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Creator | Title | Description | Subject | Date |
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Seger, Jon | 1998 Sewall Wright Award: William Donald Hamilton | The Sewall Wright Award was established in 1991 to honor active investigators who have contributed in especially significant ways to the conceptual unification of the biological sciences. This year's recipient is William D. Hamilton of Oxford University. Beginning in the 1960s with his papers on the... | Evolution; Biological; Research | 1999 |
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Olivera, Baldomero M. | ?O-Conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2 | The ?O-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus, belonging to the O-superfamily of conotoxins with three disulfide bridges. They have attracted attention because they are inhibitors of tetrodotoxin-insensitive voltage-gated sodium channels (NaV1.8) and could therefore ... | | 2007 |
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Dearing, Maria-Denise | [Dearing_Database_Pilot] | [Database deposited March 08, 2013, as part of a pilot project, eResearch Committee, University of Utah.] [This description should include information that explains the dataset in detail in a manner that would be useful to potential reuse. The contact information for the primary investigator should ... | [Creator keywords here.] | 2013-03-08 |
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Sekercioglu, Cagan | A birders quide to Turkey | As I write, it is early December and the woods outside my window lay dusted with snow like a holiday card by Currier and Ives. A minute ago, I looked up and caught a glimpse of an adult Cooper's Hawk dashing swiftly through the trees. It swooped up, landed on a branch, then briefly shook its tail an... | | 2006-01-01 |
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Dale, Colin | A novel human-infection-derived bacterium provides insights into the evolutionary origins of mutualistic insect-bacterial symbioses | Despite extensive study, little is known about the origins of the mutualistic bacterial endosymbionts that inhabit approximately 10% of the world's insects. In this study, we characterized a novel opportunistic human pathogen, designated ‘‘strain HS,'' and found that it is a close relative of th... | | 2012-01-01 |
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Crespo, Jose Guillermo | A review of chemosensation and related behavior in aquatic insects | Insects that are secondarily adapted to aquatic environments are able to sense odors from a diverse array of sources. The antenna of these insects, as in all insects, is the main chemosensory structure and its input to the brain allows for integration of sensory information that ultimately ends in b... | | 2011-09-13 |
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Adler, Frederick R. | A time since recovery model with varying rates of loss of immunity | For many infectious diseases, immunity wanes over time. The majority of SIRS models assume that this loss of immunity takes place at a constant rate. We study temporary immunity within a SIRS model structure if the rate of loss of immunity can depend on the time since recovery from disease.We determ... | | 2012-01-01 |
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Olivera, Baldomero M.; McIntosh, J. Michael; Hillyard, David R. | A-superfamily of conotoxins: structural and functional divergence | The generation of functional novelty in proteins encoded by a gene superfamily is seldom well documented. In this report, we define the A-conotoxin superfamily, which is widely expressed in venoms of the predatory cone snails (Conus), and show how gene products that diverge considerably in stru... | Conotoxins; A-superfamily conotoxin | 2004-02-03 |
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| AAMC Award for Distinguished Research presentation for 1998 | This is a 3 minutes, 51 seconds video of the presentation of the American Association of Medical Colleges' Award for Distinguished Research to Mario Capecchi and Oliver Smithies for their independent work as pioneers in gene targeting. | Transgenic mice; Gene targeting; Genetic engineering; Mutagenesis; Capecchi, Mario R.; Science - Awards - United States; Smithies, Oliver; Awards presentations | 1998 |
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Ehleringer, James R. ; Cerling, Thure E. | Aberrant water homeostasis detected by stable isotope analysis | While isotopes are frequently used as tracers in investigations of disease physiology (i.e., 14C labeled glucose), few studies have examined the impact that disease, and disease-related alterations in metabolism, may have on stable isotope ratios at natural abundance levels. The isotopic composition... | | 2010-07-21 |
11 |
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Capecchi, Mario R. | Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. | Mice with targeted disruptions in Hox genes have been generated to evaluate the role of the Hox complex in determining the mammalian body plan. This complex of 38 genes encodes transcription factors that specify regional information along the embryonic axes. Early in vertebrate evolution an ancestra... | Alleles; Animals; Bone and Bones; Carpal Bones | 2003-09-02 |
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Beckerle, Mary C. | Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets | Talin is a high molecular weight protein localized at adhesion plaques in fibroblasts. It binds vinculin and integrin and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton. | Talin | 1989 |
13 |
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Shapiro, Michael D. | Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer | The molecular mechanisms underlying major phenotypic changes that have evolved repeatedly in nature are generally unknown. Pelvic loss in different natural populations of threespine stickleback fish has occurred by regulatory mutations deleting a tissue-specific enhancer of the Pituitary homeobox t... | Adaptive evolution; Pelvic reduction; Pituitary homeobox transcription factor 1; Pitx1; Gasterosteus aculeatus | 2010-01-14 |
