Honors Theses Open Access
 
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76 Watson, AndrePatterns of parasitism in a common Utah RodentMale-biased parasitism, where males are more commonly infected with and have higher parasite loads, is common across vertebrate taxa. Several factors could be driving this pattern. The immunocompetence handicap hypothesis suggests that higher testosterone levels in males suppress immune function whi...2022
77 Radhakrishnan, ParvathiPI3K inhibitors as potential new therapy against breast cancer progressionReceptor tyrosine kinases (RTKs) and their pleiotropic effectors play key roles in metastasis. Met and Ron are RTKs that have been shown to contribute to tumor growth and metastasis in both animal models and in patients. Recently, an alternative Ron isoform known as "short-form" Ron (sfRon) was asso...Breast - Cancer - Treatment - Research; Protein - tyrosine kinase - inhibitors - Therapeutic use; Enzyme inhibitors - Therapeutic use. - Research; Biology - Research2014-05
78 Lee, HaniPost-traumatic headache: an opportunity to develop new preclinical models for better understanding of pathology and treatmentPost-traumatic headache (PTH) is identified as one of the most frequent symptoms following traumatic brain injury (TBI) (Faux & Sheedy, 2008). Despite the high prevalence, there are currently no treatments which specifically target PTH. Instead of etiology-specific treatments, individuals suffering ...2022
79 Peterson, JohnPotential Therapeutic Inhibition of Epigenetic Modulator LSDI in Glioblastoma MultiformeGlioblastoma (GBM) is the most common primary brain tumor in adults, and while advances in surgery, radiation, and standard chemotherapies have improved survival in this disease marginally over the years, the outcomes for most patients remain disappointing (Bhat, 2013). Recent studies have identifie...
80 Trakhimets, AlesiaPre-clinical trials of anti-neoplastic drugs using zebrafish with T-cell cancerNote: To agree with NCBI nomenclature guidelines, human gene abbreviations are italicized and capitalized; human protein abbreviations are non-italicized and capitalized, and zebrafish gene abbreviations are italicized in lowercase. T lymphocytes, or T-cells, are blood cells that normally fight vira...Antineoplastic agents - Testing; Zebra danio2013-04
81 Lindley, ClaraPre-surgery inflammatory and angiogenesis biomarkers as predictors of 12-month cancer-related distress: results from the colocare studyBackground Patients with colorectal cancer commonly suffer from complex psychological distress. Elevated distress may be linked to systemic biomarkers. We investigated associations of biomarkers of inflammation and angiogenesis with cancer-related distress (CTXD) score. Methods N = 315 patients (sta...2023
82 Orton, CodyPresynaptic bouton and postsynaptic Kenyon cell claw morphology with synaptic plasticity in drosophilaMy thesis aims at determining whether or not neural activity affects connectivity in the Drosophila melanogaster olfactory circuit. Specifically, I am testing whether sensory activity is required for Projection neurons and Kenyon cell morphology. Therefore, my primary and central question is: does s...2021
83 Christensen, KianaQuantifying Patterns of Squamate Dental ComplexitySquamate reptiles are ideal subjects for investigating relationships between diet and dentition patterns because they exhibit wide dietary diversity and taxonomic abundance. Most previous research is qualitative and limited to a basic assessment of the influence diet has on dentition (Hotton, 1955; ...2020
84 Ellis, James H.Refractory status epilepticus and chronic kidney disease in a large pedigree due to a variant in the mitochondrial encoded trna phenylalanine (MT-TF) geneMitochondrial disorders present with a wide spectrum of neurological manifestations. Clinical syndromes are described largely by phenotypic indicators. Epilepsy is a common but not universal feature. Myoclonus epilepsy with ragged red fibers (MERRF) is a common clinical syndrome that presents with e...2018
85 Bader, CecilyThe Response of Arabidopsis Mutant BPS1-2 on Salt MediaHow would our world change if salt tolerance could be engineered in plants? The Arabidopsis mutant bps1-2 has been shown to respond differently on salt media than a nonmutated plant would. In normal conditions, the bps1-2 mutant will arrest development in the root and shoot shortly after germination...2017
86 Excell, KaterinaThe role of amyloid precursor protein in a model of alzheimer's diseaseAlzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ...2022
87 Nau, AdamThe role of heparan sulfate in maintaining stereotyped birdsongSong learning in Zebra Finches (Taeniopygia guttata) occurs during a critical period between 30-90 post hatch days, and involves acquisition of an acoustic model and a sensorimotor period of increasingly improving imitation of this model. Young birds sing highly variable songs early during this pe...Birdsongs - Research; Zebra finch - Research; Songbirds - Behavior; Heparan sulfate; Taeniopygia guttata; Neural circuitry2016-04
