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1 Seger, Jon1998 Sewall Wright Award: William Donald HamiltonThe Sewall Wright Award was established in 1991 to honor active investigators who have contributed in especially significant ways to the conceptual unification of the biological sciences. This year's recipient is William D. Hamilton of Oxford University. Beginning in the 1960s with his papers on the...Evolution; Biological; Research1999
2 Olivera, Baldomero M.?O-Conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2The ?O-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus, belonging to the O-superfamily of conotoxins with three disulfide bridges. They have attracted attention because they are inhibitors of tetrodotoxin-insensitive voltage-gated sodium channels (NaV1.8) and could therefore ...2007
3 Dearing, Maria-Denise[Dearing_Database_Pilot][Database deposited March 08, 2013, as part of a pilot project, eResearch Committee, University of Utah.] [This description should include information that explains the dataset in detail in a manner that would be useful to potential reuse. The contact information for the primary investigator should ...[Creator keywords here.]2013-03-08
4 Sekercioglu, CaganA birders quide to TurkeyAs I write, it is early December and the woods outside my window lay dusted with snow like a holiday card by Currier and Ives. A minute ago, I looked up and caught a glimpse of an adult Cooper's Hawk dashing swiftly through the trees. It swooped up, landed on a branch, then briefly shook its tail an...2006-01-01
5 Dale, ColinA novel human-infection-derived bacterium provides insights into the evolutionary origins of mutualistic insect-bacterial symbiosesDespite extensive study, little is known about the origins of the mutualistic bacterial endosymbionts that inhabit approximately 10% of the world's insects. In this study, we characterized a novel opportunistic human pathogen, designated ‘‘strain HS,'' and found that it is a close relative of th...2012-01-01
6 Crespo, Jose GuillermoA review of chemosensation and related behavior in aquatic insectsInsects that are secondarily adapted to aquatic environments are able to sense odors from a diverse array of sources. The antenna of these insects, as in all insects, is the main chemosensory structure and its input to the brain allows for integration of sensory information that ultimately ends in b...2011-09-13
7 Adler, Frederick R.A time since recovery model with varying rates of loss of immunityFor many infectious diseases, immunity wanes over time. The majority of SIRS models assume that this loss of immunity takes place at a constant rate. We study temporary immunity within a SIRS model structure if the rate of loss of immunity can depend on the time since recovery from disease.We determ...2012-01-01
8 Olivera, Baldomero M.; McIntosh, J. Michael; Hillyard, David R.A-superfamily of conotoxins: structural and functional divergenceThe generation of functional novelty in proteins encoded by a gene superfamily is seldom well documented. In this report, we define the A-conotoxin superfamily, which is widely expressed in venoms of the predatory cone snails (Conus), and show how gene products that diverge considerably in stru...Conotoxins; A-superfamily conotoxin2004-02-03
9 AAMC Award for Distinguished Research presentation for 1998This is a 3 minutes, 51 seconds video of the presentation of the American Association of Medical Colleges' Award for Distinguished Research to Mario Capecchi and Oliver Smithies for their independent work as pioneers in gene targeting.Transgenic mice; Gene targeting; Genetic engineering; Mutagenesis; Capecchi, Mario R.; Science - Awards - United States; Smithies, Oliver; Awards presentations1998
10 Ehleringer, James R. ; Cerling, Thure E.Aberrant water homeostasis detected by stable isotope analysisWhile isotopes are frequently used as tracers in investigations of disease physiology (i.e., 14C labeled glucose), few studies have examined the impact that disease, and disease-related alterations in metabolism, may have on stable isotope ratios at natural abundance levels. The isotopic composition...2010-07-21
11 Capecchi, Mario R.Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11.Mice with targeted disruptions in Hox genes have been generated to evaluate the role of the Hox complex in determining the mammalian body plan. This complex of 38 genes encodes transcription factors that specify regional information along the embryonic axes. Early in vertebrate evolution an ancestra...Alleles; Animals; Bone and Bones; Carpal Bones2003-09-02
12 Beckerle, Mary C.Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human plateletsTalin is a high molecular weight protein localized at adhesion plaques in fibroblasts. It binds vinculin and integrin and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.Talin1989
13 Shapiro, Michael D.Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancerThe molecular mechanisms underlying major phenotypic changes that have evolved repeatedly in nature are generally unknown. Pelvic loss in different natural populations of threespine stickleback fish has occurred by regulatory mutations deleting a tissue-specific enhancer of the Pituitary homeobox t...Adaptive evolution; Pelvic reduction; Pituitary homeobox transcription factor 1; Pitx1; Gasterosteus aculeatus2010-01-14
14 Beckerle, Mary C.Adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to the tumor-promoting phorbol esterTalin is a high molecular weight phosphoprotein that is localized at adhesion plaques. We have found that talin phosphorylation increases 3.0-fold upon exposure of chicken embryo fibroblasts to the tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate.Talin; Vinculin; Chicken embryo fibroblasts1990
15 Adler, Frederick R.Aggregation and stability in parasite-host modelsThis paper generalizes the two-dimensional approximation of models of macroparasites on homogeneous populations developed by Anderson & May (1978), focusing on how the dispersion (the variance to mean ratio) of the equilibrium distribution of parasites on hosts is related to the stability of the equ...Aggregation; Stability; Host-parasite models1992-04
16 Albert Lasker Awards Ceremony, 2001This is the 1 hour, 45 minutes, and 41 seconds video of the Lasker Awards Ceremony and Banquet held in September, 2001. The Albert Lasker Award for Basic Medical Research was given to Mario R. Capecchi, Oliver Smithies, and Martin Evans for their work in genetic research. Martin Evans discovered h...Capecchi, Mario R.; Gene targeting; Embryonic stem cells; Transgenic mice; Genetic engineering; Science - Awards - United States; Smithies, Oliver; Evans, Martin J.; Awards presentations2001
17 Coley, Phyllis D.; Lokvam, John; Kursar, Thomas A.Allelochemic function for a primary metabolite: the case of L-tyrosine hyper-production in Inga umbellifera (Fabaceae)Young leaves of tropical forest trees experience far higher herbivory pressure than mature leaves of the same species. Selection on young leaves has led to diverse forms of defense chemical expression. Though most allelochemicals are secondary metabolites, allelochemic function for a primary metabol...5-amino-4-hydroxy-pentanoic acid; Panama; Barro Colorado Island; Fabaceae; Inga umbellifera; Primary metabolite; Heliothis virescens2006
18 Beckerle, Mary C.ALP-enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegansMutations that affect the Z-disk-associated ALP-Enigma proteins have been linked to human muscular and cardiac diseases. Despite their clear physiological significance for human health, the mechanism of action of ALP-Enigma proteins is largely unknown. In Caenorhabditis elegans, the ALP-Enigma prot...Actin; Caenorhabditis elegans; Contractility; alp-1 mutants; Z-disks; Kettin2009
19 Capecchi, Mario R.Altered enzymes in drug-resistant variants of mammalian tissue culture cells.Two selective procedures are compared in an effort to isolate variants of mouse L cells containing structural gene mutations. Among the resulting variant cloned cell lines are found two types of alterations in theenzyme hypoxanthine phosphoribosyl transferase (EC 2.4.2.8.) (1): enzyme with altered ...Drug Resistance; Azaguanine; Clone Cells; Hypoxanthines1973-11
20 Adler, Frederick R.Alternating host cell tropism shapes the persistence, evolution and coexistence of Epstein-Barr virus infections in humanEpstein-Barr virus (EBV) infects and can persist in a majority of people worldwide. Within an infected host, EBV targets two major cell types, B cells and epithelial cells, and viruses emerging from one cell type preferentially infect the other. We use mathematical models to understand why EBV infec...2011
21 Adler, Frederick R.Alternating host cell tropism shapes the persistence, evolution and coexistence of Epstein-Barr virus infections in humanEpstein-Barr virus (EBV) infects and can persist in a majority of people worldwide. Within an infected host, EBV targets two major cell types, B cells and epithelial cells, and viruses emerging from one cell type preferentially infect the other. We use mathematical models to understand why EBV infec...2010
22 Olivera, Baldomero M.Alternative splicing in the pore-forming region of shaker potassium channelsWe have cloned cDNAs for the shaker potassium channel gene from the spiny lobster Panulirus interruptus. As previously found in Drosophila, there is alternative splicing at the 59 and 39 ends of the coding region. However, in Panulirus shaker, alternative splicing also occurs within the pore-forming...Panulirus interruptus; Conotoxins; Shaker; Stomatogastric ganglion; Pore-forming region; Alternative splicing1997
23 Coffin, Cheryl M.; Capecchi, Mario R.Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has...Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors2004-11-01
24 Olivera, Baldomero M.Aminoglycoside effects on voltage-sensitive calcium channels and neurotoxicityTo the Editor: Since ototoxicity and neuromuscular toxicity of aminoglycoside antibiotics are reversed by calcium, 1,2 and presynaptic events appear to be involved in aminoglycoside-induced neuromuscular blockade, 3,4 we suspected a role for voltage-sensitive calcium channels in aminoglycoside neuro...Conotoxins1987
25 Schmind, Alexis VAn embryonic-like subpopulation is present in regenerating heartsZebrafish regenerate injured heart tissue through cardiomyocyte dedifferentiation, but it's unclear which cell subpopulations are involved.zebrafish heart regeneration; medaka; cardiomyocytes2021
26 Clayton, Dale H.An experimental test of the effects of behavioral and immunological defenses against vectors: do they interact to protect birds from blood parasites?Background: Blood-feeding arthropods can harm their hosts in many ways, such as through direct tissue damage and anemia, but also by distracting hosts from foraging or watching for predators. Blood-borne pathogens transmitted by arthropods can further harm the host. Thus, effective behavioral and im...2014-01-01
