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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Gilbert, John | A novel tool to capture neural activity across an entire brain using C-FOS as an indicator | Immunohistochemical staining for the expression of the immediate early gene c-Fos is a powerful tool to measure neuronal activation of neurons across an entire brain. The results of c-Fos immunostaining are often quantified by counting the number of immunolabeled cells in a region of interest (ROI) ... | Brain - Localization of functions - Research; Brain - Physiology - Research; Brain mapping - Research; Memory - Research; Mice as laboratory animals - Research; Brain activity; Immunohistochemical staining | 2016-05 |
| 2 |
 | Sharma, Kapil | Analyzing the relationship between PDM2 and B-catenin proteins in human cancers | Tumorigenesis is promoted by the manipulation of several co-factors and pathways, in which PKM2 and P-catenin proteins play a significant role in a variety of cancers. New research states that these two hegemonic cancer proteins directly bind with each other and may provide a new angle for cance... | Pyruvate kinase - Research; Tumorigensis - Research | 2016-04 |
| 3 |
 | Tarboton, Paisley | Characterization of Apoptosis and Inhibitory Neurons in Cortical Organoids Generated from Human Induced Pluripotent Stem Cells. | Modeling human brain diseases in a laboratory setting is critical to understanding the underlying pathology and developing new treatments for patients. Organoids are 3D tissue cultures that provide a promising way to model human brain development in vitro and have been used previously to gain novel ... | 2018 | |
| 4 |
 | Slominski, Emma N. | Comparison of transcranial MR-guided focused ultrasound phase correction simulations to clinically measured MRTI | Essential tremor and Parkinson's disease are neurological disorders causing involuntary shaking that affects an estimated 8 million people in the United States. Transcranial Magnetic Resonance-guided Focused Ultrasound (tcMRgFUS) is a noninvasive alternative method of treating tremors to the invasiv... | 2021 | |
| 5 |
 | Sowards, Steffan | Computational fluid dynamics modeling for Respiratory airflow patterns of python regius | The phylogenetic distribution and mechanisms underpinning unidirectional pulmonary airflow, in which gases pass through a portion of the lung in an identical direction during both aspiration and expiration, are poorly understood. Until recently, it was thought this pattern of flow required unique fe... | simulated | 2018 |
| 6 |
 | Young, Michael | The Contributions of Elastin to Ligament Viscoelasticty | Ligaments exhibit viscoelastic behavior in response to strain. This behavior protects joints from injury during loading. Collagen is the primary structural component of ligaments, but does not account fully for the viscoelastic behavior. Elastin is another structural protein in ligaments, and provid... | 2017 | |
| 7 |
 | Adams, Samuel I. | Correcting acoustic phase aberrations in focused ultrasound treatments for breast cancer | Breast cancer is the most diagnosed cancer worldwide. Early-stage localized cancers are currently treated with surgical lumpectomy and radiation. Focused ultrasound is a disruptive technology that can replace conventional surgical and radiation therapies to provide noninvasive cancer treatment. This... | 2021 | |
| 8 |
 | Gajiwala, Snehal | Determining the variability of depressive brain circuitry among healthy subjects for deep brain stimulation | Deep Brain Stimulation (DBS) is being evaluated to treat Treatment-Resistant Depression, though it has shown mixed results. We believe that variability within the fiber tracts of the brain may account for these outcome differences. In this study, we attempt to characterize this potential variation.... | Brain stimulation - Therapeutic use - Research; Depression, Mental - Treatment - Research; Deep brain stimulation; Depressive brain circuitry; Fiber tracts; Tractography | 2016-05 |
| 9 |
 | Luo, Shirley | Development of a bioabsorbalbe active release antimicrobial coating for orthopedic implants | Orthopedic implantations often create an opportunity for biofilm-related infections to arise. Patients infected with biofilm must often undergo additional surgeries for repair or replacement, which puts them at a greater risk of osteomyelitis, sepsis, and other complications including death [17]. T... | Orthopedic implants - Research; Anti-infective agents - Research; Staphyloccoccal infections - Prevention and control - Research; Antimicrobial coating; Staphylococcus aureus | 2016-05 |
| 10 |
 | Ingold, Alexander | Development of a Utah optrode array for large scale optogenetics in non-human primate cortex: analysis of spatial excitation pattern using C-FOS expression | A central goal in neuroscience is to understand how neural circuits generate the computations that underlie neuronal responses, sensory perception, and behavior. This requires manipulating their activity and determining the results of these manipulations. Optogenetics is a versatile laboratory techn... | 2022 | |
| 11 |
 | Radhakrishnan, Sridharan | Development of Low-Cost system for Myoelectric Prosthesis Control | The upper limb prosthetics field has advanced to where artificial hands can mimic human motions based on electrical signals emitted from muscular activation and can even open and close proportionate to the amplitude of signal they receive. However, these prostheses are very expensive, with some cost... | 2020 | |
| 12 |
 | Hyer, Christina Cottrell | Effect of M1 Matrix Protein on Hemagglutinin Expression and Influenza Virus-Like Particle Production in Trichoplusia NI | Virus-like particles (VLPs) are a new and effective flu vaccine approach. VLPs are non-infectious and can produce robust immune responses. Flu VLPs are typically created by co-expressing the flu hemagglutinin (HA) surface antigen and the matrix protein M1-which assists in viral and VLP budding-in cu... | 2017 | |
