|
|
Creator | Title | Description | Subject | Date |
1 |
|
Hinchman, Colin | 4D flow characteristics of left atrial blood flow after atrial fibrillation | Atrial fibrillation is the most prevalent cardiac arrhythmia and causes increased risk for stroke, yet accurate pathophysiological diagnosis remains a challenge. This study aimed to further investigate the physiologic biomarkers in the left atrium (LA) related to atrial fibrillation (AF) using 4D fl... | | 2019 |
2 |
|
Temme, Jack | A closer look at aberrant muscle function | When a skeletal muscle is inhibited from operating at its full function it is called an aberrant muscle. Such inhibition tends to occur after joint trauma in order to protect the injured area from further aggravation. However, inhibition can linger after the injury is healed, which negatively impact... | | 2021 |
3 |
|
German, Massiell | A genetic analysis of VSX2 function in the mouse eye | Vsx2 is a homeodomain-containing transcription factor essential for maintenance of neuroretinal identity and neurogenesis. Vsx2 is believed to function via mechanisms that are strictly cell-intrinsic. However, recent research reveals evidence for involvement of Vsx2-mediated cell non-autonomous mech... | Neurogenesis - physiology | 2012-05 |
4 |
|
Sperber, Alexander M. | A novel approach to differentiating cardiac fibroblasts from induced pluripotent stem cells | Heart disease remains the leading cause of death in the United States, and such disease is caused by electrical, chemical, or biomechanical imbalances in the heart. The two most abundant cells comprising the heart that are responsible for these functions are cardiomyocytes and cardiac fibroblasts. I... | | 2022 |
5 |
|
Shapiro, Darien | Activation of transient receptor potential ankyrin-1 by wood smoke particulate material | Exposure to wood smoke particulate matter (WSPM) has been linked to exacerbation of pre-existing respiratory conditions such as asthma, development of chronic obstructive pulmonary disease (COPD), and premature deaths. While it is clear that WSPM exposure is hazardous to human health, the molecular ... | Smoke - Physiological effect | 2012-05 |
6 |
|
Calder, Dallen | Adipocyte enhancer binding protein 1 (AEBP1) as a potential therapeutic target to combat cardiac fibrosis | Fibrosis is one of the major hallmarks of heart failure (HF) progression and is characterized by fibroblast activation and excess extracellular matrix (EMC) deposition. RNA sequencing of myocardial tissue acquired from HF patients showed a significant upregulation of adipocyte enhancer binding prote... | | 2022 |
7 |
|
Isom, Anika | Amniotic fluid treatment of vocal fold injury in an in vivo rabbit model | Hyaluronic acid (HA) injectables are a standard treatment for vocal fold injuries in both clinical and research settings. Results from these treatments are not permanent, however, and may vary in effectiveness. Because of this, there is a significant clinical interest in finding an alternative for H... | Vocal folds; rheology; wound healing of vocal folds; hyaluronic acid; amniotic fluid; regenerative medicine | 2022 |
8 |
|
Luong, Katie | An examination of the relationship between positive covid-19 infection and vaccine hesitancy within the Utah recover study population | Vaccine hesitancy is defined by the World Health Organization as a "delay in acceptance or refusal of vaccines despite availability of vaccination services," and is affected by a wide range of factors. Some of these factors identified in the literature include perceived safety and importance of vacc... | | 2023 |
9 |
|
Brown, Audrey | Analyzing response patterns of olfactory bulb glomeruli at low odorant concentration regimes | Sensory input to the olfactory system begins with the binding of an odorant molecule to an olfactory receptor (OR) contained on the surface of an olfactory sensory neuron (OSN). Olfactory bulb (OB) glomeruli receive information from OSNs containing the same OR type and are thought to help process se... | | 2021 |
10 |
|
Kober, Derek | Anthropogenic Climate Change and Pollen Trends: Analyzing genera-specific impacts and correlations with temperature and precipitation across the United States (1990-2018) | Studies have shown that human-driven climate change is associated with both higher airborne pollen concentrations and extended allergy seasons. Research particularly indicates that the concentration of pollen is positively correlated to increasing temperatures. This study aims to analyze the pollen ... | | 2023 |
11 |
|
Rohaj, Aarushi | Apoptosis efficiency of the transfected elephant and human P35 vectors in P53 varying leiomyosarcoma cells | Comparative Oncology is an approach that integrates and connects commonly occurring cancers seen in animals, into studies focused on cancer biology, prevention, and treatment in humans. Studies show that natural mechanisms can suppress cancer 1,000 times more adequately in certain animals than in hu... | | 2021 |
12 |
|
Mallender, Zachary | Assay of the dreem device on sleep metrics and an exploration of sleep staging in chronic short sleepers during time in bed extension | Despite clear and plentiful research that sleeping less than seven hours per night has a wide array of health consequences, a large portion of American adults report sleeping less than seven hours per night and thus receive chronic insufficient sleep. Many studies exploring the consequences of insuf... | | 2022 |
13 |
|
