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Creator | Title | Description | Subject | Date |
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Seger, Jon | 1998 Sewall Wright Award: William Donald Hamilton | The Sewall Wright Award was established in 1991 to honor active investigators who have contributed in especially significant ways to the conceptual unification of the biological sciences. This year's recipient is William D. Hamilton of Oxford University. Beginning in the 1960s with his papers on the... | Evolution; Biological; Research | 1999 |
| 2 |
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Sekercioglu, Cagan | A birders quide to Turkey | As I write, it is early December and the woods outside my window lay dusted with snow like a holiday card by Currier and Ives. A minute ago, I looked up and caught a glimpse of an adult Cooper's Hawk dashing swiftly through the trees. It swooped up, landed on a branch, then briefly shook its tail an... | | 2006-01-01 |
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Olivera, Baldomero M.; McIntosh, J. Michael; Hillyard, David R. | A-superfamily of conotoxins: structural and functional divergence | The generation of functional novelty in proteins encoded by a gene superfamily is seldom well documented. In this report, we define the A-conotoxin superfamily, which is widely expressed in venoms of the predatory cone snails (Conus), and show how gene products that diverge considerably in stru... | Conotoxins; A-superfamily conotoxin | 2004-02-03 |
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| AAMC Award for Distinguished Research presentation for 1998 | This is a 3 minutes, 51 seconds video of the presentation of the American Association of Medical Colleges' Award for Distinguished Research to Mario Capecchi and Oliver Smithies for their independent work as pioneers in gene targeting. | Transgenic mice; Gene targeting; Genetic engineering; Mutagenesis; Capecchi, Mario R.; Science - Awards - United States; Smithies, Oliver; Awards presentations | 1998 |
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Capecchi, Mario R. | Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. | Mice with targeted disruptions in Hox genes have been generated to evaluate the role of the Hox complex in determining the mammalian body plan. This complex of 38 genes encodes transcription factors that specify regional information along the embryonic axes. Early in vertebrate evolution an ancestra... | Alleles; Animals; Bone and Bones; Carpal Bones | 2003-09-02 |
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Beckerle, Mary C. | Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets | Talin is a high molecular weight protein localized at adhesion plaques in fibroblasts. It binds vinculin and integrin and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton. | Talin | 1989 |
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Beckerle, Mary C. | Adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to the tumor-promoting phorbol ester | Talin is a high molecular weight phosphoprotein that is localized at adhesion plaques. We have found that talin phosphorylation increases 3.0-fold upon exposure of chicken embryo fibroblasts to the tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate. | Talin; Vinculin; Chicken embryo fibroblasts | 1990 |
| 8 |
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Adler, Frederick R. | Aggregation and stability in parasite-host models | This paper generalizes the two-dimensional approximation of models of macroparasites on homogeneous populations developed by Anderson & May (1978), focusing on how the dispersion (the variance to mean ratio) of the equilibrium distribution of parasites on hosts is related to the stability of the equ... | Aggregation; Stability; Host-parasite models | 1992-04 |
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| Albert Lasker Awards Ceremony, 2001 | This is the 1 hour, 45 minutes, and 41 seconds video of the Lasker Awards Ceremony and Banquet held in September, 2001. The Albert Lasker Award for Basic Medical Research was given to Mario R. Capecchi, Oliver Smithies, and Martin Evans for their work in genetic research. Martin Evans discovered h... | Capecchi, Mario R.; Gene targeting; Embryonic stem cells; Transgenic mice; Genetic engineering; Science - Awards - United States; Smithies, Oliver; Evans, Martin J.; Awards presentations | 2001 |
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Coley, Phyllis D.; Lokvam, John; Kursar, Thomas A. | Allelochemic function for a primary metabolite: the case of L-tyrosine hyper-production in Inga umbellifera (Fabaceae) | Young leaves of tropical forest trees experience far higher herbivory pressure than mature leaves of the same species. Selection on young leaves has led to diverse forms of defense chemical expression. Though most allelochemicals are secondary metabolites, allelochemic function for a primary metabol... | 5-amino-4-hydroxy-pentanoic acid; Panama; Barro Colorado Island; Fabaceae; Inga umbellifera; Primary metabolite; Heliothis virescens | 2006 |
| 11 |
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Capecchi, Mario R. | Altered enzymes in drug-resistant variants of mammalian tissue culture cells. | Two selective procedures are compared in an effort to isolate variants of mouse L cells containing structural gene mutations. Among the resulting variant cloned cell lines are found two types of alterations in theenzyme hypoxanthine phosphoribosyl transferase (EC 2.4.2.8.) (1): enzyme with altered ... | Drug Resistance; Azaguanine; Clone Cells; Hypoxanthines | 1973-11 |
| 12 |
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Olivera, Baldomero M. | Alternative splicing in the pore-forming region of shaker potassium channels | We have cloned cDNAs for the shaker potassium channel gene from the spiny lobster Panulirus interruptus. As previously found in Drosophila, there is alternative splicing at the 59 and 39 ends of the coding region. However, in Panulirus shaker, alternative splicing also occurs within the pore-forming... | Panulirus interruptus; Conotoxins; Shaker; Stomatogastric ganglion; Pore-forming region; Alternative splicing | 1997 |
| 13 |
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Coffin, Cheryl M.; Capecchi, Mario R. | Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. | Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has... | Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors | 2004-11-01 |
