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Creator | Title | Description | Subject | Date |
| 1 |
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Thomas, Kirk R.; Capecchi, Mario R. | Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian. cell nuclei | We have examined the mechanism of homologous recombination between plasmid molecules coinjected into cultured mammalian cells. Cell lines containing recombinant DNA molecules were obtained by selecting for the reconstruction of a functional Neor gene from two plasmids that bear different amber mutat... | Animals; Cells, Cultured; DNA Restriction Enzymes; Kinetics | 1985-01 |
| 2 |
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Francis, Leslie | Recent developments in genetic diagnosis: some ethical and legal implications | This essay outlines some of the ethical complexities genetic technology poses in two areas of decision-making: when to perform genetic testing and what to do with the information gained from genetic testing. | Genetic Technology; Genetic Testing; Ethics | 1986 |
| 3 |
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Francis, Leslie | Permissiveness and control (Book Review) | A review of the book "Permissiveness and Control". | Books; Philosophy | 1981-10 |
| 4 |
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Capecchi, Mario R.; Mansour, Suzanne L.; Thomas, Kirk R. | Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. | Gene targeting--homologous recombination of DNA sequences residing in the chromosome with newly introduced DNA sequences--in mouse embryo-derived stem cells promises to provide a means to generate mice of any desired genotype. We describe a positive nd negative selection procedure that enriches 2,00... | Animals; Clone Cells; Restriction Mapping; Stem Cells | 1988-11-24 |
| 5 |
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Digre, Kathleen B.; Warner, Judith E. A.; Bernstein, Paul S.; Alder, Stephen C. | Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertension | We quantified vitamin A in the cerebrospinal fluid of patients with idiopathic intracranial hypertension, elevated intracranial pressure of other causes and normal intracranial pressure. Vitamin A could be detected by high-pressure liquid chromatography in most of the specimens. There was a signific... | Chromatography, High Pressure Liquid; Headache | 2002-11 |
| 6 |
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Hunt, Steven C.; Adams, Ted; Hopkins, Paul N.; Hunt, Steven C. | ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes | Adipose triglyceride lipase (ATGL) was recently described to predominantly perform the initial step in triglyceride hydrolysis and therefore seems to play a pivotal role in the lipolytic catabolism of stored fat in adipose tissue. In the first study investigating genetic variations within the ATGL g... | Diabete, Type 2; ATGL; Fat; Triglycerides | 2006 |
| 7 |
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Kriesel, John D.; Spruance, Spotswood L. | Rocky Mountain spotted fever following cardiac transplantation. | ROCKY MOUNTAIN SPOTTED FEVER was first recognized in the early 1 900s in the Snake River Valley of Idaho and the Bitterroot Valley of western Montana.t In 1909, Howard Taylor Ricketts established the ixodid tick as the vector for the disease.2 Following the tick bite, the incubation period aver... | Male; Adult; Humans | 1993 |
| 8 |
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Thomas, Kirk R.; Capecchi, Mario R. | Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei. | Heteroduplexes were prepared from two plasmids, pRH4-14/TK and pRH5-8/TK, containing different amber mutations in the neomycin resistance gene (Neor). The Neor gene was engineered to be expressed in both bacterial and mammalian cells. A functional Neor gene conferred kanamycin resistance to bacteria... | Cell Nucleus; Cells, Cultured; Microinjections | 1985-01 |
| 9 |
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Kriesel, John D.; Maulden, Sarah Annamarie; Spruance, Spotswood L. | Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation. | Herpes simplex viruses (HSVs) infect epithelial cells, become localized in neurons, and can reactivate in response to a variety of stimuli, including ultraviolet light and hyperthermia. The sequence of gene activation during viral replication is known, but the molecular linkage between exogenous sti... | Mice, Inbred BALB C; Tumor Necrosis Factor-alpha; Virus Activation | 1997 |
| 10 |
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Capecchi, Mario R.; Bernstein, Kenneth E.; Thomas, Kirk R. | Targeting genes for self-excision in the germ line | A procedure is described that directs the self-induced deletion of DNA sequences as they pass through the male germ line of mice. The testes-specific promoter from the angiotensin-converting enzyme gene was used to drive expression of the Cre-recombinase gene. Cre was linked to the selectable marker... | Cre-recombinase; Hoxa3; Chimeric mice | 1999-06-15 |
| 11 |
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Kriesel, John D.; Gooch, Willis M.; Pavia, Andrew T. | Invasive sinonasal disease due to Scopulariopsis candida: case report and review of scopulariopsosis. | Sinonasal infection with fungi of the order Mucorales--termed mucormycosis or zygomycosis--is sometimes seen in immunosuppressed patients, including those with diabetic ketoacidosis and malignancy. We describe a case of invasive sinonasal infection with Scopulariopsis candida (not among the Mucorale... | Granulocyte Colony-Stimulating Factor; Itraconazole; Maxillary Sinus | 1994 |
| 12 |
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Kriesel, John D.; Spruance, Spotswood L. | Treatment of herpes simplex labialis. | Recurrent herpes simplex labialis is associated with mild morbidity, but remains a significant problem for people with frequent and/or severe recurrences. Both topical and peroral episodic antiviral treatments of recurrences are modestly effective at reducing the duration of signs and symptoms. Rece... | Randomized Controlled Trials; Steroids; Drug Administration Routes | 2002 |
| 13 |
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Francis, Leslie | In the realm of legal and moral Philosophy; (Book Review) | Reviews the book `In the Realm of Legal and Moral Philosophy;,' by Matthew H. Kramer. | Books; Philosophy | 2001-01 |
| 14 |
