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| Creator | Title | Description | Subject | Date | ||
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Capecchi, Mario R. | Housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. | Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism occurring in most cell types. However, this housekeeping gene is expressed at very high levels in a number of mammalian tissues including the lactating mammary epithelium, suggesting additional roles for XOR in these tiss... | Body Weight; Cell Differentiation; Cell Membrane; Epithelium | 2002-12-15 |
| 2 |
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Capecchi, Mario R. | Xanthine oxidoreductase is central to the evolution and function of the innate immune system. | The housekeeping enzyme xanthine oxidoreductase (XOR) has been studied intensively over the past 100 years, yet the complexity of its in vivo function is still poorly understood. A large body of literature focuses on the different catalyltic forms of XOR and their importance in the synthesis of reac... | Animals; Gene Expression Regulation, Enzymologic; Humans; Immune System; Models, Biological | 2003-09-01 |
| 3 |
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Capecchi, Mario R. | Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice | While nephrologists often observe reduced hematocrit associated with inhibitors of angiotensin-converting enzyme (ACE), the basis for this effect is not well understood. We now report that two strains of ACE knockout mice have a normocytic anemia associated with elevated plasma erythropoietin levels... | ACE | 2000-10-31 |
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