Honors Theses Open Access
 
Filters: Department: "Biomedical Engineering" Collection: "ir_htoa"
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CreatorTitleDescriptionSubjectDate
1 Flach, BrianExamining the effects of whisker trimming on mouse brain cell growthHoxb8 microglia are a particular breed of scavenger cells in the brain which have been related to obsessive compulsive disorder (OCD)-like behavior among other behavioral disorders. These cells have been found to reach full maturity during a period of neurological development known as the critical ...Obsessive-compulsive disorder - Research; Microglia - Research; Mice as laboratory animals - Research; Whiskers; Scavenger cells; Hoxb8 microglia2016-04
2 Black, Taylor MadisonImpacts of Tobacco Smoke Exposure and Outlier Body Mass Indices on Pediatric Asthma OutcomesThere are seven million children in the United States impacted by asthma [1]. When assessing the severity of a child's asthma, it is important to take into account risk factors known to affect child hood asthma. Two such risk factors that are modifiable include parental tobacco smoke exposure (TSE)...Asthma - Child; Tobacco smoke - Health aspects - United States2015-05
3 Uchida, Kimberly AkimiPost-translational regulation of the tumor suppressor PDCD4Expression of the tumor suppressor Programmed cell death 4 (PDCD4) is correlated with better survival outcomes in several types of cancer. When PDCD4 is coexpressed with protein arginine methyltransferase 5, however, this trend does not hold true, suggesting that PDCD4 methylation is involved in the...Tumor suppressor proteins - Regulation2013-12
4 Newton, JamesSocial behaviors in the developing Danio Rerio larva and adult DanionellaLarval zebrafish (Danio rerio) in most respects excel as an animal model in the study of neural networks, due to their small size and optical transparency. These traits permit optogenetic manipulation and live neuronal imaging of the entire brain, which when paired with behavioral analysis, have pot...Zebrafish (Zebra danio) - behavior; Zebrafish - embryology; Zebrafish - physiology2016-04
5 Singh, AnandPolyurethane molecular weight determination in catheters via gel permeation chromatographyAntimicrobial catheter extrusions are loaded with an antiseptic drug in order to help prevent catheter-related infections. Previous research has shown that polymer molecular weight (Mw) can be used to control drug loading levels. Polyurethane based resin and catheter shaft extrusion samples were cho...Catheters - Research; Bacterial diseases - Prevention; Drug loading levels; Gel permeation chromatography; Diffusion distance; Antimicrobial catheter extrustions; Catheter shaft extrusions; Bacterial Infections; MATLAB2016-05
6 Kodele, ChristianMultivalent Human Serum Albumin - Rituximab Fab' Conjugates Induce Apoptosis in Lymphoma CellsNon-Hodgkin lymphoma (NHL) is an immune disease, mostly of B-cell origin (85%), as well as the ninth leading cause of cancer death in the United States. Although treatments for NHLs greatly improved following the FDA approval of Rituximab (RTX), refractive malignancies still occur that are nonrespon...2018
7 Tripathy, AnuragNickel-Functionalized Solid-State Titania Nanotube Array for the Electrochemical Detection of Breath-Based Biomarkers in Colorectal CancerColorectal cancer (CRC) is the second most common cancer in the United States with approximately 137,000 new cases each year, 50,000 of which are fatal due to belated screenings [1]. The gold-standard detection method is colonoscopy, a direct visualization tool that facilitates the removal of minor ...2019
8 Khoury, MarkMuscle activity changes due to immobilization and partial weight bearing of the lower legTibial fractures account for half a million hospitalizations per year. Although clinical treatment of tibial fractures requires immobilization of the affected limb and partial weight bearing (PWB) prescriptions, the effects of this treatment protocol on gait and muscle activity have not been studied...Muscles -- Physiology; Tibia -- Wounds and injuries; Muscle activity; Partial weight bearing2015-05
9 Harding, Anna NeiblingLow-Cost Surface Electromyogtraphy Sleeve for Quick and Repeatable Decoding of Motor IntentSurface electromyography (sEMG) is a noninvasive way to decode motor intent for applications such as prosthesis control, virtual reality, and stroke or spinal cord rehabilitation. State-of-the-art methods of decoding motor intent used in myoelectric prostheses have limited capabilities, partially du...2019
10 Frederiksen, HunterPharmacokinetics of Locally Delivered Vancomycin as a Powder & in a HydrogelOrthopedic surgeons currently administer powder vancomycin directly over surgical sites in order to mitigate infections. Local antibiotic administration has been effective at reducing infections; however, there have been few preliminary studies investigating the pharmacokinetics of locally delivered...2018
11 Wang, MinnaManaging limited ECG access in a clinical cardiac electrophysiology settingElectrocardiographic Imaging (ECGI) is a computational approach that seeks to reconstruct cardiac electrical activity with high precision from body surface ECGs by solving a numerical inverse problem. Though there have been great advancements in ECGI, there is still a need for progress in specific a...Electrocardiography - Research; Heart - Diseases - Diagnosis; Body surface potentials2016-05
12 Javdan, ShwanTargeted HPMA copolymer-gemcitabine conjugates for the treatment of ovarian carcinomaEach year in the United States, over 14,000 women die from ovarian cancer. Anthracyclines-a class of chemotherapeutics-have long been the primary treatment for this and many other cancers, yet they often leave patients with cardiotoxicity, hepatotoxicity, and a number of other adverse effects. Polym...Ovaries -- Cancer -- Treatment; Polymeric drug delivery systems; Polymer-drug conjugates; pHPMA2015-12
