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Capecchi, Mario R. | Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein. | The 180-amino acid core of the TATA-binding protein (TBPcore) is conserved from Archae bacteria to man. Vertebrate TBPs contain, in addition, a large and highly conserved N-terminal region that is not found in other phyla. We have generated a line of mice in which the tbp allele is replaced with a v... | Mice, Knockout; Cells, Cultured; Fibroblasts; Embryo | 2003-02-21 |
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