Honors Theses Open Access
 
Filters: Department: "Biomedical Engineering" Collection: "ir_htoa"
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26 Singh, AnandPolyurethane molecular weight determination in catheters via gel permeation chromatographyAntimicrobial catheter extrusions are loaded with an antiseptic drug in order to help prevent catheter-related infections. Previous research has shown that polymer molecular weight (Mw) can be used to control drug loading levels. Polyurethane based resin and catheter shaft extrusion samples were cho...Catheters - Research; Bacterial diseases - Prevention; Drug loading levels; Gel permeation chromatography; Diffusion distance; Antimicrobial catheter extrustions; Catheter shaft extrusions; Bacterial Infections; MATLAB2016-05
27 Palmieri, NikoleValidation of a nonlinear optimization algorithm for reconstruction of diffused imagesLiving tissue is a diffusive light-scattering medium, preventing traditional fluorescence microscopy from being used as a diagnostic imaging modality. To determine microscopy from being used as a diagnostic imaging modality. To determine whether the nonlinear optimization algorithm developed for C...Diagnostic imaging; Mathematical optimization; Image processing; Diffusion distance; Computational Cannula Microscopy; Nonlinear optimization; MATLAB2016-04
28 Armstrong, Blair P.Lower critical solution temperature behavior of elastin-coiled-coil polymer, a potential platform for treatment of non-hodgkin's lymphomaNon-Hodgkin's lymphoma takes the lives of 20,000 Americans each year. When traditional therapies fail, clinicians have turned to a drug, rituximab, for treatment. However, rituximab is now curative for less than 50% of patients and new treatments are needed. Drug-free macromolecular therapeutics (DF...2021
29 Wang, Karissa M.Transcription factor NFATc1's signaling pathway and role in cardiomyocyte functionAtrial fibrillation (AF) is the most common sustained arrhythmia. It affects as many as 6.1 million people in the United States and increases their risk of stroke by 4-5 times. AF is evidently a very serious condition, but the scientific community does not yet fully understand its underlying mechani...2020
30 Loftus, Patrick D.Agonist binding of herg K+ channels inhibits epithelial cell extrusion but not apoptosis in MDCK monolayers; providing possibilities to cancer metastasis regulationMetastasis is commonly referred to as cancerous cell movement from an original site to one or more sites elsewhere in the body. When these moving cancerous cells are malignant, an individual's chance of survival is decreased. In order for epithelial cells to move they are detached from the epitheliu...Biomedical Engineering2012-01
31 Citterman, Abigail R.Low frequencies improve intensity discrimination for electrocutaneous artificial sensory feedbackThe current standard of care for those living with upper-limb loss is unsatisfactory, with up to 50% of amputees abandoning their prostheses, citing unintuitive use and a lack of sensory feedback as critical factors. Electrocutaneous stimulation uses electrodes on the skin to evoke tactile sensation...2022
32 Schlegel, Isabelle B.Peptide-fab conjugates to improve treatment of neovascular age-related macular degenerationAge-Related Macular Degeneration (AMD), a chronic disease of the eye and leading cause of blindness in Americans over 50, is often treated with agents that inhibit Vascular Endothelial Growth Factor (VEGF). Ranibizumab is an anti-VEGF antibody fragment (Fab) effective at treating over 90% of AMD pat...2021
33 Tara L. DeansUnraveling the Q system function in prokaryotes2024
34 Ruan, TingEndogenous ceramide contributes to cardiovascular complications in Type II diabetes by decreasing the association between PP2A and I2PP2ACardiovascular complications are the leading cause of death in individuals with conditions associated with insulin resistance, e.g. type 2 diabetes, diet-induced obesity. In patients with type 2 diabetes, cardiovascular complications are 2-4 times more prevalent. One common cardiovascular complicati...Ceramides - Physiological effect; Diabetic angiopathies2014
35 Kodele, ChristianMultivalent Human Serum Albumin - Rituximab Fab' Conjugates Induce Apoptosis in Lymphoma CellsNon-Hodgkin lymphoma (NHL) is an immune disease, mostly of B-cell origin (85%), as well as the ninth leading cause of cancer death in the United States. Although treatments for NHLs greatly improved following the FDA approval of Rituximab (RTX), refractive malignancies still occur that are nonrespon...2018