14 |
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Beckerle, Mary C. | Adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to the tumor-promoting phorbol ester | Talin is a high molecular weight phosphoprotein that is localized at adhesion plaques. We have found that talin phosphorylation increases 3.0-fold upon exposure of chicken embryo fibroblasts to the tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate. | Talin; Vinculin; Chicken embryo fibroblasts | 1990 |
15 |
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Adler, Frederick R. | Aggregation and stability in parasite-host models | This paper generalizes the two-dimensional approximation of models of macroparasites on homogeneous populations developed by Anderson & May (1978), focusing on how the dispersion (the variance to mean ratio) of the equilibrium distribution of parasites on hosts is related to the stability of the equ... | Aggregation; Stability; Host-parasite models | 1992-04 |
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| Albert Lasker Awards Ceremony, 2001 | This is the 1 hour, 45 minutes, and 41 seconds video of the Lasker Awards Ceremony and Banquet held in September, 2001. The Albert Lasker Award for Basic Medical Research was given to Mario R. Capecchi, Oliver Smithies, and Martin Evans for their work in genetic research. Martin Evans discovered h... | Capecchi, Mario R.; Gene targeting; Embryonic stem cells; Transgenic mice; Genetic engineering; Science - Awards - United States; Smithies, Oliver; Evans, Martin J.; Awards presentations | 2001 |
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Coley, Phyllis D.; Lokvam, John; Kursar, Thomas A. | Allelochemic function for a primary metabolite: the case of L-tyrosine hyper-production in Inga umbellifera (Fabaceae) | Young leaves of tropical forest trees experience far higher herbivory pressure than mature leaves of the same species. Selection on young leaves has led to diverse forms of defense chemical expression. Though most allelochemicals are secondary metabolites, allelochemic function for a primary metabol... | 5-amino-4-hydroxy-pentanoic acid; Panama; Barro Colorado Island; Fabaceae; Inga umbellifera; Primary metabolite; Heliothis virescens | 2006 |
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Beckerle, Mary C. | ALP-enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans | Mutations that affect the Z-disk-associated ALP-Enigma proteins have been linked to human muscular and cardiac diseases. Despite their clear physiological significance for human health, the mechanism of action of ALP-Enigma proteins is largely unknown. In Caenorhabditis elegans, the ALP-Enigma prot... | Actin; Caenorhabditis elegans; Contractility; alp-1 mutants; Z-disks; Kettin | 2009 |
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Capecchi, Mario R. | Altered enzymes in drug-resistant variants of mammalian tissue culture cells. | Two selective procedures are compared in an effort to isolate variants of mouse L cells containing structural gene mutations. Among the resulting variant cloned cell lines are found two types of alterations in theenzyme hypoxanthine phosphoribosyl transferase (EC 2.4.2.8.) (1): enzyme with altered ... | Drug Resistance; Azaguanine; Clone Cells; Hypoxanthines | 1973-11 |
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Adler, Frederick R. | Alternating host cell tropism shapes the persistence, evolution and coexistence of Epstein-Barr virus infections in human | Epstein-Barr virus (EBV) infects and can persist in a majority of people worldwide. Within an infected host, EBV targets two major cell types, B cells and epithelial cells, and viruses emerging from one cell type preferentially infect the other. We use mathematical models to understand why EBV infec... | | 2011 |
21 |
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Adler, Frederick R. | Alternating host cell tropism shapes the persistence, evolution and coexistence of Epstein-Barr virus infections in human | Epstein-Barr virus (EBV) infects and can persist in a majority of people worldwide. Within an infected host, EBV targets two major cell types, B cells and epithelial cells, and viruses emerging from one cell type preferentially infect the other. We use mathematical models to understand why EBV infec... | | 2010 |
22 |
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Olivera, Baldomero M. | Alternative splicing in the pore-forming region of shaker potassium channels | We have cloned cDNAs for the shaker potassium channel gene from the spiny lobster Panulirus interruptus. As previously found in Drosophila, there is alternative splicing at the 59 and 39 ends of the coding region. However, in Panulirus shaker, alternative splicing also occurs within the pore-forming... | Panulirus interruptus; Conotoxins; Shaker; Stomatogastric ganglion; Pore-forming region; Alternative splicing | 1997 |
23 |
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Coffin, Cheryl M.; Capecchi, Mario R. | Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. | Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has... | Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors | 2004-11-01 |
24 |
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Olivera, Baldomero M. | Aminoglycoside effects on voltage-sensitive calcium channels and neurotoxicity | To the Editor: Since ototoxicity and neuromuscular toxicity of aminoglycoside antibiotics are reversed by calcium, 1,2 and presynaptic events appear to be involved in aminoglycoside-induced neuromuscular blockade, 3,4 we suspected a role for voltage-sensitive calcium channels in aminoglycoside neuro... | Conotoxins | 1987 |
25 |
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Schmind, Alexis V | An embryonic-like subpopulation is present in regenerating hearts | Zebrafish regenerate injured heart tissue through cardiomyocyte dedifferentiation, but it's unclear which cell subpopulations are involved. | zebrafish heart regeneration; medaka; cardiomyocytes | 2021 |
26 |
