Creator | Title | Description | Subject | Date | ||
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1 | Koblanski, Kasper | Liver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilization | Insulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin... | 2022 | ||
2 | Ruan, Ting | Endogenous ceramide contributes to cardiovascular complications in Type II diabetes by decreasing the association between PP2A and I2PP2A | Cardiovascular complications are the leading cause of death in individuals with conditions associated with insulin resistance, e.g. type 2 diabetes, diet-induced obesity. In patients with type 2 diabetes, cardiovascular complications are 2-4 times more prevalent. One common cardiovascular complicati... | Ceramides - Physiological effect; Diabetic angiopathies | 2014 | |
3 | Lei, Jeffrey KaChon | Increased gluti expression in mouse cardiomyocytes preserves mitochondrial function but is insufficient to attenuate pressure overload-induced contractile dysfunction | Lifelong over-expression of GLUT1 transporter in the heart has been shown to preserve contractile function after aortic constriction. However it is unclear whether this protective effect is due to GLUT1 overexpression itself or due to reprogramming of heart metabolism as a result of long-term increa... | Bioengineering | 2013-04 | |
4 | Stewart, Caden | Paternal diet modulates naturalistic foraging in mice and interacts with cacna1c genetic effects to shape decision sequences | Some of the largest challenges facing the healthcare system stem from the dual epidemics of obesity and mental disorders. Obesity can alter an organism's epigenetics, and these changes may be passed on to offspring, which in turn may alter mental health. The purpose of this study is to investigate t... | 2022 |