27 Parkinson, John StansfieldAn unorthodox sensory adaptation site in the E. coli serine chemoreceptorThe serine chemoreceptor of E. coli contains four canonical methylation sites for sensory adaptation that lie near inter-subunit helix interfaces of the Tsr homodimer. An unexplored fifth methylation site, E502, lies at an intra-subunit helix interface, closest to the HAMP domain that controls input...2014-01-01
28 Sperry, John S.Analysis of circular bordered pit function I. Angiosperm vessels with homogenous pit membranesA model predicted pit and vessel conductivity, the air-seed pressure for cavitation, and the implosion pressure causing vessel collapse. Predictions were based on measurements from 27 angiosperm species with circular bordered pits and air-seed pressures of 0.2-11.3 MPa. Vessel implosion pressure exc...Functional wood anatomy; hydraulic architecture; plant biomechanics2004
29 Sperry, John S.Analysis of circular bordered pit function II. Gymnosperm tracheids with torus-margo pit membranesA model of xylem conduit function was applied to gymnosperm tracheids with torus-margo pit membranes for comparison with angiosperm vessels. Tracheids from 17 gymnosperm tree species with circular bordered pits and air-seed pressures from 0.8 to 11.8 MPa were analyzed. Tracheids were more reinforced...Functional wood anatomy; hydraulic architecture; plant biomechanics2004
30 Beckerle, Mary C.Analysis of the roles of microtubules and actin in erythrophore intracellular motilityThe Holocentrus erythrophore, a red pigment cell, represents a model system for the study of organized intracellular transport. We have investigated the possibility that microtubules and actin are integral components of the pigment translocating motility machine.Actin; Actomyosin; Erythrophore; Pigment1983
31 Sperry, John S.Anatomy of the palm Rhapis excelsa, IX. Xylem structure of the leaf insertionSTEMS OF PERENNIAL PLANTS, particularly trees, represent a considerable investment in biomass. Trees can survive even under the most adverse conditions, but only if the hydraulic integrity of the stem is preserved. A very important and vulnerable part of the stem is the xylem. As water is pulled int...Palm stems; Palm stem anatomy; Palm leaves; Leaf insertion; Vessel network; Vessel-length distribution; Primary vascular stem tissue; Hydraulic architechture; Water column1983
32 Sperry, John S.Anatomy of the palm Rhapis excelsa, VIII. Vessel network and vessel-length distribution in the stemTHE CONCEPT of the vessel, a conducting unit consisting of a series of vessel elements lined up end to end, has been known for well over a century (e.g., Hartig, 1878). The fact that vessels are of limited length is of considerable functional importance. If a vessel is damaged (for example, by an in...Palm stems; Palm stem anatomy; Vessel network; Vessel-length distribution; Primary vascular stem tissue; Hydraulic architechture; Water column1982
33 Davidson, Diane W.Ant-plant symbioses in Africa and the neotropics : history, biogeography and diversitySymbiotic ant-plant relationships afford an excellent opportunity to analyze the effects of both historical and ecological factors on the evolution of mutualisms. Occurring in tropical forests throughout the world, all myrmecophytic plants provide food and permanent housing to ants; the ants, in t...Ant-plant symbiosis; Africa; Neotropics; Myrmecophytes; Plant-ants1993
34 Coley, Phyllis D.Antifungal depsidone metabolites from Cordyceps dipterigena, an endophytic fungus antagonistic to the phytopathogen gibberella fujikuroiAmong thirty four endophytic fungal strains screened for in vitro antagonism, the endophytic fungus Cordyceps dipterigena was found to strongly inhibit mycelial growth of the plant pathogenic fungus Gibberella fujikuroi. Two new depsidone metabolites, cordycepsidone A (1) and cordycepsidone B (2), w...2012
35 Bowling, David R.Assessing filtering of mountaintop CO2 mole fractions for application to inverse models of biosphere-atmosphere carbon exchangeThere is a widely recognized need to improve our understanding of biosphere-atmosphere carbon exchanges in areas of complex terrain including the United States Mountain West. CO2 fluxes over mountainous terrain are often difficult to measure due to unusual and complicated influences associated with ...2012-01-01
36 Hughes, Kelly T.ATPase-Independent Type-III Protein Secretion in Salmonella entericaType-III protein secretion systems are utilized by gram-negative pathogens to secrete building blocks of the bacterial flagellum, virulence effectors from the cytoplasm into host cells, and structural subunits of the needle complex. The flagellar type-III secretion apparatus utilizes both the energy...2014-01-01
37 Beckerle, Mary C.Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and AktThis study delineates a mechanism for antiapoptotic signaling initiated by atrial natriuretic peptide (ANP) stimulation leading to elevation of cGMP levels and subsequent nuclear accumulation of Akt kinase associated with zyxin, a cytoskeletal LIM-domain protein. Nuclear targeting of zyxin induces r...Zyxin; Akt; Cyclic guanosine monophosphate2005
38 Gesteland, Raymond F.; Ives, Jeffrey T.; Stockham, Thomas G.Automated film reader for DNA sequencing based on homomorphic deconvolutionAn automated reader for electrophoresis based DNA sequencing methods is described that provides fast and accurate sequence determination. Digitized sequencing lanes are processed with homomorphic blind deconvolution in preparation for peak detection, interlane alignment, peak refinement and base cal...Sequence Analysis; Electrophoresis; Automated Film Reader; Homomorphic Deconvolution1994
39 Jorgensen, ErikAxon regeneration genes identified by RNAi screening in C. elegansAxons of the mammalian CNS lose the ability to regenerate soon after development due to both an inhibitory CNS environment and the loss of cell-intrinsic factors necessary for regeneration. The complex molecular events required for robust regeneration of mature neurons are not fully understood, part...2014-01-01
40 Jorgensen, ErikAxons break in animals lacking B-spectrinAxons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in β-spectrin mutants spontaneously break.2007
41 Bastiani, MichaelAxons break in animals lacking β-spectrinAxons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in β-spectrin mutants spontaneously break.Mutants; Dendrites; Morphology2007
42 Hughes, Kelly T.Bacterial flagellin-specific chaperone FliS interacts with anti-sigma factor FlgMFlagella are extracellular organelles that propel bacteria. Each flagellum consists of a basal body, a hook, and a filament. The major protein of the filament is flagellin. To prevent premature polymerization of newly synthesized flagellin molecules, FliS, the flagellin-specific chaperone, binds fla...2014-01-01
43 Olivera, Baldomero M.Bacteriophage Mu DNA replication in vitroAn in vitro system for bacteriophage Mu DNA replication using lysates on cellophane discs is described. Mu replication was monitored by DNA hybridization. Using a thermoinducible Mu Iysogen, 30-50% of all DNA synthesis in vitro was Mu-specific.Bacteriophage Mu1983
44 Adler, Frederick R.Balance of terror: an alternative mechanism for competitive trade-offs and its implications for invading speciesThis article uses models to propose an explanation for three observations in community ecology: the apparent overreaction of prey to attack by specialist predators, the existence of a common trade-off among components of competitive ability in communities of unrelated competitors, and the ability of...Models; Curve; Native1999
45 Ehleringer, James R.Bayesian integration of isotope ratio for geographic sourcing of castor beansRecent years have seen an increase in the forensic interest associated with the poison ricin, which is extracted from the seeds of the Ricinus communis plant. Both light element (C, N, O, and H) and strontium (Sr) isotope ratios have previously been used to associate organic material with geographic...2012-01-01
46 Coley, Phyllis D.Beneficios y costos de defensa en un arbusto del neotrópicoLOS beneficios y costos son de importancia capital para las teorfas de optimization de las defensas de las plantas. El beneficio es la ganancia de aptitud para reducir el herbivorismo; el costo es la perdida de aptitud al comprometer recursos en defensa. Evaluamos los beneficios y los costos de def...Psychotria horizontalis; Isla de Barro Colorado; Costos de defense; Celdas de exclusion; Herbivorismo; Defensa de las plantas; Taninos; Dureza; Tropicos; Benefit; Beneficios2007
47 Coley, Phyllis D.Benefits and costs of defense in a neotropical shrubBenefits and costs are central to optimality theories of plant defense. Benefit is the gain in fitness to reducing herbivory and cost is the loss in fitness to committing resources to defense. We evaluate the benefits and costs of defense in a neotropical shrub, Psychotria horizontalis. Plants were ...Cost of defense; Growth-defense trade-off; Exclosures; Field experiment; Herbivory; Panama; Psychotria horizontalis; Rubiaceae; Tannins; Toughness; Tropics1995
48 Coley, Phyllis D.Between-species differences in leaf defenses of tropical treesRates of herbivory and patterns of leaf defense are presented for light-demanding and shade-tolerant tree species growing in a lowland rainforest in Panama. More than 85 percent of the annual leaf damage is due to grazing by insects. There are over three orders of magnitude difference between specie...Herbivory; Interspecific variation; Panama; Growth rate; Shade tolerance; Treefall gaps; Tropical forest; Understory; Tannins; Alkaloids1987
49 Yamaguchi, AyakoBilateral coordination of vocal pathways in African clawed frogs, Xenopus laevisThis poster describes how bilateral coordination of motor programs are achieved in the central vocal pathways of African clawed frogs.Vocalizations; Central pattern generator; Motor programs; Bilateral coordination2014
50 Goller, FranzBilateral syringeal contributions to song in the zebra finchAlthough central control of song production has been investigated extensively in the zebra finch (Taeniopygia guttata), much less is known about peripheral vocal motor dynamics during song.Electromyographic activity; Sound souces; Unilateral2004
51 Beckerle, Mary C.Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeletonLIM domains are present in a number of proteins including transcription factors, a protooncogene product, and the adhesion plaque protein zyxin. The LIM domain exhibits a characteristic arrangement of cysteine and histidine residues and represents a novel zinc binding sequence (Michelsen et al., ...Zyxin; Cysteine-rich proteins; cCRP; Actin; LIM domains1994
52 Olivera, Baldomero M.Biochemical characterization of ?M-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of ?M-conotoxinsConus snail (Conus) venoms are a valuable source of pharmacologically active compounds; some of the peptide toxin families from the snail venoms are known to interact with potassium channels. We report the purification, synthesis, and characterization of ?M-conotoxin RIIIJ from the venom of a fish-...2010
