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1 Godfrey, RoseA porcine model for the development and testing of preoperative skin preparationsClinical preoperative skin preparations (PSPs) do not eradicate skin flora dwelling in the deepest dermal regions. Survivors constitute a persistent infection risk. In search of solutions, we created a porcine model intended for PSP developmental testing. This model employed microbiological techniqu...2022
2 Arave, Rowan A.AKT1 activation promotes the development of melanoma metastasisMetastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu...Melanoma - Genetics - Research; Metastasis - Genetics - Research; Biochemistry; Genetics2015-12
3 Arnoholt, AlaynaAn analysis on the influence of anxiety in post error slowingAnxiety disorders are among the most common mental disorders and affect 15.7 million Americans each year (Lépine, 2002, p. 4). Anxiety is associated with reduced productivity, physical distress, and other diseases such as depression. Anxiety could also be influential in error response (Compton et a...2021
4 Zhu, JudyAnalysis of the pH-dependent equilibrium relationship between the guanine oxidation products 5-guanidinohydantoin and iminoallantoinOxidation of 2'-deoxyguanosine (dG) results in the major two-electron product 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) that can undergo further oxidation to other products. One such product is 5-guanidinohydantoin (dGh) that is highly mutagenic and has been found in vivo. The ring architecture of d...Oxidation; guanine oxidation products; 5-guanidinohydantoin; Iminoallantoin; Equilibrium relationship2015-05
5 Edwards, Jennifer LynnApplication of a TBHP-mediated Wacker-type oxidation to internal alkenesThe Wacker oxidation allows access to methyl ketones from terminal alkenes. This transformation is important for industrial, synthetic, and medicinal chemists, as carbonyls are present in many natural and pharmaceutical products. With the carbonyl, a wide variety of reactions become available, such ...Wacker-type oxidatioin - Research; TBHP2013-05
6 Pecchia-Bekkum, AnnikaApplications of controlled DNA assembly and disassembly in biosensing and responsive drug deliveryDeoxyribonucleic acid (DNA) provides many exciting functions outside of simply encoding genetic information. Herein, we report two techniques to control the assembly and disassembly of nucleic acids. Within these techniques, DNA is used as a programmable material for biosensing and drug delivery. In...Nucleic acids - Biotechnology2013-08
7 Burga, Carlos AlbertoBinary superlattices of semiconductor nanocrystals : a path towards possible high-temperature superconductivityThis thesis provides a platform to experimentally test Dr. Daniel Mattis' theoretical work on the possible superconductive behavior of nanostructured intrinsic semiconductors1-2. The theoretical work hinged on the nano-scale architecture of semiconductors. Therefore, using various types of semicondu...Semiconductor nanocrystals; Superconductivity; Superlattices as materials2013-05
8 Rose, StevenBiofuel cells for self powered arsenic detectionResearch in the Minteer group has centered on procedures for immobilizing enzymes and organelles on carbon electrodes for use in sensory and fuel cell applications. Similar strategies have been used to prepare a series of electrodes capable of pyruvate oxidation which, in the presence of arsenic, wi...Fuel cells; Arsenic - Detection2013-05
9 Galinat, ShelbyBipyrimidine solubility modeling for applications in NON-Aqueous redox flow batteriesEnergy storage research has undergone transformative changes in the past 50 years. The increasingly concerning threat of climate change has emphasized the need for energy storage technology to facilitate renewable energy incorporation into the grid. Without energy storage, the fluctuations of wind a...2022
10 Simonsen, KyleBreast cancer knowledge and attitudes among women in ArmeniaBackground: Breast cancer, the most common invasive cancer among women, has high incidence and mortality rates among women in the Republic of Armenia. Advanced stage at detection limits treatment options and contributes to high morbidity and mortality. Understanding women's breast cancer knowledge a...Breast - Cancer; Breast - Cancer - Patients - Attitudes; Breast - Cancer - Patients - Armenia (Republic)2013-07