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Clayton, Dale H. | An experimental test of the effects of behavioral and immunological defenses against vectors: do they interact to protect birds from blood parasites? | Background: Blood-feeding arthropods can harm their hosts in many ways, such as through direct tissue damage and anemia, but also by distracting hosts from foraging or watching for predators. Blood-borne pathogens transmitted by arthropods can further harm the host. Thus, effective behavioral and im... | | 2014-01-01 |
27 |
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Parkinson, John Stansfield | An unorthodox sensory adaptation site in the E. coli serine chemoreceptor | The serine chemoreceptor of E. coli contains four canonical methylation sites for sensory adaptation that lie near inter-subunit helix interfaces of the Tsr homodimer. An unexplored fifth methylation site, E502, lies at an intra-subunit helix interface, closest to the HAMP domain that controls input... | | 2014-01-01 |
28 |
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Sperry, John S. | Analysis of circular bordered pit function I. Angiosperm vessels with homogenous pit membranes | A model predicted pit and vessel conductivity, the air-seed pressure for cavitation, and the implosion pressure causing vessel collapse. Predictions were based on measurements from 27 angiosperm species with circular bordered pits and air-seed pressures of 0.2-11.3 MPa. Vessel implosion pressure exc... | Functional wood anatomy; hydraulic architecture; plant biomechanics | 2004 |
29 |
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Sperry, John S. | Analysis of circular bordered pit function II. Gymnosperm tracheids with torus-margo pit membranes | A model of xylem conduit function was applied to gymnosperm tracheids with torus-margo pit membranes for comparison with angiosperm vessels. Tracheids from 17 gymnosperm tree species with circular bordered pits and air-seed pressures from 0.8 to 11.8 MPa were analyzed. Tracheids were more reinforced... | Functional wood anatomy; hydraulic architecture; plant biomechanics | 2004 |
30 |
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Beckerle, Mary C. | Analysis of the roles of microtubules and actin in erythrophore intracellular motility | The Holocentrus erythrophore, a red pigment cell, represents a model system for the study of organized intracellular transport. We have investigated the possibility that microtubules and actin are integral components of the pigment translocating motility machine. | Actin; Actomyosin; Erythrophore; Pigment | 1983 |
31 |
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Sperry, John S. | Anatomy of the palm Rhapis excelsa, IX. Xylem structure of the leaf insertion | STEMS OF PERENNIAL PLANTS, particularly trees, represent a considerable investment in biomass. Trees can survive even under the most adverse conditions, but only if the hydraulic integrity of the stem is preserved. A very important and vulnerable part of the stem is the xylem. As water is pulled int... | Palm stems; Palm stem anatomy; Palm leaves; Leaf insertion; Vessel network; Vessel-length distribution; Primary vascular stem tissue; Hydraulic architechture; Water column | 1983 |
32 |
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Sperry, John S. | Anatomy of the palm Rhapis excelsa, VIII. Vessel network and vessel-length distribution in the stem | THE CONCEPT of the vessel, a conducting unit consisting of a series of vessel elements lined up end to end, has been known for well over a century (e.g., Hartig, 1878). The fact that vessels are of limited length is of considerable functional importance. If a vessel is damaged (for example, by an in... | Palm stems; Palm stem anatomy; Vessel network; Vessel-length distribution; Primary vascular stem tissue; Hydraulic architechture; Water column | 1982 |
33 |
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Davidson, Diane W. | Ant-plant symbioses in Africa and the neotropics : history, biogeography and diversity | Symbiotic ant-plant relationships afford an excellent opportunity to analyze the effects of both historical and ecological factors on the evolution of mutualisms. Occurring in tropical forests throughout the world, all myrmecophytic plants provide food and permanent housing to ants; the ants, in t... | Ant-plant symbiosis; Africa; Neotropics; Myrmecophytes; Plant-ants | 1993 |
34 |
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Coley, Phyllis D. | Antifungal depsidone metabolites from Cordyceps dipterigena, an endophytic fungus antagonistic to the phytopathogen gibberella fujikuroi | Among thirty four endophytic fungal strains screened for in vitro antagonism, the endophytic fungus Cordyceps dipterigena was found to strongly inhibit mycelial growth of the plant pathogenic fungus Gibberella fujikuroi. Two new depsidone metabolites, cordycepsidone A (1) and cordycepsidone B (2), w... | | 2012 |
35 |
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Bowling, David R. | Assessing filtering of mountaintop CO2 mole fractions for application to inverse models of biosphere-atmosphere carbon exchange | There is a widely recognized need to improve our understanding of biosphere-atmosphere carbon exchanges in areas of complex terrain including the United States Mountain West. CO2 fluxes over mountainous terrain are often difficult to measure due to unusual and complicated influences associated with ... | | 2012-01-01 |
36 |
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Hughes, Kelly T. | ATPase-Independent Type-III Protein Secretion in Salmonella enterica | Type-III protein secretion systems are utilized by gram-negative pathogens to secrete building blocks of the bacterial flagellum, virulence effectors from the cytoplasm into host cells, and structural subunits of the needle complex. The flagellar type-III secretion apparatus utilizes both the energy... | | 2014-01-01 |
37 |
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Beckerle, Mary C. | Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt | This study delineates a mechanism for antiapoptotic signaling initiated by atrial natriuretic peptide (ANP) stimulation leading to elevation of cGMP levels and subsequent nuclear accumulation of Akt kinase associated with zyxin, a cytoskeletal LIM-domain protein. Nuclear targeting of zyxin induces r... | Zyxin; Akt; Cyclic guanosine monophosphate | 2005 |
38 |