53 Olivera, Baldomero M.Biochemical studies of ω-conotoxin GVIA; a peptide toxin inhibiting voltage-sensitive Ca++ channelsThe fish-hunting cone snails use their venom to quickly paralyze their more agile prey. In the last few years, our laboratories have carried out a program of analyzing biologically active components present in the fish-hunting cone snail venoms (Cruz et al. 1985; Olivera et al. 1985). We have concen...Conotoxins; Calcium channels; Conus geographus; Venom1987
54 Horvath, Martin P.Biochemistry of Cone Snail toxin activationCone snails use venom to capture prey for food and for defense against predators. The venom is composed of over 100 active peptides that target specific receptors in the nervous system. Several of these peptides have the potential to become medicine for treatment of pain, depression, seizures, and n...biochemistry; horvath; olivera; cone snail; toxin; nmda; elution; buffers; sparse matrix test; protease; protein; purification; neurotoxin; conotoxin2013
55 Seger, Jon; Davidson, Diane W.Biological richness of desertsA desert is "waterless," "treeless," "barren," "remote," "uninteresting," and "presumably uninhabited," according to the authoritative Oxford English Dictionary. The word is derived from deserere, a Latin verb meaning "to leave." In English, to desert is still to "abandon," "forsake," or "fail." Bec...Desert life; Desert biodiversity1995
56 Clayton, Dale H.Biology, ecology, and evolution of chewing liceChewing lice are small, dorsoventrally compressed insects and are parasites of virtually all birds (Fig. 1) and some mammals (Fig. 2). Many chewing lice are host specific, being found on only a single species of host. All chewing lice are permanent ectoparasites and complete their entire life c...Chewing lice2003
57 Sekercioglu, CaganBirding economics: conservation through commodificationIn the long-run, the quality of our birding (and the length of our lists) depends on our success in conserving birds and their habitats. Who would not love to see a Labrador Duck during a pelagic trip, have Carolina Parakeets fly overhead on a CBC, or photograph a Bachman's Warbler foraging in a can...2003-01-01
58 Olivera, Baldomero M.Block of Shaker K+ channels by ĸ-conotoxin PVIIA is state dependentĸ-conotoxin PVIIA is the first conotoxin known to interact with voltage-gated potassium channels by inhibiting Shaker-mediated currents. We studied the mechanism of inhibition and concluded that PVIIA blocks the ion pore with a 1:1 stoichiometry and that binding to open or closed channels is very d...Conotoxins; k-conotoxin PVIIA; Potassium channel blockers; Shaker K+ channels1999
59 Ehleringer, James R.Burning coal seams in southern Utah: a natural system for studies of plant responses to elevated CO2In the Burning Hills and Smoky Mountains of southern Utah (USA), coal deposits exposed to the surface have been ignited by lightning and have been burning for periods of years to over a century. We examined one of these sites, where the below-ground combustion of this low-sulfur coal releases gases ...Coal fires; Elevated CO2; Isotope ratios; Atriplex confertifolia; Salsola iberica; Gutierrezia sarothrae1997
60 Jorgensen, ErikCaenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic developmentThe neurotransmitter GABA has been proposed to play a role during nervous system development. We show that the Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase (GAD), the GABA biosynthetic enzyme. unc-25 is expressed specifically in GABAergic neurons. Null mutations in unc-25...1999
61 Jorgensen, ErikCaenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesiclesRab molecules regulate vesicular trafficking in many different exocytic and endocytic transport pathways in eukaryotic cells. In neurons, rab3 has been proposed to play a crucial role in regulating synaptic vesicle release. To elucidate the role of rab3 in synaptic transmission, we isolated and cha...1997
62 Jorgensen, ErikCaenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptorIonotropic GABA receptors generally require the products of three subunit genes. By contrast, the GABA receptor needed for locomotion in Caenorhabditis elegans requires only the unc-49 gene. We cloned unc-49 and demonstrated that it possesses an unusual overlapping gene structure.1999
63 Olivera, Baldomero M.Calcium channel antagonists: ω-conotoxin defines a new high affinity siteThe ω-conotoxins, a class of Ca2+ channel antagonists from fish-hunting marine snails, have recently been described (Olivera, B. M., McIntosh, J. M., Zeikus, R., Gray, W. R., Varga, J., Rivier, J., de Santos, V., and Cruz, L. J. (1985) Science, 230, 1338-1343). One of these peptide neurotoxins...Conotoxins; Calcium channels; Synaptosomes; Neurotoxins1986
64 Yamaguchi, AyakoCall initiation in African clawed frogsSociety for Neuroscience Meeting 2016vocalizations; Xenopus laevis2016
65 Jorgensen, Erik; Schuske, Kimberly R.CAPS and syntaxin dock dense core vesicles to the plasma membrane in neuronsDocking to the plasma membrane prepares vesicles for rapid release. Here, we describe a mechanism for dense core vesicle docking in neurons. In Caenorhabditis elegons motor neurons, dense core vesicles dock at the plasma membrane but are excluded from active zones at synapses.2008
66 Hultine, KevinCarbon and nitrogen allocation to male and female reproduction in Rocky Mountain Douglas-fir (Pseudotsuga menziesii var. glauca, Pinaceae)We measured carbon (respiration, photosynthesis, and production) and nitrogen allocation to male and female cones of Rocky Mountain Douglas-fir (Pseudotsuga menziesii var. glauca) to quantify gender-specific: (1) resource allocation to reproduction, and (2) contribution to carbon costs of reproducti...Gender; photosynthesis; resource allocation2000
67 Ehleringer, James R.Carbon isotope discrimination and water relations of oak hybrid populations in southwestern UtahThe evergreen oak Quercus turbinella and the deciduous Q. gambelii form natural hybrids in southwestern Utah and northern Arizona. Hybrid individuals also are found in northern Utah in a region where only Q. gambelii currently exists, indicating that Q. turbinella has recently retreated southward. ...Quercus turbinella; Oak hybrids; Leaf structure; Leaf nitrogen; Carbon isotope discrimination; Water potential; Oak ecology2000
68 Ehleringer, James R.Carbon isotope discrimination in the C4 shrub Atriplex confertifolia along a salinity gradientCarbon isotope discrimination (∆) was measured for leaves of Atriplex confertifolia along a salinity gradi~ ent in northern Utah. Over this gradient, the variation of ∆ values was high for a C4 species, and the ∆ values were positively correlated with salinity in both years of the study. Of th...Carbon isotope ratio; Salt stress; Bundle sheath leakiness; Halophyte; Atriplex confertifolia; Salinity gradient1995
69 Ehleringer, James R.Carbon isotope dynamics in Abies amabilis stands in the CascadesCarbon isotope ratios (d13C) of canopy air and carbon isotope discrimination at the ecosystem level were studied in three montane Pacific silver fir (Abies amabilis (Dougl. ex Loud.) Dougl. ex J. Forbes) stands, an old-growth and two younger stands. Spatial and temporal variations of canopy CO2 con...Carbon isotopes; Pacific silver fir; Carbon budget; Soil respiration; Cascade Mountains1998
70 Ehleringer, James R.Carbon isotope ratios in belowground carbon cycle processesAnalyses of carbon isotope ratios (δ13C) in soil organic matter (SOM) and soil respired CO2 provide insights into dynamics of the carbon cycle. δ13C analyses do not provide direct measures of soil CO2 efflux rates but are useful as a constraint in carbon cycle models. In many cases, δ13C analyses...Below ground processes; Ecosystems; Carbon cycle; Carbon isotope ratio; Ecosystem processes; Global change; Soil organic carbon; Soil organic matter2000
71 Ehleringer, James R.Carbon isotope ratios of Atacama Desert plants reflect hyperaridity of region in northern ChileLeaf carbon isotope ratios were measured on plants from the coastal portions of the Atacama Desert at Pan de Azucar and Paposo, Chile. Most species possessed C3 photosynthesis, although there were several CAM species, indications of some facultative CAM species, and only one C4 species. The carbon i...Atacama Desert; Carbon isotope ratio; Intercellular carbon dioxide concentration; Hyperaridity1998
72 Sekercioglu, CaganCauses and consequences of bird extinctionsIncreased human domination of the planet has caused the declines and extinctions of countless species. Each species has not only intrinsic value, but ecological functions of organisms are also essential for the integrity of ecosystems that allow people to benefit from essential free ecosystem servic...2003-01-01
73 Torti, Sylvia D.; Coley, Phyllis D.; Kursar, Thomas A.Causes and consequences of monodominance in tropical lowland forestsTropical canopy dominance in lowland, well-drained forests by one plant species is a long-standing conundrum in tropical biology. Research now shows that dominance is not the result of one trait or mechanism. We suggest that the striking dominance of Gilbertiodendron dewevrei in the Ituri Forest of ...Monodominance; Gilbertiodendron dewevrei; Ituri Forest; Understory2001
74 Sperry, John S.Cavitation fatigue - the weakening of cavitation resistance of xylem and its reversibilityXylem function is essential for the growth and survival of higher land plants. Xylem must not only be efficient under favorable conditions to facilitate high rates of stomatal conductance and carbon uptake, but it should also remain functional under drought conditions, when water potential (Ψ) dro...Cavitation fatigue; Drought; Pit membrane2003
75 Davidson, Diane W.Cecropia and its biotic defensesIn all the world, the genus Cecropia is unrivaled for the number of myrmecophytes, or true "antplants" counted among its species (McKey & Davidson, 1993). Based on the proportion of Cecropia species producing Mullerian bodies in at least some parts of their distribution, myrmecophytes comprise the ...Myrmecophytes; Mullerian bodies; Pearl bodies2005
76 Bastiani, MichaelCell-cell interactions during the migration of an identified commissural growth cone in the embryonic grasshopperOne of the fascicles of the posterior commissure of the embryonic grasshopper is pioneered by an individually identifiable neuron named Q1. Q1 initially grows along a longitudinal pathway established by another pioneer neuron, MPl, and then crosses to the midline, where it meets and fasciculates wi...Commissure; Pathfinding; Filopodia1993
77 Gesteland, Raymond F.Cell-free synthesis of herpes simplex virus proteinsPolyribosomes isolated from herpes simplex virus type I (HSV-1)-infected cells have been used to program a eucaryotic cell-free translation system. At least 10 HSV-specific polypeptides, with apparent molecular weights of 25,000 to 160,000, are synthesized by wild-type HSV-infected polyribosomes. Po...Viral Proteins; Herpes Simplex; Peptide Biosynthesis; Thymidine Kinase1977
