You've searched: Department: "Internal Medicine" Collection: "ir_uspace"
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1 Griffiths, Marie M.; Sawitzke, Allen D.; Cannon, Grant W.Exacerbation of collagen-induced arthritis in rats by rat cytomegalovirus is antigen-specific.Collagen-Induced Arthritis (CIA) is an experimentally induced and genetically controlled animal model of chronic joint inflammation. In rats, there are informative strain differences in susceptibility to CIA. DA rats (RT1avl) develop severe CIA after immunization with bovine (BII), chick (CII), or h...Autoimmunity; Flow Cytometry; Rats, Inbred Strains; Sex Factors1994
2 Francis, LeslieJustice through trust: disability and the Outlier problem in Social Contract TheoryThe article focuses on the flaws of the social contract theory. It explores how hostile the social contract as a bargaining process has been thought to distance disabled people from contract-based justice. It analyzes the argument that the history of social contract theory exclude the people with di...Consensus, social sciences; Discrimination; Social contract; Social ethics; Sociology of disability2005-10
3 Thomas, Kirk R.; Capecchi, Mario R.Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.Injection of homologous DNA sequences into nuclei of cultured mammalian cells induces mutations in the cognate chromosomal gene. It appears that these mutations result from incorrect repair of a heteroduplex formed between the introduced and the chromosomal sequence. This phenomenon is termed 'heter...Animals; Cell Line; Drug Resistance, Microbial; Fibroblasts; Mice; Models, Genetic; Neomycin; Plasmids1986-11-06
4 Francis, LeslieRecent developments in genetic diagnosis: some ethical and legal implicationsThis essay outlines some of the ethical complexities genetic technology poses in two areas of decision-making: when to perform genetic testing and what to do with the information gained from genetic testing.Genetic Technology; Genetic Testing; Ethics1986
5 Battin, Margaret P.Death ethics: religious and cultural values in prolonging and ending life (book review)A review of the book "Death Ethics: Religious and Cultural Values in Prolonging and Ending Life" by Kenneth L. Vaux.Books; Life; End of life1994-07
6 Thomas, Kirk R.; Capecchi, Mario R.Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian. cell nucleiWe have examined the mechanism of homologous recombination between plasmid molecules coinjected into cultured mammalian cells. Cell lines containing recombinant DNA molecules were obtained by selecting for the reconstruction of a functional Neor gene from two plasmids that bear different amber mutat...Animals; Cells, Cultured; DNA Restriction Enzymes; Kinetics1985-01
7 Capecchi, Mario R.; Mansour, Suzanne L.; Thomas, Kirk R.Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes.Gene targeting--homologous recombination of DNA sequences residing in the chromosome with newly introduced DNA sequences--in mouse embryo-derived stem cells promises to provide a means to generate mice of any desired genotype. We describe a positive nd negative selection procedure that enriches 2,00...Animals; Clone Cells; Restriction Mapping; Stem Cells1988-11-24
8 Lopansri, Bert; Stoddard, Gregory J.; Hobbs, Maurine R.; Granger, Donald LeeElevated plasma phenylalanine in severe malaria and implications for pathophysiology of neurological complications.Cerebral malaria is associated with decreased production of nitric oxide and decreased levels of its precursor, l-arginine. Abnormal amino acid metabolism may thus be an important factor in malaria pathogenesis. We sought to determine if other amino acid abnormalities are associated with disease sev...Dystonia; Phenylalanine Hydroxylase; Tyrosine2006-06-01
9 Digre, Kathleen B.; Warner, Judith E. A.; Bernstein, Paul S.; Alder, Stephen C.Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertensionWe quantified vitamin A in the cerebrospinal fluid of patients with idiopathic intracranial hypertension, elevated intracranial pressure of other causes and normal intracranial pressure. Vitamin A could be detected by high-pressure liquid chromatography in most of the specimens. There was a signific...Chromatography, High Pressure Liquid; Headache2002-11
10 Hunt, Steven C.Association of egg consumption and calcified atherosclerotic plaque in the coronary arteries: The NHLBI Family Heart StudyBackground and Aims: Eggs are a ubiquitous and important source of dietary cholesterol and nutrients, yet their relationship to coronary heart disease (CHD) remains unclear. While some data have suggested a positive association between egg consumption and CHD, especially among diabetic subjects, lim...2014-01-01
11 Eichwald, Ernst; Capecchi, Mario R.; Thomas, Kirk R.Mouse model for the delta F508 allele of cystic fibrosisThe most common cause of cystic fibrosis is a mutation that deletes phenylalanine 508 in cystic fibrosis transmembrane conductance regulator (CFTR). The delta F508 protein is misprocessed and degraded rather than traveling to the apical membrane. We used a novel strategy to introduce the delta F508 ...Digestive System; Disease Models, Animal; Electrolytes; Mice, Inbred C57BL1995-10
12 Nebeker, Jonathan R.; Samore, Matthew HHypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the research on adverse drug events and reports (RADAR) projectOBJECTIVES: We undertook the review of all available cases of hypersensitivity reactions after placement of a drug-eluting stent (DES) and classified potential causes. BACKGROUND: Six months after the approval of the first DES, the Food and Drug Administration (FDA) reported 50 hypersensitivity reac...Drug Hypersensitivity; Coronary Vessels2006
