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Creator | Title | Description | Subject | Date |
| 26 |
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Ehleringer, James R. | Carbon isotope discrimination and water relations of oak hybrid populations in southwestern Utah | The evergreen oak Quercus turbinella and the deciduous Q. gambelii form natural hybrids in southwestern Utah and northern Arizona. Hybrid individuals also are found in northern Utah in a region where only Q. gambelii currently exists, indicating that Q. turbinella has recently retreated southward. ... | Quercus turbinella; Oak hybrids; Leaf structure; Leaf nitrogen; Carbon isotope discrimination; Water potential; Oak ecology | 2000 |
| 27 |
 |
Gesteland, Raymond F.; Atkins, John F.; Ingram, Jennifer A.; Kelly, Paul J.; Grentzmann, Guido | Dual-luciferase reporter system for studying recoding signals | A new reporter system has been developed for measuring translation coupling efficiency of recoding mechanisms such as frameshifting or readthrough. A recoding test sequence is cloned in between the renilla and firefly luciferase reporter genes and the two luciferase activities are subsequently measu... | Amino Acid Sequence; Genes, Reporter; HIV; Antizyme; Translation | 1998 |
| 28 |
 |
Capecchi, Mario R.; Bernstein, Kenneth E.; Thomas, Kirk R. | Targeting genes for self-excision in the germ line | A procedure is described that directs the self-induced deletion of DNA sequences as they pass through the male germ line of mice. The testes-specific promoter from the angiotensin-converting enzyme gene was used to drive expression of the Cre-recombinase gene. Cre was linked to the selectable marker... | Cre-recombinase; Hoxa3; Chimeric mice | 1999-06-15 |
| 29 |
 |
Beckerle, Mary C. | Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression | Members of the cysteine-rich protein (CRP) family are evolutionarily conserved proteins that have been implicated in the processes of cell proliferation and differentiation. In particular, one CRP family member has been shown to be an essential regulator of cardiac and skeletal muscle development. | LIM domains; Chicken fibroblasts; Zyxin; Actinin; Protein expression; Cysteine-rich proteins | 1997 |
| 30 |
 |
Ehleringer, James R. | Gas exchange, δ13C, and heterotrophy for Castilleja linariifolia and Orthocarpus tolmiei, facultative root hemiparasites on Artemisia tridentata | Gas exchange and carbon isotope ratios were measured on 2 facultative hemiparasites, Castilleja linarifolia Benth. (Indian paintbrush; Scrophulariaceae) and Orthocarpus tolmiei I-I. & A. (Tolmie owl clover; Scrophulariaceae), and their Artemisia tridentata L. (big sagebrush; Asteraceae) hosts. Photo... | Heterotrophy; Hemiparasite; Carbon isotope ratios; Shrub ecology; Castilleja linarifolia; Orthocarpus tolmiei; Artemisia tridentata | 1996 |
| 31 |
 |
Ehleringer, James R. | Intra- and interspecific variation for summer precipitation use in pinyon-juniper woodlands | In the arid southwest of North America, winter precipitation penetrates to deep soil layers, whereas summer"monsoon" precipitation generally wets only surface layers. Use of these spatially separated water sources was determined for three dominant tree species of the pinyon-juniper ecosystem at six ... | D/H ratios; Juniperus osteosperma; Pinus edulis; pinyon-juniper ecosystem; plant water sources; precipitation use; Quercus gambelii; roots; Photosynthetic gas exchange; Monsoon | 2000 |
| 32 |
 |
Beckerle, Mary C. | Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus | Integrin-dependent cell adhesion to specific extracellular matrix molecules has been demonstrated to trigger dramatic changes in gene expression that can affect cell fate. However, little is understood about the molecular mechanism by which events at sites of cell-substratum adhesion are communicate... | Zyxin; Cytosol; Nuclear export signal | 1997 |
| 33 |
 |
Capecchi, Mario R. | Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene. | DNA sequences homologous to the v-abl oncogene were isolated from a Caenorhabditis elegans genomic library by their ability to hybridize with a v-src probe. The DNA sequence of 2465 nucleotides of one clone was determined. This region corresponds to the 5' protein kinase domain of v-abl plus approxi... | Amino Acid Sequence; Animals; Base Sequence; Gene Expression Regulation; Transcription, Genetic | 1986-04 |
| 34 |
 |
Capecchi, Mario R. | Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase. | We have examined the effect of cell cycle position on homologous recombination between plasmid molecules coinjected into synchronized rat fibroblasts. Recombination activity was found to be low in G1 and to rise 10- to 15-fold, peaking in early to mid-S phase. | Cell Line; Kinetics; Plasmids | 1986-06 |
| 35 |
 |
Sperry, John S. | Cavitation fatigue - the weakening of cavitation resistance of xylem and its reversibility | Xylem function is essential for the growth and survival of higher land plants. Xylem must not only be efficient under favorable conditions to facilitate high rates of stomatal conductance and carbon uptake, but it should also remain functional under drought conditions, when water potential (Ψ) dro... | Cavitation fatigue; Drought; Pit membrane | 2003 |
| 36 |
 |
