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1 Kriesel, John D.; Spruance, Spotswood L.Treatment of herpes simplex labialis.Recurrent herpes simplex labialis is associated with mild morbidity, but remains a significant problem for people with frequent and/or severe recurrences. Both topical and peroral episodic antiviral treatments of recurrences are modestly effective at reducing the duration of signs and symptoms. Rece...Randomized Controlled Trials; Steroids; Drug Administration Routes2002
2 Kriesel, John D.; Spruance, Spotswood L.; Daynes, Raymond A.Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease.Nucleic acid vaccinations with plasmids pWW65, containing the sequence for herpes simplex type 2 (HSV-2) gD2, and pRSVnt, lacking the gD sequence, were studied. Groups of mice were immunized with pWW65 alone, pWW65 plus 1,25-dihydroxyvitamin-D3 (D3), or pRSVnt. Clinical disease (vaginitis), serum an...Mice, Inbred BALB C; Plasmids; Viral Vaccines1996
3 Kriesel, John D.; Spruance, Spotswood L.Rocky Mountain spotted fever following cardiac transplantation.ROCKY MOUNTAIN SPOTTED FEVER was first recognized in the early 1 900s in the Snake River Valley of Idaho and the Bitterroot Valley of western Montana.t In 1909, Howard Taylor Ricketts established the ixodid tick as the vector for the disease.2 Following the tick bite, the incubation period aver...Male; Adult; Humans1993
4 Kriesel, John D.; Maulden, Sarah Annamarie; Spruance, Spotswood L.Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation.Herpes simplex viruses (HSVs) infect epithelial cells, become localized in neurons, and can reactivate in response to a variety of stimuli, including ultraviolet light and hyperthermia. The sequence of gene activation during viral replication is known, but the molecular linkage between exogenous sti...Mice, Inbred BALB C; Tumor Necrosis Factor-alpha; Virus Activation1997
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