13 Griffiths, Marie M.; Cole Barry C.; Cannon, Grant W.T-cell receptors and collagen induced arthritis in H-2r mice.Mouse strains B10, B10.RIII, RIIIS/J and the F1 and backcross progeny arising from them were tested for susceptibility to porcine type II collagen-induced arthritis (PII-CIA). The clinically severe arthritis of rapid onset that is characteristic of PII-immunized B10.RIII mice developed predominantly...Genotype; Mice, Inbred C57BL; Sex Characteristics; T-Lymphocytes1993
14 Digre, Kathleen B.; Gouw, Launce G.; Harris, Catherine P.; Haines, John H.; Ptacek, L.J.Autosomal dominant cerebellar ataxia with retinal degeneration: clinical, neuropathologic, and genetic analysis of a large kindred.The autosomal dominant cerebellar ataxias (ADCA) comprise a heterogeneous group of neurologic disorders characterized by degeneration of the cerebellum, spinal cord, and brainstem. Genetic analysis has revealed two loci, SCA1 on chromosome 6p, and SCA2 on chromosome 12q, responsible for some ADCA. W...Retinal Degeneration; Cerebellar Ataxia; Genetic Analysis1994-08
15 Francis, LeslieRoles of the family in making health care decisions for incompetent patientsThis article is about the roles of the family in making health care decisions for incompetent patients. It argues that complex moral reasons call for the participation of families in decision making for incompetents. However, these moral reasons do not support a single model of the family's role for...Family; Health Care Decisions; Patients; Family Rights2006-06-16
16 Nebeker, Jonathan R.pSCANNER: Patient-centered scalable national network for effectiveness researchThis article describes the patient-centered Scalable National Network for Effectiveness Research (pSCANNER), which is part of the recently formed PCORnet, a national network composed of learning healthcare systems and patient-powered research networks funded by the Patient Centered Outcomes Research...2014-01-01
17 Kriesel, John D.; Gooch, Willis M.; Pavia, Andrew T.Invasive sinonasal disease due to Scopulariopsis candida: case report and review of scopulariopsosis.Sinonasal infection with fungi of the order Mucorales--termed mucormycosis or zygomycosis--is sometimes seen in immunosuppressed patients, including those with diabetic ketoacidosis and malignancy. We describe a case of invasive sinonasal infection with Scopulariopsis candida (not among the Mucorale...Granulocyte Colony-Stimulating Factor; Itraconazole; Maxillary Sinus1994
18 Kriesel, John D.; Spruance, Spotswood L.Treatment of herpes simplex labialis.Recurrent herpes simplex labialis is associated with mild morbidity, but remains a significant problem for people with frequent and/or severe recurrences. Both topical and peroral episodic antiviral treatments of recurrences are modestly effective at reducing the duration of signs and symptoms. Rece...Randomized Controlled Trials; Steroids; Drug Administration Routes2002
19 Battin, Margaret P.Textbook of healthcare ethics (Book Review)Reviews the book `Textbook of Healthcare Ethics,' by Erich H. Loewy.Books; Ethics; Healthcare2001-09-17
20 Cannon, Grant W.; Clegg, Daniel O.; Moncur, Carolee; Willardson, DebraInter-observer reliability of the Spondylitis Functional Index Instrument for assessing spondylarthropathies.OBJECTIVE: To study the Spondylitis Functional Index (SFI) by having two physical therapists observe patients with spondylitis perform various tasks listed on the instrument. The physical therapists' observations were compared with each other and with the self-reported abilities of the patients. ...Spondylitis Functional Index (SFI); physical therapists; sulfasalazine1996-06
21 Drews, Frank; Westenskow, Dwayne R.; Agutter, James A.; Strayer, David LeeDevelopment and evaluation of a anesthesia drug displayBACKGROUND: Usable real-time displays of intravenous anesthetic concentrations and effects could significantly enhance intraoperative clinical decision-making. Pharmacokinetic models are available to estimate past, present, and future drug effect-site concentrations, and pharmacodynamic models are a...Blood Pressure; Computer Graphics; Patient Simulation2002-03
22 Hobbs, Maurine R.; Granger, Donald LeeInducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic populationPolymorphisms in the inducible nitric oxide synthase gene (NOS2) promoter have been associated with clinical outcome from malaria. These include a CCTTT repeat (CCTTTn) 2.5 kilobases upstream from the NOS2 transcription start site, and two single nucleotide substitutions: G-->C at position -954 (G-9...Papua New Guinea; Oceanic Ancestry Group; Repetitive Sequences, Nucleic Acid2003
23 Capecchi, Mario R.; Bernstein, Kenneth E.; Thomas, Kirk R.Targeting genes for self-excision in the germ lineA procedure is described that directs the self-induced deletion of DNA sequences as they pass through the male germ line of mice. The testes-specific promoter from the angiotensin-converting enzyme gene was used to drive expression of the Cre-recombinase gene. Cre was linked to the selectable marker...Cre-recombinase; Hoxa3; Chimeric mice1999-06-15
24 Francis, LesliePermissiveness and control (Book Review)A review of the book "Permissiveness and Control".Books; Philosophy1981-10
25 Thomas, Kirk R.; Capecchi, Mario R.Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei.Heteroduplexes were prepared from two plasmids, pRH4-14/TK and pRH5-8/TK, containing different amber mutations in the neomycin resistance gene (Neor). The Neor gene was engineered to be expressed in both bacterial and mammalian cells. A functional Neor gene conferred kanamycin resistance to bacteria...Cell Nucleus; Cells, Cultured; Microinjections1985-01
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