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CreatorTitleDescriptionSubjectDate
76 Capecchi, Mario R.Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.Biochemical transformation of thymidine-kinase-deficient (TK-) mouse L cells is enhanced 20 to 40 fold when microinjected plasmid DNA contains regions of the genomes of Rous sarcoma virus or simian virus 40 in addition to the complete herpes simplex virus tk gene, irrespective of the orientation and...Animals; Base Sequence; Genes, Viral; Plasmids; Thymidine Kinase1983-07-01
77 Capecchi, Mario R.Hoxc13 mutant mice lack external hairHox genes are usually expressed temporally and spatially in a colinear manner with respect to their positions in the Hox complex. Consistent with the expected pattern for a paralogous group 13 member, early embryonic Hoxc13 expression is found in the nails and tail. Hoxc13 is also expressed in vibri...Filiform papillae; Homozygotes; Paralogous1998-01-01
78 Coffin, Cheryl M.; Capecchi, Mario R.Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has...Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors2004-11-01
79 Jorgensen, ErikMutations in β-spectrin disrupt axon outgrowth and sarcomere structureB-Spectrin is a major component of the membrane skeleton, a structure found at the plasma membrane of most animal cells. B-Spectrin and the membrane skeleton have been proposed to stabilize cell membranes, generate cell polarity, or localize specific membrane proteins. We demonstrate that the Caen...2000
80 Olivera, Baldomero M.P-superfamily conopeptidesThe present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor peptides.2006
81 Davidson, Diane W.Granivory in the Chihuahuan Desert: interactions within and between trophic levelsWe investigated the effects of Chihuahuan Desert granivores on three seasonal classes of plant resource species, the effects of these resource classes on one another, and the ways in which interactions through plant resources affect the abundances of seed consumers. At our study site, three seasona...Annual plant; Ant; Competition; Community; Desert; Ecosystem structure; Experiment; Granivore; Indirect interaction; Rodent; Population cycles; Seed predation1985
82 Davidson, Diane W.Granivory in the Chihuahuan desert: interactions within and between trophic levelsWe investigated the effects of Chihuahuan Desert granivores on three seasonal classes of plant resource species, the effects of these resource classes on one another, and the ways in which interactions through plant resources affect the abundances of seed consumers. At our study site, three seasona...Annual plant; Ant; Competition; Community; Desert; Ecosystem structure; Experiment; Granivore; Indirect interaction; Rodent; Population cycles; Seed predation1985
83 Beckerle, Mary C.Targeting of zyxin to sites of actin membrane interaction and to the nucleusThe localization of proteins to particular intracellular compartments often regulates their functions. Zyxin is a LIM protein found prominently at sites of cell adhesion, faintly in leading lamellipodia, and transiently in cell nuclei. Here we have performed a domain analysis to identify regions in ...Zyxin; Actin; LIM domains; Focal adhesions; Lamellipodia; Cytoskeletal architecture2001
84 Beckerle, Mary C.CRP1, a LIM domain protein implicated in muscle differentiation, interacts with α-actininMembers of the cysteine-rich protein (CRP) family are LIM domain proteins that have been implicated in muscle differentiation. One strategy for defining the mechanism by which CRPs potentiate myogenesis is to characterize the repertoire of CRP binding partners.CRP1; Cysteine-rich proteins; Actinin; Protein-protein interactions; LIM domains1997
85 Beckerle, Mary C.Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesisA genetic hierarchy of interactions, involving myogenic regulatory factors of the MyoD and myocyte enhancer-binding 2 (MEF2) families, serves to elaborate and maintain the differentiated muscle phenotype through transcriptional regulation of muscle-specific target genes.LIM domains; Cysteine-rich proteins1999
86 Olivera, Baldomero M.; McIntosh, J. Michael; Hillyard, David R.A-superfamily of conotoxins: structural and functional divergenceThe generation of functional novelty in proteins encoded by a gene superfamily is seldom well documented. In this report, we define the A-conotoxin superfamily, which is widely expressed in venoms of the predatory cone snails (Conus), and show how gene products that diverge considerably in stru...Conotoxins; A-superfamily conotoxin2004-02-03
87 Olivera, Baldomero M.T-superfamily of conotoxinsWe report the discovery and initial characterization of the T-superfamily of conotoxins. Eight different T-superfamily peptides from five Conus species were identified; they share a consensus signal sequence, and a conserved arrangement of cysteine residues (- -CC- -CC-). T-superfamily peptides...Conotoxins; T-superfamily1999
88 Bastiani, MichaelDevelopmental expression of REGA-1, a regionally expressed glial antigen in the central nervous system of grasshopper embryosGlial cells are a large component of the developing nervous system, appearing before the onset of axon outgrowth in a variety of developing systems. Their time of appearance and their location in conjunction with developing axon pathways may allow them to define the position of axon pathways.Antibody; Axons; Pathways1991