11 Visser, JoshuaCharacterization of G-quadruplexes in DNA repair protein gene sequences and the effects of oxidized guanine lesions on DNA base insertion and elongationGuanine (G) is one of the four nucleo bases that make up the complex macromolecule deoxyribonucleic acid (DNA). In addition to its ability to Watson-Crick base pair with cytidine (C), guanine can base pair with itself vianon-canonical, Hoogsteen base pairing and form a secondary structure of DNA ca...DNA repair - Research; G proteins - Pathophysiology - Research; Oxidation, Physiological - Research; Membrane homogenization; Synthetic blood; Artificial oxygen carriers2016-05
12 Nicolo, TeraCharacterization of mitochondria-modified electrodesIn order to develop an herbicide sensor, yeast, potato, and bovine heart mitochondria were isolated and immobilized onto Toray paper electrodes. Cyclic voltammetry showed two redox peaks at 186 ± 14 mV vs. SCE and -357 ± 24 mV vs. SCE with an E1/2 of -128 mV. Scan rate studies suggested the proces...Electrodes; Herbicides - Detection2013-05
13 Odendahl, NathanComparison of popular force fields for molecular modeling of proteins applied to ice binding of the tenebrio molitor antifreeze proteinIce Binding Proteins (IBPs) are a class of proteins that affect the melting and freezing temperatures of ice. While substantial research has been conducted to understand the properties of IBPs, experimental and molecular dynamics simulations have not satisfactorily explained the mechanism of the i...Antifreeze proteins - Research; Ice binding proteins; Tenebrio molitor; Antifreeze protein; Force fields2016-04
14 Besic, ArnelCreation and characterization of organic mixed conductorsOrganic mixed ionic electronic conductors (OMIECs) are conjugated polymers that conduct both ions and electrons. These materials are promising for applications in healthcare and energy technologies, including biosensors and batteries. An obstacle for using these materials in next-generation technolo...2024
15 Peterson, Joseph RyanDeflagration and detonation modeling of heterogeneous condensed phase explosivesA modeling approach to the deflagration and detonation phenomena is employed to study a variety of explosive scenarios. An engineering model for macroscale reaction of energetic materials over the wide range of explosive reaction from deflagration to detonation is developed based upon solid foundati...Deflagration phenomena; Detonation phenomena; mesoscale model2012-05
16 Lim, Koun (Kasha)Deglycoyslation of glucose oxidase and its application within high power enzymatic fuel cellsTo compensate for the increase of carbon dioxide level and the energy exhaust, an enzymatic fuel cell (EFC) has been investigated by researchers. In the paper, a chemical oxidative deglycosylation of an enzyme was investigated to furture improve EFCs. By deglycosylating an enzyme, the distance betwe...Fuel cells - Research; Electric power - Research; Deglycosylation; Enzymatic fuel cell; Glucose oxidase2016-04
17 Munn, JacksonDetermining microbial community composition and methane flux or red butte canyon sediment over timeMethane is a potent greenhouse gas that is released from the soil into the atmosphere, which contributes heavily to global warming. One potential way of reducing the amount of methane in the air is through studying methane consuming bacteria (methanotrophs) and how they interact with other microbes ...2022
18 Sanders, SaraDevelopment of a novel, coumarin-europium sensor for reactive oxidizing speciesThe synthetic framework has been developed for two fluorescent probes of Reactive Oxidizing Species (RoxS) based on a coumarin-europium fluorescence pair. The coumarin moiety's selectivity for hydrogen peroxide coupled with 620 nm shifted emission of the europium will make these novel sensors biolog...Reactive Oxygen Species - analysis2012-05
19 Lutz, KevinDiscovery of platinum (II) cocrystals with highly fluorinated cyanocarbonsThis thesis investigates new platinum(II) complex cocrystals with highly fluorinated cyanoaromatics. While π stacking compounds of polycyclic aromatic hydrocarbons and cyanoaromatics have been reported, interactions with transition metal complexes have yet to be explored. Crystal structures for (pp...2023