| 13 |
 | Grimmett, Rollin | Effects of Hypoxia and High Fat Diet on D. Melanogaster Heart Physiology | Heart disease severely affects millions of people worldwide, and is caused by various environmental and genetic factors. The aim of this study is to examine the combined physiological effects of hypoxia and a high fat diet (two known causes) on Drosophila Melanogaster heart structure. Sets of adult ... | 2017 | |
| 14 |
 | Sedley, Andrew | Egocentric Navigation in a Morris Water Maze for Testing Memory Formation in Mice | Mouse models are crucial to understanding not only sensory and cognitive neurological processes, but also diseases, disabilities, and responses to pharmacological or surgical treatments. Behavioral tests are essential assets in the description of these models. The Morris Water Maze is a common behav... | 2018 | |
| 15 |
 | Flach, Brian | Examining the effects of whisker trimming on mouse brain cell growth | Hoxb8 microglia are a particular breed of scavenger cells in the brain which have been related to obsessive compulsive disorder (OCD)-like behavior among other behavioral disorders. These cells have been found to reach full maturity during a period of neurological development known as the critical ... | Obsessive-compulsive disorder - Research; Microglia - Research; Mice as laboratory animals - Research; Whiskers; Scavenger cells; Hoxb8 microglia | 2016-04 |
| 16 |
 | Kendell, Isaac | Immunomodulation improves cancer cell clearance by T cells during multi-antigent T cell hybridizer therapy | Treatment of hematopoietic malignancies is challenging due to systemic side effects of current treatments and the possibility of relapse. Multi-antigen T cell hybridizer (MATCH) therapy is a novel treatment system composed of antibody fragments conjugated with morpholino oligonucleotides, which hybr... | 2024 | |
| 17 |
 | Thomas, Payton J | Importance sampling techniques for genetic circuit analysis | Genetic circuits have been identified as a promising technology that could revolutionize several areas, including biofuels, biomanufacturing, and medicine. Despite the tremendous potential of this technology, there are significant challenges associated with its development and implementation. One of... | 2023 | |
| 18 |
 | Vetter, Mikey | Inhibition of FAK and AKT as potential therapies for melanoma brain metastasis | Brain metastasis is the leading cause of death in patients with advanced melanoma. Melanoma diagnoses nearly reached 100,000 in 2019, and melanoma patients make up 10% of all patients with brain metastasis [1]. The roles of the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinos... | vehicle control; previously | 2021 |
| 19 |
 | Koblanski, Kasper | Liver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilization | Insulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin... | 2022 | |
| 20 |
 | Citterman, Abigail R. | Low frequencies improve intensity discrimination for electrocutaneous artificial sensory feedback | The current standard of care for those living with upper-limb loss is unsatisfactory, with up to 50% of amputees abandoning their prostheses, citing unintuitive use and a lack of sensory feedback as critical factors. Electrocutaneous stimulation uses electrodes on the skin to evoke tactile sensation... | 2022 | |
| 21 |
 | Harding, Anna Neibling | Low-Cost Surface Electromyogtraphy Sleeve for Quick and Repeatable Decoding of Motor Intent | Surface electromyography (sEMG) is a noninvasive way to decode motor intent for applications such as prosthesis control, virtual reality, and stroke or spinal cord rehabilitation. State-of-the-art methods of decoding motor intent used in myoelectric prostheses have limited capabilities, partially du... | 2019 | |
| 22 |
 | Armstrong, Blair P. | Lower critical solution temperature behavior of elastin-coiled-coil polymer, a potential platform for treatment of non-hodgkin's lymphoma | Non-Hodgkin's lymphoma takes the lives of 20,000 Americans each year. When traditional therapies fail, clinicians have turned to a drug, rituximab, for treatment. However, rituximab is now curative for less than 50% of patients and new treatments are needed. Drug-free macromolecular therapeutics (DF... | 2021 | |
| 23 |
 | Wang, Minna | Managing limited ECG access in a clinical cardiac electrophysiology setting | Electrocardiographic Imaging (ECGI) is a computational approach that seeks to reconstruct cardiac electrical activity with high precision from body surface ECGs by solving a numerical inverse problem. Though there have been great advancements in ECGI, there is still a need for progress in specific a... | Electrocardiography - Research; Heart - Diseases - Diagnosis; Body surface potentials | 2016-05 |
| 24 |
 | Kodele, Christian | Multivalent Human Serum Albumin - Rituximab Fab' Conjugates Induce Apoptosis in Lymphoma Cells | Non-Hodgkin lymphoma (NHL) is an immune disease, mostly of B-cell origin (85%), as well as the ninth leading cause of cancer death in the United States. Although treatments for NHLs greatly improved following the FDA approval of Rituximab (RTX), refractive malignancies still occur that are nonrespon... | 2018 | |
| 25 |
 | Richards, Grace | My lung health: shared decision making for lung cancer screening | Lung cancer is the deadliest cancer in the United States. In 2019, around 140,000 deaths occurred in the Untied States due to lung cancer. Low-dose CT screening to detect lung cancer is an effective tool for preventing these deaths, but the screening has some harms associated with it in addition to ... | 2023 |