that are lined by endodermal cell-derived epithelium. Although they occur mostly in the spine, they can occur intracranially, most often in the posterior fossa. Neurenteric cysts that are located in the anterior cervicomedullary...2005
14 Digre, Kathleen B.Serum vitamin A concentration is elevated in idiopathic intracranial hypertension.OBJECTIVE: The primary purpose was to investigate whether serum vitamin A concentration is associated with idiopathic intracranial hypertension (IIH). The secondary aim was to obtain pilot data regarding the amount of vitamin A ingested by patients and controls. BACKGROUND: Vitamin A is an attractiv...Vitamin A; Retinol; Idiopathic intracranial hypertension; Chromatography2007-02-01
15 Dailey, Andrew T.; Moore, Kevin R.Value of MR neurography for evaluating extraspinal neuropathic leg pain: a pictorial essaySummary: Fifteen patients with neuropathic leg pain referable to the lumbosacral plexus or sciatic nerve underwent high-resolution MR neurography. Thirteen of the patients also underwent routine MR imaging of the lumbar segments of the spinal cord before undergoing MR neurography. Using phased-array...MR neurography; Neuropathic leg pain; Extraspinal; Lumbosacral plexus2001
16 Schmidt, Meic H.; Apfelbaum, Ronald I.Chylorrhea: a rare complication of thoracoscopic discectomy of the thoracolumbar junctionThe thoracic duct along with the cisterna chyli is a major lymphatic pathway near the anterior thoracolumbar spine. Despite the fragile nature of the lymphatic system and its proximity to the spinal column, chylorrhea is rarely encountered by spine surgeons. The authors present a unique case of chyl...Chylous leak; Thoracoscopy; Thoracic spine; Thoracoscopic discectomy; Thoracolumbar junction; Chylorrhea2007
17 Kestle, John R. W.Intervertebral disc embolization resulting in spinal cord infarctionA case of spinal cord infarction resulting from embolization of fibrocartilaginous intervertebral disc material is presented. Cases from the literature are reviewed and the theories of pathogenesis are discussed. In all reported cases the diagnosis was not made until postmortem examination.Spinal cord infarction; Nucleus pulposus; Intervertebral disc; Embolization1989
18 Kestle, John R. W.Ventriculoperitoneal shunts in children: indications, equipment and techniquesThe decision to implant a ventriculoperitoneal shunt in a child with ventriculomegaly should not be taken lightly. Once a shunt has been implanted, it is very difficult to determine that it is no longer necessary, and therefore the initial decision is very important. Sometimes the need is obvious, s...2008
19 Couldwell, William T.Communication between malignant glioma cells and vascular endothelial cells through gap junctionsObject. Extensive invasion and angiogenesis are hallmark features of malignant gliomas. Communication between malignant glioma cells and surrounding astrocytes occurs, resulting in transformation of the astrocytic phenotype. In the present study, the authors examined whether malignant glioma cells a...2003-01-01
20 Kestle, John R. W.; Brockmeyer, Douglas LeeOutcomes after decompressive craniectomy for severe traumatic brain injury in childrenObject. Severe traumatic brain injury (TBI) is often accompanied by early death due to transtentorial herniation. Decompressive craniectomy, performed alone or in conjunction with evacuation of the mass lesion, can reduce the incidence of raised intracranial pressure (ICP). In this paper the authors...Traumatic brain injury; Decompressive craniectomy; Pediatric neurosurgery2006
21 Couldwell, William T.Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. a comparison between staurosporine and tamoxifenWE HAVE PREVIOUSLY demonstrated that the proliferation of established human glioma cell lines correlated with protein kinase C (PKC) activity and that a relatively selective PKC inhibitor, staurosporine, inhibits glioma cell proliferation. The purpose of this study was to determine whether low-passa...Staurosporin; Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Glioma cell lines1993
22 Couldwell, William T.; Gottfried, Oren N.Distal ventriculoperitoneal shunt failure secondary to clostridium difficile colitisDistal ventriculoperitoneal shunt obstruction is typically associated with cerebrospinal fluid (CSF) infection, fluid pseudocysts, bowel obstruction, bowel perforation, or improper shunt placement in the abdomen. We describe a unique etiology for distal shunt obstruction secondary to Clostridium di...2005-01-01
23 Couldwell, William T.Distal ventriculoperitoneal shunt failure secondary to Clostridium Difficile ColitisDistal ventriculoperitoneal shunt obstruction is typically associated with cerebrospinal fluid (CSF) infection, fluid pseudocysts, bowel obstruction, bowel perforation, or improper shunt placement in the abdomen. We describe a unique etiology for distal shunt obstruction secondary to Clostridium dif...Shunt Failure2005-03
24 Couldwell, William T.Experience with use of extended length peritoneal shunt cathetersThe placement of a ventriculoperitoneal (VP) shunt is the current treatment of choice for diversion of cerebrospinal fluid associated with hydrocephalus. Although there are a host of reported potential abdominal complications related to the procedure, they are notably uncommon. The authors report t...1996
25 Couldwell, William T.; Schmidt, Meic H.; MacDonald, Joel D.; Jensen, Randy L.Hypophysial transposition (hypophysopexy) for radiosurgical treatment of pituitary tumors involving the cavernous sinusStereotactic radiosurgery (SRS) is performed with increasing frequency in the treatment of residual or recurrent pituitary adenomas. Its major associated risk in these cases of residual or recurrent pituitary tumor adjacent to normal functional pituitary gland is radiation exposure to the pituitary,...Pituitary tumor; Cavernous sinus; Hypopituitarism; Stereotactic radiosurgery; Transsphenoidal surgery; Pituitary transposition2003
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