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Gesteland, Raymond F.; Ives, Jeffrey T.; Stockham, Thomas G. | Automated film reader for DNA sequencing based on homomorphic deconvolution | An automated reader for electrophoresis based DNA sequencing methods is described that provides fast and accurate sequence determination. Digitized sequencing lanes are processed with homomorphic blind deconvolution in preparation for peak detection, interlane alignment, peak refinement and base cal... | Sequence Analysis; Electrophoresis; Automated Film Reader; Homomorphic Deconvolution | 1994 |
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Jorgensen, Erik | Axon regeneration genes identified by RNAi screening in C. elegans | Axons of the mammalian CNS lose the ability to regenerate soon after development due to both an inhibitory CNS environment and the loss of cell-intrinsic factors necessary for regeneration. The complex molecular events required for robust regeneration of mature neurons are not fully understood, part... | | 2014-01-01 |
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Jorgensen, Erik | Axons break in animals lacking B-spectrin | Axons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in β-spectrin mutants spontaneously break. | | 2007 |
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Bastiani, Michael | Axons break in animals lacking β-spectrin | Axons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in β-spectrin mutants spontaneously break. | Mutants; Dendrites; Morphology | 2007 |
42 |
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Hughes, Kelly T. | Bacterial flagellin-specific chaperone FliS interacts with anti-sigma factor FlgM | Flagella are extracellular organelles that propel bacteria. Each flagellum consists of a basal body, a hook, and a filament. The major protein of the filament is flagellin. To prevent premature polymerization of newly synthesized flagellin molecules, FliS, the flagellin-specific chaperone, binds fla... | | 2014-01-01 |
43 |
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Olivera, Baldomero M. | Bacteriophage Mu DNA replication in vitro | An in vitro system for bacteriophage Mu DNA replication using lysates on cellophane discs is described. Mu replication was monitored by DNA hybridization. Using a thermoinducible Mu Iysogen, 30-50% of all DNA synthesis in vitro was Mu-specific. | Bacteriophage Mu | 1983 |
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Adler, Frederick R. | Balance of terror: an alternative mechanism for competitive trade-offs and its implications for invading species | This article uses models to propose an explanation for three observations in community ecology: the apparent overreaction of prey to attack by specialist predators, the existence of a common trade-off among components of competitive ability in communities of unrelated competitors, and the ability of... | Models; Curve; Native | 1999 |
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Ehleringer, James R. | Bayesian integration of isotope ratio for geographic sourcing of castor beans | Recent years have seen an increase in the forensic interest associated with the poison ricin, which is extracted from the seeds of the Ricinus communis plant. Both light element (C, N, O, and H) and strontium (Sr) isotope ratios have previously been used to associate organic material with geographic... | | 2012-01-01 |
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Coley, Phyllis D. | Beneficios y costos de defensa en un arbusto del neotrópico | LOS beneficios y costos son de importancia capital para las teorfas de optimization de las defensas de las plantas. El beneficio es la ganancia de aptitud para reducir el herbivorismo; el costo es la perdida de aptitud al comprometer recursos en defensa. Evaluamos los beneficios y los costos de def... | Psychotria horizontalis; Isla de Barro Colorado; Costos de defense; Celdas de exclusion; Herbivorismo; Defensa de las plantas; Taninos; Dureza; Tropicos; Benefit; Beneficios | 2007 |
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Coley, Phyllis D. | Benefits and costs of defense in a neotropical shrub | Benefits and costs are central to optimality theories of plant defense. Benefit is the gain in fitness to reducing herbivory and cost is the loss in fitness to committing resources to defense. We evaluate the benefits and costs of defense in a neotropical shrub, Psychotria horizontalis. Plants were ... | Cost of defense; Growth-defense trade-off; Exclosures; Field experiment; Herbivory; Panama; Psychotria horizontalis; Rubiaceae; Tannins; Toughness; Tropics | 1995 |
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Coley, Phyllis D. | Between-species differences in leaf defenses of tropical trees | Rates of herbivory and patterns of leaf defense are presented for light-demanding and shade-tolerant tree species growing in a lowland rainforest in Panama. More than 85 percent of the annual leaf damage is due to grazing by insects. There are over three orders of magnitude difference between specie... | Herbivory; Interspecific variation; Panama; Growth rate; Shade tolerance; Treefall gaps; Tropical forest; Understory; Tannins; Alkaloids | 1987 |
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Yamaguchi, Ayako | Bilateral coordination of vocal pathways in African clawed frogs, Xenopus laevis | This poster describes how bilateral coordination of motor programs are achieved in the central vocal pathways of African clawed frogs. | Vocalizations; Central pattern generator; Motor programs; Bilateral coordination | 2014 |
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Goller, Franz | Bilateral syringeal contributions to song in the zebra finch | Although central control of song production has been investigated extensively in the zebra finch (Taeniopygia guttata), much less is known about peripheral vocal motor dynamics during song. | Electromyographic activity; Sound souces; Unilateral | 2004 |
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Beckerle, Mary C. | Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton | LIM domains are present in a number of proteins including transcription factors, a protooncogene product, and the adhesion plaque protein zyxin. The LIM domain exhibits a characteristic arrangement of cysteine and histidine residues and represents a novel zinc binding sequence (Michelsen et al., ... | Zyxin; Cysteine-rich proteins; cCRP; Actin; LIM domains | 1994 |