Estrada, Johanna | BCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Philadelphia cromosome-positive leukemia | CML 1s caused by a random reciprocal translocation that joins the ABL1 gene on chromosome 9, with the BCR gene on chromosome 22. The result is the formation of the oncogenic BCR-ABL1 gene. This derivative chromosome is widely known as the Philadelphia Chromosome (Ph+), and it encodes a deregulated, ... | Leukemia -- Genetic aspects -- Research Leukemia -- Treatment -- Research | 2014-04 |
14 |
|
Ganesh, Kajal | Beyond the neural circuits: examining women's metal health in India alongside the complex manifestation of OCD and anxiety in mice | Mental health literacy (MHL) is a critical concept that refers to the recognition, mitigation, and prevention of mental health disorders. Increased MHL is achievable through funding research on the brain and mental health disorders, aiming to normalize patient struggles, provide clear explanations f... | | 2024 |
15 |
|
Tazehabadi, Tara | Bioinformatics to detect functional interactions important for the DNA repair enzyme mutyh | DNA is the blueprint of all biological life as it provides the means necessary for sharing of genetic information. DNA is formed and stabilized by interactions between four unique bases, Adenine (A), Cytosine (C), Guanine (G), and Thymine (T) which come together in predetermined patterns to create a... | | 2022 |
16 |
|
Beseris, Ethan | Biological impact protection in human facial hair | Our study investigated selective mechanisms that influenced the evolution of facial hair in human males (Homo sapiens). Beards are often perceived as an indicator of masculinity and social dominance in men, suggesting that they may play a role in male contest competition. Some authors propose that t... | | 2018 |
17 |
|
Furrer, Summer | Cellular and subcellular localization patterns of hepatitis delta virus in sjogren's syndrome salivary gland tissue | Primary Sjogren's syndrome (pSS) is an autoimmune disorder, predominantly affecting women, that causes dry eyes, dry mouth, fatigue, and other extraglandular manifestations (Le Goff et al., 2017). It has been shown that chronic pathogen exposure can lead to development of autoimmune diseases such as... | | 2022 |
18 |
|
Thomas, Nikita | Cellular ultrastructure of C. elegans nervous system | Determining the ultrastructural organization of the nervous system is a key step in understanding how complex behavior is generated. For a nervous system to function, it must be wired accurately. A complete wiring diagram, referred to as a connectome, can be created by tracing neuronal profiles thro... | Caenorhabditis elegans - Nervous system | 2013-05 |
19 |
|
Andersen, Kara | Cervical dorsal root ganglion imaging for studying neuronal nocicieptive ciruit changes in migranine models | Migraine neuroscience is a field in its infancy, with migraine being a remarkably common yet poorly understood sensory circuit disorder. It is characterized by attacks of unilateral, throbbing craniofacial pain, with sensitivity to movement, visual, auditory, and other afferent inputs. Migraines can... | | 2022 |
20 |
|
Larson, Brooke | Chacterization of signaling to the degradative pathways of the cell | Protein degradation in cells is a complex network of pathways that are distinct from each other but highly interconnected. Understanding how proteins are degraded in cells is important for understanding and developing treatments for diseases such as lysosomal storage diseases and neurodegenerative d... | | 2023 |
21 |
|
Jensen, Madeline | Changes in microbial diversity in storm-water green infrastructure | Increased urbanization has led to excess nutrients in urban ecosystems. Stormwater Green Infrastructure (SGI) is a method to capture these nutrients and prevent runoff. However, an increased understanding of ecosystem processes is needed to create more efficient SGIs. Past studies have shown that pl... | | 2022 |
22 |
|
Barbeau, William | Characterization of a New Ribosome Associated Quality Control Pathway | Proteins are life's double edged sword. Proteins are essential macromolecules of life, and the tasks that some proteins accomplish are quite marvelous. At the same time, if proteins misfold they have the potential to kill the cell that harbors them. It is becoming increasingly clear that proteins ha... | Ribosomes - Research | 2016-12 |
23 |
|
Bell, Marisa | Characterization of Polyphenols in I. Umbellifera | Secondary metabolites in plants, including polyphenolics, may be responsible, in part, for diversity in the tropics. Variation in chemical defense among species of trees encourages specificity in herbivorous insects. Due to the short lifespan of insects compared to trees, diversity in chemical defen... | | 2018 |
24 |
|
Little, Nancy Ann | Characterizing and mapping l(3)7E103 a gene required for Drosophila dorsal closure | Dorsal closure in the fruit fly Drosophila melanogaster is a complex morphogenetic process dependent upon three embryonic tissues: the lateral epidermis, leading edge epidermis, and amnioserosa. Additionally, the Jun N-terminal Kinase (JNK) and Decapentaplegic (Dpp) signaling cascades are required f... | Drosophila melanogaster - Genetics; Drosophila melanogaster - Embryology | 2013-05 |
25 |
|
Richards, Jackson | Chasing channels: Progress in calcium channel localization in the C. Elegans synapse | Calcium channels play a crucial role in neurotransmission by facilitating the flow of calcium ions necessary for synaptic vesicle fusion and neurotransmitter release. Different types of calcium channels participate in this process in the neurons of the nematode C. elegans. L- and N-type channels res... | Calcium channels; Synaptic vesicles; Caenorhabditis elegans | 2013-05 |