78 Bastiani, MichaelCentral projections of the stretch receptor neurons of crayfish: segmental gradients of synaptic probability and strengthThe 20 stretch receptor neurons (SRs) of the crayfish abdomen send axons into the CNS that then project both to the brain and to the last abdominal ganglion, G6 (Bastiani and Mulloney, 1988). In G6, we recorded intracellularly from different kinds of neurons postsynaptic to SR axons.Axons; Synapses; SR1988
79 Bastiani, MichaelCentral projections of the stretch receptor neurons of crayfish: structure, variation, and postembryonic growthEach stretch receptor neuron (SR) of the crayfish abdomen projects from its peripherally located soma an axon that enters the CNS through the second nerve (N2) of its segmental ganglion. CoZ+ backfills of N2 revealed that this axon bifurcates, sending one branch to the brain and the other to the te...Abdomen; Axon; Ganglion1988
80 Gesteland, Raymond F.Characterization of lysozyme messenger and lysozyme synthesized in vitroIn vitro systems for protein systhesis have been in wide use for about 10 years. In most of the early work protein synthesis was measured by following the incorporation of radioactive amino acids into acid precipitable material. This test cannot distinguish between the synthesis of complete, activ...Lysozyme Messenger; Lysozyme Synthesized; Protein Synthesis1969
81 Beckerle, Mary C.Characterization of the interaction between zyxin and members of the Ena/Vasodilator-stimulated Phosphoprotein family of proteinsZyxin contains a proline-rich N-terminal domain that is similar to the C-terminal domain in the ActA protein of the bacteria, Listeria monocytogenes. We screened the entire amino acid sequence of human zyxin for Menainteracting peptides and found that, as with ActA, proline-rich sequences were the s...Zyxin; Actin; Listeria monocytogenes; Proline-rich repeats; Cell spreading2000
82 Capecchi, Mario R.Characterization of three proteins involved in polypeptide chain termination.At each stage of elongation, the growing polypeptide chain is bound to the ribosome-messenger RNA complex through the transfer RNA of the most recently incorporated amino acid residue. When the chain is complete, the last polypeptide-transfer RNA (tuna) ester linkage is cleaved, releasing the chain ...Anti-Bacterial Agents; Phenylalanine; Stimulation, Chemical1969
83 Coley, Phyllis D.Chemical and bioactive natural products from microthyriaceae sp., an endophytic fungus from a tropical grassIn screening for natural products with antiparasitic activity, an endophytic fungus, strain F2611, isolated from above-ground tissue of the tropical grass Paspalum conjugatum (Poaceae) in Panama, was chosen for bioactive principle elucidation. Cultivation on malt extract agar (MEA) followed by bioas...2014-01-01
84 Blair, David F.Chemical and spectroscopic evidence for the formation of a ferryl Fea3 intermediate during turnover of cytochrome c oxidaseWhen partially reduced cytochrome c oxidase samples are reoxidized with dioxygen, an EPR-silent dioxygen intermediate, which is at the three-electron level of dioxygen reduction, is trapped at the dioxygen reduction site. The intermediate has novel spectral features at 580 and 537 nm. Combined op...Cytochrome c oxidase; EPR; Fea3 intermediate; Reduction1986
85 Sekercioglu, CaganChewing lice (phthiraptera) found on songbirds (Passeriformes) in TurkeyObjective: This study was performed to detect chewing lice species found on the songbirds at Lake Kuyucuk bird ringing station in the Kars province located in eastern Turkey. Methods: Chewing lice were collected from songbirds captured between September and October 2009. Fifty-one birds belonging t...2011-01-01
86 Sekercioglu, CaganChewing lice (phthiraptera) species found on birds along the Aras River, lgdir, Eastern TurkeyChewing lice were sampled from the birds captured and ringed between September-October 2009 at the Aras River (Yukarı Çıyrıklı, Tuzluca, Iğdır) bird ringing station in eastern Turkey. Eighty-one bird specimens of 23 species were examined for lice infestation. All lice collected from the birds...2011-01-01
87 Sekercioglu, CaganChewing lice (Phthiraptera) species found on Turkish shorebirds (Charadriiformes)Approximately 4.500 species of lice have been so far described, with about 4.000 species seen on birds and with 3.000 species in the suborder Ischnocera 1. There are 465 bird species so far recorded in Turkey and the actual total is likely to exceed 500 species. However, the chewing lice fauna of th...2010-01-01
88 Bohs, Lynn A.Chloroplast DNA phylogeny of Solanum sect on Las ocarpaSolanum section Lasiocarpa includes about a dozen species with a center of diversity in the NewWorld tropics. Solanum lasiocarpum and S. repandum (sometimes considered to be conspecific as S. ferox) have an Old World distribution in Asia and the Pacific Islands. Several species in this section produ...Solanum; trn; Lasiocarpa2004
89 Capecchi, Mario R.Choose your target.The technology of modifying endogenous genes has recently been extended from mice to Drosophila and sheep. Concurrently, genomic sequencing is uncovering thousands of previously uncharacterized genes. Armed with today's technologies, what are our best options for delineating the functions of these n...Animals; Mice; Sheep2000-09-13
90 Capecchi, Mario R.Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA rec...Animals, Newborn; Crosses, Genetic1997-10-14
91 Yamaguchi, AyakoCoding rate and duration of vocalizations of the frog , Xenopus laevisVocalizations involve complex rhythmic motor patterns, but the underlying temporal coding mechanisms in the nervous system are poorly understood. Using a recently developed whole-brain preparation from which "fictive" vocalizations are readily elicited in vitro, we investigated the cellular basis of...2012-08-29
92 Clayton, Dale H.Coevolutionary history of ecological replicates: comparing phylogenies of wing and body lice to Columbiform hostsPhylogenies depict the history of speciation for groups of organisms. Comparing the phylogenies of interacting groups can reveal instances of tandem speciation, or "cospeciation" (Brooks and McLennan, 1991; Hoberg et al., 1997; Paterson and Gray, 1997). Understanding the conditions under which cosp...Feather lice; Wing lice; Body lice; Cospeciation2003
93 Coley, Phyllis D.Coibanoles, a new class of meroterpeniods produced by pycnoporus sanguineusThree new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites ?coibanoles A?C? in reference to...2012
94 Coley, Phyllis D.; Kursar, Thomas A.Colonization of tropical rain forest leaves by epiphylls: effects of site and host plant leaf lifetimeIn humid tropical regions, leaves are frequently colonized by epiphylls (Richards 1954, Pocs 1978, 1982). Lichens and liverworts usually dominate, although mosses, algae, and cyanobacteria can also occur (Winkler 1971, Smith 1982). The interactions between epiphylls and host leaves have not been wel...Tropical forest; Epiphylls; Panama; Hybanthus prunifolius; Light interception1993
95 Olivera, Baldomero M.Combined proteomic and transcriptomic interrogation of the venom gland of conus geographus uncovers novel components and functional compartmentalizationCone snails are highly successful marine predators that use complex venoms to capture prey. At any given time, hundreds of toxins (conotoxins) are synthesized in the secretory epithelial cells of the venom gland, a long and convoluted organ that can measure 4 times the length of the snail's body. In...2014-01-01
96 Clayton, Dale H.Common grackle anting with lime fruit and its effect on ectoparasitesAnting is stereotyped behavior in which birds ex- pose themselves to fluid-secreting ants or other pun- gent substances. During "active" anting a bird crush- es an ant in the bill and rubs it frenetically through its plumage (Rothschild and Clay 1952). During "passive" anting a bird entices ants to ...Quiscalus quiscala; Columbicola columbae; Anting; Ectoparasites1993
97 Clayton, Dale H.Comparative effects of mites and lice on the reproductive success of rock doves (Columba livia)We report experimental data comparing the effects of Mesostigmatid mites and Ischnoceran lice on the reproductive performance of a single group of captive rock doves (Columba livid). Several components of host reproductive success were compared for the two groups, including number of eggs laid, hatc...Ectoparasites; Reproduction; Rock doves; Columba livia; Ischnocera; Mites; Lice1995
98 Davidson, Diane W.Comparative structure of harvester ant communities in arid Australia and North AmericaIn the Australian arid zone, the species richness of ants is greater and that of mammalian granivores is less than in North American deserts. This study aimed to determine if the structure of harvester ant communities differs from that seen in North American deserts, focussing on differences relate...Species; Rodents; Diversity1988
99 Clayton, Dale H.; Bush, Sarah ElizabethComparative transmission dynamics of competing parasite speciesCompetition-colonization trade-off models explain the coexistence of competing species in terms of a trade-off between competitive ability and the ability to colonize competitor-free patches of habitat. A simple prediction of these models is that inferior competitors will be superior dispersers. Thi...Bird lice; Campanulotes compar; Coexistence; Colonization; Columba livia; Columbicola columbae; Competition; Dispersal; Parasite; Phoresis; Specificity; Pseudolynchia canariensis; Phthiraptera2008
100 Hultine, KevinComparison of methods to estimate Ephemeral Channel Recharge, Walnut Gulch, San Pedro River Basin, ArizonaEphemeral channel transmission loss represents an important groundwater surface water exchange in arid and semiarid regions and is potentially a significant source of recharge at the basin scale. Copyright [year] American Geophysical Union. Reproduced by permission of American Geophysical Union. ...Transport; Transmission; Balance2004
101 Beckerle, Mary C.Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expressionMembers of the cysteine-rich protein (CRP) family are evolutionarily conserved proteins that have been implicated in the processes of cell proliferation and differentiation. In particular, one CRP family member has been shown to be an essential regulator of cardiac and skeletal muscle development.LIM domains; Chicken fibroblasts; Zyxin; Actinin; Protein expression; Cysteine-rich proteins1997
102 Davidson, Diane W.Competition and the structure of granivore communitiesWe trace the development of our investigations of granivory in desert ecosystems, illustrating the synthesis of the comparative and experimental approaches and noting the essential contributions of both. In the process, we also call attention to several major difficulties inherent to experimentatio...Granivory; Competition; Desert Ecosystems; Competitive investigations; Experimental investigations1980
