Honors Theses Open Access
 
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1 Armstrong, Blair P.Lower critical solution temperature behavior of elastin-coiled-coil polymer, a potential platform for treatment of non-hodgkin's lymphomaNon-Hodgkin's lymphoma takes the lives of 20,000 Americans each year. When traditional therapies fail, clinicians have turned to a drug, rituximab, for treatment. However, rituximab is now curative for less than 50% of patients and new treatments are needed. Drug-free macromolecular therapeutics (DF...2021
2 Adams, Samuel I.Correcting acoustic phase aberrations in focused ultrasound treatments for breast cancerBreast cancer is the most diagnosed cancer worldwide. Early-stage localized cancers are currently treated with surgical lumpectomy and radiation. Focused ultrasound is a disruptive technology that can replace conventional surgical and radiation therapies to provide noninvasive cancer treatment. This...2021
3 Tiwari, SarthakUtilizing light scattering spectroscopy and machine learning to differentiate heterogenous tissue samplesCurrent biopsy approaches either lack depth penetration or real-time analysis. Light scattering spectroscopy (LSS) aims to address these issues, and our goal is to investigate the use of LSS for identifying cardiac conduction tissues. LSS data were collected from donor tissue samples and created a 3...2023
4 Thomas, Payton JImportance sampling techniques for genetic circuit analysisGenetic circuits have been identified as a promising technology that could revolutionize several areas, including biofuels, biomanufacturing, and medicine. Despite the tremendous potential of this technology, there are significant challenges associated with its development and implementation. One of...2023
5 Richards, GraceMy lung health: shared decision making for lung cancer screeningLung cancer is the deadliest cancer in the United States. In 2019, around 140,000 deaths occurred in the Untied States due to lung cancer. Low-dose CT screening to detect lung cancer is an effective tool for preventing these deaths, but the screening has some harms associated with it in addition to ...2023
6 Schlegel, Isabelle B.Peptide-fab conjugates to improve treatment of neovascular age-related macular degenerationAge-Related Macular Degeneration (AMD), a chronic disease of the eye and leading cause of blindness in Americans over 50, is often treated with agents that inhibit Vascular Endothelial Growth Factor (VEGF). Ranibizumab is an anti-VEGF antibody fragment (Fab) effective at treating over 90% of AMD pat...2021
7 Koblanski, KasperLiver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilizationInsulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin...2022
8 Wankier, Zakary S.Use of computer tomography imaging to observe increased distal-end cortical bone around a percutaneous osseointegrated implantOsseointegration (OI) is being used for the direct skeletal attachment of prosthetic limbs using an intramedullary stem that extends percutaneously from the subject's residual limb. For this technology to be successful, bone ingrowth and remodeling around the implant must occur. Physicians need an e...2022
9 Citterman, Abigail R.Low frequencies improve intensity discrimination for electrocutaneous artificial sensory feedbackThe current standard of care for those living with upper-limb loss is unsatisfactory, with up to 50% of amputees abandoning their prostheses, citing unintuitive use and a lack of sensory feedback as critical factors. Electrocutaneous stimulation uses electrodes on the skin to evoke tactile sensation...2022
10 Young, MichaelThe Contributions of Elastin to Ligament ViscoelastictyLigaments exhibit viscoelastic behavior in response to strain. This behavior protects joints from injury during loading. Collagen is the primary structural component of ligaments, but does not account fully for the viscoelastic behavior. Elastin is another structural protein in ligaments, and provid...2017
11 Hyer, Christina CottrellEffect of M1 Matrix Protein on Hemagglutinin Expression and Influenza Virus-Like Particle Production in Trichoplusia NIVirus-like particles (VLPs) are a new and effective flu vaccine approach. VLPs are non-infectious and can produce robust immune responses. Flu VLPs are typically created by co-expressing the flu hemagglutinin (HA) surface antigen and the matrix protein M1-which assists in viral and VLP budding-in cu...2017
12 Grimmett, RollinEffects of Hypoxia and High Fat Diet on D. Melanogaster Heart PhysiologyHeart disease severely affects millions of people worldwide, and is caused by various environmental and genetic factors. The aim of this study is to examine the combined physiological effects of hypoxia and a high fat diet (two known causes) on Drosophila Melanogaster heart structure. Sets of adult ...2017
13 Tarboton, PaisleyCharacterization of Apoptosis and Inhibitory Neurons in Cortical Organoids Generated from Human Induced Pluripotent Stem Cells.Modeling human brain diseases in a laboratory setting is critical to understanding the underlying pathology and developing new treatments for patients. Organoids are 3D tissue cultures that provide a promising way to model human brain development in vitro and have been used previously to gain novel ...2018