26 |
|
Garzella, Erin | Coinfection of Malaria and gammaherpesvirus in B cells and macrophages | Malaria kills over 600,000 people a year. 67% of those deaths are children under five and pregnant women. Some children get malaria, but they do not die. The reasons for this are not completely understood. Malaria is caused by the Plasmodium parasite, and in sub-Saharan Africa Plasmodium falciparum ... | | 2023 |
27 |
|
Yamada, Kaylene | Comparing Tollerance of Neotoma Lepida on Native Versus Novel Toxic Diets | Herbivorous animals often ingest plants that protect themselves with chemicals, and these toxins typically differ in composition from plant to plant. For instance, juniper (Juniperus osteosperma) is dominated by terpenes, such as α-pinene, whereas creosote bush (Larrea tridentata) contains a cockta... | | 2017 |
28 |
|
Tennant, Karrin | Competitive nighttime stomatal response of Populus Trichocarpa during drought | Stomata are critical valves responsible for gas exchange on the leaf level. They control rates of transpiration and as such play a crucial role in terrestrial water cycling. When stomata open, water molecules in the intracellular leaf space are subject to evaporation, especially in dry conditions. T... | | 2021 |
29 |
|
Neville, Roselyn | Constitutively activated AKT is not sufficient to keep cells alive following epithelial cell extrusion | The PI3 kinase (PI3K)/AKT signaling pathway regulates many fundamental behaviors of the cell. If any of the key members of this pathway are deregulated, it can lead to malignant changes in the cell. AKT enhances the survival of cells by inhibiting pro-apoptotic processes, and promoting pathways for ... | PI3K/AKT - Chemistry; Cancer metastasis | 2014-05 |
30 |
|
Streeter, Forest | Deficiency in regulator of G-Protein signaling, LOCO, protects D. Melanogaster from effects of a high Salt diet | Gerontology and studies of aging have been grappling with the effects of a westernized diet for decades now. Some of these effects include diseases related to overconsumption such as obesity, diabetes, hypertension, cardiovascular disease, stroke, and many more. These pathologies are now contributor... | | 2021 |
31 |
|
Evans, Kathryn S. | Defining the interaction between ETV4 and mediator subunit MED25 | Chromosomal rearrangements resulting in an overexpression of a subset of ETS transcription factors (ETV1, ETV4, ETV5, and ERG) are found in over 50% of prostate cancers (Tomlins et al., 2005). ERG and ETV1 have both shared and distinct gene targets, yet overexpression of ETV1 is often found to be as... | Transcription factors; Prostate -- Cancer -- Genetic aspects; ETV4 | 2015-05 |
32 |
|
Gardner, Jenna | The Disparity Between Student Science Writing and Professional Sciencetific Writing | There exists a disparity between student scientific writing and professional scientific writing. The audience, format, and intention of student papers as presented in the science classroom is different from those in the scientific field where the goal is to fully convince an unfamiliar audience and ... | | 2017 |
33 |
|
Chen, Jason J. | Dissecting the genetic and learned components of oscine birdsong | The interplay of genetically encoded and learned components in the development of the learned vocal signals of birdsong and human speech in not fully understood (Forstmeier et al, 2009). The fact that song is a learned vocal behavior does not imply the lack of a genetic basis in acquiring vocalizati... | Birdsongs -- Research; Songbirds -- Genetics -- Research; Zebra finch -- Research; Nature and nurture -- Research; birdsong; Taeniopygia guttata | 2015-12 |
34 |
|
Dart, Emily | Diversity and metabolic potential of microbial communities in a site of continental serpentinization | The geochemical process of serpentinization releases energy and organic carbon: two of the basic requirements need ed to support life. Sites of active serpentinization in the deep subsurface provide the intriguing possibility of a non-photosynthetically -supported biosphere. However, serpentinizatio... | Microbial ecology - Research; Serpentine - Environmental aspects; Gros Morne National Park (N.L.); Syntrophomonadaceae; Serpentinizaiton; Tabeland Ophiolite | 2016-05 |
35 |
|
Wiese, Claudia | DNA metabarcoding of trnL intron using the minion device to assess BEE foraging from Pollen | In recent decades many bee species, including Apis mellifera (European honeybee), have experienced worldwide population declines. In this paper we tested a novel molecular approach to evaluate foraging of A. mellifera Specifically, we sequenced trnL (UAA) intron DNA barcodes from isolated pollen fro... | | 2023 |
36 |
|
Kim, Bum Jun | Does ceramide contribute to vascular dysfunction in mice with type 1 diabetes? | Approximately 2 million individuals have type 1 diabetes (T1D) in the United States. Cardiovascular disease is 2-4-fold more prevalent in these patients but the mechanism(s) is unclear. Recently, we showed that the sphingolipid ceramide contributes to arterial dysfunction and hypertension in mice wi... | Ceramide - Research; Type 1 Diabetes; Mice as laboratory animals | 2012-05 |
37 |
|
Prestgard-Duke, Michael | Dynamin localization in Caenorhabditis Elegans | Dynamin is a 100-KDa GTPase that is essential for endocytosis. The classic model of endocytosis is a sequential mechanism: first, cell membrane is bent and internalized via the formation of a clathrin coat; next, dynamin facilitates GTP hydrolysis, resulting in membrane scission as the newly formed ... | Caenorhabditis elegans; Guanosine triphosphatase; Endocytosis | 2014-05 |
