Honors Theses Open Access
 
Filters: Department: "Chemistry" Collection: "ir_htoa"
1 - 25 of 9
Number of results to display per page
CreatorTitleDescriptionSubjectDate
1 Kent, AlexandraDNA split aptamers as a biosensing platform for the detection of small drug moleculesPrescription drug overdose and abuse is a leading cause of death in the United States. It is a serious issue and has become increasingly problematic as opioids are being prescribed with a higher frequency. For this reason, fast, accurate detection of small drug molecules is crucial. The current stan...Drug testing; Biosensors; DNA split aptamers
2 Pecchia-Bekkum, AnnikaApplications of controlled DNA assembly and disassembly in biosensing and responsive drug deliveryDeoxyribonucleic acid (DNA) provides many exciting functions outside of simply encoding genetic information. Herein, we report two techniques to control the assembly and disassembly of nucleic acids. Within these techniques, DNA is used as a programmable material for biosensing and drug delivery. In...Nucleic acids - Biotechnology2013-08
3 Arave, Rowan A.AKT1 activation promotes the development of melanoma metastasisMetastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu...Melanoma - Genetics - Research; Metastasis - Genetics - Research; Biochemistry; Genetics2015-12
4 Visser, JoshuaCharacterization of G-quadruplexes in DNA repair protein gene sequences and the effects of oxidized guanine lesions on DNA base insertion and elongationGuanine (G) is one of the four nucleo bases that make up the complex macromolecule deoxyribonucleic acid (DNA). In addition to its ability to Watson-Crick base pair with cytidine (C), guanine can base pair with itself vianon-canonical, Hoogsteen base pairing and form a secondary structure of DNA ca...DNA repair - Research; G proteins - Pathophysiology - Research; Oxidation, Physiological - Research; Membrane homogenization; Synthetic blood; Artificial oxygen carriers2016-05
5 Fan, HuijunExamination of Y-Deterium isotope effects for the solvolysis of model isoprenoid compoundsModel isoprenoid compounds can undergo two distinct pathways, dissociative or associative nucleophilic substitution depending on the conditions used. The dissociative pathway consists of two steps, involving a carbocation intermediate where the formation of that carbocation is rate determining. The ...Isopentenoids; Solvolysis; Deuterium - Isotopes2012-05
6 Owen, Cameron J.Infrared Multiple Photon Dissociation Spectroscopy and Guided Ion Beam Tandem Mass Spectrometry: Experimental and Theoretical investigations of Transition Metal and Lanthandie CationsEmployment of Free Electron Lasers (FELs) and a Guided Ion Beam Tandem Mass Spectrometer (GIBMS) has allowed for the spectroscopic and spectrometric investigations of a variety of ionic complexes, respectively. The data presented in Chapters 2 and 3 of this thesis were obtained using two FELs locate...2019
7 Cantrell, Rachel Lou-La VonneSynthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization ChemistryAs bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant...2020
8 Zhu, JudyAnalysis of the pH-dependent equilibrium relationship between the guanine oxidation products 5-guanidinohydantoin and iminoallantoinOxidation of 2'-deoxyguanosine (dG) results in the major two-electron product 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) that can undergo further oxidation to other products. One such product is 5-guanidinohydantoin (dGh) that is highly mutagenic and has been found in vivo. The ring architecture of d...Oxidation; guanine oxidation products; 5-guanidinohydantoin; Iminoallantoin; Equilibrium relationship2015-05
9 Godfrey, RoseA porcine model for the development and testing of preoperative skin preparationsClinical preoperative skin preparations (PSPs) do not eradicate skin flora dwelling in the deepest dermal regions. Survivors constitute a persistent infection risk. In search of solutions, we created a porcine model intended for PSP developmental testing. This model employed microbiological techniqu...2022
1 - 25 of 9