89 Coley, Phyllis D.Between-species differences in leaf defenses of tropical treesRates of herbivory and patterns of leaf defense are presented for light-demanding and shade-tolerant tree species growing in a lowland rainforest in Panama. More than 85 percent of the annual leaf damage is due to grazing by insects. There are over three orders of magnitude difference between specie...Herbivory; Interspecific variation; Panama; Growth rate; Shade tolerance; Treefall gaps; Tropical forest; Understory; Tannins; Alkaloids1987
90 Sperry, John S.Evaluation of Murray's law in Psilotum nudum (Psilotaceae), an analogue of ancestral vascular plantsPrevious work has shown that the xylem of seed plants follows Murray's law when conduits do not provide structural support to the plant. Here, compliance with Murray's law was tested in the stem photosynthesizer Psilotum nudum, a seedless vascular plant. Psilotum nudum was chosen because the central...Conduit furcation number; hydraulic architecture; Murray's law2005
91 Adler, Frederick R.Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosisLung function, acute pulmonary exacerbations (APE), and weight are the best clinical predictors of survival in cystic fibrosis (CF); however, underlying mechanisms are incompletely understood. Biomarkers of current disease state predictive of future outcomes might identify mechanisms and provide tre...2012-01-01
92 Gesteland, Raymond F.; Atkins, John F.; Felden, Brice; McCutcheon, John P.Probing the structure of the Escherichia coli 10Sa RNA (tmRNA)The conformation of the Escherichia coli 10Sa RNA (tmRNA) in solution was investigated using chemical and enzymatic probes. Single- and double-stranded domains were identified by hydrolysis of tmRNA in imidazole buffer and by lead(II)-induced cleavages. Ribonucleases T1 and S1 were used to map unpai...Covariation; Pseudoknot; Structural Probing; 10Sa RNA; tmRNA1997
93 Olivera, Baldomero M.Bacteriophage Mu DNA replication in vitroAn in vitro system for bacteriophage Mu DNA replication using lysates on cellophane discs is described. Mu replication was monitored by DNA hybridization. Using a thermoinducible Mu Iysogen, 30-50% of all DNA synthesis in vitro was Mu-specific.Bacteriophage Mu1983
94 Thomas, Kirk R.; Capecchi, Mario R.Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei.Heteroduplexes were prepared from two plasmids, pRH4-14/TK and pRH5-8/TK, containing different amber mutations in the neomycin resistance gene (Neor). The Neor gene was engineered to be expressed in both bacterial and mammalian cells. A functional Neor gene conferred kanamycin resistance to bacteria...Cell Nucleus; Cells, Cultured; Microinjections1985-01
95 Sperry, John S.Embolized conduits of rice (Oryza sativa, poaceae) refill despite negative xylem pressureEmbolism reversal in rice plants was studied by testing the plant's ability to refill embolized conduits while xylem pressures were substantially negative. Intact, potted plants were water-stressed to a xylem pressure of -1.88 + 0.1 MPa and a 66.3 + 3.8% loss of xylem conductivity (PLC) by cavitatio...Embolism; novel revilling; Oryza2005
96 Davidson, Diane W.Granivory in a desert ecosystem: experimental evidence for indirect facilitation of ants by rodentsTwo major groups of desert granivores, ants and rodents, coexist as permanent residents of local desert habitats in southwestern North America. At our Sonoran Desert study site, both of the major taxa exhibited short-term increase in density when the other taxon was experimentally removed. Over the...Ants; Arizona; Desert annuals; Facilitation; Granivory; Indirect mutualism; Rodents; Seed predation; Sonoran Desert1984
97 Davidson, Diane W.Dispersal adaptations of some acacia species in the Australian arid zoneMost Australian representatives of the genus Acacia have diaspores with arillate appendages indicative of adaptation for active dispersal by animals. Based on physical and chemical characteristics of these arils and mechanisms of diaspore presentation, a number of arid zone acacias can be distingu...Acacia; Australian arid zone; Dispersal ecology; Fruit quality; Myrmecochory; Ornithochory; Seed parasitoids; Soil nutrients1984
98 Capecchi, Mario R.; Tvrdik, PetrHoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry.Formation of neuronal circuits in the head requires the coordinated development of neurons within the central nervous system (CNS) and neural crest-derived peripheral target tissues. Hoxb1, which is expressed throughout rhombomere 4 (r4), has been shown to be required for the specification of facial...Rhombomere 4; Branchiomotor; Cranial Nerve2004-07-04
99 Baehr, Wolfgang; Frederick, Jeanne M.; Church-Kopish, Jill; Howes, KimberlyMutant rhodopsin transgene expression on a null backgroundPURPOSE. To study mechanisms leading to photoreceptor degeneration in mouse models for autosomal dominant retinitis pigmentosa (adRP) based on the rhodopsin P23H mutation. METHODS. Mice of a transgenic line expressing a rhodopsin triple mutant, V20G, P23H, and P27L (GHL), were mated with rhodopsin (...Mutant Rhodopsin; Photoreceptor Degeneration; Autosomal Dominant Retinitis Pigmentosa; Rhodopsin2001-03
100 Capecchi, Mario R.; Thomas, Kirk R.High frequency targeting of genes to specific sites in the mammalian genomeWe corrected a defective gene residing in the chromosome of a mammalian cell by injecting into the nucleus copies of the same gene carrying a different mutation. We determined how the number, the arrangement, and the chromosomal position of the integrated gene, as well as the number of injected mo...Homologous recombination; Mutant genes; Mammalian genome1986
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