38 |
|
Curtis, Kaili Breann | The Effect of Inflammatory Components on Influenza a Virulence Evolution | The methodology for passaging influenza A virus in the mouse model has widely been established. However, traditional infection methods involving the inoculation of lung homogenates fail to account for the possible effects of host-associated factors on measures of virulence and in the virulence evolu... | | 2020 |
39 |
|
Azadpour, Elmera | The effect of inorganic VS organic fertilizer on an urban lawn in Salt Lake City, Utah | | | 2019 |
40 |
|
Kasera, Shalini | Effect of IUGR and supplemental DHA on molecular mediators of hepatic lipid accumulation in the rat | Intrauterine growth restriction (IUGR) refers to failure of the fetus to achieve its genetic growth potential in utero and is commonly caused by uteroplacental insufficiency secondary to maternal hypertensive disorders. A hallmark of IUGR is a decrease in circulating docosahexaenoic acid (DHA), an �... | | 2022 |
41 |
|
| Effects of Acute Hypoxia and High pCO2 on Total Protein Content and Metabolic Enzyme Activity in Rockfishes (Sebastes SPP.) | Climate change is altering ocean chemistry and wind-driven upwelling regimes. In the California Current System (CCS), these changes are exposing nearshore fishes to increasing levels of high pCO2 and hypoxia. These stressors co-occur during upwelling events, lasting hours to days, and both have the ... | | 2019 |
42 |
|
Chong, Alisha | Effects of increasing sleep duration on C-Reactive protein, insulin sensitivity, and blood pressure in adults with habitual short sleep | Short sleep, cardiovascular disease, and type 2 diabetes are all highly prevalent health issues in modern society. Previous findings demonstrate that obtaining short sleep is linked to an increased risk of cardiometabolic diseases such as type 2 diabetes and heart disease. However, the mechanisms un... | | 2023 |
43 |
|
Chong, Alisha | Effects of increasing sleep duration on C-reactive protein, insulin sensitivity, and blood pressure in adults with habitual short sleep | Effective literature instruction is an essential part of building secondary students' analytical skills, cultural capital, empathy, and sense of belonging in school. In this paper, I hypothesize that English language learners may not receive the same opportunities as their English-proficient peers t... | translanguaging; literary fluency; emergent bilinguals; language arts; English language learners; secondary education | 2023 |
44 |
|
Smith, Sarah | Effects of Mitochondrial Mobility on Astrocyte Function | Within the brain, astrocytes provide support and influence the excitability of neurons by regulating the extracellular levels of potassium (K+) and glutamate. These glial cells play a vital role in neural homeostasis by regulating the concentration of neurotransmitters at the synapse, therefore modu... | | 2018 |
45 |
|
Lebrecht, Maranda | Effects of ventilatory regimens on the prevalence of a common gastrointestinal disease in neonates | Necrotizing Enterocolitis, or NEC, is a common intestinal disease of preterm neonates. It is believed that bacterial colonization increases the risk of NEC. This study examines whether the type of ventilation of the neonate, either mechanical ventilation (MV) or non-invasive support (NIS), and the ... | Enterocolitis, Neonatal necrotizing - Research; Newborn infants - Diseases; Sheep as laboratory animals - Research; Necrotizing enterocolitis; Lymphocytes | 2016-05 |
46 |
|
Muehlman, Jayanti | Effects of Wind-Generated Underwater Noise on Southern right Whale Group Dynamic | The goal of this study was to investigate whether underwater noise affects the grouping behavior of southern right-whale (Eubalaena australis) mother-calf pairs at Península Valdés, Argentina. This area is a major calving ground for the population that occupies the western South Atlantic. Two larg... | | 2020 |
47 |
|
Mercer, Marianne | Establishing a System for Structure-Function analysis of the Novel Role that NUP153 Plays in Nuclear Assembly | In mitosis, equal partitioning of DNA between daughter cells requires an integrated series of events. At the start of anaphase the chromatin separates and forms two chromatin discs. This chromatin is then targeted by nuclear membrane proteins and membrane to form the nuclear envelope. These membrane... | | 2018 |
48 |
|
Bell, Anthony W. | The expansion of pinyon-juniper woodland and the appearance of peromyscus truel in the Toiyabe range of central Nevada | In the early twentieth century field biologists from the University of California Museum of Vertebrate Zoology conducted vertebrate faunal surveys throughout the Great Basin region. Over the past several years we have been conducting resurveys of many of the localities visited by MVZ scientists. Our... | Piñon mouse -- Nevada -- Toiyabe Range; Piñon mouse -- Habitat -- Nevada -- Toiyabe Range; Piñon mouse -- Climatic factors -- Nevada -- Toiyabe Range | 2012-05 |
49 |
|
Reimers, Noelle | Exploring the role of lipied metabolism in hepatocellular carcinoma | Hepatocellular carcinoma (HCC) is an aggressive cancer with poor survival rates and limited treatment options whose prevalence is expected to increase up to 137% by 2030. Existing therapies outside of liver resection or transplantation have poor efficacy, and few new treatment options have been deve... | | 2021 |
