1 - 25 of 20
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 |
Slominski, Emma N. | Comparison of transcranial MR-guided focused ultrasound phase correction simulations to clinically measured MRTI | Essential tremor and Parkinson's disease are neurological disorders causing involuntary shaking that affects an estimated 8 million people in the United States. Transcranial Magnetic Resonance-guided Focused Ultrasound (tcMRgFUS) is a noninvasive alternative method of treating tremors to the invasiv... | 2021 | |
| 2 |
 |
Adams, Samuel I. | Correcting acoustic phase aberrations in focused ultrasound treatments for breast cancer | Breast cancer is the most diagnosed cancer worldwide. Early-stage localized cancers are currently treated with surgical lumpectomy and radiation. Focused ultrasound is a disruptive technology that can replace conventional surgical and radiation therapies to provide noninvasive cancer treatment. This... | 2021 | |
| 3 |
 |
Ingold, Alexander | Development of a Utah optrode array for large scale optogenetics in non-human primate cortex: analysis of spatial excitation pattern using C-FOS expression | A central goal in neuroscience is to understand how neural circuits generate the computations that underlie neuronal responses, sensory perception, and behavior. This requires manipulating their activity and determining the results of these manipulations. Optogenetics is a versatile laboratory techn... | 2022 | |
| 4 |
 |
Radhakrishnan, Sridharan | Development of Low-Cost system for Myoelectric Prosthesis Control | The upper limb prosthetics field has advanced to where artificial hands can mimic human motions based on electrical signals emitted from muscular activation and can even open and close proportionate to the amplitude of signal they receive. However, these prostheses are very expensive, with some cost... | 2020 | |
| 5 |
 |
Kendell, Isaac | Immunomodulation improves cancer cell clearance by T cells during multi-antigent T cell hybridizer therapy | Treatment of hematopoietic malignancies is challenging due to systemic side effects of current treatments and the possibility of relapse. Multi-antigen T cell hybridizer (MATCH) therapy is a novel treatment system composed of antibody fragments conjugated with morpholino oligonucleotides, which hybr... | 2024 | |
| 6 |
 |
Thomas, Payton J | Importance sampling techniques for genetic circuit analysis | Genetic circuits have been identified as a promising technology that could revolutionize several areas, including biofuels, biomanufacturing, and medicine. Despite the tremendous potential of this technology, there are significant challenges associated with its development and implementation. One of... | 2023 | |
| 7 |
 |
Koblanski, Kasper | Liver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilization | Insulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin... | 2022 | |
| 8 |
 |
Citterman, Abigail R. | Low frequencies improve intensity discrimination for electrocutaneous artificial sensory feedback | The current standard of care for those living with upper-limb loss is unsatisfactory, with up to 50% of amputees abandoning their prostheses, citing unintuitive use and a lack of sensory feedback as critical factors. Electrocutaneous stimulation uses electrodes on the skin to evoke tactile sensation... | 2022 | |
| 9 |
 |
Harding, Anna Neibling | Low-Cost Surface Electromyogtraphy Sleeve for Quick and Repeatable Decoding of Motor Intent | Surface electromyography (sEMG) is a noninvasive way to decode motor intent for applications such as prosthesis control, virtual reality, and stroke or spinal cord rehabilitation. State-of-the-art methods of decoding motor intent used in myoelectric prostheses have limited capabilities, partially du... | 2019 | |
| 10 |
 |
Armstrong, Blair P. | Lower critical solution temperature behavior of elastin-coiled-coil polymer, a potential platform for treatment of non-hodgkin's lymphoma | Non-Hodgkin's lymphoma takes the lives of 20,000 Americans each year. When traditional therapies fail, clinicians have turned to a drug, rituximab, for treatment. However, rituximab is now curative for less than 50% of patients and new treatments are needed. Drug-free macromolecular therapeutics (DF... | 2021 | |
| 11 |
 |