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Olivera, Baldomero M. | Aminoglycoside effects on voltage-sensitive calcium channels and neurotoxicity | To the Editor: Since ototoxicity and neuromuscular toxicity of aminoglycoside antibiotics are reversed by calcium, 1,2 and presynaptic events appear to be involved in aminoglycoside-induced neuromuscular blockade, 3,4 we suspected a role for voltage-sensitive calcium channels in aminoglycoside neuro... | Conotoxins | 1987 |
| 15 |
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Sperry, John S. | Analysis of circular bordered pit function I. Angiosperm vessels with homogenous pit membranes | A model predicted pit and vessel conductivity, the air-seed pressure for cavitation, and the implosion pressure causing vessel collapse. Predictions were based on measurements from 27 angiosperm species with circular bordered pits and air-seed pressures of 0.2-11.3 MPa. Vessel implosion pressure exc... | Functional wood anatomy; hydraulic architecture; plant biomechanics | 2004 |
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Sperry, John S. | Analysis of circular bordered pit function II. Gymnosperm tracheids with torus-margo pit membranes | A model of xylem conduit function was applied to gymnosperm tracheids with torus-margo pit membranes for comparison with angiosperm vessels. Tracheids from 17 gymnosperm tree species with circular bordered pits and air-seed pressures from 0.8 to 11.8 MPa were analyzed. Tracheids were more reinforced... | Functional wood anatomy; hydraulic architecture; plant biomechanics | 2004 |
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Beckerle, Mary C. | Analysis of the roles of microtubules and actin in erythrophore intracellular motility | The Holocentrus erythrophore, a red pigment cell, represents a model system for the study of organized intracellular transport. We have investigated the possibility that microtubules and actin are integral components of the pigment translocating motility machine. | Actin; Actomyosin; Erythrophore; Pigment | 1983 |
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Sperry, John S. | Anatomy of the palm Rhapis excelsa, IX. Xylem structure of the leaf insertion | STEMS OF PERENNIAL PLANTS, particularly trees, represent a considerable investment in biomass. Trees can survive even under the most adverse conditions, but only if the hydraulic integrity of the stem is preserved. A very important and vulnerable part of the stem is the xylem. As water is pulled int... | Palm stems; Palm stem anatomy; Palm leaves; Leaf insertion; Vessel network; Vessel-length distribution; Primary vascular stem tissue; Hydraulic architechture; Water column | 1983 |
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Sperry, John S. | Anatomy of the palm Rhapis excelsa, VIII. Vessel network and vessel-length distribution in the stem | THE CONCEPT of the vessel, a conducting unit consisting of a series of vessel elements lined up end to end, has been known for well over a century (e.g., Hartig, 1878). The fact that vessels are of limited length is of considerable functional importance. If a vessel is damaged (for example, by an in... | Palm stems; Palm stem anatomy; Vessel network; Vessel-length distribution; Primary vascular stem tissue; Hydraulic architechture; Water column | 1982 |
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Davidson, Diane W. | Ant-plant symbioses in Africa and the neotropics : history, biogeography and diversity | Symbiotic ant-plant relationships afford an excellent opportunity to analyze the effects of both historical and ecological factors on the evolution of mutualisms. Occurring in tropical forests throughout the world, all myrmecophytic plants provide food and permanent housing to ants; the ants, in t... | Ant-plant symbiosis; Africa; Neotropics; Myrmecophytes; Plant-ants | 1993 |
| 21 |
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Beckerle, Mary C. | Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt | This study delineates a mechanism for antiapoptotic signaling initiated by atrial natriuretic peptide (ANP) stimulation leading to elevation of cGMP levels and subsequent nuclear accumulation of Akt kinase associated with zyxin, a cytoskeletal LIM-domain protein. Nuclear targeting of zyxin induces r... | Zyxin; Akt; Cyclic guanosine monophosphate | 2005 |
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Gesteland, Raymond F.; Ives, Jeffrey T.; Stockham, Thomas G. | Automated film reader for DNA sequencing based on homomorphic deconvolution | An automated reader for electrophoresis based DNA sequencing methods is described that provides fast and accurate sequence determination. Digitized sequencing lanes are processed with homomorphic blind deconvolution in preparation for peak detection, interlane alignment, peak refinement and base cal... | Sequence Analysis; Electrophoresis; Automated Film Reader; Homomorphic Deconvolution | 1994 |
| 23 |
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Olivera, Baldomero M. | Bacteriophage Mu DNA replication in vitro | An in vitro system for bacteriophage Mu DNA replication using lysates on cellophane discs is described. Mu replication was monitored by DNA hybridization. Using a thermoinducible Mu Iysogen, 30-50% of all DNA synthesis in vitro was Mu-specific. | Bacteriophage Mu | 1983 |
| 24 |
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Adler, Frederick R. | Balance of terror: an alternative mechanism for competitive trade-offs and its implications for invading species | This article uses models to propose an explanation for three observations in community ecology: the apparent overreaction of prey to attack by specialist predators, the existence of a common trade-off among components of competitive ability in communities of unrelated competitors, and the ability of... | Models; Curve; Native | 1999 |
| 25 |
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Coley, Phyllis D. | Benefits and costs of defense in a neotropical shrub | Benefits and costs are central to optimality theories of plant defense. Benefit is the gain in fitness to reducing herbivory and cost is the loss in fitness to committing resources to defense. We evaluate the benefits and costs of defense in a neotropical shrub, Psychotria horizontalis. Plants were ... | Cost of defense; Growth-defense trade-off; Exclosures; Field experiment; Herbivory; Panama; Psychotria horizontalis; Rubiaceae; Tannins; Toughness; Tropics | 1995 |