50 |
|
Davis, Kacey A. | Expression and Purification of Augertoxins: Searching for Novel Protein Folds in Venomous Marine Snails | This study describes a method for bacterial expression and purification of previously uncharacterized proteins. The proteins chosen for this study come from auger snail toxins, which have evolved to help the snail hunt and kill their prey. Evolutionary pressure between predator and prey selects for ... | | 2018 |
51 |
|
Chure, Griffin Daniel | FLHE influences cellular morphology through control of flagellar assembly in escherichia coli | The bacterial flagellar motor is a complex nanomachine composed of thousands of individual protein subunits. One of these proteins, FlhE, has not been studied in depth and its function is not completely understood. The flhE gene is cotranscribed with flhB and flhA in the flhBAE flagellar operon. In ... | Escherichia coli; Flagella (Microbiology) | 2013-05 |
52 |
|
Pham, John V. | The function of the protein VCP/CDC48-associated mitochondrial stress-responsive 1 in mammals | Although mitochondrial dysfunction has been linked to many human diseases, mitochondrial interacting proteins and protein quality controls are just beginning to be understood. The objective of our study was to characterize the function of the VMS1 protein in mammals. We determined the role of Vms1 o... | Mitochondrial disorders; Mitochondrial diseases - genetics; VMS1 | 2012-05 |
53 |
|
Gardner, Shalyce | Functional test for possible genetic modifiers of piga defficiency | PIGA deficiency is a rare X-linked recessive disorder that lacks effective treatment options. A protein encoded by the PIGA gene catalyzed the first step in biosynthesis of Glycosylphatidylinositol (GPI) anchors. Partial loss of function mutations in PIGA can prevent a cell from being able to synthe... | | 2023 |
54 |
|
Borrowman, William | Gas exchange of co-occurring plant species of the Great Basin Desert in an irrigated common garden | The majority of plants in the Great Basin ecosystem have adapted to cope with drought during summer. While general characteristics of these plants have been studied in non-managed environments it is important to investigate the physiology of these plants when additional water is supplied. In this ... | Urban heat island -- Prevention; Desert plants -- Ecology -- Great Basin -- Research; Plant ecophysiology -- Research; Irrigation -- Environmental aspects; Red Butte Garden (Salt Lake City, Utah) | 2014-04 |
55 |
|
Loret, Amy | Genetic Modifiers of Severity in Collagen VI-Related Muscular Dystrophy | Collagen VI-related muscular dystrophies (COL6-RD) display phenotypic heterogeneity that includes mild Bethlem myopathy (BM), intermediate (INT), and severe Ullrich congenital muscular dystrophy (UCMD) phenotypes. COL6-RD are characterized by mutations within the collagen VI genes (COL6A1, COL6A2, a... | | 2019 |
56 |
|
Rahmati, Kasra | Genetically Modified Chemotaxis Signaling Protein Chey Binds to the Rotor Protein Flin to Control the Direction of Flagellar Rotation in Escherichia Coli | Bacterial chemotaxis is the directed movement of a bacterium in response to environmental chemical stimuli. Cells of E. coli, for example, swim by rotating their flagella and direct their movement by regulating reversals between counterclockwise (CCW) and clockwise (CW) rotation. The switch from CCW... | | 2020 |
57 |
|
Acosta, Lehi | Genotype-dependent susceptibility to influenza and titer-virulence discordance | The influenza a virus (IAV) is a major source of human mortality and both recent and anticipated pandemics make understanding this major human pathogen of paramount importance1,2. The use of mouse models allows us to experimentally manipulate critical variables to more fully understand the dynamics ... | Influenza A virus - Research; Mice as laboratory animals - Research; Transmissibility; Virulence; Viral titers; Erythropoeintin | 2016-05 |
58 |
|
Willis, Hannah | Habitat factors influencing carnivore site usage in Sarikamis, Kars Turkey | In a world where natural areas are increasingly developed and fragmented, an understanding of spatial ecology is critical for proper land management that benefits both people and nature. Traditionally, policy makers have relied on the use of a single, charismatic species to serve as a protective umb... | | 2020 |
59 |
|
Kutschke, Michael | Hip joint center differences between dual fluoroscopy, functional hip, and coda - establishing a reference standard | Measurements of joint angles, moments, and forces may be highly sensitive to positional changes in the center of a joint. Due to its deep location, the human hip joint center (HJC) can be difficult to determine. Previous studies have defined the HJC relative to external landmarks using infrared moti... | Hip joint; Hip joint center | 2015-05 |
60 |
|
Thomas, Nathaniel | The HIV-protective bystander effect in macrophages is viral glycoprotein dependent and likely conferred via upregulation of ISG IFITM3 | During an immune response against a specific antigen, often during viral infections, T cells not specific to the antigen can be activated, a phenomenon known as bystander response. The "bystander response" has been studied extensively in T cells, but when examined for macrophages through the lens of... | | 2022 |
61 |
|
