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1 Clayton, Dale H.Reciprocal natural selection on host-parasite phenotypesCoevolution is evolution in one species in response to selection imposed by a second species, followed by evolution in the second species in response to reciprocal selection imposed by the first species. Although reciprocal selection is a prerequisite of coevolution, it has seldom been documented in...Host-parasite phenotypes; Ectoparasites; Virulence; Fitness1999
2 Olivera, Baldomero M.Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptorsBackground: Can dicarba bridges (stapling) replace noncovalent interactions that stabilize helical conformation of neuroactivepeptides? Results: A rational design, synthesis, structural, and functional characterization of stapled conG analogs that target NMDAreceptors is reported. Conclusion: Staple...2012-01-01
3 Sperry, John S.Anatomy of the palm Rhapis excelsa, VIII. Vessel network and vessel-length distribution in the stemTHE CONCEPT of the vessel, a conducting unit consisting of a series of vessel elements lined up end to end, has been known for well over a century (e.g., Hartig, 1878). The fact that vessels are of limited length is of considerable functional importance. If a vessel is damaged (for example, by an in...Palm stems; Palm stem anatomy; Vessel network; Vessel-length distribution; Primary vascular stem tissue; Hydraulic architechture; Water column1982
4 Olivera, Baldomero M.; McIntosh, J. MichaelNuclear magnetic resonance solution conformation of α-conotoxin AuIB, an α3ß4 subtype-selective neuronal nicotinic acetylcholine receptor antagonistThe neuronal nicotinic acetylcholine receptors constitute a highly diverse group, with subtypes consisting of pentameric combinations of α and ß subunits. α-Conotoxins are a homologous series of small peptides that antagonize these receptors. We present the three-dimensional solution structure ...Conotoxins; a-conotoxin AuIB2000
5 Olivera, Baldomero M.; McIntosh, J. Michael; Yoshikami, Dojuα-Conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptorsMany venomous organisms produce toxins that disrupt neuromuscular communication to paralyze their prey. One common class of such toxins comprises nicotinic acetylcholine receptor antagonists (nAChRs). Thus, most toxins that act on nAChRs are targeted to the neuromuscular subtype. The toxin chara...Conotoxins; Conotoxin GIC; Conus geographus; Peptide antagonists2002
6 Olivera, Baldomero M.; Hillyard, David R.ConotoxinsMany successful animal and plant families have developed distinctive biochemical strategies; one of the more unusual examples is found in a group of marine gastropods, the cone snails (Conus) (1). These animals have evolved a specialized biochemistry of small constrained peptides, the conotoxins. Th...Conotoxins1991
7 Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. MichaelNew α-conotoxin which targets α3ß2 nicotinic acetylcholine receptorsWe have isolated a 16-amino acid peptide from the venom of the marine snail Conus magus which potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3ß2 subunits. This peptide, named a-conotoxin MII, was identified by electrophysiologically screening venom fractions against cl...Conotoxins; a-conotoxin MII; Conus magus1996
8 Olivera, Baldomero M.; Gray, William Robert; Hillyard, David R.μ-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypesWe report the characterization of a new sodium channel blocker, m-conotoxin PIIIA (m-PIIIA). The peptide has been synthesized chemically and its disulfide bridging pattern determined.Conotoxins; m-Conotoxin PIIIA; Sodium channel blockers1998
9 Goller, FranzSuperfast vocal muscles control song production in songbirdsBirdsong is a widely used model for vocal learning and human speech, which exhibits high temporal and acoustic diversity. Rapid acoustic modulations are thought to arise from the vocal organ, the syrinx, by passive interactions between the two independent sound generators or intrinsic nonlinear dyna...Vocal muscles; Syringeal muscles; Sturnus vulgaris2008
10 Sperry, John S.Hydraulic architecture of palmsThe water transport and storage system of palms is adapted to maintain the primary stem xylem functional over the life of the shoot, and in spite of severe drought. However, our structural information far exceeds our knowledge of vascular function, and these functional considerations bring more que...Hydraulic architecture; Rhapis excelsa; Cavitation1995
11 Olivera, Baldomero M.; ; McIntosh, J. Michaelα-Conotoxin AuIB selective blocks α3ß4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine releaseNeuronal nicotinic acetylcholine receptors (nAChRs) with putative α3ß4-subunits have been implicated in the mediation of signaling in various systems, including ganglionic transmission peripherally and nicotine-evoked neurotransmitter release centrally. However, progress in the characterization of...Conotoxins; a-Conotoxin AuIB; Norepinephrine release1998
12 Clayton, Dale H.Does avian malaria reduce fledging success: an experimental test of the selection hypothesisLike many parasites, avian haematozoa are often found at lower infection intensities in older birds than young birds. One explanation, known as the "selection" hypothesis, is that infected young birds die before reaching adulthood, thus removing the highest infection intensities from the host popul...2013-01-01
