|
|
Creator | Title | Description | Subject | Date |
1 |
|
Loftus, Patrick D. | Agonist binding of herg K+ channels inhibits epithelial cell extrusion but not apoptosis in MDCK monolayers; providing possibilities to cancer metastasis regulation | Metastasis is commonly referred to as cancerous cell movement from an original site to one or more sites elsewhere in the body. When these moving cancerous cells are malignant, an individual's chance of survival is decreased. In order for epithelial cells to move they are detached from the epitheliu... | Biomedical Engineering | 2012-01 |
2 |
|
Marler, Tyler | The role of gangliar plexi in the treatment of atrial fibrillation | Introduction: Gangliar plexi (GP) are bundles of interconnected neurons found embedded in FPs (FPs) surrounding the atria of the heart. The function of these neurons is controversial but they may form a localized control system for the heart and play a role in the induction of atrial fibrillation (A... | Atrial fibrillation Treatment; Gangliar plexi | 2012-05 |
3 |
|
Johnson, Rhiannon | Thermal modulation of the semicircular canal afferent response in the oyster toadfish, opsanus tau | Current cochlear implant devices provide limited hearing ability to the deaf through electrical stimulation of the auditory nerve. Recent studies have shown that pulsed infrared (IR) radiation can also be used to stimulate the inner ear neurons and has the potential to be used in prostheses to help ... | Biomedical Engineering | 2012-05 |
4 |
|
Lei, Jeffrey KaChon | Increased gluti expression in mouse cardiomyocytes preserves mitochondrial function but is insufficient to attenuate pressure overload-induced contractile dysfunction | Lifelong over-expression of GLUT1 transporter in the heart has been shown to preserve contractile function after aortic constriction. However it is unclear whether this protective effect is due to GLUT1 overexpression itself or due to reprogramming of heart metabolism as a result of long-term increa... | Bioengineering | 2013-04 |
5 |
|
Uchida, Kimberly Akimi | Post-translational regulation of the tumor suppressor PDCD4 | Expression of the tumor suppressor Programmed cell death 4 (PDCD4) is correlated with better survival outcomes in several types of cancer. When PDCD4 is coexpressed with protein arginine methyltransferase 5, however, this trend does not hold true, suggesting that PDCD4 methylation is involved in the... | Tumor suppressor proteins - Regulation | 2013-12 |
6 |
|
Ruan, Ting | Endogenous ceramide contributes to cardiovascular complications in Type II diabetes by decreasing the association between PP2A and I2PP2A | Cardiovascular complications are the leading cause of death in individuals with conditions associated with insulin resistance, e.g. type 2 diabetes, diet-induced obesity. In patients with type 2 diabetes, cardiovascular complications are 2-4 times more prevalent. One common cardiovascular complicati... | Ceramides - Physiological effect; Diabetic angiopathies | 2014 |
7 |
|
Anjewierden, Scott | Automated kinematic analysis of pre-pluse inhibition in larval zebrafish | Animals differentially ignore or attend to sensory information depending on their immediate environment. A significant example of this phenomenon is audiomotorpre-pulse inhibition (PPI), in which the startle response to a loud noise is suppressed by a preceding stimulus of lower intensity. This a... | Zebra danio - Development; Kinematics - Research; Kinematic parameters; Swim kinematics; Pre-pulse inhibition | 2014-12 |
8 |
|
Taggart, Maxwell M. | A novel MRI-based screening method for assessing atrio-esophageal fistula risk following cardia ablation | Atrio-esophageal fistulas affect 1 in 2000 patients who undergo cardiac ablation procedures with a mortality rate of 93%. Methods for detecting atrio-esophageal fistula formation that are objective and non-invasive could reduce the mortality associated with this disease. This study was performed ret... | Magnetic resonance imaging; Cardia ablation; Trio-esophageal fistual | 2014-12 |
9 |
|
Black, Taylor Madison | Impacts of Tobacco Smoke Exposure and Outlier Body Mass Indices on Pediatric Asthma Outcomes | There are seven million children in the United States impacted by asthma [1]. When assessing the severity of a child's asthma, it is important to take into account risk factors known to affect child hood asthma. Two such risk factors that are modifiable include parental tobacco smoke exposure (TSE)... | Asthma - Child; Tobacco smoke - Health aspects - United States | 2015-05 |