Lan, Yung-Chi | HYPO-osmolarity and glucose starvation localizes slm1 to mitochondria- A novel stress response pathway | Synthetic Lethal with Mss4 1 (Slm1) is a key protein found in the crossroad of the Membrane Compartment of Can1 (MCC) and the Membrane Compartment of TORC2 (MCT). The two compartments on the plasma membrane of budding yeast (Saccharomyces cerevisiae) are responsible for APC transporter regulation an... | | 2022 |
62 |
|
Weaver, Bradley | Hypoxia and the mesenchymal transition in glioma | Recent advances in targeted therapy for cancer have had little influence on survival for patients diagnosed with Glioblastoma (GBM, WHO Grade IV tumors), and median survival time remains stagnant at 12-15 months post diagnosis. Genomic profiling of GBM indicates clear phenotypic subsets of these tum... | Glioblastoma multiforme; Gliomas; Hypoxia; Mesenchymal transition | 2014-04 |
63 |
|
Fackler, Anderson N. | Identification of Kin-20 and UNC-119 Knockout suppressors associated with neuronal development and maintenance in C. elegans | Neurons comprise the nervous system-the essential signaling and communication system for nearly all multicellular organisms. To coordinate cells across an entire organism, they must grow to be relatively long. Therefore, neurons extend axons from the cell body. Immature neurons extend growth cones a... | | 2018 |
64 |
|
Johnson, KariAnne Rencher | Identification of PASK substrates and/or interacting proteins | PAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live... | Biology | 2012-05 |
65 |
|
| Identification of potential causes for increased central line associated bloostream infection rates in the University of Utah NICU | The University of Utah Newborn Intensive Care Unit (UUNICU) has seen a recent increase in rate of Central Line Associated Bloodstream Infection (CLABSI) after an extended period of 965 days with no CLABSI's. Unfortunately, in the last three years, infection rate has been on average 2.6 CLABSI per ye... | | 2023 |
66 |
|
Varghese, Alyssa A. | Identification of virulence factors in invasive haemophilus influenzae isolates causing disease in Utah Children | Haemophilus influenzae can cause serious disease in children. After widespread use of the H. influenzae serotype b (Hib) vaccine, H. influenzae serotype a (Hia) became a significant cause of invasive infection in Utah. Although most Utah Hia isolates belong to a sequence type theorized to be less in... | | 2021 |
67 |
|
Ong, Elaine | Identifying Natural Genetic Modifiers of Apoptosis and Retinal Degeneration | Apoptosis, or cell death, is an integral part of many diseases such as neurodegeneration, retinal degeneration, and cancer, yet it is unclear how apoptosis varies among individuals in a population. Retinitis pigmentosa (RP) is a retinal degeneration disease characterized by phenotypic heterogeneity ... | | 2018 |
68 |
|
Au, Alexander | Impact of population density of left atrial remodeling in patients with atrial fibrillation | Atrial fibrillation (AF), the most common cardiac arrhythmia and a leading cause of stroke, is characterized by structural changes, or remodeling, in tissues of the left atrium (LA). Late Gadolinium-Enhancement Magnetic Resonance Imaging (LGE-MRI) can noninvasively detect remodeling in the LA, allow... | Atrial fibrillation Treatment | 2012-05 |
69 |
|
Pearson, Cassidy | Major Urinary Protiens as a signal of genetic Quality and Infection status | The Hamilton-Zuk hypothesis suggests that susceptibility to infectious disease is so important that many physical traits, particularly secondary sexual characters, will evolve to signal genetic quality for resistance to prospective mates. We expanded upon this theory using the house mouse (Mus muscu... | | 2018 |
70 |
|
Shimko, Tyler | Mapping suppressors of premature sperm activation in C. Elegans | The sperm of the roundworm Caenorhabditis elegans move by a crawling motion, in contrast to mammalian sperm, which exhibit a swimming motion. This method of locomotion makes the sperm of C. elegans an excellent model for examining cell motility. In order to become motile, the sperm must undergo the ... | Caenorhabditis elegans -- Spermatozoa; Sperm activation | 2015-05 |
71 |
|
Guernsey, Michael | Mclr is not solely responsible for pigmentation variation among domestic pigeons | Feather pigmentation in the domesticated rock pigeon, Columba livia, is stunningly diverse. Plumage pigmentation in this, and other, columbid (pigeon and dove) species plays an important role in mate choice and thus is a driving factor in the process of sexual selection. To study the genetic basis o... | | 2012 |
72 |
|
Green, Austin | Measuring occupancy and occurrence of medium and large mammals in Red Butte Canyon Research Natural Area using motion-activated camera traps | With expanding urbanization and development, human encroachment on wilderness areas continues to increase. In Utah, much of the once pristine and untouched mountain ecosystems of the Wasatch Front have been developed for recreation and other human use, and this increasing human-wildlife interaction... | Red Butte Canyon (Salt Lake County, Utah); Wilderness area monitoring - United States; Wildlife conservation - Utah | |
73 |
|
Astin, Holly M. | Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish | | | 2016 |
74 |
|
Astin, M. Holly | Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish | The liver X receptors (LXRs) are important regulators of lipid and cholesterol metabolism and control diverse pathways in development, reproduction, metabolism, immunity and inflammation. Thus, LXRs have potential as therapeutic targets for diseases as diverse as lipid disorders, atherosclerosis... | Liver X receptors - Research; Zebrafish - genetics | 2016-08 |
