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Filters: Department: "Biology" Collection: "ir_htoa"
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1 Beseris, EthanBiological impact protection in human facial hairOur study investigated selective mechanisms that influenced the evolution of facial hair in human males (Homo sapiens). Beards are often perceived as an indicator of masculinity and social dominance in men, suggesting that they may play a role in male contest competition. Some authors propose that t...2018
2 Haerter, NatalieThe role dimethyl fumarate has on Remyelination in a Theiler's murine encephalomyelitis virus model of multiple sclerosisThere is a lack of, and a huge need for, therapy options that can stimulate remyelination in multiple sclerosis. Dimethyl fumarate (DMF) (Tecfidera™) is a promising treatment option which is administered orally. DMF is immunomodulatory and has been shown to have potential neuroprotection propertie...neuroprotection; virus; therapy2023
3 Chure, Griffin DanielFLHE influences cellular morphology through control of flagellar assembly in escherichia coliThe bacterial flagellar motor is a complex nanomachine composed of thousands of individual protein subunits. One of these proteins, FlhE, has not been studied in depth and its function is not completely understood. The flhE gene is cotranscribed with flhB and flhA in the flhBAE flagellar operon. In ...Escherichia coli; Flagella (Microbiology)2013-05
4 Nau, AdamThe role of heparan sulfate in maintaining stereotyped birdsongSong learning in Zebra Finches (Taeniopygia guttata) occurs during a critical period between 30-90 post hatch days, and involves acquisition of an acoustic model and a sensorimotor period of increasingly improving imitation of this model. Young birds sing highly variable songs early during this pe...Birdsongs - Research; Zebra finch - Research; Songbirds - Behavior; Heparan sulfate; Taeniopygia guttata; Neural circuitry2016-04
5 Bell, MarisaCharacterization of Polyphenols in I. UmbelliferaSecondary metabolites in plants, including polyphenolics, may be responsible, in part, for diversity in the tropics. Variation in chemical defense among species of trees encourages specificity in herbivorous insects. Due to the short lifespan of insects compared to trees, diversity in chemical defen...2018
6 Roestenburg, JessicaTesting the Perceptual Salience of Spectral Content in Zebra Finch SongBirds actively adjust the resonance properties of the upper vocal tract during singing, which results in specific harmonic structures of song elements. To what degree upper vocal tract filtering is relevant for the perceptual salience of song is poorly understood. This research utilizes (1) a biolog...2018
7 Excell, KaterinaThe role of amyloid precursor protein in a model of alzheimer's diseaseAlzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ...2022
8 Richards, JacksonChasing channels: Progress in calcium channel localization in the C. Elegans synapseCalcium channels play a crucial role in neurotransmission by facilitating the flow of calcium ions necessary for synaptic vesicle fusion and neurotransmitter release. Different types of calcium channels participate in this process in the neurons of the nematode C. elegans. L- and N-type channels res...Calcium channels; Synaptic vesicles; Caenorhabditis elegans2013-05
9 Amaechi, AyanaUnderstanding sex differences in early predictors of pathological aggression with a mouse modelAntisocial behavior (ASB) is characterized by aggression, violence, drug use, thrillseeking behavior, and delinquent behavior. While childhood and adolescent maltreatment contribute to the ontogeny of this condition, converging evidence suggests that genetic factors play an equally important role. T...MAOA; pathological aggression; sex differences; stress; early development; animal models2021
10 Au, AlexanderImpact of population density of left atrial remodeling in patients with atrial fibrillationAtrial fibrillation (AF), the most common cardiac arrhythmia and a leading cause of stroke, is characterized by structural changes, or remodeling, in tissues of the left atrium (LA). Late Gadolinium-Enhancement Magnetic Resonance Imaging (LGE-MRI) can noninvasively detect remodeling in the LA, allow...Atrial fibrillation Treatment2012-05
11 Mallender, ZacharyAssay of the dreem device on sleep metrics and an exploration of sleep staging in chronic short sleepers during time in bed extensionDespite clear and plentiful research that sleeping less than seven hours per night has a wide array of health consequences, a large portion of American adults report sleeping less than seven hours per night and thus receive chronic insufficient sleep. Many studies exploring the consequences of insuf...2022
12 Isom, AnikaAmniotic fluid treatment of vocal fold injury in an in vivo rabbit modelHyaluronic acid (HA) injectables are a standard treatment for vocal fold injuries in both clinical and research settings. Results from these treatments are not permanent, however, and may vary in effectiveness. Because of this, there is a significant clinical interest in finding an alternative for H...Vocal folds; rheology; wound healing of vocal folds; hyaluronic acid; amniotic fluid; regenerative medicine2022
