Honors Theses Open Access
 
Filters: Department: "Chemistry" Format: "application/pdf" Collection: "ir_htoa" Year End: 2016
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1 Arave, Rowan A.AKT1 activation promotes the development of melanoma metastasisMetastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu...Melanoma; genetics; research; metastasis; genetics; research; biochemistry; genetics2015-12
2 Zhu, JudyAnalysis of the pH-dependent equilibrium relationship between the guanine oxidation products 5-guanidinohydantoin and iminoallantoinOxidation of 2'-deoxyguanosine (dG) results in the major two-electron product 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) that can undergo further oxidation to other products. One such product is 5-guanidinohydantoin (dGh) that is highly mutagenic and has been found in vivo. The ring architecture of d...Oxidation; guanine oxidation products; 5-guanidinohydantoin; iminoallantoin; equilibrium relationship2015-05
3 Edwards, Jennifer LynnApplication of a TBHP-mediated Wacker-type oxidation to internal alkenesThe Wacker oxidation allows access to methyl ketones from terminal alkenes. This transformation is important for industrial, synthetic, and medicinal chemists, as carbonyls are present in many natural and pharmaceutical products. With the carbonyl, a wide variety of reactions become available, such ...Wacker-type oxidatioin; research; TBHP2013-05
4 Pecchia-Bekkum, AnnikaApplications of controlled DNA assembly and disassembly in biosensing and responsive drug deliveryDeoxyribonucleic acid (DNA) provides many exciting functions outside of simply encoding genetic information. Herein, we report two techniques to control the assembly and disassembly of nucleic acids. Within these techniques, DNA is used as a programmable material for biosensing and drug delivery. In...Nucleic acids; biotechnology2013-08
5 Burga, Carlos AlbertoBinary superlattices of semiconductor nanocrystals : a path towards possible high-temperature superconductivityThis thesis provides a platform to experimentally test Dr. Daniel Mattis' theoretical work on the possible superconductive behavior of nanostructured intrinsic semiconductors1-2. The theoretical work hinged on the nano-scale architecture of semiconductors. Therefore, using various types of semicondu...Semiconductor nanocrystals; Superconductivity; Superlattices as materials2013-05
6 Rose, StevenBiofuel cells for self powered arsenic detectionResearch in the Minteer group has centered on procedures for immobilizing enzymes and organelles on carbon electrodes for use in sensory and fuel cell applications. Similar strategies have been used to prepare a series of electrodes capable of pyruvate oxidation which, in the presence of arsenic, wi...Fuel cells; Arsenic - Detection2013-05
7 Simonsen, KyleBreast cancer knowledge and attitudes among women in ArmeniaBackground: Breast cancer, the most common invasive cancer among women, has high incidence and mortality rates among women in the Republic of Armenia. Advanced stage at detection limits treatment options and contributes to high morbidity and mortality. Understanding women's breast cancer knowledge a...Breast - Cancer; Breast - Cancer - Patients - Attitudes; Breast - Cancer - Patients - Armenia (Republic)2013-07
8 Visser, JoshuaCharacterization of G-quadruplexes in DNA repair protein gene sequences and the effects of oxidized guanine lesions on DNA base insertion and elongationGuanine (G) is one of the four nucleo bases that make up the complex macromolecule deoxyribonucleic acid (DNA). In addition to its ability to Watson-Crick base pair with cytidine (C), guanine can base pair with itself vianon-canonical, Hoogsteen base pairing and form a secondary structure of DNA ca...DNA repair - Research; G proteins - Pathophysiology - Research; Oxidation, Physiological - Research; Membrane homogenization; Synthetic blood; Artificial oxygen carriers2016-05
9 Nicolo, TeraCharacterization of mitochondria-modified electrodesIn order to develop an herbicide sensor, yeast, potato, and bovine heart mitochondria were isolated and immobilized onto Toray paper electrodes. Cyclic voltammetry showed two redox peaks at 186 ± 14 mV vs. SCE and -357 ± 24 mV vs. SCE with an E1/2 of -128 mV. Scan rate studies suggested the proces...Electrodes; Herbicides - Detection2013-05
10 Odendahl, NathanComparison of popular force fields for molecular modeling of proteins applied to ice binding of the tenebrio molitor antifreeze proteinIce Binding Proteins (IBPs) are a class of proteins that affect the melting and freezing temperatures of ice. While substantial research has been conducted to understand the properties of IBPs, experimental and molecular dynamics simulations have not satisfactorily explained the mechanism of the i...Antifreeze proteins - Research; Ice binding proteins; Tenebrio molitor; Antifreeze protein; Force fields2016-04