103 Olivera, Baldomero M.; Parks, Thomas N.Conantokin-T: a γ-carboxyglutamate containing peptide with N-methyl-D-aspartate antagonist activityConantokin-T, a 21-amino acid peptide which induces sleep-like symptoms in young mice was purified from the venom of the fish-hunting cone snail, Conus tulipa. The amino acid sequence of the peptide was determined and verified by chemical synthesis. The peptide has 4 residues of the modified amino ...Conotoxins; Conantokin-T; N-methyl-D-aspartate antagonist; Conus tulipa1990
104 Seger, JonConditional relatedness, recombination, and the chromosome numbers of insectsIf two polymorphic loci are out of phase equilibrium, a homozygote at one of these loci is more highly related to its kin, at the other locus, than is an equivalent heterozygote. As a result, selection can favor (1) phenotypic responses to relative heterozygosity, and (2) increased recombination bet...Coefficients of relatedness; Conditional relatedness1983
105 Olivera, Baldomero M.Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magusWe describe the purification and first biochemical characterization of an enzymatic activity in venom from the marine snail Conus magus. This enzyme, named conodipine-M, is a novel phospholipase A2 with a molecular mass of 13.6 ĸDa and is comprised of two polypeptide chains linked by one or more di...Conotoxins; Conodipine-M; Conus magus1994
106 Olivera, Baldomero M.; Gray, William RobertConotoxin MI: disulfide bonding and conformational statesThe toxic peptide from Conus magus venom (conotoxin MI) is a 14-amino acid peptide (McIntosh, M., Cruz, L. J., Hunkapiller, M. W., Gray, W. R., and Olivera, B. M. (1982) Arch. Biochem. Biophys. 218, 329-334) which inhibits the acetylcholine ceptor. In this work we have confirmed the primary structu...Conotoxins; Disulfide bonding; Venom; Conus magus1983
107 Olivera, Baldomero M.; Hillyard, David R.ConotoxinsMany successful animal and plant families have developed distinctive biochemical strategies; one of the more unusual examples is found in a group of marine gastropods, the cone snails (Conus) (1). These animals have evolved a specialized biochemistry of small constrained peptides, the conotoxins. Th...Conotoxins1991
108 Potts, Wayne K.Consequences of self and foreign superantigen interaction with specific VB elements of the murine TCR aBThe aB T-cell receptor (TCRaB) recognizes a ligand composed of an antigen fragment complexed with a product of the major histocompatibility complex (MHC). The repertoire of receptors is limited both by the germ line of receptor variable elements and by selective events that take place during T-cell ...Toxins; Repertoire; Expression1989
109 Beckerle, Mary C.; Clark, Kathleen A.Conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegansWe describe here the molecular and functional characterization of the Caenorhabditis elegans unc-97 gene, whose gene product constitutes a novel component of muscular adherens junctions. UNC-97 and homologues from several other species define the PINCH family, a family of LIM proteins whose modula...LIM domains; Caenorhabditis elegans; UNC-97; Adherens junction; Touch neuron; Muscle development1999
110 Adler, Frederick R.Construction of multidimensional clustered patternsEcological processes often depend upon the patterning, as well as the absolute density, of resources. In this paper, we develop methods for describing pattern from the perspective of the organism encountering and exploiting the resources, and for reconstructing pattern from the description.Algorithms; clustered resources; foraging1994
111 Goller, FranzContributions of expiratory muscles to song production in zebra finchesBirdsong production requires coordinated activity of syringeal and respiratory muscles, Phonation occurs during the expiratory phase of the respiratory cycle, and expiratory muscles generate the pressure head for sound production.Phonation; Syringeal muscles; Air sac pressure1999
112 Olivera, Baldomero M.; Gray, William RobertContryphan is a D-tryptophan-containing Conus peptideIn this report, we document for the first time the occurrence of D-tryptophan in a normally translated polypeptide, contryphan. The peptide, isolated from the venom of the fish-hunting marine snail Conus radiatus, produces the "stiff-tail" syndrome in mice.Conotoxins; Contryphan; D-tryptophan; Conus peptides; Conus radiatus; Stiff-tail syndrome1996
113 Olivera, Baldomero M.; Gray, William Robert; Yoshikami, DojuConus geographus toxins that discriminate between neuronal and muscle sodium channelsWe describe the properties of a family of 22-amino acid peptides, the μ-conotoxins, which are useful probes for investigating voltage-dependent sodium channels of excitable tissues. The μ-conotoxins are present in the venom of the piscivorous marine snail, Conus geographus L. We have purified even...Conus geographus; Venom; Conotoxins; Sodium channels; Neurotoxins1985
114 Olivera, Baldomero M.; McIntosh, J. MichaelConus peptides as tools for the neuroscientistRecombinant DNA technology has had a powerful impact on understanding receptors and ion channels, the key components in the nervous system that are involved in intercellular communication. Cloning genes encoding these proteins has revealed that for every receptor and ion channel type, multiple molec...Conus peptides; Conotoxins1993
115 Olivera, Baldomero M.Conus peptides: biodiversity-based discovery and exogenomicsThe venoms of the ~700 species of predatory cone snails (genus Conus) are being systematically characterized. Each Conus species contains 100-200 small, highly structured venom peptides (colloquially known as conotoxins), which are synthesized and secreted in a venom duct (for overviews, see Refs. ...Conotoxins; Conus peptides; Exogenomics2006
116 Olivera, Baldomero M.Conus peptides: phylogenetic range of biological activityThe major function of the venoms of the predatory marine snails belonging to the genus Conus is to paralyze prey. Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less activity on homologous receptor targets in more distant taxa....Conus peptides; Conopeptides; Conotoxins1992
117 Olivera, Baldomero M.Conus venom peptides, receptor and ion channel targets, and drug design: 50 million years of neuropharmacologyThe predatory cone snails (Conus) are among the most successful living marine animals (~500 living species). Each Conus species is a specialist in neuropharmacology, and uses venom to capture prey, to escape from and defend against predators and possibly to deter competitors. An individual cone...Conotoxins1997
118 Goller, FranzCoordination and synergism between visual and vocal display in the brown-headed cowbirdsSexually selected acoustic signaling is accompanied by visual displays in many birds. The motor integration of visual and vocal displays has not been extensively studied. Brown-headed cowbirds (Molothrus ater) "puff up" prior to song, move their wings during the song and conclude with a bow. The ...Acoustic signaling; Wing display; Synergistic interaction2003
119 Sekercioglu, CaganCorrelates of elevational specialisation in Southeast Asian tropical birdsThe understanding of elevational selectivity in extremely rich tropical biotas is critical to the study of accelerating human-mediated environmental changes (e.g., deforestation and global climate warming). This paper explores the characteristics of Southeast Asian birds that are altitudinal special...2012-01-01
120 Carrier, David R.Coupled evolution of breathing and locomotion as a game of leapfrogBecause the increase in metabolic rate related to locomotor activity places demands on the cardiorespiratory apparatus, it is not surprising that the evolution of breathing and of locomotion are coupled. As the respiratory faculty becomes more refined, increasingly aerobic life strategies can be exp...Evolution; Coupled evolution; Breathing; Locomotion; Cardiorespiratory apparatus2006
121 Capecchi, Mario R.Creating mice with targeted disruptions in protooncogenes and homeobox genes, NIH Director's Lecture given May 21, 1992This is an audio transcript of a 1 hour, 2 minutes and 12 seconds lecture given at the National Institutes of Health by Mario Capecchi on 1992/05/21. Beginning with a short summary of the mechanics of gene transfer and the ability to create germline chimera with mutations that become hereditary wit...Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Mutagenesis; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype1992
122 Capecchi, Mario R.Critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in miceAngiotensin-converting enzyme (ACE) generates the vasoconstrictor angiotensin II, which plays a critical role in maintenance of blood pressure in mammals. Although significant ACE activity is found in plasma, the majority of the enzyme is bound to tissues such as the vascular endothelium. We used ta...Blood pressure; ACE activity; Enzyme1997-03-06
123 Bohs, Lynn A.Crossing studies in Cyphomandra (Solanaceae) and their systematic and evolutionary significanceA crossing program involving eight species of Cyphomandra was instituted to elucidate systematic relationships between the taxa and evolutionary mechanisms operating in the genus. The results show that gametophytic self-incompatibility is widespread in Cyphomandra. Pollen tubes were able to reach ...Solanum maternum; Crossing studies1991
124 Beckerle, Mary C.CRP1, a LIM domain protein implicated in muscle differentiation, interacts with α-actininMembers of the cysteine-rich protein (CRP) family are LIM domain proteins that have been implicated in muscle differentiation. One strategy for defining the mechanism by which CRPs potentiate myogenesis is to characterize the repertoire of CRP binding partners.CRP1; Cysteine-rich proteins; Actinin; Protein-protein interactions; LIM domains1997
125 Gesteland, Raymond F.; Krapcho, Karen J.; Talbot, Phil; Thulin, CraigCrystallization of the MS2 translational repressor alone and complexed to bromouridineThe coat protein from the MS2 bacteriophage plays a dual role by encapsidating viral RNA and also by binding RNA as a translational repressor. In order to study the isolated dimer in a conformation not influenced by capsid interactions, a mutant molecule was crystallized that is defective in capsid ...Crystallization; RNA Bacteriophage; RNA Hairpin; Translational Repressor1995
126 Shapiro, Michael D.Cynodont from the Upper Triassic of East Greenland: tooth replacement and double-rootednessA new genus and species of cynodont from the Upper Triassic Fleming Fjord Formation of East Greenland possesses double-rooted postcanine teeth and a nonalternate pattern of tooth replacement. The specimen represents an addition to the known diversity of Early Mesozoic taxa with multi-rooted dentitio...Mitredon cromptoni; Cynodont; Upper Triassic; East Greenland; Fleming Fjord Formation; Tooth replacement; Double-rootedness; Multi-rooted dentition2001
127 Bohs, Lynn A.Cyphomandra (Solanaceae)Cyphomandra betacea (Cavanilles) Sendtner Syn. Cyphomandra crassifotia (Ortega) Kuntze, Solanum betacea Cavanilles, Solanwn crassifolium Ortega. Ref. FB 13(5B/1) 1962: 12; Bohs, 1986: 170. Cultivated tree. Andean II. 1000-3000 m. Voucher: Nunez et al. 8257 (MO!) Depts.: AM, CU, HU, SMCyphomandra; Solanum1993