14 Harding, Anna NeiblingLow-Cost Surface Electromyogtraphy Sleeve for Quick and Repeatable Decoding of Motor IntentSurface electromyography (sEMG) is a noninvasive way to decode motor intent for applications such as prosthesis control, virtual reality, and stroke or spinal cord rehabilitation. State-of-the-art methods of decoding motor intent used in myoelectric prostheses have limited capabilities, partially du...2019
15 Frederiksen, HunterPharmacokinetics of Locally Delivered Vancomycin as a Powder & in a HydrogelOrthopedic surgeons currently administer powder vancomycin directly over surgical sites in order to mitigate infections. Local antibiotic administration has been effective at reducing infections; however, there have been few preliminary studies investigating the pharmacokinetics of locally delivered...2018
16 Tripathy, AnuragNickel-Functionalized Solid-State Titania Nanotube Array for the Electrochemical Detection of Breath-Based Biomarkers in Colorectal CancerColorectal cancer (CRC) is the second most common cancer in the United States with approximately 137,000 new cases each year, 50,000 of which are fatal due to belated screenings [1]. The gold-standard detection method is colonoscopy, a direct visualization tool that facilitates the removal of minor ...2019
17 Wang, Karissa M.Transcription factor NFATc1's signaling pathway and role in cardiomyocyte functionAtrial fibrillation (AF) is the most common sustained arrhythmia. It affects as many as 6.1 million people in the United States and increases their risk of stroke by 4-5 times. AF is evidently a very serious condition, but the scientific community does not yet fully understand its underlying mechani...2020
18 Radhakrishnan, SridharanDevelopment of Low-Cost system for Myoelectric Prosthesis ControlThe upper limb prosthetics field has advanced to where artificial hands can mimic human motions based on electrical signals emitted from muscular activation and can even open and close proportionate to the amplitude of signal they receive. However, these prostheses are very expensive, with some cost...2020
19 Novy, JennaSelective and Localized Marking of Activated Dendritic Spines Using a Novel Genetic Construct, SlayrThe brain's ability to store memory is as remarkable as it is complex. The mechanism behind memory storage is still not fully understood and has become an essential question in the neuroscience field. Long-term memories are thought to form via the strengthening of specific connections between neuron...2020
20 Sowards, SteffanComputational fluid dynamics modeling for Respiratory airflow patterns of python regiusThe phylogenetic distribution and mechanisms underpinning unidirectional pulmonary airflow, in which gases pass through a portion of the lung in an identical direction during both aspiration and expiration, are poorly understood. Until recently, it was thought this pattern of flow required unique fe...2018
21 Sedley, AndrewEgocentric Navigation in a Morris Water Maze for Testing Memory Formation in MiceMouse models are crucial to understanding not only sensory and cognitive neurological processes, but also diseases, disabilities, and responses to pharmacological or surgical treatments. Behavioral tests are essential assets in the description of these models. The Morris Water Maze is a common behav...2018
22 Kodele, ChristianMultivalent Human Serum Albumin - Rituximab Fab' Conjugates Induce Apoptosis in Lymphoma CellsNon-Hodgkin lymphoma (NHL) is an immune disease, mostly of B-cell origin (85%), as well as the ninth leading cause of cancer death in the United States. Although treatments for NHLs greatly improved following the FDA approval of Rituximab (RTX), refractive malignancies still occur that are nonrespon...2018
23 Uchida, Kimberly AkimiPost-translational regulation of the tumor suppressor PDCD4Expression of the tumor suppressor Programmed cell death 4 (PDCD4) is correlated with better survival outcomes in several types of cancer. When PDCD4 is coexpressed with protein arginine methyltransferase 5, however, this trend does not hold true, suggesting that PDCD4 methylation is involved in the...Tumor suppressor proteins - Regulation2013-12
24 Ruan, TingEndogenous ceramide contributes to cardiovascular complications in Type II diabetes by decreasing the association between PP2A and I2PP2ACardiovascular complications are the leading cause of death in individuals with conditions associated with insulin resistance, e.g. type 2 diabetes, diet-induced obesity. In patients with type 2 diabetes, cardiovascular complications are 2-4 times more prevalent. One common cardiovascular complicati...Ceramides - Physiological effect; Diabetic angiopathies2014
25 Marler, TylerThe role of gangliar plexi in the treatment of atrial fibrillationIntroduction: Gangliar plexi (GP) are bundles of interconnected neurons found embedded in FPs (FPs) surrounding the atria of the heart. The function of these neurons is controversial but they may form a localized control system for the heart and play a role in the induction of atrial fibrillation (A...Atrial fibrillation Treatment; Gangliar plexi2012-05
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