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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
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Capecchi, Mario R.; Mansour, Suzanne L.; Thomas, Kirk R. | Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. | Gene targeting--homologous recombination of DNA sequences residing in the chromosome with newly introduced DNA sequences--in mouse embryo-derived stem cells promises to provide a means to generate mice of any desired genotype. We describe a positive nd negative selection procedure that enriches 2,00... | Animals; Clone Cells; Restriction Mapping; Stem Cells | 1988-11-24 |
| 2 |
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Baehr, Wolfgang | Human interstitial retinoid-binding protein. Gene structure and primary structure | Interstitial retinoid-binding protein (IRBP) is synthesized and secreted by rod photoreceptor cells into the interphotoreceptor matrix and is known to bind retinoids and fatty acids. We have used cDNA clones encoding human IRBP to isolate a 15-kilobase genomic fragment that encompasses the complete ... | Molecular Sequence Data; Eye Proteins; Retinol-Binding Proteins; Messenger RNA | 1989-05-15 |
| 3 |
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Creel, Donnell J.; Leventhal, Audie G. | Retinal projections in tyrosinase-negative albino cats | Retinal projections were examined in two tyrosinase-negative albino cats using autoradiographic techniques. Cats from this colony have pink eyes; their retinal pigment epithelium, ciliary body, and iris epithelium are completely devoid of melanin pigment. Test breeding for five generations indicates... | Cats; Albinism; Vision; Autoradiography; Retina | 1982-07 |
| 4 |
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Baehr, Wolfgang | Tissue-specific expression in transgenic mice directed by the 5'-flanking sequences of the human gene encoding interphotoreceptor retinoid-binding protein | Interphotoreceptor retinoid-binding protein (IRBP) is an extracellular protein that has been suggested to participate in the visual process as a carrier for visual retinoids. A chimeric gene composed of the human IRBP promoter fused to the bacterial reporter gene chloramphenicol acetyltransferase (C... | Restriction Mapping; Nucleic Acid Hybridization; Mice; Gene Expression | 1990-05-25 |
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