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Olivera, Baldomero M. | Biochemical characterization of ?M-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of ?M-conotoxins | Conus snail (Conus) venoms are a valuable source of pharmacologically active compounds; some of the peptide toxin families from the snail venoms are known to interact with potassium channels. We report the purification, synthesis, and characterization of ?M-conotoxin RIIIJ from the venom of a fish-... | | 2010 |
53 |
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Olivera, Baldomero M. | Biochemical studies of ω-conotoxin GVIA; a peptide toxin inhibiting voltage-sensitive Ca++ channels | The fish-hunting cone snails use their venom to quickly paralyze their more agile prey. In the last few years, our laboratories have carried out a program of analyzing biologically active components present in the fish-hunting cone snail venoms (Cruz et al. 1985; Olivera et al. 1985). We have concen... | Conotoxins; Calcium channels; Conus geographus; Venom | 1987 |
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Horvath, Martin P. | Biochemistry of Cone Snail toxin activation | Cone snails use venom to capture prey for food and for defense against predators. The venom is composed of over 100 active peptides that target specific receptors in the nervous system. Several of these peptides have the potential to become medicine for treatment of pain, depression, seizures, and n... | biochemistry; horvath; olivera; cone snail; toxin; nmda; elution; buffers; sparse matrix test; protease; protein; purification; neurotoxin; conotoxin | 2013 |
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Seger, Jon; Davidson, Diane W. | Biological richness of deserts | A desert is "waterless," "treeless," "barren," "remote," "uninteresting," and "presumably uninhabited," according to the authoritative Oxford English Dictionary. The word is derived from deserere, a Latin verb meaning "to leave." In English, to desert is still to "abandon," "forsake," or "fail." Bec... | Desert life; Desert biodiversity | 1995 |
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Clayton, Dale H. | Biology, ecology, and evolution of chewing lice | Chewing lice are small, dorsoventrally compressed insects and are parasites of virtually all birds (Fig. 1) and some mammals (Fig. 2). Many chewing lice are host specific, being found on only a single species of host. All chewing lice are permanent ectoparasites and complete their entire life c... | Chewing lice | 2003 |
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Sekercioglu, Cagan | Birding economics: conservation through commodification | In the long-run, the quality of our birding (and the length of our lists) depends on our success in conserving birds and their habitats. Who would not love to see a Labrador Duck during a pelagic trip, have Carolina Parakeets fly overhead on a CBC, or photograph a Bachman's Warbler foraging in a can... | | 2003-01-01 |
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Olivera, Baldomero M. | Block of Shaker K+ channels by ĸ-conotoxin PVIIA is state dependent | ĸ-conotoxin PVIIA is the first conotoxin known to interact with voltage-gated potassium channels by inhibiting Shaker-mediated currents. We studied the mechanism of inhibition and concluded that PVIIA blocks the ion pore with a 1:1 stoichiometry and that binding to open or closed channels is very d... | Conotoxins; k-conotoxin PVIIA; Potassium channel blockers; Shaker K+ channels | 1999 |
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Ehleringer, James R. | Burning coal seams in southern Utah: a natural system for studies of plant responses to elevated CO2 | In the Burning Hills and Smoky Mountains of southern Utah (USA), coal deposits exposed to the surface have been ignited by lightning and have been burning for periods of years to over a century. We examined one of these sites, where the below-ground combustion of this low-sulfur coal releases gases ... | Coal fires; Elevated CO2; Isotope ratios; Atriplex confertifolia; Salsola iberica; Gutierrezia sarothrae | 1997 |
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Jorgensen, Erik | Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development | The neurotransmitter GABA has been proposed to play a role during nervous system development. We show that the Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase (GAD), the GABA biosynthetic enzyme. unc-25 is expressed specifically in GABAergic neurons. Null mutations in unc-25... | | 1999 |
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Jorgensen, Erik | Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles | Rab molecules regulate vesicular trafficking in many different exocytic and endocytic transport pathways in eukaryotic cells. In neurons, rab3 has been proposed to play a crucial role in regulating synaptic vesicle release. To elucidate the role of rab3 in synaptic transmission, we isolated and cha... | | 1997 |
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Jorgensen, Erik | Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor | Ionotropic GABA receptors generally require the products of three subunit genes. By contrast, the GABA receptor needed for locomotion in Caenorhabditis elegans requires only the unc-49 gene. We cloned unc-49 and demonstrated that it possesses an unusual overlapping gene structure. | | 1999 |
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Olivera, Baldomero M. | Calcium channel antagonists: ω-conotoxin defines a new high affinity site | The ω-conotoxins, a class of Ca2+ channel antagonists from fish-hunting marine snails, have recently been described (Olivera, B. M., McIntosh, J. M., Zeikus, R., Gray, W. R., Varga, J., Rivier, J., de Santos, V., and Cruz, L. J. (1985) Science, 230, 1338-1343). One of these peptide neurotoxins... | Conotoxins; Calcium channels; Synaptosomes; Neurotoxins | 1986 |
