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Creator | Title | Description | Subject | Date |
| 1 |
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Schmidt, Meic H. | Is vertebral augmentation the right choice for cancer patients with painful vertebral compression fractures? | Cancer-related fractures of the spine are different from osteoporotic ones, not only in pathogenesis but also in natural history and treatment. Higher class evidence now supports offering balloon kyphoplasty to a patient with cancer, provided that the pain is significant in intensity, has a position... | | 2012-01-01 |
| 2 |
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Couldwell, William T. | Sellar and parasellar metastatic tumors | The sellar and parasellar (SPS) region is a complex area rich in vital neurovascular structures a first manifestation of a systemic malignancy. Metastases to this region are rare; breast cancer is the most common source among those that metastasize to the SPS region. Ophthalmoplegia, headache, retro... | | 2012-01-01 |
| 3 |
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Couldwell, William T.; Jensen, Randy L.; Gillespie, David L. | Celecoxib inhibits meningioma tumor growth in a mouse xenograft model | Background: Treatments for recurrent meningiomas are limited. We previously demonstrated universal expression of COX-2 in meningiomas and dose-dependent growth inhibition in vitro with celecoxib, a COX-2 inhibitor. We therefore tested the effects of celecoxib on meningioma growth in a mouse xenograf... | Meningioma; Cyclooxygenase-2; COX-2; Celecoxib | 2007 |
| 4 |
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Couldwell, William T. | Multifocal inflammatory leukoencephalopathy associated with levamisole and 5-fluorouracil: case report | LEVAMISOLE AND 5-FLUOROURACIL have now become the standard chemotherapeutic regimen for patients with Stage 111 colon carcinoma. A case of multifocal inflammatory leukoencephalopathy secondary to levamisole alone or combination of levamisole and 5-fluorouracil is reported. Magnetic resonance imaging... | Autopsy; Levamisole; Multifocal inflammatory leukoencephalopathy | 1994 |
| 5 |
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Couldwell, William T. | Pituitary gland metastasis from adenocarcinoma of the prostate | A case of prostatic carcinoma metastasis to the pituitary gland is reported. The presentation and rarity of such a lesion is addressed. The literature review yielded only isolated case reports of symptomatic brain metastases unassociated with bone disease from adenocarcinoma of the prostate. The man... | Prostate; Pituitary gland; Adenocarcinoma; Metastasis; Transsphenoidal surgery | 1989 |
| 6 |
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Couldwell, William T.; Gillespie, David L. | Ubiquitous expression of cyclooxygenase-2 in meningiomas and decrease in cell growth following in vitro treatment with the inhibitor celecoxib: potential therapeutic application | Object. Meningiomas are the second most common symptomatic primary central nervous system tumor in adults. Findings of epidemiological studies link meningiomas with a history of head trauma, indicating a causal relationship between the inflammatory response and meningioma tumorigenesis. Cyclooxygena... | | 2005-09 |
| 7 |
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Schmidt, Meic H.; Kestle, John R. W. | Treatment of metastatic spinal epidural disease: a review of the literature | Object. Spinal cord compression is one of the most dreaded complications of metastatic cancer. It can lead to a number of sequelae, including pain, spinal instability, neurological deficits, and a reduction in the patient's quality of life. Except in selected circumstances, treatment is palliative. ... | Spinal cord compression; Metastasis; Radiation therapy; Stereotactic radiosurgery | 2003 |
| 8 |
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Digre, Kathleen B.; Blumenthal, Deborah T.; Salzman, Karen L.; Jensen, Randy L.; Dunson, William A. | Early pathologic findings and long-term improvement in anti-Ma2-associated encephalitis. | A 67-year-old man sequentially developed anti-Ma2-associated paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule-assoc... | Paraneoplastic neurologic disorders; Encephalitis; Neoplasm;Herpes Simplex | 2006-07-11 |
| 9 |
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Schmidt, Meic H. | Role of photodynamic therapy in posterior fossa brain tumors: a preclinical study in a canine glioma model | Photodynamic therapy was studied in dogs with and without posterior fossa glioblastomas. This mode of therapy consisted of intravenous administration of Photofrin-II at doses ranging from 0.75 to 4 mg/kg 24 hours prior to laser light irradiation in the posterior fossa. Tissue levels of Photofrin-l... | Brain neoplasm; Posterior fossa; Photodynamic therapy; Glioblastomas; Dog; Photofrin-II; Canine glioma model | 1993 |
| 10 |
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Couldwell, William T. | Astrocytoma cell line | TO THE EDITOR: It has long been established clinically that patients with neurofibromatosis Type 1 (NF1) have an increased susceptibility to develop many central and peripheral tumors. The nature of the genetic alterations underlying NF1 have recently begun to be characterized. It has been demo... | | 2001 |
| 11 |
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Couldwell, William T. | Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. a comparison between staurosporine and tamoxifen | WE HAVE PREVIOUSLY demonstrated that the proliferation of established human glioma cell lines correlated with protein kinase C (PKC) activity and that a relatively selective PKC inhibitor, staurosporine, inhibits glioma cell proliferation. The purpose of this study was to determine whether low-passa... | Staurosporin; Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Glioma cell lines | 1993 |
| 12 |
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Couldwell, William T.; Viskochil, David H.; Fults, Daniel Webster | Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications | NEUROFIBROMATOSIS 1 (NF1) IS A common autosomal dominant disease characterized by complex and multicellular neurofibroma tumors. Significant advances have been made in the research of the cellular, genetic, and molecular biology of NF1. The NF1 gene was identified by positional cloning. The function... | Loss of heterozygosity; Malignant peripheral nerve sheath tumor; Plexiform Neurofibroma; Spinal neurofibroma | 2006 |
| 13 |
