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CreatorTitleDescriptionSubjectDate
1 Johnson, RhiannonThermal modulation of the semicircular canal afferent response in the oyster toadfish, opsanus tauCurrent cochlear implant devices provide limited hearing ability to the deaf through electrical stimulation of the auditory nerve. Recent studies have shown that pulsed infrared (IR) radiation can also be used to stimulate the inner ear neurons and has the potential to be used in prostheses to help ...Biomedical Engineering2012-05
2 Wang, MinnaManaging limited ECG access in a clinical cardiac electrophysiology settingElectrocardiographic Imaging (ECGI) is a computational approach that seeks to reconstruct cardiac electrical activity with high precision from body surface ECGs by solving a numerical inverse problem. Though there have been great advancements in ECGI, there is still a need for progress in specific a...Electrocardiography - Research; Heart - Diseases - Diagnosis; Body surface potentials2016-05
3 Adams, IsabelPelvic floor acceleration is damped compared to skeletal acceleration while walkingOne in four American women suffer from pelvic floor disorders (PFDs) [1]. Current research shows the cause of pelvic organ prolapse is multifactorial, with risk factors including vaginal childbirth and advancing age [2]. To facilitate the development of prevention strategies and treatments to minimi...2023
4 Tiwari, SarthakUtilizing light scattering spectroscopy and machine learning to differentiate heterogenous tissue samplesCurrent biopsy approaches either lack depth penetration or real-time analysis. Light scattering spectroscopy (LSS) aims to address these issues, and our goal is to investigate the use of LSS for identifying cardiac conduction tissues. LSS data were collected from donor tissue samples and created a 3...2023
5 Khoury, MarkMuscle activity changes due to immobilization and partial weight bearing of the lower legTibial fractures account for half a million hospitalizations per year. Although clinical treatment of tibial fractures requires immobilization of the affected limb and partial weight bearing (PWB) prescriptions, the effects of this treatment protocol on gait and muscle activity have not been studied...Muscles -- Physiology; Tibia -- Wounds and injuries; Muscle activity; Partial weight bearing2015-05
6 Radhakrishnan, SridharanDevelopment of Low-Cost system for Myoelectric Prosthesis ControlThe upper limb prosthetics field has advanced to where artificial hands can mimic human motions based on electrical signals emitted from muscular activation and can even open and close proportionate to the amplitude of signal they receive. However, these prostheses are very expensive, with some cost...2020
7 Harding, Anna NeiblingLow-Cost Surface Electromyogtraphy Sleeve for Quick and Repeatable Decoding of Motor IntentSurface electromyography (sEMG) is a noninvasive way to decode motor intent for applications such as prosthesis control, virtual reality, and stroke or spinal cord rehabilitation. State-of-the-art methods of decoding motor intent used in myoelectric prostheses have limited capabilities, partially du...2019
8 Gajiwala, SnehalDetermining the variability of depressive brain circuitry among healthy subjects for deep brain stimulationDeep Brain Stimulation (DBS) is being evaluated to treat Treatment-Resistant Depression, though it has shown mixed results. We believe that variability within the fiber tracts of the brain may account for these outcome differences. In this study, we attempt to characterize this potential variation....Brain stimulation - Therapeutic use - Research; Depression, Mental - Treatment - Research; Deep brain stimulation; Depressive brain circuitry; Fiber tracts; Tractography2016-05
9 Black, Taylor MadisonImpacts of Tobacco Smoke Exposure and Outlier Body Mass Indices on Pediatric Asthma OutcomesThere are seven million children in the United States impacted by asthma [1]. When assessing the severity of a child's asthma, it is important to take into account risk factors known to affect child hood asthma. Two such risk factors that are modifiable include parental tobacco smoke exposure (TSE)...Asthma - Child; Tobacco smoke - Health aspects - United States2015-05
10 Stewart, CadenPaternal diet modulates naturalistic foraging in mice and interacts with cacna1c genetic effects to shape decision sequencesSome of the largest challenges facing the healthcare system stem from the dual epidemics of obesity and mental disorders. Obesity can alter an organism's epigenetics, and these changes may be passed on to offspring, which in turn may alter mental health. The purpose of this study is to investigate t...2022
11 Adams, Samuel I.Correcting acoustic phase aberrations in focused ultrasound treatments for breast cancerBreast cancer is the most diagnosed cancer worldwide. Early-stage localized cancers are currently treated with surgical lumpectomy and radiation. Focused ultrasound is a disruptive technology that can replace conventional surgical and radiation therapies to provide noninvasive cancer treatment. This...2021
12 Waller, Rosalie G.Exome sequence comparison of seventy-seven multiple myeloma cases identifies potential risk allelesMultiple Myeloma (MM) is a heritable cancer of plasma cells with poor prognosis. Although a few genomic risk-loci have been identified for MM, no risk variants have been published that explain MM heritability. We hypothesize MM heritability is due to rare germ-line variants that can be discovered th...Multiple myeloma -- Genetic aspects; Exomes; Exome sequence; Risk alleles2015-05