88 Russell, NicoleThe Role of Introns Within Alpha Conotoxin Genes in Cone SnailsCone snails, of which there are more than 600 species, have attracted a lot of attention. Cone snails, found in warm tropical waters across the world, are predators and produce venoms comprising diverse toxins. These toxins, termed conotoxins, have been the subject of a great amount of research. Whi...2016
89 Wang, ZhirongThe role of the autism-associated gene kirrel3 in synapse formationAlterations in the gene Kirrel3 are repeatedly associated with intellectual disability and autism. Kirrel3 regulates synapse formation in C. elegans but the role of Kirrel3 in synapse formation in the mammalian brain is unknown. In mice, Kirrel3 is expressed in specific cell types throughout the bra...Autism -- Genetic aspects; Synapses; Kirrel3 gene; Synapse formation2015-04
90 Wheeler, MayaRole of WNT-Dependent Neurogenesis in Functional Recovery Following Spinal Cord InjuryIn humans and other adult mammals, spinal cord injury leads to a permanent loss of motor and sensory function. The biggest obstacle to recovery is the inability of severed axons and neurons to regenerate. During embryogenesis, all vertebrates have a population of neural stem cells called radial glia...2019
91 Kannan, Sarmishta DiraviamThe Role that Lysosomes and Autophagy play in Alveolar soft parts Sarcoma, clear cell Sarcoma and Synovial SarcomaSarcomas are cancer of the connective tissue and are very deadly group of cancers. Two of the sarcoma types, alveolar soft parts sarcoma (ASPS) and clear cell sarcoma (CCS) have a unique vacuolar morphology. This unique morphology is absent in synovial sarcoma (SS). We believe that the unusual morph...2017
92 Nguyen, NamRoles of Transient Receptor Potenitial Ankyrin-1 and Vanilloid-3 in Endoplasmic Reticulum stress and Cytotoxicity in Lung Epithelial CellsAir pollution is a growing global health issue with considerable local relevance. In particular, exposure to wood smoke particulate matter (WSPM) is associated with the development and exacerbation of chronic inflammatory conditions and irreversible damage of the airways and alveoli. However, exact ...2020
93 Hunter, SamuelSignaling Role of the Hamp Domain in the Escherichia Coli Serine ChemoreceptorThe chemoreceptor Tsr enables Escherichia coli to track serine gradients in its environment. Binding of serine to the periplasmic domain propagates a signaling conformational change through other domains of the chemoreceptor molecule to modulate the activity of CheA, a kinase associated with t...Chemoreceptors - Research2016-07
94 Blair, Coral DeanSnakes as a possible winter reservoir for Western equine encephalitis virusviruses; equine; snakes1964
95 Yang, KevinThe Soluble (PRO) Renin Receptor does not Influence Lithium-Induced Diabetes Insipidus but does Provoke Beigning of White Adipose Tissue in MiceEarlier we reported that the recombinant soluble (pro) renin receptor sPRR-His upregulates renal aquoporin-2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy ...
96 Peterson, MikalSomatic chromosome pairing in interspecific drosophila hybrid and hybried rescue crossesHomologous chromosomes of somatic tissue pair together in Drosophila. One current model proposes that somatic pairing starts in an undirected manner; when sites on the chromosome, called "buttons", come into contact and pair. Then, after this initial pairing, the rest of the chromosome then synapses...2022
97 Olivia HansonSpinal cord injury-induced neuropathic pain & the gut microbiome: a reviewMost spinal cord injuries (SCI) result in spinal cord injury-induced neuropathic pain (SCINP). SCI-NP is a major healthcare concern given the extensive burden it places on both patients and the healthcare system. This, coupled with the lack of effective and available treatments for those suffering f...2022
98 Auduong, PriscillaSpinal muscular atrophy modeled in drosophila melanogasterSpinal Muscular Atrophy (SMA) is the most commonly inherited cause of death in children (Park, Kariya, & Monani, 2010 for review). This disease is characterized by a loss of motor neurons which leads to muscle degeneration, paralysis, and eventual death by respiratory failure (Monani, 2005 for revie...Spinal muscular atrophy - Research; Drosophila melanogaster - Researcher2012-05
99 Hahm, SuhyunStressors of varying properties induce differences in the modulation of behavior and biologyStress induces enduring behavioral and biological consequences. Despite its pervasiveness, the biological and neural processes underlying its effects remain largely unknown. The existing literature generally examines the repercussions of stress from the aspect of a single stressor; however, stressor...2022
100 Skedros, Gregory AthanasiosStructural and material changes in the sheep radius from newborn to adult: Functional adaptation versus developmental constraintBones that exhibit marked changes in structural and material characteristics during ontogeny are potentially useful for studying the mechanisms that produce functional adaptations. The diaphyseal region of the sheep radius was examined because it is relatively simply loaded in cranial-caudal bending...Functional adaptations - Sheep; Developmental constraint - Sheep; Ontogeny2015-08
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