10 |
|
Khoury, Mark | Muscle activity changes due to immobilization and partial weight bearing of the lower leg | Tibial fractures account for half a million hospitalizations per year. Although clinical treatment of tibial fractures requires immobilization of the affected limb and partial weight bearing (PWB) prescriptions, the effects of this treatment protocol on gait and muscle activity have not been studied... | Muscles -- Physiology; Tibia -- Wounds and injuries; Muscle activity; Partial weight bearing | 2015-05 |
11 |
|
Waller, Rosalie G. | Exome sequence comparison of seventy-seven multiple myeloma cases identifies potential risk alleles | Multiple Myeloma (MM) is a heritable cancer of plasma cells with poor prognosis. Although a few genomic risk-loci have been identified for MM, no risk variants have been published that explain MM heritability. We hypothesize MM heritability is due to rare germ-line variants that can be discovered th... | Multiple myeloma -- Genetic aspects; Exomes; Exome sequence; Risk alleles | 2015-05 |
12 |
|
Javdan, Shwan | Targeted HPMA copolymer-gemcitabine conjugates for the treatment of ovarian carcinoma | Each year in the United States, over 14,000 women die from ovarian cancer. Anthracyclines-a class of chemotherapeutics-have long been the primary treatment for this and many other cancers, yet they often leave patients with cardiotoxicity, hepatotoxicity, and a number of other adverse effects. Polym... | Ovaries -- Cancer -- Treatment; Polymeric drug delivery systems; Polymer-drug conjugates; pHPMA | 2015-12 |
13 |
|
Flach, Brian | Examining the effects of whisker trimming on mouse brain cell growth | Hoxb8 microglia are a particular breed of scavenger cells in the brain which have been related to obsessive compulsive disorder (OCD)-like behavior among other behavioral disorders. These cells have been found to reach full maturity during a period of neurological development known as the critical ... | Obsessive-compulsive disorder - Research; Microglia - Research; Mice as laboratory animals - Research; Whiskers; Scavenger cells; Hoxb8 microglia | 2016-04 |
14 |
|
Newton, James | Social behaviors in the developing Danio Rerio larva and adult Danionella | Larval zebrafish (Danio rerio) in most respects excel as an animal model in the study of neural networks, due to their small size and optical transparency. These traits permit optogenetic manipulation and live neuronal imaging of the entire brain, which when paired with behavioral analysis, have pot... | Zebrafish (Zebra danio) - behavior; Zebrafish - embryology; Zebrafish - physiology | 2016-04 |
15 |
|
Lietzke, Stephanie | Removal of endotoxins from recombinant antithrombin | Endotoxins (also known as lipopolysaccharides or ETs) are a pyrogenic byproduct of the breakdown of gram-negative bacterial cell-walls, such as E. coli. They cause fever and septic shock in humans, and are therefore highly regulated by the FDA and USP. ETs are a common contaminant in recombinant pr... | Endotoxins - Research; Antithrombins - Therapeutic use; Sheep as laboratory animals - Research; endotoxin removal; Angiogenesis | 2016-04 |
16 |
|
Sharma, Kapil | Analyzing the relationship between PDM2 and B-catenin proteins in human cancers | Tumorigenesis is promoted by the manipulation of several co-factors and pathways, in which PKM2 and P-catenin proteins play a significant role in a variety of cancers. New research states that these two hegemonic cancer proteins directly bind with each other and may provide a new angle for cance... | Pyruvate kinase - Research; Tumorigensis - Research | 2016-04 |
17 |
|
Palmieri, Nikole | Validation of a nonlinear optimization algorithm for reconstruction of diffused images | Living tissue is a diffusive light-scattering medium, preventing traditional fluorescence microscopy from being used as a diagnostic imaging modality. To determine microscopy from being used as a diagnostic imaging modality. To determine whether the nonlinear optimization algorithm developed for C... | Diagnostic imaging; Mathematical optimization; Image processing; Diffusion distance; Computational Cannula Microscopy; Nonlinear optimization; MATLAB | 2016-04 |
18 |
|