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Yamaguchi, Ayako | Call initiation in African clawed frogs | Society for Neuroscience Meeting 2016 | vocalizations; Xenopus laevis | 2016 |
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Jorgensen, Erik; Schuske, Kimberly R. | CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons | Docking to the plasma membrane prepares vesicles for rapid release. Here, we describe a mechanism for dense core vesicle docking in neurons. In Caenorhabditis elegons motor neurons, dense core vesicles dock at the plasma membrane but are excluded from active zones at synapses. | | 2008 |
66 |
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Hultine, Kevin | Carbon and nitrogen allocation to male and female reproduction in Rocky Mountain Douglas-fir (Pseudotsuga menziesii var. glauca, Pinaceae) | We measured carbon (respiration, photosynthesis, and production) and nitrogen allocation to male and female cones of Rocky Mountain Douglas-fir (Pseudotsuga menziesii var. glauca) to quantify gender-specific: (1) resource allocation to reproduction, and (2) contribution to carbon costs of reproducti... | Gender; photosynthesis; resource allocation | 2000 |
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Ehleringer, James R. | Carbon isotope discrimination and water relations of oak hybrid populations in southwestern Utah | The evergreen oak Quercus turbinella and the deciduous Q. gambelii form natural hybrids in southwestern Utah and northern Arizona. Hybrid individuals also are found in northern Utah in a region where only Q. gambelii currently exists, indicating that Q. turbinella has recently retreated southward. ... | Quercus turbinella; Oak hybrids; Leaf structure; Leaf nitrogen; Carbon isotope discrimination; Water potential; Oak ecology | 2000 |
68 |
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Ehleringer, James R. | Carbon isotope discrimination in the C4 shrub Atriplex confertifolia along a salinity gradient | Carbon isotope discrimination (∆) was measured for leaves of Atriplex confertifolia along a salinity gradi~ ent in northern Utah. Over this gradient, the variation of ∆ values was high for a C4 species, and the ∆ values were positively correlated with salinity in both years of the study. Of th... | Carbon isotope ratio; Salt stress; Bundle sheath leakiness; Halophyte; Atriplex confertifolia; Salinity gradient | 1995 |
69 |
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Ehleringer, James R. | Carbon isotope dynamics in Abies amabilis stands in the Cascades | Carbon isotope ratios (d13C) of canopy air and carbon isotope discrimination at the ecosystem level were studied in three montane Pacific silver fir (Abies amabilis (Dougl. ex Loud.) Dougl. ex J. Forbes) stands, an old-growth and two younger stands. Spatial and temporal variations of canopy CO2 con... | Carbon isotopes; Pacific silver fir; Carbon budget; Soil respiration; Cascade Mountains | 1998 |
70 |
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Ehleringer, James R. | Carbon isotope ratios in belowground carbon cycle processes | Analyses of carbon isotope ratios (δ13C) in soil organic matter (SOM) and soil respired CO2 provide insights into dynamics of the carbon cycle. δ13C analyses do not provide direct measures of soil CO2 efflux rates but are useful as a constraint in carbon cycle models. In many cases, δ13C analyses... | Below ground processes; Ecosystems; Carbon cycle; Carbon isotope ratio; Ecosystem processes; Global change; Soil organic carbon; Soil organic matter | 2000 |
71 |
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Ehleringer, James R. | Carbon isotope ratios of Atacama Desert plants reflect hyperaridity of region in northern Chile | Leaf carbon isotope ratios were measured on plants from the coastal portions of the Atacama Desert at Pan de Azucar and Paposo, Chile. Most species possessed C3 photosynthesis, although there were several CAM species, indications of some facultative CAM species, and only one C4 species. The carbon i... | Atacama Desert; Carbon isotope ratio; Intercellular carbon dioxide concentration; Hyperaridity | 1998 |
72 |
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Sekercioglu, Cagan | Causes and consequences of bird extinctions | Increased human domination of the planet has caused the declines and extinctions of countless species. Each species has not only intrinsic value, but ecological functions of organisms are also essential for the integrity of ecosystems that allow people to benefit from essential free ecosystem servic... | | 2003-01-01 |
73 |
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Torti, Sylvia D.; Coley, Phyllis D.; Kursar, Thomas A. | Causes and consequences of monodominance in tropical lowland forests | Tropical canopy dominance in lowland, well-drained forests by one plant species is a long-standing conundrum in tropical biology. Research now shows that dominance is not the result of one trait or mechanism. We suggest that the striking dominance of Gilbertiodendron dewevrei in the Ituri Forest of ... | Monodominance; Gilbertiodendron dewevrei; Ituri Forest; Understory | 2001 |
74 |
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Sperry, John S. | Cavitation fatigue - the weakening of cavitation resistance of xylem and its reversibility | Xylem function is essential for the growth and survival of higher land plants. Xylem must not only be efficient under favorable conditions to facilitate high rates of stomatal conductance and carbon uptake, but it should also remain functional under drought conditions, when water potential (Ψ) dro... | Cavitation fatigue; Drought; Pit membrane | 2003 |
75 |
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Davidson, Diane W. | Cecropia and its biotic defenses | In all the world, the genus Cecropia is unrivaled for the number of myrmecophytes, or true "antplants" counted among its species (McKey & Davidson, 1993). Based on the proportion of Cecropia species producing Mullerian bodies in at least some parts of their distribution, myrmecophytes comprise the ... | Myrmecophytes; Mullerian bodies; Pearl bodies | 2005 |
76 |