13 Novy, JennaSelective and Localized Marking of Activated Dendritic Spines Using a Novel Genetic Construct, SlayrThe brain's ability to store memory is as remarkable as it is complex. The mechanism behind memory storage is still not fully understood and has become an essential question in the neuroscience field. Long-term memories are thought to form via the strengthening of specific connections between neuron...2020
14 Lietzke, StephanieRemoval of endotoxins from recombinant antithrombinEndotoxins (also known as lipopolysaccharides or ETs) are a pyrogenic byproduct of the breakdown of gram-negative bacterial cell-walls, such as E. coli. They cause fever and septic shock in humans, and are therefore highly regulated by the FDA and USP. ETs are a common contaminant in recombinant pr...Endotoxins - Research; Antithrombins - Therapeutic use; Sheep as laboratory animals - Research; endotoxin removal; Angiogenesis2016-04
15 Marler, TylerThe role of gangliar plexi in the treatment of atrial fibrillationIntroduction: Gangliar plexi (GP) are bundles of interconnected neurons found embedded in FPs (FPs) surrounding the atria of the heart. The function of these neurons is controversial but they may form a localized control system for the heart and play a role in the induction of atrial fibrillation (A...Atrial fibrillation Treatment; Gangliar plexi2012-05
16 Sharma, KapilAnalyzing the relationship between PDM2 and B-catenin proteins in human cancersTumorigenesis is promoted by the manipulation of several co-factors and pathways, in which PKM2 and P-catenin proteins play a significant role in a variety of cancers. New research states that these two hegemonic cancer proteins directly bind with each other and may provide a new angle for cance...Pyruvate kinase - Research; Tumorigensis - Research2016-04
17 Anjewierden, ScottAutomated kinematic analysis of pre-pluse inhibition in larval zebrafishAnimals differentially ignore or attend to sensory information depending on their immediate environment. A significant example of this phenomenon is audiomotorpre-pulse inhibition (PPI), in which the startle response to a loud noise is suppressed by a preceding stimulus of lower intensity. This a...Zebra danio - Development; Kinematics - Research; Kinematic parameters; Swim kinematics; Pre-pulse inhibition2014-12
18 Sowards, SteffanComputational fluid dynamics modeling for Respiratory airflow patterns of python regiusThe phylogenetic distribution and mechanisms underpinning unidirectional pulmonary airflow, in which gases pass through a portion of the lung in an identical direction during both aspiration and expiration, are poorly understood. Until recently, it was thought this pattern of flow required unique fe...2018
19 Gajiwala, SnehalDetermining the variability of depressive brain circuitry among healthy subjects for deep brain stimulationDeep Brain Stimulation (DBS) is being evaluated to treat Treatment-Resistant Depression, though it has shown mixed results. We believe that variability within the fiber tracts of the brain may account for these outcome differences. In this study, we attempt to characterize this potential variation....Brain stimulation - Therapeutic use - Research; Depression, Mental - Treatment - Research; Deep brain stimulation; Depressive brain circuitry; Fiber tracts; Tractography2016-05
20 Luo, ShirleyDevelopment of a bioabsorbalbe active release antimicrobial coating for orthopedic implantsOrthopedic implantations often create an opportunity for biofilm-related infections to arise. Patients infected with biofilm must often undergo additional surgeries for repair or replacement, which puts them at a greater risk of osteomyelitis, sepsis, and other complications including death [17]. T...Orthopedic implants - Research; Anti-infective agents - Research; Staphyloccoccal infections - Prevention and control - Research; Antimicrobial coating; Staphylococcus aureus2016-05
21 Radhakrishnan, SridharanDevelopment of Low-Cost system for Myoelectric Prosthesis ControlThe upper limb prosthetics field has advanced to where artificial hands can mimic human motions based on electrical signals emitted from muscular activation and can even open and close proportionate to the amplitude of signal they receive. However, these prostheses are very expensive, with some cost...2020
22 Thomas, Payton JImportance sampling techniques for genetic circuit analysisGenetic circuits have been identified as a promising technology that could revolutionize several areas, including biofuels, biomanufacturing, and medicine. Despite the tremendous potential of this technology, there are significant challenges associated with its development and implementation. One of...2023
23 Koblanski, KasperLiver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilizationInsulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin...2022
24 Wankier, Zakary S.Use of computer tomography imaging to observe increased distal-end cortical bone around a percutaneous osseointegrated implantOsseointegration (OI) is being used for the direct skeletal attachment of prosthetic limbs using an intramedullary stem that extends percutaneously from the subject's residual limb. For this technology to be successful, bone ingrowth and remodeling around the implant must occur. Physicians need an e...2022
25 Hyer, Christina CottrellEffect of M1 Matrix Protein on Hemagglutinin Expression and Influenza Virus-Like Particle Production in Trichoplusia NIVirus-like particles (VLPs) are a new and effective flu vaccine approach. VLPs are non-infectious and can produce robust immune responses. Flu VLPs are typically created by co-expressing the flu hemagglutinin (HA) surface antigen and the matrix protein M1-which assists in viral and VLP budding-in cu...2017
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