20 Kent, AlexandraDNA split aptamers as a biosensing platform for the detection of small drug moleculesPrescription drug overdose and abuse is a leading cause of death in the United States. It is a serious issue and has become increasingly problematic as opioids are being prescribed with a higher frequency. For this reason, fast, accurate detection of small drug molecules is crucial. The current stan...Drug testing; Biosensors; DNA split aptamers
21 Kim, Alexander H.DPP Signal Regulation Through O-Linked GlycosylationDorsal closure in Drosophila is an embryogenic event that involves coordinated cellular shape changes. A series of interconnected signaling cascades are utilized to accomplish this task, one of which is the Decapentaplegic (Dpp) pathway. Dpp is a member of the TFG-β family of secreted cytokines, wh...2017
22 Ballif, MicahDrugs and Pregnancy: Clinical Management with a Cystic Fibrosis FocusDespite the large number of women who become pregnant and use a medication during their pregnancy, there is very little information about the safety of the majority of medications. Most drugs approved by the FDA have undetermined teratogenic risk, but their use is prevalent in the management of dise...2019
23 Eric SchmidtEffects of carbon sources on secondary metabolite production by teredinibacter turnerae2023
24 Bischoff, AmandaElucidating the Mechanism and Predicting the Selectivity of the bis(Pyridine) Silver Permanganate OxidatiinThe Movassaghi group has recently reported several total syntheses of epipolythiodiketopiperazine derivatives (ETPs), a class of natural products with potent biological activity. A crucial step in their synthesis oxidizes two to four tertiary C-H bonds to form tertiary alcohols using (bis)pyridine s...2016
25 Cocke, Rebecca C.Evaluating the Catalytic Activity of Iron and Nickel Impurities in Bare High-Pressure High-Temperature NanodiamondMany metal nanoparticles are used as catalysts for various reactions and are held on supports. High-Pressure High-Temperature nanodiamonds (HPHT ND) are able to support metal nanoparticles even under strenuous chemical environments due to their robust nature. The production of HPHT ND includes the u...2018
26 Fernandez, FlorenceEvaluation of environmental education in high school science courses across Salt Lake City, UtahWhile the effects of pollution become Incredibly more evident in the air of the Salt Lake Valley, many Utah high school students still lack the knowledge and information necessary to take preventative and immediate actions to protect their health and their environment. In this study, the reasons for...Environmental education -- Utah -- Salt Lake City; Science -- Study and teaching -- Utah -- Salt Lake City; Air -- Pollution -- Utah -- Salt Lake City2015-05
27 Fan, HuijunExamination of Y-Deterium isotope effects for the solvolysis of model isoprenoid compoundsModel isoprenoid compounds can undergo two distinct pathways, dissociative or associative nucleophilic substitution depending on the conditions used. The dissociative pathway consists of two steps, involving a carbocation intermediate where the formation of that carbocation is rate determining. The ...Isopentenoids; Solvolysis; Deuterium - Isotopes2012-05
28 Spurlock, Ella K.Exploration of the 2-dimensional π-d conjugated coordination polymer Cu-benzenehexathoilCoordination polymers (CPs) are a type of atomically precise material that has long been an area of study for materials chemists. Recently, research has advanced with twodimensional conjugated CPs as detailed synthetic schemes are developed to create highly atomically ordered, large-area sheets. The...2022
29 Coplan, Caitlin DeniseFabrication and Application of Aluminum NanostructuresPlasmonics, the phenomenon resulting from light interactions with nanoscale structures, is an active field for nanoscale manipulation of light. By varying the metal, size, and shape, plasmonic nanostructures can be tuned to interact with a broad spectral range of light. Commonly used plasmonic mater...2019
30 Borodai, Anastasia S.Faraday @ Home Continuing Faraday from the "U" to the YouthRecent attention has been brought to light in the United States regarding the lack of students pursuing STEM disciplines and degree programs. There is a considerable amount of research on the importance of STEM (Science, Technology, Engineering and Math) Education at an early onset age. With this is...2017