128 Bohs, Lynn A.Cyphomandra (Solanaceae)Unusual ecological aspects of Cyphomandra include its pollination syndrome and herbivore relationships. Male euglossine bees may be important pollinators of Cyphomandra flowers, and the primary attractants may not be pollen, but odor substances secreted by the anther connectives. Specialized herbi...Cyphomandra; Latin America1994
129 Beckerle, Mary C.Cysteine-rich protein family of highly related LIM domain proteinsHere we describe a family of closely related LIM domain proteins in avian cells. The LIM motif defines a zinc-binding domain that is found in a variety of transcriptional regulators, proto-oncogene products, and proteins associated with sites of cell-substratum contact. One type of LIM-domain protei...LIM domains; Chicken embryo fibroblasts; Quail embryo fibroblasts; Cell growth; Cell development; Cysteine-rich proteins1995
130 Beckerle, Mary C.Cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiationIn this report, an antisense RNA strategy has allowed us to show that disruption of ALP expression affects the expression of the muscle transcription factors myogenin and MyoD, resulting in the inhibition of muscle differentiation. Introduction of a MyoD expression construct into ALP-antisense cells...Skeletal muscle; PDZ-LIM protein; Actin; Actinin-associated LIM proteins; Serum response factor; Cytoskeletal architecture2007
131 Clayton, Dale H.Darwins finches combat introduced nest parasites with fumigated cottonIntroduced parasites are a threat to biodiversity when naïve hosts lack effective defenses against such parasites [1]. Several parasites have recently colonized the Galápagos Islands, threatening native bird populations [2]. For example, the introduced parasitic nest fly Philornis downsi (Diptera:...2014-01-01
132 Adler, Frederick R.Deconvolution of isotope signals from bundles of multiple hairsSegmental analysis of hair has been used in diverse fields ranging from forensics to ecology to measure the concentration of substances such as drugs and isotopes. Multiple hairs are typically combined into a bundle for segmental analysis to obtain a high-resolution series of measurements. Individua...2014-01-01
133 Adler, Frederick R.Defended fortresses or moving targets? Another model of inducible defenses inspired by military metaphorsWe use a common framework to compare three models of plant strategies to confront herbivory: constitutive defense, optimal inducible defense, and the "moving target." Plants with constitutive defenses retain a fixed defensive phenotype. Plants with optimal inducible defenses respond to attack by inc...Constitutive defense; optimal inducible defense; phenotype1994
134 Olivera, Baldomero M.Defining a clade by morphological, molecular, and toxinological criteria: distinctive forms related to Conus praecellens A. Adams, 1854 (Gastropoda: Conidae)We carried out a definition of the Conus praecellens A. Adams, 1854, species group using a combination of comparative morphological data, molecular phylogeny based on standard genetic markers, and toxinological markers. Prior to this work, Conus praecellens was generally postulated to belong to a cl...Turriconus; 12SrRNA sequences; Phylogenetic analysis; Conus praecellens; Exogenes2010
135 Farmer, Colleen G.Dendrobates auratus (green and black poison dart frog). Larval PredationDendrobates auratus was intentionally introduced onto the island of O'ahu, Hawai'i in 1932 from Taboga Island, Panama for mosquito control. Phelsuma laticauda was accidentally introduced from Madagascar in 1996 to the University of Hawaii at Manoa. Both species are well established in the Manoa Val...Dendrobates auratus; Phelsuma laticauda2007
136 Adler, Frederick R.Departure time versus departure rate: how to forage optimally when you are stupidForagers unable to leave a patch at the optimal moment must act as constrained foragers. Extending the results of Houston and McNamara (1985), we compare a blundering forager that leaves patches at a constant rate with an unconstrained optimal forager that leaves patches at the optimal time.Blundering Foragers; Foraging; Marginal Value Theorem1999
137 Capecchi, Mario R.Detection of targeted GFP-Hox gene fuogenesissions during mouse embry.The ability to use a vital cell marker to study mouse embryogenesis will open new avenues of experimental research. Recently, the use of transgenic mice, containing multiple copies of the jellyfish gene encoding the green fluorescent protein (GFP), has begun to realize this potential. Here, we show ...Chimera; Crosses, Genetic; Gestational Age; Green Fluorescent Proteins; Mice, Inbred C57BL; Phenotype1998-10-27
138 Yamaguchi, AyakoDevelopment of an acute method to deliver transgenes into the brains of adult Xenopus laevisThe central vocal pathway of the African clawed frog, Xenopus laevis, is a powerful vertebrate model to understand mechanisms underlying central pattern generation. However, fast and efficient methods of introducing exogenous genes into the neurons of adult X. laevis are currently not available. Her...viral vector; vesicular stomatitis virus; Xenopus laevis; transgene; neurons; vocalizations; central pattern generator; electroporation2018
139 Yamaguchi, AyakoDevelopment of techniques to deliver transgenes into neurons of amphibiansSociety for Neuroscience Meeting 2017viral vector; Xenopus laevis; vocalizations2017
140 Capecchi, Mario R.Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6.Gene targeting in mouse embryo-derived stem cells has been used to generate mice with a disruption in the homeobox gene Hox-1.6. Mice heterozygous at the Hox-1.6 locus appear normal, whereas Hox-1.6-/Hox-1.6- mice die at or shortly after birth. These homozygotes exhibit profound defects in the forma...Chromosome Mapping; Genetic Vectors; Mice, Inbred C57BL2002-06-27
141 Bastiani, MichaelDevelopmental expression and biochemical analysis of Conulin, a protein secreted from a subset of neuronal growth conesIn this report, we analyze the developmental pattern of expression of a new grasshopper protein, Conulin, using the monoclonal antibody 7D2 on whole-mount embryos and dissociated neurons. We also have examined its biochemical properties by immunoblot analysis. Conulin is a protein expressed by a su...Conulin; Growth cone-specific protein; Secreted protein; Selective tasciculation; CNS-specific protein; Pathfinding1996
142 Bastiani, MichaelDevelopmental expression of REGA-1, a regionally expressed glial antigen in the central nervous system of grasshopper embryosGlial cells are a large component of the developing nervous system, appearing before the onset of axon outgrowth in a variety of developing systems. Their time of appearance and their location in conjunction with developing axon pathways may allow them to define the position of axon pathways.Antibody; Axons; Pathways1991
143 Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. MichaelDifferential targeting of nicotinic acetylcholine receptors by novel αA-conotoxinsWe describe the isolation and characterization of two peptide toxins from Conus ermineus venom targeted to nicotinic acetylcholine receptors (nAChRs). The peptide structures have been confirmed by mass spectrometry and chemical synthesis. In contrast to the 12-18 residue, 4 Cys-containing α-co...Conotoxins; aA-conotoxins; Conus ermineus; Peptide toxins1997
144 Crespo, Jose GuillermoDislodgement effect of natural semiochemicals released by disturbed triatomines: a possible alternative monitoring toolThe quick detection of domestic and peridomestic triatomines in their environments becomes difficult without the use of dislodgement substances that flush them out from their shelters. At present, tetramethrin 0.2% is being widely used in control programs. Although it is an efficient dislodging agen...2013-01-01
145 Davidson, Diane W.Dispersal adaptations of some acacia species in the Australian arid zoneMost Australian representatives of the genus Acacia have diaspores with arillate appendages indicative of adaptation for active dispersal by animals. Based on physical and chemical characteristics of these arils and mechanisms of diaspore presentation, a number of arid zone acacias can be distingu...Acacia; Australian arid zone; Dispersal ecology; Fruit quality; Myrmecochory; Ornithochory; Seed parasitoids; Soil nutrients1984
146 Coley, Phyllis D.Disponibilidad de recursos y defensas de las plantas frente al herbivorismoEl grado de herbivorismo y la eficacia de las defensas muestran amplias variaciones en las especies de plantas. La disponibilidad de recursos en el ambiente se propone como el mayor determinante de la cantidad y tipo de defensas de las plantas. Cuando los recursos son limitados, las plantas de cre...Defensas; Plantas; Herbivorismo2007
147 Capecchi, Mario R.; Mansour, Suzanne L.; Thomas, Kirk R.Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes.Gene targeting--homologous recombination of DNA sequences residing in the chromosome with newly introduced DNA sequences--in mouse embryo-derived stem cells promises to provide a means to generate mice of any desired genotype. We describe a positive nd negative selection procedure that enriches 2,00...Animals; Clone Cells; Restriction Mapping; Stem Cells1988-11-24
148 Yamaguchi, AyakoDistinct neural control of vocal phases in frog callsThis poster describes how the connections within the central vocal pathways of African clawed frogs are responsible for coordinating distinct part of their calls.Vocalizations; Central pattern generators, Motor programs2013
149 Olivera, Baldomero M.Distinction among neuronal subtypes of voltage-activated sodium channels by μ-conotoxin PIIIAThe functional properties of most sodium channels are too similar to permit identification of specific sodium channel types underlying macroscopic current. Such discrimination would be particularly advantageous in the nervous system in which different sodium channel family isoforms are coexpressed i...Conotoxins; m-conotoxin2000
150 Shapiro, Michael D.Divergence, convergence, and the ancestry of feral populations in the domestic rock pigeonDomestic pigeons are spectacularly diverse and exhibit variation in more traits than any other bird species [1]. In The Origin of Species, Charles Darwin repeatedly calls attention to the striking variation among domestic pigeon breeds - generated by thousands of years of artificial selection on a s...2010
151 Shapiro, Michael D.Divergence, convergence, and the ancestry of feral populations in the domestic rock pigeonStringham, Sydney A.; Mulroy, Elisabeth E.; Xing, Jinchuan; Record, David; Guernsey, Michael W.; Aldenhoven, Jaclyn T.; Osborne, Edward J.
152 Shapiro, Michael D.Divergence, convergence, and the ancestry of feral populations in the domestic rock pigeonStringham, Sydney A.; Mulroy, Elisabeth E.; Xing, Jinchuan; Record, David; Guernsey, Michael W.; Aldenhoven, Jaclyn T.; Osborne, Edward J.