75 |
|
Alexander, Amanda | Parental conflict with adult children | Parental conflict with adult children is something that is well known anecdotally, but has rarely been studied in light of other, more serious conflicts between parents and their children. However, parental conflict with adult children (adult being defined as between the ages of 18 and 25) is someth... | Adult children - Family relationships; Adult children - Psychology | 2012-05 |
76 |
|
Watson, Andre | Patterns of parasitism in a common Utah Rodent | Male-biased parasitism, where males are more commonly infected with and have higher parasite loads, is common across vertebrate taxa. Several factors could be driving this pattern. The immunocompetence handicap hypothesis suggests that higher testosterone levels in males suppress immune function whi... | | 2022 |
77 |
|
Radhakrishnan, Parvathi | PI3K inhibitors as potential new therapy against breast cancer progression | Receptor tyrosine kinases (RTKs) and their pleiotropic effectors play key roles in metastasis. Met and Ron are RTKs that have been shown to contribute to tumor growth and metastasis in both animal models and in patients. Recently, an alternative Ron isoform known as "short-form" Ron (sfRon) was asso... | Breast - Cancer - Treatment - Research; Protein - tyrosine kinase - inhibitors - Therapeutic use; Enzyme inhibitors - Therapeutic use. - Research; Biology - Research | 2014-05 |
78 |
|
Lee, Hani | Post-traumatic headache: an opportunity to develop new preclinical models for better understanding of pathology and treatment | Post-traumatic headache (PTH) is identified as one of the most frequent symptoms following traumatic brain injury (TBI) (Faux & Sheedy, 2008). Despite the high prevalence, there are currently no treatments which specifically target PTH. Instead of etiology-specific treatments, individuals suffering ... | | 2022 |
79 |
|
Peterson, John | Potential Therapeutic Inhibition of Epigenetic Modulator LSDI in Glioblastoma Multiforme | Glioblastoma (GBM) is the most common primary brain tumor in adults, and while advances in surgery, radiation, and standard chemotherapies have improved survival in this disease marginally over the years, the outcomes for most patients remain disappointing (Bhat, 2013). Recent studies have identifie... | | |
80 |
|
Trakhimets, Alesia | Pre-clinical trials of anti-neoplastic drugs using zebrafish with T-cell cancer | Note: To agree with NCBI nomenclature guidelines, human gene abbreviations are italicized and capitalized; human protein abbreviations are non-italicized and capitalized, and zebrafish gene abbreviations are italicized in lowercase. T lymphocytes, or T-cells, are blood cells that normally fight vira... | Antineoplastic agents - Testing; Zebra danio | 2013-04 |
81 |
|
Lindley, Clara | Pre-surgery inflammatory and angiogenesis biomarkers as predictors of 12-month cancer-related distress: results from the colocare study | Background Patients with colorectal cancer commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cancer-related distress (CTXD) score. Methods N = 315 patients (sta... | | 2023 |
82 |
|
Orton, Cody | Presynaptic bouton and postsynaptic Kenyon cell claw morphology with synaptic plasticity in drosophila | My thesis aims at determining whether or not neural activity affects connectivity in the Drosophila melanogaster olfactory circuit. Specifically, I am testing whether sensory activity is required for Projection neurons and Kenyon cell morphology. Therefore, my primary and central question is: does s... | | 2021 |
83 |
|
Christensen, Kiana | Quantifying Patterns of Squamate Dental Complexity | Squamate reptiles are ideal subjects for investigating relationships between diet and dentition patterns because they exhibit wide dietary diversity and taxonomic abundance. Most previous research is qualitative and limited to a basic assessment of the influence diet has on dentition (Hotton, 1955; ... | | 2020 |
84 |
|
Ellis, James H. | Refractory status epilepticus and chronic kidney disease in a large pedigree due to a variant in the mitochondrial encoded trna phenylalanine (MT-TF) gene | Mitochondrial disorders present with a wide spectrum of neurological manifestations. Clinical syndromes are described largely by phenotypic indicators. Epilepsy is a common but not universal feature. Myoclonus epilepsy with ragged red fibers (MERRF) is a common clinical syndrome that presents with e... | | 2018 |
85 |
|
Bader, Cecily | The Response of Arabidopsis Mutant BPS1-2 on Salt Media | How would our world change if salt tolerance could be engineered in plants? The Arabidopsis mutant bps1-2 has been shown to respond differently on salt media than a nonmutated plant would. In normal conditions, the bps1-2 mutant will arrest development in the root and shoot shortly after germination... | | 2017 |
86 |
|
Excell, Katerina | The role of amyloid precursor protein in a model of alzheimer's disease | Alzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ... | | 2022 |
87 |
|
Nau, Adam | The role of heparan sulfate in maintaining stereotyped birdsong | Song learning in Zebra Finches (Taeniopygia guttata) occurs during a critical period between 30-90 post hatch days, and involves acquisition of an acoustic model and a sensorimotor period of increasingly improving imitation of this model. Young birds sing highly variable songs early during this pe... | Birdsongs - Research; Zebra finch - Research; Songbirds - Behavior; Heparan sulfate; Taeniopygia guttata; Neural circuitry | 2016-04 |