13 Rahmati, KasraGenetically Modified Chemotaxis Signaling Protein Chey Binds to the Rotor Protein Flin to Control the Direction of Flagellar Rotation in Escherichia ColiBacterial chemotaxis is the directed movement of a bacterium in response to environmental chemical stimuli. Cells of E. coli, for example, swim by rotating their flagella and direct their movement by regulating reversals between counterclockwise (CCW) and clockwise (CW) rotation. The switch from CCW...2020
14 Judd, David PaulTelomere proteins of Drosophila melanogaster: HipHop and MSK81DNA molecules encoding two proteins, HipHop and MSK81, were cloned into bacteria so as to make large amounts of these proteins that bind to telomeres of Drosophila (fruit fly) chromosomes. The goal was to determine whether known DNA binding motifs are present in HipHop and MSK81. Understanding how t...Biology2012-05
15 Identification of potential causes for increased central line associated bloostream infection rates in the University of Utah NICUThe University of Utah Newborn Intensive Care Unit (UUNICU) has seen a recent increase in rate of Central Line Associated Bloodstream Infection (CLABSI) after an extended period of 965 days with no CLABSI's. Unfortunately, in the last three years, infection rate has been on average 2.6 CLABSI per ye...2023
16 Young, ChelseaEffect of docosahexaenoic acid on female rat pups after controlled cortical impactPediatric traumatic brain injury (TBI) is a leading cause of death and disability in children. After an initial mechanical impact, the injury continues to evolve and propagate in a secondary injury cascade. Previous research by the Schober lab has indicated that docosahexaenoic acid (DHA) is a promi...2022
17 Johnson, KariAnne RencherIdentification of PASK substrates and/or interacting proteinsPAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live...Biology2012-05
18 Smith, SarahEffects of Mitochondrial Mobility on Astrocyte FunctionWithin the brain, astrocytes provide support and influence the excitability of neurons by regulating the extracellular levels of potassium (K+) and glutamate. These glial cells play a vital role in neural homeostasis by regulating the concentration of neurotransmitters at the synapse, therefore modu...2018
19 Chong, AlishaEffects of increasing sleep duration on C-Reactive protein, insulin sensitivity, and blood pressure in adults with habitual short sleepShort sleep, cardiovascular disease, and type 2 diabetes are all highly prevalent health issues in modern society. Previous findings demonstrate that obtaining short sleep is linked to an increased risk of cardiometabolic diseases such as type 2 diabetes and heart disease. However, the mechanisms un...2023
20 Ong, ElaineIdentifying Natural Genetic Modifiers of Apoptosis and Retinal DegenerationApoptosis, or cell death, is an integral part of many diseases such as neurodegeneration, retinal degeneration, and cancer, yet it is unclear how apoptosis varies among individuals in a population. Retinitis pigmentosa (RP) is a retinal degeneration disease characterized by phenotypic heterogeneity ...2018
21 Kannan, Sarmishta DiraviamThe Role that Lysosomes and Autophagy play in Alveolar soft parts Sarcoma, clear cell Sarcoma and Synovial SarcomaSarcomas are cancer of the connective tissue and are very deadly group of cancers. Two of the sarcoma types, alveolar soft parts sarcoma (ASPS) and clear cell sarcoma (CCS) have a unique vacuolar morphology. This unique morphology is absent in synovial sarcoma (SS). We believe that the unusual morph...2017
22 Loret, AmyGenetic Modifiers of Severity in Collagen VI-Related Muscular DystrophyCollagen VI-related muscular dystrophies (COL6-RD) display phenotypic heterogeneity that includes mild Bethlem myopathy (BM), intermediate (INT), and severe Ullrich congenital muscular dystrophy (UCMD) phenotypes. COL6-RD are characterized by mutations within the collagen VI genes (COL6A1, COL6A2, a...heterogeneity; characterized; Resulting symptoms2019
23 Chen, Jason J.Dissecting the genetic and learned components of oscine birdsongThe interplay of genetically encoded and learned components in the development of the learned vocal signals of birdsong and human speech in not fully understood (Forstmeier et al, 2009). The fact that song is a learned vocal behavior does not imply the lack of a genetic basis in acquiring vocalizati...Birdsongs -- Research; Songbirds -- Genetics -- Research; Zebra finch -- Research; Nature and nurture -- Research; birdsong; Taeniopygia guttata2015-12
24 Bader, CecilyThe Response of Arabidopsis Mutant BPS1-2 on Salt MediaHow would our world change if salt tolerance could be engineered in plants? The Arabidopsis mutant bps1-2 has been shown to respond differently on salt media than a nonmutated plant would. In normal conditions, the bps1-2 mutant will arrest development in the root and shoot shortly after germination...2017
25 Astin, Holly M.Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish2016
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