153 Coley, Phyllis D.; Lokvam, John; Kursar, Thomas A.Divergent defensive strategies of young leaves in two species of IngaIn the recently radiated genus Inga (Fabaceae), few nucleotide substitutions have accumulated among species, yet large divergences have occurred in defensive phenotypes, suggesting strong selection by herbivores. We compared herbivory and defenses of young leaves for I. goldmanii, a more derived spe...Bioassays; Flavanoids; Heliothis virescens; Herbivory; Inga goldmanii; Inga umbellifera; Leaf development; Non-protein amino acids; Phoebis philea2005
154 Olivera, Baldomero M.DNA-topoisomerase modificationThe first reports of topoisomerase modification were published in 1982 and 1983 (Mills et al. 1982; Durban et al. 1983; Ferro et al. 1983; Jongstra-Bilen et al. 1983). Although a wide variety of posttranslational modifications of DNA topoisomerases may occur, this chapter focuses only on phosphoryl...Poly(ADP-ribosylation); Serine residues1990
155 Adler, Frederick R.Do rhinoviruses follow the neutral theory? The role of cross-immunity in maintaining the diversity of the common coldOver 100 serotypes of rhinoviruses, one of the primary causes of the common cold, co-circulate in the human population. This high diversity makes it effectively impossible to develop a vaccine, even for those at risk of complications due to asthma or cystic fibrosis.Serotypes; mutation rate; immunodominance2006
156 Clayton, Dale H.Does avian malaria reduce fledging success: an experimental test of the selection hypothesisLike many parasites, avian haematozoa are often found at lower infection intensities in older birds than young birds. One explanation, known as the "selection" hypothesis, is that infected young birds die before reaching adulthood, thus removing the highest infection intensities from the host popul...2013-01-01
157 Gesteland, Raymond F.; Atkins, John F.; Ingram, Jennifer A.; Kelly, Paul J.; Grentzmann, GuidoDual-luciferase reporter system for studying recoding signalsA new reporter system has been developed for measuring translation coupling efficiency of recoding mechanisms such as frameshifting or readthrough. A recoding test sequence is cloned in between the renilla and firefly luciferase reporter genes and the two luciferase activities are subsequently measu...Amino Acid Sequence; Genes, Reporter; HIV; Antizyme; Translation1998
158 Capecchi, Mario R.Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse.The Hox genes encode a group of transcription factors essential for proper development of the mouse. Targeted mutation of the Hoxd11 gene causes reduced male fertility, vertebral transformation, carpal bone fusions, and reductions in digit length. A duplication of the Hoxd11 gene was created with th...Animals; Bone Development; Forelimb; Gene Expression Regulation, Developmental2002-09-01
159 Goller, FranzDynamical origin of spectrally rich vocalizations in birdsongBirdsong is a model system for learned vocal behavior with remarkable parallels to human vocal development and sound production mechanisms. Upper vocal tract filtering plays an important role in human speech, and its importance has recently also been recognized in birdsong. However, the mechanisms...Taeniopygia guttata; Labial oscillations; SNILC bifurcation2008-07
160 Hultine, KevinEcohydrologic significance of hydraulic redistribution in a semiarid savannaRecent studies have illuminated the process of hydraulic redistribution, defined as the translocation of soil moisture via plant root systems, but the long-term ecohydrologic significance of this process is poorly understood. Copyright [year] American Geophysical Union. Reproduced by permission...Moisture; Roots; Water2008
161 Hultine, KevinEcohydrological implications of woody plant encroachmentIncreases in the abundance or density of woody plants in historically semiarid and arid grassland ecosystems have important ecological, hydrological, and socioeconomic implications. Using a simplified water-balance model, we propose a framework for conceptualizing how woody plant encroachment is li...Carbon cycling; ecohydrology; evapotranspiration2005
162 Ehleringer, James R.; Bush, Sarah Elizabeth; Solomon, Douglas KipEcohydrology in a Colorado River riparian forest: implications for the decline of Populus fremontiiPopulus fremontii (Fremont cottonwood) was once a dominant species in desert riparian forests but has been increasingly replaced by the exotic invasive Tamarix ramosissima (saltcedar). Interspecific competition, reduced flooding frequency, and increased salinity have been implicated in the widespre...Populus fremontii; Decline; Colorado River; Utah; Invasive species; Riparian; Salinity; Sap flow; Tamarix ramosissima; Transpiration2005
163 Clayton, Dale H.Ecoimmunity in Darwin's finches: invasive parasites trigger acquired immunity in the medium ground finch (Geospiza fortis)Invasive parasites pose a serious threat to native animal populations, because hosts with no history of exposure may lack effective immune defenses. Invasive parasites are a particular threat to small, island populations [1,2]. For example, introduced malaria (Plasmodium relictum) has exacerbated t...Darwins finches; Ecoimmunity; Acquired immunity; Medium ground finch; Geospiza fortis; Invasive parasites; Novel parasites; Poxvirus avium; Nest flies; Philornis downsi2010-01-06
164 Clayton, Dale H.Ecological basis of coevolutionary historyMacroevolutionary patterns are difficult to interpret because they are the product of a time scale so vast that deterministic and chance events are hard to distinguish. Although the macroevolutionary history of a group can be reconstructed from extant species, determining the ecological context in ...2003
165 Bowling, David R.Ecological processes dominate the 13C land disequilibrium in a Rocky Mountain subalpine forestFossil fuel combustion has increased atmospheric CO2 by ≈ 115 μmol mol1 since 1750 and decreased its carbon isotope composition (δ13C) by 1.7-2‰(the 13C Suess effect). Because carbon is stored in the terrestrial biosphere for decades and longer, the δ13C of CO2 released by terrestrial ecosyst...2014-01-01
166 Davidson, Diane W.Ecological studies of neotropical ant-gardensIn a census taken in Peru's Manu National Park, 10 epiphytic angiosperms from seven plant families established principally on arboreal carton-ant nests. These "ant gardens" (AGs) were most often inhabited by parabiotic ants, Camponotus femoratus and Crematogaster cf. limata parabiotica, whose polygy...Ant competition; Ant garden; Ant-plant interaction; Coadaptation; Epiphyte; Mutualism; Parabiosis; Preadaptation; Peru; Seed dispersal; Tropical rainforest1988
167 Ehleringer, James R.; Bush, Sarah ElizabethEcophysiology of riparian cottonwood and willow before, during, and after two years of soil water removalRiparian cottonwood/willow forest assemblages are highly valued in the southwestern United States for their wildlife habitat, biodiversity, and watershed protection. Yet these forests are under considerable threat from climate change impacts on water resources and land-use activities to support hum...Riparian cottonwood; Riparian willow; Soil water removal; Coyote willow; Drought recovery; Populus fremontii; Riparian ecology; Red Butte Canyon Research Natural Area; Salix exigua; Stem sap flux; Leaf carbon isotope ratios2010
168 Ehleringer, James R.Ecosystem physiology responses to global changeMost ecosystems exposed to double ambient C02 show higher peak season net carbon uptake than those growing at current-ambient C02. For grasslands, above-ground biomass increased by an average of 14%, although individual responses for a given system and year range from negative to +85%. The wide ran...Global change ; Ecosystem physiology; Carbon budget; Temperature; Water availability; Nitrogen deposition; Ozone1999
169 Adler, Frederick R.Effect of 1918 PB1-F2 expression on influenza A virus infection kineticsRelatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alters viral po...2011
170 Adler, Frederick R.Effect of 1918 PB1-F2 expression on influenza A virus infection kineticsAbstract Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alter...2011
171 Hughes, Kelly T.The effect of cell growth phase on the regulatory cross-talk between flagellar and Spi1 virulence gene expressionThe flagellar regulon controls Salmonella biofilm formation, virulence gene expression and the production of the major surface antigen present on the cell surface: flagellin. At the top of a flagellar regulatory hierarchy is the master operon, flhDC, which encodes the FlhD4C2 transcriptional complex...2014-01-01
172 Hultine, Kevin; Bush, Sarah Elizabeth; Ehleringer, James R.Effect of gender on sap-flux-scaled transpiration in a dominant riparian tree species: Box elder (Acer negundo)Acer negundo is a dioecious riparian tree species with a spatial segregation of the sexes along soil moisture gradients. Females are typically more common in wet sites along streams (typically F/M = 1.6), whereas males are more common in drier sites away from streams (typically F/M = 0.6). Spatial s...Density; Ecosystem; Segregation2007
173 Sekercioglu, CaganThe effects of climate change on tropical birdsBirds are among the most widely studied organisms on earth and represent an important indicator group for learning about the effects of climate change - particularly in regard to the effects of climate change on tropical ecosystems. In this review, we assess the potential impacts of climate change o...2010-01-01
174 Hughes, Kelly T.The effects of codon context on in vivo translation speedWe developed a bacterial genetic system based on translation of the his operon leader peptide gene to determine the relative speed at which the ribosome reads single or multiple codons in vivo. Low frequency effects of so-called ‘‘silent'' codon changes and codon neighbor (context) effects could...2014-01-01
175 Adler, Frederick R.Effects of intraspecific density-dependence on species richness and species abundance distributionsAbstract Species richness and patterns of abundance result from the interplay between niche differences, realized as intraspecific density-dependence (IDD), and so-called neutral processes that arise when species fitnesses are similar. This paper presents an extension of neutral models that incorpo...2010
176 Davidson, Diane W.Effects of trenching on growth and survival of planted Shorea parvifolia seedlings under pioneer stands in a logged-over forestEffects of trenching on growth and survival of planted Shorea parvifolia seedlings under pioneer stands in a logged-over forest. We conducted an experiment to determine the value of trenching in reducing potentially negative effects of root competition on growth of Shorea parvifolia seedlings plant...Shorea parvifolia; Trenching; Dipterocarp seedlings; Enrichment planting; Pioneer stands; Root competition; Soil compaction; Sabah1998