13 Sekercioglu, CaganThe worldwide variation in avian clutch size across species and spaceTraits such as clutch size vary markedly across species and environmental gradients but have usually been investigated from either a comparative or a geographic perspective, respectively. We analyzed the global variation in clutch size across 5,290 bird species, excluding brood parasites and pelagic...2008-01-01
14 Clayton, Dale H.Molecular phylogeny of the dove genus Zenaida: mitochondrial and nuclear DNA sequencesWe reconstructed a phylogeny for the seven species of doves in the genus Zenaida on the basis of a combined analysis of mitochondria (ND2 and cytochrome b) and nuclear (fibrinogen intron 7) DNA sequences. This phylogeny, which is completely resolved, is well supported with all nodes showing greater...Molecular phylogeny; Dove; Nuclear DNA2000
15 Olivera, Baldomero M.; McIntosh, J. MichaelIsolation and characterization of a novel Conus peptide with apparent antinociceptive activityCone snails are tropical marine mollusks that envenomate prey with a complex mixture of neuropharmacologically active compounds. We report the discovery and biochemical characterization of a structurally unique peptide isolated from the venom of Conus marmoreus. The new peptide, mr10a, potently incr...Conotoxins; Conus peptides; Conus marmoreus; mr10a; antinociceptive activity2000
16 Olivera, Baldomero M.; Gray, William RobertNew family of Conus peptides targeted to the nicotinic acetylcholine receptorIn this work, a new family of Conus peptides, the αA-conotoxins, which target the nicotinic acetylcholine receptor, is defined. The first members of this family have been characterized from the eastern Pacific species, Conus purpurascens (the purple cone); three peptides that cause paralysis in fis...Conotoxins; Conus peptides; Conus purpurascens; Purple cone snail1995
17 Beckerle, Mary C.LIM domain-containing protein Trip6 can act as a coactivator for the v-Rel transcription factorThe retroviral oncoprotein v-Rel is a transcriptional activator in the Rel/NF-KB family of eukaryotic transcription factors. v-Rel malignantly transforms a variety of cell types in vitro and in vivo, and its transforming activity is dependent on the ability of v-Rel to bind to DNA and activate trans...LIM domains; Oncoproteins; v-Rel; Retroviral oncogene; Trip6; Coactivator; Malignant transformation; NF-kB; Two-hybrid assay1999
18 Bohs, Lynn A.Systematics of Solanum section Allophyllum (Solanaceae)Three species of Solarium are included in a new section, Solarium sect. Allophyllum. Two of the species, S. allophyllum and S. mapiriense, have been previously known; the third, S. morellifolium Bohs, is described as new. The combination of characters exhibited by members of this section, such as un...Solanum section Allophyllum; Solanum allophyllum; Solanum morellifolium; Solanum mapiriense1990
19 Capecchi, Mario R.Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA rec...Animals, Newborn; Crosses, Genetic1997-10-14
20 Olivera, Baldomero M.; Ireland, Chris M.NMR structures of conotoxinsThis review discusses the methodology, structural details, and biological implications regarding NMR structures of conotoxins. NMR and molecular modeling techniques have improved to the point that three-dimensional structures of conotoxins can now be determined with a significant degree of confiden...Conotoxins1996
21 Olivera, Baldomero M.; McIntosh, J. Michaelα-Conotoxins ImI and ImII: similar α7 nicotinic receptor antagonists act at different sitesA novel conotoxin, α-conotoxin ImII (α-CTx ImII), identified from Conus imperialis venom ducts, was chemically synthesized. A previously characterized C. imperialis conotoxin, α-conotoxin ImI (α-CTx ImI), is closely related; 9 of 12 amino acids are identical. Both α-CTx ImII and α-CTx ImI...Conotoxins; Conotoxin ImI; Conotoxin ImII2003
22 Goller, FranzExperimental support for a model of birdsong productionIn this work we present an experimental validation of a recently proposed model for the production of birdsongs. We have previously observed that driving the model with simple functions of time, which represent tensions in vocal muscles, produces a wide variety of sounds resembling birdsongs. In th...Vocal; Muscles; Syrinx2003
23 Olivera, Baldomero M.; McIntosh, J. MichaelNovel post-translational modification involving bromination of tryptophan: identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venomWe report a novel post-translational modification involving halogenation of tryptophan in peptides recovered from the venom of carnivorous marine cone snails (Conus). The residue, L-6-bromotryptophan, was identified in the sequence of a heptapeptide, isolated from Conus imperialis, a worm-hunting...Conotoxins; Conus imperialis; Conus radiatus; L-6-bromotryptophan1997
24 Beckerle, Mary C.; Yoshigi, Masaaki; Hoffman, Laura M.; Yost, H. JosephMechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcementOrgans and tissues adapt to acute or chronic mechanical stress by remodeling their actin cytoskeletons. Cells that are stimulated by cyclic stretch or shear stress in vitro undergo bimodal cytoskeletal responses that include rapid reinforcement and gradual reorientation of actin stress fibers; howev...Zyxin; Actin2005
25 Bohs, Lynn A.Four new species of Cyphomandra (Solanaceae) from South AmericaFour new species in the Neotropical genus Cyphomandra are described and illustrated. Cyphomandra pilosa and C. foetida are found on the eastern slopes of the Andes from Colombia to Peru. Cyphomandra oblongifolia is a morphologically variable species of Suriname and the Amazon basin. Cyphomandra sib...Cyphomandra1988
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