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1 Mitchell, Joyce A.Bioinformatics linkage of heterogeneous clinical and genomic information in support of personalized medicineObjectives: Biomedical Informatics as a whole faces a difficult epistemological task, since there is no foundation to explain the complexities of modeling clinical medicine and the many relationships between genotype, phenotype, and environment. This paper discusses current efforts to investigate su...2007-01-01
2 Mitchell, Joyce A.Fuzzy measures on the Gene Ontology for gene product similarityOne of the most important objects in bioinformatics is a gene product (protein or RNA). For many gene products, functional information is summarized in a set of Gene Ontology (GO) annotations. For these genes, it is reasonable to include similarity measures based on the terms found in the GO or othe...2006-01-01
3 Mitchell, Joyce A.From phenotype to genotype: issues in navigating the available information resourcesObjectives-As part of an investigation of connecting health professionals and the lay public to both disease and genomic information, we assessed the availability and nature of the data from the Human Genome Project relating to human genetic diseases. Methods-We focused on a set of single gene disea...2003-01-01
4 Mitchell, Joyce A.International efforts in nanoinformatics research applied to nanomedicineBackground: Nanomedicine and nanoinformatics are novel disciplines facing substantial challenges. Since nanomedicine involves complex and massive data analysis and management, a new discipline named nanoinformatics is now emerging to provide the vision and the informatics methods and tools needed fo...2011-01-01
5 Mitchell, Joyce A.Nanoinformatics: a new area of research in nanomedicineAbstract: Over a decade ago, nanotechnologists began research on applications of nanomaterials for medicine. This research has revealed a wide range of different challenges, as well as many opportunities. Some of these challenges are strongly related to informatics issues, dealing, for instance, wit...2012-01-01
6 Mitchell, Joyce A.Computational Feature of Selection and Classification of RET Phenotypic SeverityAlthough many reported mutations in the RET oncogene have been directly associated with hereditary thyroid carcinoma, other mutations are labelled as uncertain gene variants because they have not been clearly associated with a clinical phenotype. The process of determining the severity of a mutation...2010-01-01
7 Huser, Vojtech; Del Fiol, Gulherme; Rocha, Roberto A.Use of XML Technology for E-resources Management within a Healthcare EnterpriseProvision of access to electronic resources to clinicians is becoming increasingly important. We have created a framework for librarians to manage access to e-resources at enterprise level rather than separately at individual hospital libraries. We present our initial project requirements, implement...Biomedical informatics; E-resources; Knowledge representation; Knowledge management; XML; XSLT; Intermountain Healthcare; Medical informatics2008-03-14
8 Mitchell, Joyce A.Challenges and strategies of the Genetics Home ReferenceObjective: This paper focuses on the first two years of operation of Genetics Home Reference (GHR), a Web-based resource <http://www.ghr.nlm.nih.gov> for the general public that helps to explain the health implications of findings from the Human Genome Project. Methods and Findings: Key challenges o...2006-01-01
9 Mitchell, Joyce A.Predicting phenotypic severity of uncertain gene variants in the RET Proto-OncogeneAlthough reported gene variants in the RET oncogene have been directly associated with multiple endocrine neoplasia type 2 and hereditary medullary thyroid carcinoma, other mutations are classified as variants of uncertain significance (VUS) until the associated clinical phenotype is made clear. Cur...2011-01-01
10 Gardner, Reed M.The International Partnership for Health Informatics Education: Lessons Learned from Six Years of ExperienceBiomedical Informatics2005
11 Gardner, Reed M.Patient-Monitoring SystemsBiomedical Informatics2006
12 Mitchell, Joyce A.Evaluating the informatics for integrating biology and the bedside system for clinical researchBackground: Selecting patient cohorts is a critical, iterative, and often time-consuming aspect of studies involving human subjects; informatics tools for helping streamline the process have been identified as important infrastructure components for enabling clinical and translational research. We d...2009-01-01
13 Mitchell, Joyce A.Integrating historical clinical and financial data for pharmacological researchBackground: Retrospective research requires longitudinal data, and repositories derived from electronic health records (EHR) can be sources of such data. With Health Information Technology for Economic and Clinical Health (HITECH) Act meaningful use provisions, many institutions are expected to adop...2011-01-01
14 Mitchell, Joyce A.50 Years of informatics research on decision support: what's nextObjectives: To reflect on the history, status, and future trends of decision support in health and biomedical informatics. To highlight the new challenges posed by the complexity and diversity of genomic and clinical domains. To examine the emerging paradigms for sup - porting cost-effective, person...2011-01-01
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