31 Ridge, Rachel KatherineFlagellar Protein Flhe Influences Motility and Morphology Through Regulation of Assembly in Escherichia ColiThe bacterial flagellar motor is a remarkably complex system, comprising thousands of protein subunits and responsible for motility in numerous species. Of these proteins, FlhE is not universally conserved and is relatively understudied. Usually found cotranscribed with flhB and flhA in the flhBAE o...2017
32 Narasipura, Eshan AmruthFull synthesis of enzymatically cleavable linker between 929-designed ankyrin repeat protein and 17-dimethlyamino geldanamycinTargeted cancer therapeutics are an important and promising field of cancer research due to their ability to reduce the off target effects produced in other therapies such as chemotherapy. Antibody Drug Conjugates (ADC) are one such therapeutic that specifically target cancer cells through antibody-...2021
33 Capener, JacobG Protein-Coupled resecptor kinase 2 mediated phosphorylation for The Activation of SmoothenedThe Hedgehog (Hh) pathway is a cell signaling pathway that is involved in embryonic development and adult tissue maintenance in vertebrates. Improper functioning of this pathway can lead to developmental disorders and several forms of cancer. Despite the pathway's biological importance, the transduc...2020
34 Jones, Kathryn K.Hybrid Enzyme-Bimetallic Nanoparticle System for Tandem Oxidation CatalysisMetallic nanoparticles are commonly used as catalysts in industrial and academic settings. Recent observations that bimetallic nanoparticles can have enhanced activity over their monometallic counterparts has increased the interest in their synthesis and application to new catalytic systems. Combini...2020
35 Black, AlyssaIdentifying hybrid male sterility genes in Drosophila PseudoobscuraSpeciation, the process of one species splitting into two separate species, often involves the evolution of hybrid sterility or hybrid inviability. These reproductive isolating barriers are caused by negative interactions between genes called hybrid incompatibilities. Identifying hybrid incompatibil...Infertility, Male -- Genetic aspects Drosophila pseudoobscura -- Genetics Male sterility genes2015-05
36 Khuu, ScottIdentifying Retinoic Acid Dependent Mechanisms of Neural Crest Epithelial-Mesenchymal TransitionCancer metastasis is one of the distinguishing traits that make the disease difficult to treat. The steps of tumor invasion are similar to a process called epithelial to mesenchymal transition (EMT). Retinoic acid (RA) is shown to inhibit EMT and may cause an increased transcription of the gene, ski...2017
37 Owen, Cameron J.Infrared Multiple Photon Dissociation Spectroscopy and Guided Ion Beam Tandem Mass Spectrometry: Experimental and Theoretical investigations of Transition Metal and Lanthandie CationsEmployment of Free Electron Lasers (FELs) and a Guided Ion Beam Tandem Mass Spectrometer (GIBMS) has allowed for the spectroscopic and spectrometric investigations of a variety of ionic complexes, respectively. The data presented in Chapters 2 and 3 of this thesis were obtained using two FELs locate...2019
38 Hansen, MasonInterferon gamma inducible nampt and its role in resisting cancer cell growthThe tumor microenvironment (TME) is very complex and important due to its ability to influence the response of therapies on tumors. Immune cells infiltrate the TME and secrete inflammatory cytokines, such as interferon-gamma (IFNg), which help activate the immune system. This activation leads to an ...2023
39 Zurbuchen, RudiMacrocyclization of glucagon-like peptide (GLP-1) by thiol-ene reactionMacrocyclization of peptides helps maintain a stable alpha helical structure using a conformational constraining staple. One such peptide, glucagon-like peptide-1 (GLP-1), is a 37 amino acid peptide agonist for the GLP-1 receptor and has the ability to lower blood glucose levels and is responsible ...Peptide hormones - Receptors - Research; Ring formation (Chemistry) - Research; Macrocyndization; GLP-1; Swim kinematics; Pre-pulse inhibition2016-05
40 Franchina, Jordan AveryMeasurement of bond dissociation energies of transition metal moleculesMeasuring thermochemical and kinetic properties of chemical systems has always; been a central theme of chemistry. Knowing these properties assists us in assessing; whether or not a chemical reaction is energetically feasible, efficient, and worthwhile.; Theoretical chemistry has now developed suffi...Chemical systems; thermochemical; kinetic; modeling2018-04