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Bastiani, Michael | Cell-cell interactions during the migration of an identified commissural growth cone in the embryonic grasshopper | One of the fascicles of the posterior commissure of the embryonic grasshopper is pioneered by an individually identifiable neuron named Q1. Q1 initially grows along a longitudinal pathway established by another pioneer neuron, MPl, and then crosses to the midline, where it meets and fasciculates wi... | Commissure; Pathfinding; Filopodia | 1993 |
77 |
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Gesteland, Raymond F. | Cell-free synthesis of herpes simplex virus proteins | Polyribosomes isolated from herpes simplex virus type I (HSV-1)-infected cells have been used to program a eucaryotic cell-free translation system. At least 10 HSV-specific polypeptides, with apparent molecular weights of 25,000 to 160,000, are synthesized by wild-type HSV-infected polyribosomes. Po... | Viral Proteins; Herpes Simplex; Peptide Biosynthesis; Thymidine Kinase | 1977 |
78 |
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Bastiani, Michael | Central projections of the stretch receptor neurons of crayfish: segmental gradients of synaptic probability and strength | The 20 stretch receptor neurons (SRs) of the crayfish abdomen send axons into the CNS that then project both to the brain and to the last abdominal ganglion, G6 (Bastiani and Mulloney, 1988). In G6, we recorded intracellularly from different kinds of neurons postsynaptic to SR axons. | Axons; Synapses; SR | 1988 |
79 |
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Bastiani, Michael | Central projections of the stretch receptor neurons of crayfish: structure, variation, and postembryonic growth | Each stretch receptor neuron (SR) of the crayfish abdomen projects from its peripherally located soma an axon that enters the CNS through the second nerve (N2) of its segmental ganglion. CoZ+ backfills of N2 revealed that this axon bifurcates, sending one branch to the brain and the other to the te... | Abdomen; Axon; Ganglion | 1988 |
80 |
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Gesteland, Raymond F. | Characterization of lysozyme messenger and lysozyme synthesized in vitro | In vitro systems for protein systhesis have been in wide use for about 10 years. In most of the early work protein synthesis was measured by following the incorporation of radioactive amino acids into acid precipitable material. This test cannot distinguish between the synthesis of complete, activ... | Lysozyme Messenger; Lysozyme Synthesized; Protein Synthesis | 1969 |
81 |
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Beckerle, Mary C. | Characterization of the interaction between zyxin and members of the Ena/Vasodilator-stimulated Phosphoprotein family of proteins | Zyxin contains a proline-rich N-terminal domain that is similar to the C-terminal domain in the ActA protein of the bacteria, Listeria monocytogenes. We screened the entire amino acid sequence of human zyxin for Menainteracting peptides and found that, as with ActA, proline-rich sequences were the s... | Zyxin; Actin; Listeria monocytogenes; Proline-rich repeats; Cell spreading | 2000 |
82 |
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Capecchi, Mario R. | Characterization of three proteins involved in polypeptide chain termination. | At each stage of elongation, the growing polypeptide chain is bound to the ribosome-messenger RNA complex through the transfer RNA of the most recently incorporated amino acid residue. When the chain is complete, the last polypeptide-transfer RNA (tuna) ester linkage is cleaved, releasing the chain ... | Anti-Bacterial Agents; Phenylalanine; Stimulation, Chemical | 1969 |
83 |
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Coley, Phyllis D. | Chemical and bioactive natural products from microthyriaceae sp., an endophytic fungus from a tropical grass | In screening for natural products with antiparasitic activity, an endophytic fungus, strain F2611, isolated from above-ground tissue of the tropical grass Paspalum conjugatum (Poaceae) in Panama, was chosen for bioactive principle elucidation. Cultivation on malt extract agar (MEA) followed by bioas... | | 2014-01-01 |
84 |
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Blair, David F. | Chemical and spectroscopic evidence for the formation of a ferryl Fea3 intermediate during turnover of cytochrome c oxidase | When partially reduced cytochrome c oxidase samples are reoxidized with dioxygen, an EPR-silent dioxygen intermediate, which is at the three-electron level of dioxygen reduction, is trapped at the dioxygen reduction site. The intermediate has novel spectral features at 580 and 537 nm. Combined op... | Cytochrome c oxidase; EPR; Fea3 intermediate; Reduction | 1986 |
85 |
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Sekercioglu, Cagan | Chewing lice (phthiraptera) found on songbirds (Passeriformes) in Turkey | Objective: This study was performed to detect chewing lice species found on the songbirds at Lake Kuyucuk bird ringing station in the Kars province located in eastern Turkey. Methods: Chewing lice were collected from songbirds captured between September and October 2009. Fifty-one birds belonging t... | | 2011-01-01 |
86 |
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Sekercioglu, Cagan | Chewing lice (phthiraptera) species found on birds along the Aras River, lgdir, Eastern Turkey | Chewing lice were sampled from the birds captured and ringed between September-October 2009 at the Aras River (Yukarı Çıyrıklı, Tuzluca, Iğdır) bird ringing station in eastern Turkey. Eighty-one bird specimens of 23 species were examined for lice infestation. All lice collected from the birds... | | 2011-01-01 |
87 |
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Sekercioglu, Cagan | Chewing lice (Phthiraptera) species found on Turkish shorebirds (Charadriiformes) | Approximately 4.500 species of lice have been so far described, with about 4.000 species seen on birds and with 3.000 species in the suborder Ischnocera 1. There are 465 bird species so far recorded in Turkey and the actual total is likely to exceed 500 species. However, the chewing lice fauna of th... | | 2010-01-01 |
88 |
