Honors Theses Open Access
 
Filters: Department: "Biology" Year Graduated: "2012" Collection: "ir_htoa"
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1 Pham, John V.The function of the protein VCP/CDC48-associated mitochondrial stress-responsive 1 in mammalsAlthough mitochondrial dysfunction has been linked to many human diseases, mitochondrial interacting proteins and protein quality controls are just beginning to be understood. The objective of our study was to characterize the function of the VMS1 protein in mammals. We determined the role of Vms1 o...Mitochondrial disorders; Mitochondrial diseases - genetics; VMS12012-05
2 Alexander, AmandaParental conflict with adult childrenParental conflict with adult children is something that is well known anecdotally, but has rarely been studied in light of other, more serious conflicts between parents and their children. However, parental conflict with adult children (adult being defined as between the ages of 18 and 25) is someth...Adult children - Family relationships; Adult children - Psychology2012-05
3 Judd, David PaulTelomere proteins of Drosophila melanogaster: HipHop and MSK81DNA molecules encoding two proteins, HipHop and MSK81, were cloned into bacteria so as to make large amounts of these proteins that bind to telomeres of Drosophila (fruit fly) chromosomes. The goal was to determine whether known DNA binding motifs are present in HipHop and MSK81. Understanding how t...Biology2012-05
4 Auduong, PriscillaSpinal muscular atrophy modeled in drosophila melanogasterSpinal Muscular Atrophy (SMA) is the most commonly inherited cause of death in children (Park, Kariya, & Monani, 2010 for review). This disease is characterized by a loss of motor neurons which leads to muscle degeneration, paralysis, and eventual death by respiratory failure (Monani, 2005 for revie...Spinal muscular atrophy - Research; Drosophila melanogaster - Researcher2012-05
5 Kim, Bum JunDoes ceramide contribute to vascular dysfunction in mice with type 1 diabetes?Approximately 2 million individuals have type 1 diabetes (T1D) in the United States. Cardiovascular disease is 2-4-fold more prevalent in these patients but the mechanism(s) is unclear. Recently, we showed that the sphingolipid ceramide contributes to arterial dysfunction and hypertension in mice wi...Ceramide - Research; Type 1 Diabetes; Mice as laboratory animals2012-05
6 Johnson, KariAnne RencherIdentification of PASK substrates and/or interacting proteinsPAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live...Biology2012-05
7 Au, AlexanderImpact of population density of left atrial remodeling in patients with atrial fibrillationAtrial fibrillation (AF), the most common cardiac arrhythmia and a leading cause of stroke, is characterized by structural changes, or remodeling, in tissues of the left atrium (LA). Late Gadolinium-Enhancement Magnetic Resonance Imaging (LGE-MRI) can noninvasively detect remodeling in the LA, allow...Atrial fibrillation Treatment2012-05
8 German, MassiellA genetic analysis of VSX2 function in the mouse eyeVsx2 is a homeodomain-containing transcription factor essential for maintenance of neuroretinal identity and neurogenesis. Vsx2 is believed to function via mechanisms that are strictly cell-intrinsic. However, recent research reveals evidence for involvement of Vsx2-mediated cell non-autonomous mech...Neurogenesis - physiology2012-05
9 Shapiro, DarienActivation of transient receptor potential ankyrin-1 by wood smoke particulate materialExposure to wood smoke particulate matter (WSPM) has been linked to exacerbation of pre-existing respiratory conditions such as asthma, development of chronic obstructive pulmonary disease (COPD), and premature deaths. While it is clear that WSPM exposure is hazardous to human health, the molecular ...Smoke - Physiological effect2012-05
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