11 Peterson, Joseph RyanDeflagration and detonation modeling of heterogeneous condensed phase explosivesA modeling approach to the deflagration and detonation phenomena is employed to study a variety of explosive scenarios. An engineering model for macroscale reaction of energetic materials over the wide range of explosive reaction from deflagration to detonation is developed based upon solid foundati...Deflagration phenomena; Detonation phenomena; mesoscale model2012-05
12 Lim, Koun (Kasha)Deglycoyslation of glucose oxidase and its application within high power enzymatic fuel cellsTo compensate for the increase of carbon dioxide level and the energy exhaust, an enzymatic fuel cell (EFC) has been investigated by researchers. In the paper, a chemical oxidative deglycosylation of an enzyme was investigated to furture improve EFCs. By deglycosylating an enzyme, the distance betwe...Fuel cells - Research; Electric power - Research; Deglycosylation; Enzymatic fuel cell; Glucose oxidase2016-04
13 Sanders, SaraDevelopment of a novel, coumarin-europium sensor for reactive oxidizing speciesThe synthetic framework has been developed for two fluorescent probes of Reactive Oxidizing Species (RoxS) based on a coumarin-europium fluorescence pair. The coumarin moiety's selectivity for hydrogen peroxide coupled with 620 nm shifted emission of the europium will make these novel sensors biolog...Reactive Oxygen Species - analysis2012-05
14 Bischoff, AmandaElucidating the Mechanism and Predicting the Selectivity of the bis(Pyridine) Silver Permanganate OxidatiinThe Movassaghi group has recently reported several total syntheses of epipolythiodiketopiperazine derivatives (ETPs), a class of natural products with potent biological activity. A crucial step in their synthesis oxidizes two to four tertiary C-H bonds to form tertiary alcohols using (bis)pyridine s...2016
15 Fernandez, FlorenceEvaluation of environmental education in high school science courses across Salt Lake City, UtahWhile the effects of pollution become Incredibly more evident in the air of the Salt Lake Valley, many Utah high school students still lack the knowledge and information necessary to take preventative and immediate actions to protect their health and their environment. In this study, the reasons for...Environmental education -- Utah -- Salt Lake City; Science -- Study and teaching -- Utah -- Salt Lake City; Air -- Pollution -- Utah -- Salt Lake City2015-05
16 Fan, HuijunExamination of Y-Deterium isotope effects for the solvolysis of model isoprenoid compoundsModel isoprenoid compounds can undergo two distinct pathways, dissociative or associative nucleophilic substitution depending on the conditions used. The dissociative pathway consists of two steps, involving a carbocation intermediate where the formation of that carbocation is rate determining. The ...Isopentenoids; Solvolysis; Deuterium - Isotopes2012-05
17 Black, AlyssaIdentifying hybrid male sterility genes in Drosophila PseudoobscuraSpeciation, the process of one species splitting into two separate species, often involves the evolution of hybrid sterility or hybrid inviability. These reproductive isolating barriers are caused by negative interactions between genes called hybrid incompatibilities. Identifying hybrid incompatibil...Infertility, Male -- Genetic aspects Drosophila pseudoobscura -- Genetics Male sterility genes2015-05
18 Zurbuchen, RudiMacrocyclization of glucagon-like peptide (GLP-1) by thiol-ene reactionMacrocyclization of peptides helps maintain a stable alpha helical structure using a conformational constraining staple. One such peptide, glucagon-like peptide-1 (GLP-1), is a 37 amino acid peptide agonist for the GLP-1 receptor and has the ability to lower blood glucose levels and is responsible ...Peptide hormones - Receptors - Research; Ring formation (Chemistry) - Research; Macrocyndization; GLP-1; Swim kinematics; Pre-pulse inhibition2016-05
19 Fox, ZachThe physical effects of solvent in molecule-based magnetsMolecule-based magnets are being studied in order to expand the utility of magnets in modern devices. Advantages of molecule-based magnets include less energy intensive synthesis and greater versatility through changes to organic components of the structure. This class of materials is studied to ena...Magnets - Experiments2012-05
20 Farrall, NicholasStructural characterization of the full-length exocyst complex by transmission electron cryo-microscopyThe exocyst is a conserved octameric protein complex in eukaryotes that is essential for tethering and fusion of vesicles to the plasma membrane. Composed of eight subunits, it is essential for growth, secretion, and developmental processes and has been implicated in cell motility, autophagy, cell d...Saccaromyces cerevisaie - Cytology; Cryomiscroscopy - Research2014-05
21 Walker, KortnieUnderstanding and treating diabetic retinopathyDiabetic retinopathy is a neurovascular disease of the retina and is the leading cause of blindness in the working-age population in the United States. Complications as a result of hyperglycemia and diabetes mellitus (DM) break down the blood-retina barrier (BRB) and retinal vasculature. Current tre...Diabetic retinopathy2015-05
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