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Bohs, Lynn A. | Chloroplast DNA phylogeny of Solanum sect on Las ocarpa | Solanum section Lasiocarpa includes about a dozen species with a center of diversity in the NewWorld tropics. Solanum lasiocarpum and S. repandum (sometimes considered to be conspecific as S. ferox) have an Old World distribution in Asia and the Pacific Islands. Several species in this section produ... | Solanum; trn; Lasiocarpa | 2004 |
89 |
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Capecchi, Mario R. | Choose your target. | The technology of modifying endogenous genes has recently been extended from mice to Drosophila and sheep. Concurrently, genomic sequencing is uncovering thousands of previously uncharacterized genes. Armed with today's technologies, what are our best options for delineating the functions of these n... | Animals; Mice; Sheep | 2000-09-13 |
90 |
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Capecchi, Mario R. | Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. | The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA rec... | Animals, Newborn; Crosses, Genetic | 1997-10-14 |
91 |
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Yamaguchi, Ayako | Coding rate and duration of vocalizations of the frog , Xenopus laevis | Vocalizations involve complex rhythmic motor patterns, but the underlying temporal coding mechanisms in the nervous system are poorly understood. Using a recently developed whole-brain preparation from which "fictive" vocalizations are readily elicited in vitro, we investigated the cellular basis of... | | 2012-08-29 |
92 |
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Clayton, Dale H. | Coevolutionary history of ecological replicates: comparing phylogenies of wing and body lice to Columbiform hosts | Phylogenies depict the history of speciation for groups of organisms. Comparing the phylogenies of interacting groups can reveal instances of tandem speciation, or "cospeciation" (Brooks and McLennan, 1991; Hoberg et al., 1997; Paterson and Gray, 1997). Understanding the conditions under which cosp... | Feather lice; Wing lice; Body lice; Cospeciation | 2003 |
93 |
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Coley, Phyllis D. | Coibanoles, a new class of meroterpeniods produced by pycnoporus sanguineus | Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites ?coibanoles A?C? in reference to... | | 2012 |
94 |
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Coley, Phyllis D.; Kursar, Thomas A. | Colonization of tropical rain forest leaves by epiphylls: effects of site and host plant leaf lifetime | In humid tropical regions, leaves are frequently colonized by epiphylls (Richards 1954, Pocs 1978, 1982). Lichens and liverworts usually dominate, although mosses, algae, and cyanobacteria can also occur (Winkler 1971, Smith 1982). The interactions between epiphylls and host leaves have not been wel... | Tropical forest; Epiphylls; Panama; Hybanthus prunifolius; Light interception | 1993 |
95 |
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Olivera, Baldomero M. | Combined proteomic and transcriptomic interrogation of the venom gland of conus geographus uncovers novel components and functional compartmentalization | Cone snails are highly successful marine predators that use complex venoms to capture prey. At any given time, hundreds of toxins (conotoxins) are synthesized in the secretory epithelial cells of the venom gland, a long and convoluted organ that can measure 4 times the length of the snail's body. In... | | 2014-01-01 |
96 |
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Clayton, Dale H. | Common grackle anting with lime fruit and its effect on ectoparasites | Anting is stereotyped behavior in which birds ex- pose themselves to fluid-secreting ants or other pun- gent substances. During "active" anting a bird crush- es an ant in the bill and rubs it frenetically through its plumage (Rothschild and Clay 1952). During "passive" anting a bird entices ants to ... | Quiscalus quiscala; Columbicola columbae; Anting; Ectoparasites | 1993 |
97 |
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Clayton, Dale H. | Comparative effects of mites and lice on the reproductive success of rock doves (Columba livia) | We report experimental data comparing the effects of Mesostigmatid mites and Ischnoceran lice on the reproductive performance of a single group of captive rock doves (Columba livid). Several components of host reproductive success were compared for the two groups, including number of eggs laid, hatc... | Ectoparasites; Reproduction; Rock doves; Columba livia; Ischnocera; Mites; Lice | 1995 |
98 |
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Davidson, Diane W. | Comparative structure of harvester ant communities in arid Australia and North America | In the Australian arid zone, the species richness of ants is greater and that of mammalian granivores is less than in North American deserts. This study aimed to determine if the structure of harvester ant communities differs from that seen in North American deserts, focussing on differences relate... | Species; Rodents; Diversity | 1988 |
99 |
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Clayton, Dale H.; Bush, Sarah Elizabeth | Comparative transmission dynamics of competing parasite species | Competition-colonization trade-off models explain the coexistence of competing species in terms of a trade-off between competitive ability and the ability to colonize competitor-free patches of habitat. A simple prediction of these models is that inferior competitors will be superior dispersers. Thi... | Bird lice; Campanulotes compar; Coexistence; Colonization; Columba livia; Columbicola columbae; Competition; Dispersal; Parasite; Phoresis; Specificity; Pseudolynchia canariensis; Phthiraptera | 2008 |
100 |
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Hultine, Kevin | Comparison of methods to estimate Ephemeral Channel Recharge, Walnut Gulch, San Pedro River Basin, Arizona | Ephemeral channel transmission loss represents an important groundwater surface water exchange in arid and semiarid regions and is potentially a significant source of recharge at the basin scale. Copyright [year] American Geophysical Union. Reproduced by permission of American Geophysical Union. ... | Transport; Transmission; Balance | 2004 |