Honors Theses Open Access
 
Filters: Department: "Biomedical Engineering" Collection: "ir_htoa"
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1 Ruan, TingEndogenous ceramide contributes to cardiovascular complications in Type II diabetes by decreasing the association between PP2A and I2PP2ACardiovascular complications are the leading cause of death in individuals with conditions associated with insulin resistance, e.g. type 2 diabetes, diet-induced obesity. In patients with type 2 diabetes, cardiovascular complications are 2-4 times more prevalent. One common cardiovascular complicati...Ceramides - Physiological effect; Diabetic angiopathies2014
2 Hyer, Christina CottrellEffect of M1 Matrix Protein on Hemagglutinin Expression and Influenza Virus-Like Particle Production in Trichoplusia NIVirus-like particles (VLPs) are a new and effective flu vaccine approach. VLPs are non-infectious and can produce robust immune responses. Flu VLPs are typically created by co-expressing the flu hemagglutinin (HA) surface antigen and the matrix protein M1-which assists in viral and VLP budding-in cu...2017
3 Thomas, Payton JImportance sampling techniques for genetic circuit analysisGenetic circuits have been identified as a promising technology that could revolutionize several areas, including biofuels, biomanufacturing, and medicine. Despite the tremendous potential of this technology, there are significant challenges associated with its development and implementation. One of...2023
4 Kodele, ChristianMultivalent Human Serum Albumin - Rituximab Fab' Conjugates Induce Apoptosis in Lymphoma CellsNon-Hodgkin lymphoma (NHL) is an immune disease, mostly of B-cell origin (85%), as well as the ninth leading cause of cancer death in the United States. Although treatments for NHLs greatly improved following the FDA approval of Rituximab (RTX), refractive malignancies still occur that are nonrespon...2018
5 Uchida, Kimberly AkimiPost-translational regulation of the tumor suppressor PDCD4Expression of the tumor suppressor Programmed cell death 4 (PDCD4) is correlated with better survival outcomes in several types of cancer. When PDCD4 is coexpressed with protein arginine methyltransferase 5, however, this trend does not hold true, suggesting that PDCD4 methylation is involved in the...Tumor suppressor proteins - Regulation2013-12
6 Wankier, Zakary S.Use of computer tomography imaging to observe increased distal-end cortical bone around a percutaneous osseointegrated implantOsseointegration (OI) is being used for the direct skeletal attachment of prosthetic limbs using an intramedullary stem that extends percutaneously from the subject's residual limb. For this technology to be successful, bone ingrowth and remodeling around the implant must occur. Physicians need an e...2022
7 Koblanski, KasperLiver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilizationInsulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin...2022
8 Lei, Jeffrey KaChonIncreased gluti expression in mouse cardiomyocytes preserves mitochondrial function but is insufficient to attenuate pressure overload-induced contractile dysfunctionLifelong over-expression of GLUT1 transporter in the heart has been shown to preserve contractile function after aortic constriction. However it is unclear whether this protective effect is due to GLUT1 overexpression itself or due to reprogramming of heart metabolism as a result of long-term increa...Bioengineering2013-04
9 Young, MichaelThe Contributions of Elastin to Ligament ViscoelastictyLigaments exhibit viscoelastic behavior in response to strain. This behavior protects joints from injury during loading. Collagen is the primary structural component of ligaments, but does not account fully for the viscoelastic behavior. Elastin is another structural protein in ligaments, and provid...2017
10 Radhakrishnan, SridharanDevelopment of Low-Cost system for Myoelectric Prosthesis ControlThe upper limb prosthetics field has advanced to where artificial hands can mimic human motions based on electrical signals emitted from muscular activation and can even open and close proportionate to the amplitude of signal they receive. However, these prostheses are very expensive, with some cost...2020
11 Wang, Karissa M.Transcription factor NFATc1's signaling pathway and role in cardiomyocyte functionAtrial fibrillation (AF) is the most common sustained arrhythmia. It affects as many as 6.1 million people in the United States and increases their risk of stroke by 4-5 times. AF is evidently a very serious condition, but the scientific community does not yet fully understand its underlying mechani...2020
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