177 Coley, Phyllis D.; Kursar, Thomas A.Effects of weather on fungal abundance and richness among 25 communities in the Intermountain WestBecause moisture and temperature influence the growth of fungi, characterizing weather conditions favorable for fungi may be used to predict the abundance and richness of fungi in habitats with different climate conditions. To estimate habitat favorability to fungi, we examined the relationship of f...Intermountain West; Utah; Microclimate; Fungal prevalence2002
178 Thomas, Kirk R.; Capecchi, Mario R.Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei.Heteroduplexes were prepared from two plasmids, pRH4-14/TK and pRH5-8/TK, containing different amber mutations in the neomycin resistance gene (Neor). The Neor gene was engineered to be expressed in both bacterial and mammalian cells. A functional Neor gene conferred kanamycin resistance to bacteria...Cell Nucleus; Cells, Cultured; Microinjections1985-01
179 Gesteland, Raymond F.; Weiss, Robert B.Efficient shine- Dalgarno sequence but not translation is necessary for LacZ mRNA stability in Escherichia coliThe 5' ends of many bacterial transcripts are important in determining mRNA stability. A series of Shine-Dalgarno (SD) sequence changes showed that the complementarity of the SD sequence to the anti-SD sequence of 16S rRNA correlates with lacZ mRNA stability in Escherichia coli. Several initiation c...Protein Biosynthesis; Ribosomes; Escherichia coli; Shine-Dalgarno Sequence1994
180 Bohs, Lynn A.Eggplant origins: out of Africa, into the OrientThe eggplant (Solanum melongena L.), also known as aubergine or brinjal, has been cultivated for centuries in the Old World and is currently a crop species of global importance. Despite this, hypotheses of eggplant evolution have been fraught with controversy. Previous conclusions have relied solely...Eggplant origins; Crop domestication; Solanum melongena complex; Solanum incanum; DNA sequence; Africa; Asia2010
181 Carrier, David R.Electromyographic pattern of the gular pump in monitor lizardsGular pumping in monitor lizards is known to play an important role in lung ventilation, but its evolutionary origin has not yet been addressed. To determine whether the gular pump derives from the buccal pump of basal tetrapods or is a novel invention, we investigated the electromyographic activity...Electromyographic pattern; Gular pump; Varanus exanthematicus; Lung ventilation; Evolution2001
182 Blair, David F.Electron spin relaxation of CuA and cytochrome a in cytochrome c oxidase: comparison to heme, copper, and sulfur radical complexesThe method of continuous saturation has been used to measure the electron spin relaxation parameter T1T2 at temperatures between 10 and 50 K for a variety of S = % species including: CuA and cytochrome a of cytochrome c oxidase, the type1 copper in several blue copper proteins, the type 2 coppe...Electron spin relaxation; EPR signals; Sulfur radical complexes1984
183 Capecchi, Mario R.ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissueDuring the recruitment process of brown adipose tissue, the mRNA level of the fatty acyl chain elongase Elovl3 is elevated more than 200-fold in cold-stressed mice. We have obtained Elovl3-ablated mice and report here that, although cold-acclimated Elovl3-ablated mice experienced an increased heat l...2005-12-21
184 Sperry, John S.Embolized conduits of rice (Oryza sativa, poaceae) refill despite negative xylem pressureEmbolism reversal in rice plants was studied by testing the plant's ability to refill embolized conduits while xylem pressures were substantially negative. Intact, potted plants were water-stressed to a xylem pressure of -1.88 + 0.1 MPa and a 66.3 + 3.8% loss of xylem conductivity (PLC) by cavitatio...Embolism; novel revilling; Oryza2005
185 Potts, Wayne K.Emigration behavior of Clark's NutcrackerEruptive movements of the Clark's Nutcracker (Nucifraga columbiana) were observed during the late summer and fall of 1977, 1978 and 1979 in northern Utah and adjacent states. Over 2,000 emigrating nutcrackers were seen during these periods. Eruptions began in mid to late August, about the time nutcr...Breeding range; Flocks; Observations1981
186 Ehleringer, James R.ENSO effects on primary productivity in Southern Atacama desertIn the winter-rain southern Atacama Desert of the Coquimbo Region of Chile, El Niño - Southern Oscillation (ENSO) events modulate primary productivity. In this region, there are important changes in water availability between La Niña (dry) and El Niño (rainy) years. Using interannual comparison...El Niño; Atacama Desert; Terrestrial ecosystems; Plant productivity2006
187 Capecchi, Mario R.Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes.We describe the generation of mammalian cell lines carrying amber suppressor genes. Nonsense mutants in the herpes simplex virus thymidine kinase (HSV tk) gene, the Escherichia coli xanthine-guanine phosphoribosyl transferase (Eco-gpt) gene and the aminoglycoside 3' phosphotransferase gene of the Tn...Cercopithecus aethiops; Escherichia coli; Xenopus1982-11-30
188 Bohs, Lynn A.Ethnobotany of the genus Cyphomandra (Solanaceae)Plants of the genus Cyphomandra (Solanaceae) have long been utilized for their edible fruits in their native Latin America. The best-known species is the domesticated tree tomato or tamarillo, Cyphomandra betacea. This species, popular as a raw or cooked fruit, is widely cultivated in Andean South ...Cyphomandra; Cyphomandra betacea; Alkaloids1989
189 Ehleringer, James R.Evaluación de la capacidad estacional de utilizar eventos de preciptación en tres especies de arbustos nativos de Chile con distintos sistemas radicularesSe evaluó la capacidad estacional de utilizar un evento de precipitación en tres especies arbustivas con diferentes sistemas radiculares (dimórficos: Balbisia peduncularis, Senna cumingii; profundo: Haplopappus parvifolius) en la Quebrada El Romeral, norte-centro de Chile. El sitio posee un clima...Fuentes de agua; Proporción de isótopos estables; Sistema radicular; Desertificación; Zonas áridas; Chile; Water sources; Stable isotopes ratio; Root system; Arid zone; Balbisia peduncularis; Senna cummingii; Haplopappus parvifolius2002
190 Sperry, John S.Evaluation of Murray's law in Psilotum nudum (Psilotaceae), an analogue of ancestral vascular plantsPrevious work has shown that the xylem of seed plants follows Murray's law when conduits do not provide structural support to the plant. Here, compliance with Murray's law was tested in the stem photosynthesizer Psilotum nudum, a seedless vascular plant. Psilotum nudum was chosen because the central...Conduit furcation number; hydraulic architecture; Murray's law2005
191 Seger, JonEvidence for a cryptic species complex in the ant parasitoid Apocephalus paraponerae (Diptera: Phoridae)Cryptic species complexes occur in many taxa, in particular in the insect order Diptera. Here we describe a possible new cryptic species complex in the family Phoridae. Three lines of evidence suggest that Apocephalus paraponerae, an ant parasitoid, is actually a complex of at least four genetically...Host; Sequence; Populations2001
192 Carrier, David R.Evidence for endothermic ancestors of crocodiles at the stem of archosaur evolutionPhysiological, anatomical, and developmental features of the crocodilian heart support the paleontological evidence that the ancestors of living crocodilians were active and endothermic, but the lineage reverted to ectothermy when it invaded the aquatic, ambush predator niche. In endotherms, there i...Endothermy; ectothermy; Archosaur evolution; Archosaurs; Crocodilian heart2004
193 Beckerle, Mary C.Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated plateletsActivation of blood platelets triggers a series of responses leading to the formation and retraction of blood clots. Among these responses is the establishment of integrin-mediated transmembrane connections between extracellular matrix components and the actin cytoskeleton of the platelet.Actin; GPIIb-IIIa1993
194 Adler, Frederick R.Evolution of forager responses to inducible defensesMost theoretical and empirical investigations of inducible defenses have focused on identifying conditions that favor the evolution of inducibility by the prey species. These analyses outline the essential consequences of frequency-dependent benefits of deploying the defense, degrees of predictabili...Predation; Cues; Phenotypes1999
195 Seger, JonEvolution of individuality by Leo W. BussMetazoans seldom reproduce vegetatively; they often die of cancer; and they almost always sequester their germ lines. Plants often reproduce vegetatively, seldom die of cancer, and almost never sequester a germ line. Buss argues that these and many other patterns can all be understood in a unified w...Cell lines; Hierarchy; Biology1988
196 Potts, Wayne K.Evolution of mating preferences and major histocompatibility complex genesHouse mice prefer mates genetically dissimilar at the major histocompatibility complex (MHC). The highly polymorphic MHC genes control immunological self/nonself recognition; therefore, this mating preference may function to provide "good genes" for an individual's offspring. However, the evidence ...Inbreeding; Parasites; Recognition1999
197 Sperry, John S.Evolution of water transport and xylem structureLand plants need water to replace the evaporation that occurs while atmospheric CO2 is diffusing into photosynthetic tissue. The water-for-carbon exchange rate is poor, and evolutionary history indicates a progression of innovations for cheap water transport--beginning in order with capillary sucti...Cavitation; Vessels; Plants2003
198 Davidson, Diane W.Evolutionary ecology of symbiotic ant-plant relationshipsAbstract.--A tabular survey of ant-plant symbioses worldwide summarizes aspects of the evolutionary ecology of these associations. Remarkable similarities between ant-plant symbioses in disjunct tropical regions result from convergent and parallel evolution of similarly preadapted ants and plants. ...Symbioses; Evolution; Taxonomic1993
199 Gesteland, Raymond F.; Atkins, John F.Evolutionary specialization of recoding: frameshifting in the expression of S. cerevisiae antizyme mRNA is via an atypical antizyme shift site but is still +1An autoregulatory translational shift to the +1 frame is required for the expression of ornithine decarboxylase antizyme from fungi to mammals. In most eukaryotes, including all vertebrates and a majority of the studied fungi/yeast, the site on antizyme mRNA where the shift occurs is UCC-UGA. The me...Antizyme; ODC; Polyamines; Frameshifting2006
200 Davidson, Diane W.Experimental manipulation of food bodies in CecropiaNeotropical Cecropia trees range from Mexico to Argentina and are typical of disturbed habitats. Cecropia plants provide food and housing for the ants in return for known or presumed protection from herbivores and vine cover. Glycogen-rich Mullerian bodies (MB's) are the predominant food source for ...Mullerian bodies; Trichilia; Cecropia tessmannii; Cecropia pungara1992
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