13 Taggart, Maxwell M.A novel MRI-based screening method for assessing atrio-esophageal fistula risk following cardia ablationAtrio-esophageal fistulas affect 1 in 2000 patients who undergo cardiac ablation procedures with a mortality rate of 93%. Methods for detecting atrio-esophageal fistula formation that are objective and non-invasive could reduce the mortality associated with this disease. This study was performed ret...Magnetic resonance imaging; Cardia ablation; Trio-esophageal fistual2014-12
14 Wankier, Zakary S.Use of computer tomography imaging to observe increased distal-end cortical bone around a percutaneous osseointegrated implantOsseointegration (OI) is being used for the direct skeletal attachment of prosthetic limbs using an intramedullary stem that extends percutaneously from the subject's residual limb. For this technology to be successful, bone ingrowth and remodeling around the implant must occur. Physicians need an e...2022
15 Grimmett, RollinEffects of Hypoxia and High Fat Diet on D. Melanogaster Heart PhysiologyHeart disease severely affects millions of people worldwide, and is caused by various environmental and genetic factors. The aim of this study is to examine the combined physiological effects of hypoxia and a high fat diet (two known causes) on Drosophila Melanogaster heart structure. Sets of adult ...2017
16 Lei, Jeffrey KaChonIncreased gluti expression in mouse cardiomyocytes preserves mitochondrial function but is insufficient to attenuate pressure overload-induced contractile dysfunctionLifelong over-expression of GLUT1 transporter in the heart has been shown to preserve contractile function after aortic constriction. However it is unclear whether this protective effect is due to GLUT1 overexpression itself or due to reprogramming of heart metabolism as a result of long-term increa...Bioengineering2013-04
17 Gilbert, JohnA novel tool to capture neural activity across an entire brain using C-FOS as an indicatorImmunohistochemical staining for the expression of the immediate early gene c-Fos is a powerful tool to measure neuronal activation of neurons across an entire brain. The results of c-Fos immunostaining are often quantified by counting the number of immunolabeled cells in a region of interest (ROI) ...Brain - Localization of functions - Research; Brain - Physiology - Research; Brain mapping - Research; Memory - Research; Mice as laboratory animals - Research; Brain activity; Immunohistochemical staining2016-05
18 Anjewierden, ScottAutomated kinematic analysis of pre-pluse inhibition in larval zebrafishAnimals differentially ignore or attend to sensory information depending on their immediate environment. A significant example of this phenomenon is audiomotorpre-pulse inhibition (PPI), in which the startle response to a loud noise is suppressed by a preceding stimulus of lower intensity. This a...Zebra danio - Development; Kinematics - Research; Kinematic parameters; Swim kinematics; Pre-pulse inhibition2014-12
19 Luo, ShirleyDevelopment of a bioabsorbalbe active release antimicrobial coating for orthopedic implantsOrthopedic implantations often create an opportunity for biofilm-related infections to arise. Patients infected with biofilm must often undergo additional surgeries for repair or replacement, which puts them at a greater risk of osteomyelitis, sepsis, and other complications including death [17]. T...Orthopedic implants - Research; Anti-infective agents - Research; Staphyloccoccal infections - Prevention and control - Research; Antimicrobial coating; Staphylococcus aureus2016-05
20 Flach, BrianExamining the effects of whisker trimming on mouse brain cell growthHoxb8 microglia are a particular breed of scavenger cells in the brain which have been related to obsessive compulsive disorder (OCD)-like behavior among other behavioral disorders. These cells have been found to reach full maturity during a period of neurological development known as the critical ...Obsessive-compulsive disorder - Research; Microglia - Research; Mice as laboratory animals - Research; Whiskers; Scavenger cells; Hoxb8 microglia2016-04
21 Sowards, SteffanComputational fluid dynamics modeling for Respiratory airflow patterns of python regiusThe phylogenetic distribution and mechanisms underpinning unidirectional pulmonary airflow, in which gases pass through a portion of the lung in an identical direction during both aspiration and expiration, are poorly understood. Until recently, it was thought this pattern of flow required unique fe...2018
22 Kendell, IsaacImmunomodulation improves cancer cell clearance by T cells during multi-antigent T cell hybridizer therapyTreatment of hematopoietic malignancies is challenging due to systemic side effects of current treatments and the possibility of relapse. Multi-antigen T cell hybridizer (MATCH) therapy is a novel treatment system composed of antibody fragments conjugated with morpholino oligonucleotides, which hybr...2024
23 Young, MichaelThe Contributions of Elastin to Ligament ViscoelastictyLigaments exhibit viscoelastic behavior in response to strain. This behavior protects joints from injury during loading. Collagen is the primary structural component of ligaments, but does not account fully for the viscoelastic behavior. Elastin is another structural protein in ligaments, and provid...2017
24 Slominski, Emma N.Comparison of transcranial MR-guided focused ultrasound phase correction simulations to clinically measured MRTIEssential tremor and Parkinson's disease are neurological disorders causing involuntary shaking that affects an estimated 8 million people in the United States. Transcranial Magnetic Resonance-guided Focused Ultrasound (tcMRgFUS) is a noninvasive alternative method of treating tremors to the invasiv...2021
25 Koblanski, KasperLiver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilizationInsulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin...2022
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