41 Wang, Alisonmechanistic studies of the electrocatalytic reducation of Co2 to Co: a BPY-MN(CO)3coome model2023
42 Scholl, WallisNanomite-Decorated Nanoparticles as Surface-Enhanced Spectroscopy SubstratedSurface-enhanced spectroscopy substrates utilize the localized surface plasmon resonance of nanoparticles for optical, photocatalysis, and biological and chemical sensing applications. Plasmonic anisotropic nanoparticles with sharp tips focus the electromagnetic field of the localized surface plasmo...2020
43 Cowley, JacobOptimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynesIn order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the...2021
44 Fox, ZachThe physical effects of solvent in molecule-based magnetsMolecule-based magnets are being studied in order to expand the utility of magnets in modern devices. Advantages of molecule-based magnets include less energy intensive synthesis and greater versatility through changes to organic components of the structure. This class of materials is studied to ena...Magnets - Experiments2012-05
45 Duffin, CalderSequence Activity Relaqtionships in a Radical Sam Peptide MaturaseRibosomally synthesized and post-translationally modified peptide Tte1186a and several point mutation variants are synthesized using solid phase peptide synthesis with FMOC amino acids. Substrate recognition and thioether linkage formation from the radical S-adenosyl methionine Tte1186 maturase is d...2020
46 Olsen, NicholasSimple Molecular Models for Chiral CrystallizationChiral molecules play an important role in many biological processes.1 Important chiral biomolecules include certain amino acids, sugars, DNA, RNA, and many proteins. Chiral molecules have enantiomers, mirror-image isomers that cannot be superimposed on each other. The classic analogy to enantiomers...2020
47 Farrall, NicholasStructural characterization of the full-length exocyst complex by transmission electron cryo-microscopyThe exocyst is a conserved octameric protein complex in eukaryotes that is essential for tethering and fusion of vesicles to the plasma membrane. Composed of eight subunits, it is essential for growth, secretion, and developmental processes and has been implicated in cell motility, autophagy, cell d...Saccaromyces cerevisaie - Cytology; Cryomiscroscopy - Research2014-05
48 Reece, Eric J.Synthesis and Characterization of Proton Conducting Silica Nano-Particles for use in Polymer Electrolyte Membrane Fuel CellsOne of the fastest growing fields in scientific research is alternative energy. This has led to an investigation into the various aspects of fuel cells and their components due to their highly efficient energy conversion and low CO2 emissions. The efficiency of fuel cells is highly dependent on the ...2019
49 Cantrell, Rachel Lou-La VonneSynthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization ChemistryAs bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant...2020
50 Randolph, CharlotteSynthesis of VLC-Pufas relating to macular degenerative diseasesVery Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs) are non-dietary fatty acids that are more than 24 carbons long and include more than one double bond. The specific compound we have focused on is 32:6 n-3: a 32-carbon molecule having 6 cis alkenes with the alkenes beginning at the omega 3 carb...2022
51 Aderibigbe, JustisTrends in the usage of bidentate phosphines as ligands in nickel catalysis of hydrogenation reactionsA critically important process in catalysis is the formation of an active catalyst from the combination of a metal precursor and a ligand, as the efficacy of this reaction governs the amount of active catalyst. This review is a compacted but comprehensive review of reactions catalyzed by nickel and ...2021
52 Walker, KortnieUnderstanding and treating diabetic retinopathyDiabetic retinopathy is a neurovascular disease of the retina and is the leading cause of blindness in the working-age population in the United States. Complications as a result of hyperglycemia and diabetes mellitus (DM) break down the blood-retina barrier (BRB) and retinal vasculature. Current tre...Diabetic retinopathy2015-05
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