Richards, Grace | My lung health: shared decision making for lung cancer screening | Lung cancer is the deadliest cancer in the United States. In 2019, around 140,000 deaths occurred in the Untied States due to lung cancer. Low-dose CT screening to detect lung cancer is an effective tool for preventing these deaths, but the screening has some harms associated with it in addition to ... | 2023 | |
| 12 |
 |
Tripathy, Anurag | Nickel-Functionalized Solid-State Titania Nanotube Array for the Electrochemical Detection of Breath-Based Biomarkers in Colorectal Cancer | Colorectal cancer (CRC) is the second most common cancer in the United States with approximately 137,000 new cases each year, 50,000 of which are fatal due to belated screenings [1]. The gold-standard detection method is colonoscopy, a direct visualization tool that facilitates the removal of minor ... | 2019 | |
| 13 |
 |
Stewart, Caden | Paternal diet modulates naturalistic foraging in mice and interacts with cacna1c genetic effects to shape decision sequences | Some of the largest challenges facing the healthcare system stem from the dual epidemics of obesity and mental disorders. Obesity can alter an organism's epigenetics, and these changes may be passed on to offspring, which in turn may alter mental health. The purpose of this study is to investigate t... | 2022 | |
| 14 |
 |
Adams, Isabel | Pelvic floor acceleration is damped compared to skeletal acceleration while walking | One in four American women suffer from pelvic floor disorders (PFDs) [1]. Current research shows the cause of pelvic organ prolapse is multifactorial, with risk factors including vaginal childbirth and advancing age [2]. To facilitate the development of prevention strategies and treatments to minimi... | 2023 | |
| 15 |
 |
Schlegel, Isabelle B. | Peptide-fab conjugates to improve treatment of neovascular age-related macular degeneration | Age-Related Macular Degeneration (AMD), a chronic disease of the eye and leading cause of blindness in Americans over 50, is often treated with agents that inhibit Vascular Endothelial Growth Factor (VEGF). Ranibizumab is an anti-VEGF antibody fragment (Fab) effective at treating over 90% of AMD pat... | 2021 | |
| 16 |
 |
Novy, Jenna | Selective and Localized Marking of Activated Dendritic Spines Using a Novel Genetic Construct, Slayr | The brain's ability to store memory is as remarkable as it is complex. The mechanism behind memory storage is still not fully understood and has become an essential question in the neuroscience field. Long-term memories are thought to form via the strengthening of specific connections between neuron... | 2020 | |
| 17 |
 |
Wang, Karissa M. | Transcription factor NFATc1's signaling pathway and role in cardiomyocyte function | Atrial fibrillation (AF) is the most common sustained arrhythmia. It affects as many as 6.1 million people in the United States and increases their risk of stroke by 4-5 times. AF is evidently a very serious condition, but the scientific community does not yet fully understand its underlying mechani... | 2020 | |
| 18 |
 |
Leyendecker, Peyton | Unraveling the Q system function in prokaryotes | Expanding the prokaryotic synthetic biology toolbox is a promising strategy for enhancing control of gene expression. More specifically, understanding the eukaryotic Q system activation of the T7 promoter in prokaryotes can enable enhanced engineering applications for research and biomedicine. Here,... | 2024 | |
| 19 |
 |
Wankier, Zakary S. | Use of computer tomography imaging to observe increased distal-end cortical bone around a percutaneous osseointegrated implant | Osseointegration (OI) is being used for the direct skeletal attachment of prosthetic limbs using an intramedullary stem that extends percutaneously from the subject's residual limb. For this technology to be successful, bone ingrowth and remodeling around the implant must occur. Physicians need an e... | 2022 | |
| 20 |
 |
Tiwari, Sarthak | Utilizing light scattering spectroscopy and machine learning to differentiate heterogenous tissue samples | Current biopsy approaches either lack depth penetration or real-time analysis. Light scattering spectroscopy (LSS) aims to address these issues, and our goal is to investigate the use of LSS for identifying cardiac conduction tissues. LSS data were collected from donor tissue samples and created a 3... | 2023 |
1 - 25 of 20