Singh, Anand | Polyurethane molecular weight determination in catheters via gel permeation chromatography | Antimicrobial catheter extrusions are loaded with an antiseptic drug in order to help prevent catheter-related infections. Previous research has shown that polymer molecular weight (Mw) can be used to control drug loading levels. Polyurethane based resin and catheter shaft extrusion samples were cho... | Catheters - Research; Bacterial diseases - Prevention; Drug loading levels; Gel permeation chromatography; Diffusion distance; Antimicrobial catheter extrustions; Catheter shaft extrusions; Bacterial Infections; MATLAB | 2016-05 |
19 |
|
Wang, Minna | Managing limited ECG access in a clinical cardiac electrophysiology setting | Electrocardiographic Imaging (ECGI) is a computational approach that seeks to reconstruct cardiac electrical activity with high precision from body surface ECGs by solving a numerical inverse problem. Though there have been great advancements in ECGI, there is still a need for progress in specific a... | Electrocardiography - Research; Heart - Diseases - Diagnosis; Body surface potentials | 2016-05 |
20 |
|
Gajiwala, Snehal | Determining the variability of depressive brain circuitry among healthy subjects for deep brain stimulation | Deep Brain Stimulation (DBS) is being evaluated to treat Treatment-Resistant Depression, though it has shown mixed results. We believe that variability within the fiber tracts of the brain may account for these outcome differences. In this study, we attempt to characterize this potential variation.... | Brain stimulation - Therapeutic use - Research; Depression, Mental - Treatment - Research; Deep brain stimulation; Depressive brain circuitry; Fiber tracts; Tractography | 2016-05 |
21 |
|
Luo, Shirley | Development of a bioabsorbalbe active release antimicrobial coating for orthopedic implants | Orthopedic implantations often create an opportunity for biofilm-related infections to arise. Patients infected with biofilm must often undergo additional surgeries for repair or replacement, which puts them at a greater risk of osteomyelitis, sepsis, and other complications including death [17]. T... | Orthopedic implants - Research; Anti-infective agents - Research; Staphyloccoccal infections - Prevention and control - Research; Antimicrobial coating; Staphylococcus aureus | 2016-05 |
22 |
|
Davidson, Olivia | Utilizing synthetic biology to improve platelet transfusion outcomes | Platelets are essential to blood clotting. Due to a high risk of bacterial infection, donor platelets have short shelf -lives. As a result, being able to maintain a constant supply of platelets in vitro would be clinically valuable. This could be accomplished by using synthetic biology to guide stem... | Blood platelets - Transfusion - Research; Stem cells - Therapeutic use; Synthetic biology; Hematopoietic stem cells; Erthropoientin | 2016-05 |
23 |
|
Gilbert, John | A novel tool to capture neural activity across an entire brain using C-FOS as an indicator | Immunohistochemical staining for the expression of the immediate early gene c-Fos is a powerful tool to measure neuronal activation of neurons across an entire brain. The results of c-Fos immunostaining are often quantified by counting the number of immunolabeled cells in a region of interest (ROI) ... | Brain - Localization of functions - Research; Brain - Physiology - Research; Brain mapping - Research; Memory - Research; Mice as laboratory animals - Research; Brain activity; Immunohistochemical staining | 2016-05 |
24 |
|
Hyer, Christina Cottrell | Effect of M1 Matrix Protein on Hemagglutinin Expression and Influenza Virus-Like Particle Production in Trichoplusia NI | Virus-like particles (VLPs) are a new and effective flu vaccine approach. VLPs are non-infectious and can produce robust immune responses. Flu VLPs are typically created by co-expressing the flu hemagglutinin (HA) surface antigen and the matrix protein M1-which assists in viral and VLP budding-in cu... | | 2017 |
25 |
|
Young, Michael | The Contributions of Elastin to Ligament Viscoelasticty | Ligaments exhibit viscoelastic behavior in response to strain. This behavior protects joints from injury during loading. Collagen is the primary structural component of ligaments, but does not account fully for the viscoelastic behavior. Elastin is another structural protein in ligaments, and provid... | | 2017 |