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Francis, Leslie | Penn Central Transportation Company v. New York City: easy taking-clause cases make uncertain Law. | In Penn Central Transportation Company v. New York City, the Supreme Court held that New York City's Landmarks Preservation Law as applied to Grand Central Terminal was not a "taking" of property for which compensation is constitutionally required. The decision has been hailed as a major victory for... | Law; Compensation; Property Rights; Landmarks Preservation Law; Supreme Court Rulings | 2006-06-16 |
| 15 |
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Thomas, Kirk R.; Capecchi, Mario R. | Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. | Injection of homologous DNA sequences into nuclei of cultured mammalian cells induces mutations in the cognate chromosomal gene. It appears that these mutations result from incorrect repair of a heteroduplex formed between the introduced and the chromosomal sequence. This phenomenon is termed 'heter... | Animals; Cell Line; Drug Resistance, Microbial; Fibroblasts; Mice; Models, Genetic; Neomycin; Plasmids | 1986-11-06 |
| 16 |
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Francis, Leslie | Eminent domain compensation in the Western states: a critique of the fair market value model | Both the United States Constitution and the constitutions of the states of the intermountain west and the Pacific Coast prohibit the state from taking property without paying just compensation. Thus, there are two basic issues in any eminent domain case. First, has governmental interference with pro... | Eminent domain; Compensation; Governmental interference; Fair Market Value | 2006-06-16 |
| 17 |
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Hunt, Steven C. | Association of egg consumption and calcified atherosclerotic plaque in the coronary arteries: The NHLBI Family Heart Study | Background and Aims: Eggs are a ubiquitous and important source of dietary cholesterol and nutrients, yet their relationship to coronary heart disease (CHD) remains unclear. While some data have suggested a positive association between egg consumption and CHD, especially among diabetic subjects, lim... | | 2014-01-01 |
| 18 |
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Thomas, Kirk R.; Capecchi, Mario R. | Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. | The int-1 proto-oncogene was first identified as a gene activated in virally induced mouse mammary tumours. Expression studies, however, suggest that the normal function of this gene may be in spermatogenesis and in the development of the central nervous system. Genes sharing sequence similarity wit... | Animals; Blastocyst; Cell Line; Chimera; DNA; Female; Genotype; Heterozygote; Homozygote; Male; Mice, Inbred C57BL; Motor Activity | 1990-08-30 |
| 19 |
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Eichwald, Ernst; Capecchi, Mario R.; Thomas, Kirk R. | Mouse model for the delta F508 allele of cystic fibrosis | The most common cause of cystic fibrosis is a mutation that deletes phenylalanine 508 in cystic fibrosis transmembrane conductance regulator (CFTR). The delta F508 protein is misprocessed and degraded rather than traveling to the apical membrane. We used a novel strategy to introduce the delta F508 ... | Digestive System; Disease Models, Animal; Electrolytes; Mice, Inbred C57BL | 1995-10 |
| 20 |
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Francis, Leslie | Justice through trust: disability and the Outlier problem in Social Contract Theory | The article focuses on the flaws of the social contract theory. It explores how hostile the social contract as a bargaining process has been thought to distance disabled people from contract-based justice. It analyzes the argument that the history of social contract theory exclude the people with di... | Consensus, social sciences; Discrimination; Social contract; Social ethics; Sociology of disability | 2005-10 |
| 21 |
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Battin, Margaret P. | Age-rationing and the just distribution of health care: Is there a duty to die? | The author analyzes the argument that a policy involving distributive justice in the allocation of scarce health care resources, based on the strategy of rational self interest maximation under a veil of ignorance (Rawls/Daniels), would result in an age rationing system of voluntary, socially encour... | Health care providers; Death; Euthanasia | 1987-01 |
| 22 |
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Lopansri, Bert; Stoddard, Gregory J.; Hobbs, Maurine R.; Granger, Donald Lee | Elevated plasma phenylalanine in severe malaria and implications for pathophysiology of neurological complications. | Cerebral malaria is associated with decreased production of nitric oxide and decreased levels of its precursor, l-arginine. Abnormal amino acid metabolism may thus be an important factor in malaria pathogenesis. We sought to determine if other amino acid abnormalities are associated with disease sev... | Dystonia; Phenylalanine Hydroxylase; Tyrosine | 2006-06-01 |
| 23 |
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Battin, Margaret P. | Death ethics: religious and cultural values in prolonging and ending life (book review) | A review of the book "Death Ethics: Religious and Cultural Values in Prolonging and Ending Life" by Kenneth L. Vaux. | Books; Life; End of life | 1994-07 |
| 24 |
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Thomas, Kirk R. | Cytochrome P450 2B diversity and dietary novelty in the herbivorous, desert woodrat (Neotoma lepida) | Detoxification enzymes play a key role in plant-herbivore interactions, contributing to the on-going evolution of ecosystem functional diversity. Mammalian detoxification systems have been well studied by the medical and pharmacological industries to understand human drug metabolism; however, little... | | 2012-01-01 |
| 25 |
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Francis, Leslie | Roles of the family in making health care decisions for incompetent patients | This article is about the roles of the family in making health care decisions for incompetent patients. It argues that complex moral reasons call for the participation of families in decision making for incompetents. However, these moral reasons do not support a single model of the family's role for... | Family; Health Care Decisions; Patients; Family Rights | 2006-06-16 |
