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| Creator | Title | Description | Subject | Date | ||
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Potts, Wayne K. | Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: can we trust congenic animals? | Congenic strains of mice are assumed to differ only at a single gene or region of the genome. These mice have great importance in evaluating the function of genes. However, their utility depends on the maintenance of this true congenic nature. Although, accumulating evidence suggests that congenic ... | Strains; Mutations; Pathogen | 2004 |
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Bastiani, Michael; Bandyopadhyay, Pradip K.; Olivera, Baldomero M.; Golic, Kent G. | Targeted mutagenesis by homologous recombination in D. melanogaster | We used a recently developed method to produce mutant alleles of five endogenous Drosophila genes, including the homolog of the p53 tumor suppressor. Transgenic expression of the FLP site-specific recombinase and the I-SceI endonuclease generates extrachromosomal linear DNA molecules in vivo. | Mutations; Drosophila; Gene targeting | 2002 |
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