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| Creator | Title | Description | Subject | Date | ||
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Kriesel, John D.; Spruance, Spotswood L. | Treatment of herpes simplex labialis. | Recurrent herpes simplex labialis is associated with mild morbidity, but remains a significant problem for people with frequent and/or severe recurrences. Both topical and peroral episodic antiviral treatments of recurrences are modestly effective at reducing the duration of signs and symptoms. Rece... | Randomized Controlled Trials; Steroids; Drug Administration Routes | 2002 |
| 2 |
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Kriesel, John D.; Spruance, Spotswood L.; Daynes, Raymond A. | Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease. | Nucleic acid vaccinations with plasmids pWW65, containing the sequence for herpes simplex type 2 (HSV-2) gD2, and pRSVnt, lacking the gD sequence, were studied. Groups of mice were immunized with pWW65 alone, pWW65 plus 1,25-dihydroxyvitamin-D3 (D3), or pRSVnt. Clinical disease (vaginitis), serum an... | Mice, Inbred BALB C; Plasmids; Viral Vaccines | 1996 |
| 3 |
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Kriesel, John D.; Maulden, Sarah Annamarie; Spruance, Spotswood L. | Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation. | Herpes simplex viruses (HSVs) infect epithelial cells, become localized in neurons, and can reactivate in response to a variety of stimuli, including ultraviolet light and hyperthermia. The sequence of gene activation during viral replication is known, but the molecular linkage between exogenous sti... | Mice, Inbred BALB C; Tumor Necrosis Factor-alpha; Virus Activation | 1997 |
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