88 |
|
Russell, Nicole | The Role of Introns Within Alpha Conotoxin Genes in Cone Snails | Cone snails, of which there are more than 600 species, have attracted a lot of attention. Cone snails, found in warm tropical waters across the world, are predators and produce venoms comprising diverse toxins. These toxins, termed conotoxins, have been the subject of a great amount of research. Whi... | | 2016 |
89 |
|
Wang, Zhirong | The role of the autism-associated gene kirrel3 in synapse formation | Alterations in the gene Kirrel3 are repeatedly associated with intellectual disability and autism. Kirrel3 regulates synapse formation in C. elegans but the role of Kirrel3 in synapse formation in the mammalian brain is unknown. In mice, Kirrel3 is expressed in specific cell types throughout the bra... | Autism -- Genetic aspects; Synapses; Kirrel3 gene; Synapse formation | 2015-04 |
90 |
|
Wheeler, Maya | Role of WNT-Dependent Neurogenesis in Functional Recovery Following Spinal Cord Injury | In humans and other adult mammals, spinal cord injury leads to a permanent loss of motor and sensory function. The biggest obstacle to recovery is the inability of severed axons and neurons to regenerate. During embryogenesis, all vertebrates have a population of neural stem cells called radial glia... | | 2019 |
91 |
|
Kannan, Sarmishta Diraviam | The Role that Lysosomes and Autophagy play in Alveolar soft parts Sarcoma, clear cell Sarcoma and Synovial Sarcoma | Sarcomas are cancer of the connective tissue and are very deadly group of cancers. Two of the sarcoma types, alveolar soft parts sarcoma (ASPS) and clear cell sarcoma (CCS) have a unique vacuolar morphology. This unique morphology is absent in synovial sarcoma (SS). We believe that the unusual morph... | | 2017 |
92 |
|
Nguyen, Nam | Roles of Transient Receptor Potenitial Ankyrin-1 and Vanilloid-3 in Endoplasmic Reticulum stress and Cytotoxicity in Lung Epithelial Cells | Air pollution is a growing global health issue with considerable local relevance. In particular, exposure to wood smoke particulate matter (WSPM) is associated with the development and exacerbation of chronic inflammatory conditions and irreversible damage of the airways and alveoli. However, exact ... | | 2020 |
93 |
|
Hunter, Samuel | Signaling Role of the Hamp Domain in the Escherichia Coli Serine Chemoreceptor | The chemoreceptor Tsr enables Escherichia coli to track serine gradients in its environment. Binding of serine to the periplasmic domain propagates a signaling conformational change through other domains of the chemoreceptor molecule to modulate the activity of CheA, a kinase associated with t... | Chemoreceptors - Research | 2016-07 |
94 |
|
Blair, Coral Dean | Snakes as a possible winter reservoir for Western equine encephalitis virus | | viruses; equine; snakes | 1964 |
95 |
|
Yang, Kevin | The Soluble (PRO) Renin Receptor does not Influence Lithium-Induced Diabetes Insipidus but does Provoke Beigning of White Adipose Tissue in Mice | Earlier we reported that the recombinant soluble (pro) renin receptor sPRR-His upregulates renal aquoporin-2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy ... | | |
96 |
|
Peterson, Mikal | Somatic chromosome pairing in interspecific drosophila hybrid and hybried rescue crosses | Homologous chromosomes of somatic tissue pair together in Drosophila. One current model proposes that somatic pairing starts in an undirected manner; when sites on the chromosome, called "buttons", come into contact and pair. Then, after this initial pairing, the rest of the chromosome then synapses... | | 2022 |
97 |
|
Olivia Hanson | Spinal cord injury-induced neuropathic pain & the gut microbiome: a review | Most spinal cord injuries (SCI) result in spinal cord injury-induced neuropathic pain (SCINP). SCI-NP is a major healthcare concern given the extensive burden it places on both patients and the healthcare system. This, coupled with the lack of effective and available treatments for those suffering f... | | 2022 |
98 |
|
Auduong, Priscilla | Spinal muscular atrophy modeled in drosophila melanogaster | Spinal Muscular Atrophy (SMA) is the most commonly inherited cause of death in children (Park, Kariya, & Monani, 2010 for review). This disease is characterized by a loss of motor neurons which leads to muscle degeneration, paralysis, and eventual death by respiratory failure (Monani, 2005 for revie... | Spinal muscular atrophy - Research; Drosophila melanogaster - Researcher | 2012-05 |
99 |
|
Hahm, Suhyun | Stressors of varying properties induce differences in the modulation of behavior and biology | Stress induces enduring behavioral and biological consequences. Despite its pervasiveness, the biological and neural processes underlying its effects remain largely unknown. The existing literature generally examines the repercussions of stress from the aspect of a single stressor; however, stressor... | | 2022 |
100 |
|
Skedros, Gregory Athanasios | Structural and material changes in the sheep radius from newborn to adult: Functional adaptation versus developmental constraint | Bones that exhibit marked changes in structural and material characteristics during ontogeny are potentially useful for studying the mechanisms that produce functional adaptations. The diaphyseal region of the sheep radius was examined because it is relatively simply loaded in cranial-caudal bending... | Functional adaptations - Sheep; Developmental constraint - Sheep; Ontogeny | 2015-08 |