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Couldwell, William T. | Metastatic melanoma to the pituitary gland | Metastasis to the pituitary gland is unusual, and occurs most often in patients with carcinomas of the breast or lung. Despite its propensity for spread to the brain, metastatic melanoma has rarely been described within the sella. Methods: We report two cases of malignant melanoma pathologically co... | | 2007 |
| 14 |
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Couldwell, William T. | Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen | PREVIOUS WORK HAS demonstrated the importance of the Protein Kinase C (PKC) signal transduction system in regulating the growth rate of malignant gliomas in vitro. Tamoxifen inhibits PKC in a minority of malignant gliomas within the micromolar concentration range in vitro, a property distinct from... | Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Chemotherapy; Glioma | 1993 |
| 15 |
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Kestle, John R. W.; Brockmeyer, Douglas Lee | Evaluation of the necessity of postoperative imaging after craniosynostosis surgery | Object. Childhood radiation exposure increases the lifetime risk of cancer from an estimated 0.07 to 0.35%. Neurological evaluation of patients after cranial vault reconstruction for synostosis repair is often complicated by pain medication, sedation, intubation, swelling, and dressings; therefore c... | Computed tomography; Cranial vault reconstruction; Pediatric neurosurgery; Radiation dose; Postoperative imaging | 2007 |
| 16 |
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Huang, Lin Eric | HIF-1? mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression | Although tumor progression involves genetic and epigenetic alterations to normal cellular biology, the underlying mechanisms of these changes remain obscure. Numerous studies have shown that hypoxia-inducible factor 1? (HIF-1?) is overexpressed in many human cancers and up-regulates a host of hypoxi... | | |
| 17 |
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Couldwell, William T. | Pituitary models | Pituitary tumor animal models provide researchers a microenvironment that simulates the clinical situation; however, in comparison with astrocytoma and meningioma tumor research where intracranial xenograft transplantations are increasingly being used to test various therapeutic modalities, in vivo ... | | 2013-01-01 |
| 18 |
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Couldwell, William T. | Increased invasive capacity of connexin43-overexpressing malignant glioma cells | Object. Malignant glioma cells, similar to astrocytes, express connexin43 (Cx43) universally but at widely varied levels. Data from previous studies have demonstrated that malignant glioma cells form functional gap junction channels among themselves as well as with astrocytes and that such a communi... | | 2003-12 |
| 19 |
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Couldwell, William T. | Inflammatory pseudotumor of the cavernous sinus and skull base | Inflammatory pseudotumor is a non-neoplastic process of unknown etiology characterized by a proliferation of connective tissue with an inflammatory infiltrate. Intracranial inflammatory pseudotumors classically involve the cavernous sinus but can also occur in the supratentorial or infratentorial c... | Intracranial neoplasm; Pseudotumor; Skull base | 2006 |
| 20 |
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Schmidt, Meic H. | Castleman disease of the spine mimicking a nerve sheath tumor | Castleman disease is a rare lymphoproliferative disease of unknown cause. In most cases, afflicted patients present with a mediastinal mass although the disease may manifest in numerous other sites, including intracranially and rarely intraspinally. The authors report on the case of a 19-year-old wo... | Castleman disease; Nerve sheath tumor | 2007 |
| 21 |
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Schmidt, Meic H. | Repeated operations for infiltrative low-grade gliomas without intervening therapy | Progression of infiltrative low-grade gliomas (LGGs) has been reported previously. The limitations of such studies include diverse histological grading systems, intervening therapy, and the lack of histological confirmation of malignant tumor progression. The aim of this study was to determine tumo... | Infiltrative low-grade gliomas; LGG; Tumor progression; Repeated operations; Tumor recurrence | 2003 |
| 22 |
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Schmidt, Meic H. | Lumbosacral ependymomas: a review of the management of intradural and extradural tumors | Object. The goal of this study was to review the management of intra- and extradural ependymomas. Spinal ependymomas most commonly occur as intramedullary tumors throughout the spinal axis. In the lumbosacral region, ependymomas are most commonly associated with the conus medullaris and cauda equina... | Intradural ependymoma; Extradural ependymoma; Lumbosacral lesion | 2003 |
| 23 |
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Couldwell, William T. | Immunology and immunotherapy of intrinsic glial tumors | Immunological aspects of glial neoplasms have been actively investigated for the past several years with particular focus on academic, diagnostic, and therapeutic objectives. As more knowledge is acquired about the cellular events relating to tumor behavior the more it appears that the immune system... | Immunology; Glial tumors | 1990 |
| 24 |
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Schmidt, Meic H. | NASA light-emitting diode medical program-progress in space flight and terrestrial applications | This work is supported and managed through the NASA Marshall Space Flight Center - SBIR Program. Studies on cells exposed to microgravity and hypergravity indicate that human cells need gravity to stimulate cell growth. As the gravitational force increases or decreases, the cell function responds in... | Terrestrial applications; Cell growth; NASA; Microgravity environment | 2000 |
| 25 |
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Schmidt, Meic H. | Minimally invasive thoracoscopic approach for anterior decompression and stabilization of metastatic spine disease | Object. The choices available in the management of metastatic spine disease are complex, and the role of surgical therapy is increasing. Recent studies have indicated that patients treated with direct surgical decompression and stabilization before radiation have better functional outcomes than thos... | Metastatic spine disease; Minimally invasive surgery; Spinal cord decompression | 2008 |