36 Tarboton, PaisleyCharacterization of Apoptosis and Inhibitory Neurons in Cortical Organoids Generated from Human Induced Pluripotent Stem Cells.Modeling human brain diseases in a laboratory setting is critical to understanding the underlying pathology and developing new treatments for patients. Organoids are 3D tissue cultures that provide a promising way to model human brain development in vitro and have been used previously to gain novel ...2018
37 Uchida, Kimberly AkimiPost-translational regulation of the tumor suppressor PDCD4Expression of the tumor suppressor Programmed cell death 4 (PDCD4) is correlated with better survival outcomes in several types of cancer. When PDCD4 is coexpressed with protein arginine methyltransferase 5, however, this trend does not hold true, suggesting that PDCD4 methylation is involved in the...Tumor suppressor proteins - Regulation2013-12
38 Marler, TylerThe role of gangliar plexi in the treatment of atrial fibrillationIntroduction: Gangliar plexi (GP) are bundles of interconnected neurons found embedded in FPs (FPs) surrounding the atria of the heart. The function of these neurons is controversial but they may form a localized control system for the heart and play a role in the induction of atrial fibrillation (A...Atrial fibrillation Treatment; Gangliar plexi2012-05
39 Hyer, Christina CottrellEffect of M1 Matrix Protein on Hemagglutinin Expression and Influenza Virus-Like Particle Production in Trichoplusia NIVirus-like particles (VLPs) are a new and effective flu vaccine approach. VLPs are non-infectious and can produce robust immune responses. Flu VLPs are typically created by co-expressing the flu hemagglutinin (HA) surface antigen and the matrix protein M1-which assists in viral and VLP budding-in cu...2017
40 Lietzke, StephanieRemoval of endotoxins from recombinant antithrombinEndotoxins (also known as lipopolysaccharides or ETs) are a pyrogenic byproduct of the breakdown of gram-negative bacterial cell-walls, such as E. coli. They cause fever and septic shock in humans, and are therefore highly regulated by the FDA and USP. ETs are a common contaminant in recombinant pr...Endotoxins - Research; Antithrombins - Therapeutic use; Sheep as laboratory animals - Research; endotoxin removal; Angiogenesis2016-04
41 Sedley, AndrewEgocentric Navigation in a Morris Water Maze for Testing Memory Formation in MiceMouse models are crucial to understanding not only sensory and cognitive neurological processes, but also diseases, disabilities, and responses to pharmacological or surgical treatments. Behavioral tests are essential assets in the description of these models. The Morris Water Maze is a common behav...2018
42 Sharma, KapilAnalyzing the relationship between PDM2 and B-catenin proteins in human cancersTumorigenesis is promoted by the manipulation of several co-factors and pathways, in which PKM2 and P-catenin proteins play a significant role in a variety of cancers. New research states that these two hegemonic cancer proteins directly bind with each other and may provide a new angle for cance...Pyruvate kinase - Research; Tumorigensis - Research2016-04
43 Tripathy, AnuragNickel-Functionalized Solid-State Titania Nanotube Array for the Electrochemical Detection of Breath-Based Biomarkers in Colorectal CancerColorectal cancer (CRC) is the second most common cancer in the United States with approximately 137,000 new cases each year, 50,000 of which are fatal due to belated screenings [1]. The gold-standard detection method is colonoscopy, a direct visualization tool that facilitates the removal of minor ...2019
44 Novy, JennaSelective and Localized Marking of Activated Dendritic Spines Using a Novel Genetic Construct, SlayrThe brain's ability to store memory is as remarkable as it is complex. The mechanism behind memory storage is still not fully understood and has become an essential question in the neuroscience field. Long-term memories are thought to form via the strengthening of specific connections between neuron...2020
45 Frederiksen, HunterPharmacokinetics of Locally Delivered Vancomycin as a Powder & in a HydrogelOrthopedic surgeons currently administer powder vancomycin directly over surgical sites in order to mitigate infections. Local antibiotic administration has been effective at reducing infections; however, there have been few preliminary studies investigating the pharmacokinetics of locally delivered...2018
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