Capecchi, Mario R. | Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. | Implantation within the mammalian uterus elicits dramatic changes in the growth, differentiation, and morphogenesis of the conceptus. This process is interrupted in mice carrying a targeted disruption of the murine evx1 gene, a homolog of the Drosophila even-skipped (eve) gene. Upon implantation, pr... | Extraembryonic; Homozygotes; Drosophila | 1994-08-15 |
| 37 |
 |
Ehleringer, James R.; Rickart, Eric Allan; Dearing, Maria-Denise | Stable isotope ratios (?15N AND ?13C) of syntopic shrews (SOREX) | Local species richness in shrew (Soricidae) assemblages is often high, and the mechanisms of ecological separation remain relatively unexplored. In this study, hair samples from 6 species of Sorex in 3 separate assemblages were analyzed for stable carbon (13C/12C) and nitrogen (15N/14N) isotope rati... | | 2004 |
| 38 |
 |
Gussin, Gary N.; Capecchi, Mario R. | Protein synthesis directed by DNA phage messengers. | Even through the amino acids corresponding to most of the 64 nucleotide triplets are now known, several important aspects of the genetic code are not yet fully understood. In particular we need more knowledge about the "punctuation marks" of the code-for example, the signals necessary for the initia... | Carbon Isotopes; Escherichia coli; Genetic Code; Methionine | 1967-09-01 |
| 39 |
 |
Capecchi, Mario R. | Gene targeting: an historical perspective | Our entry into what was going to become the field of gene targeting began in 1977. I was experimenting with the use of extremely small glass needles to inject DNA directly into the nuclei of living cells. The needles were controlled by hydraulically driven micro-manipulators and were directed into n... | Gene targeting -- History; Homologous recombination | 1998 |
| 40 |
 |
Coley, Phyllis D.; Kursar, Thomas A. | Novel DNA-based microfluorimetric method to evaluate antimalarial drug activity | This paper describes the development of a novel microfluorimetric assay to measure the inhibition of Plasmodium falciparum based on the detection of parasitic DNA by intercalation with PicoGreen®. The method was used to determine parasite inhibition profiles and 50% inhibitory concentration values ... | Microfluorimetric assay; Plasmodium falciparum; Chloroquine; Drug discovery | 2004 |
| 41 |
 |
Adler, Frederick R.; Carrier, David R. | Interaction between the X chromosome and an autosome regulates size sexual dimorphism in Portuguese Water Dogs | Size sexual dimorphism occurs in almost all mammals. In Portuguese Water Dogs, much of the difference in skeletal size between females and males is due to the interaction between a Quantitative Trait Locus (QTL) on the X-chromosome and a QTL linked to Insulin-like Growth Factor 1 (IGF-1) on the CFA... | Phenotypes; QTL; Selection | 2005 |
| 42 |
 |
Ehleringer, James R. | Population- and family-level variation of brittlebush (Encelia farinosa, Asteraceae) pubescence: its relation to drought and implications for selection in variable environments | Because leaf pubescence of the desert shrub Encelia farinosa increases in response to drought and influences photosynthesis and transpiration, we hypothesized that differences in water availability across the range of this species may result in genetic differentiation for pubescence and associated p... | Encelia farinose; Absorptance; Adaptation; Asteraceae; Desert; Drought acclimation; Leaf pubescence; maternal family variance; spatiotemporal heterogeneity | 2003 |
| 43 |
 |
Gesteland, Raymond F.; Atkins, John F.; Baranov, Pavel V. | P-site tRNA is a crucial initiator of ribosomal frameshifting | The expression of some genes requires a high proportion of ribosomes to shift at a specific site into one of the two alternative frames. This utilized frameshifting provides a unique tool for studying reading frame control. Peptidyl-tRNA slippage has been invoked to explain many cases of programmed ... | Translation; Recoding; Kinetic Model; Frameshifting; Ribosome | 2004 |
| 44 |
 |
Beckerle, Mary C. | Two muscle-specific LIM proteins in Drosophila | The LIM domain defines a zinc-binding motif found in a growing number of eukaryotic proteins that regulate cell growth and differentiation during development. Members of the cysteine-rich protein (CRP) family of LIM proteins have been implicated in muscle differentiation in vertebrates. Here we r... | LIM domains; Mlp60A; Mlp84B; Cysteine-rich proteins | 1996 |
| 45 |
 |
Ehleringer, James R. | Responses of boreal conifers to climate fluctuations: indications from tree-ring widths and carbon isotope analyses | Spatial distribution and species composition of the boreal forest are expected to change under predicted climate change scenarios. Current research indicates that water limitations control the southern boundary of the central Canadian boreal forest and temperature limitations control the northern b... | Boreal forests; Carbon budget; Picea mariana; Pinus banksiana; Carbon isotopes | 1998 |
| 46 |
 |
Davidson, Diane W. | Foraging ecology and community organization in desert seed-eating ants | Granivorous ants in the southwestern deserts of the United States are characterized by species-specific colony foraging behaviors that determine their efficiencies at utilizing seeds from different density distributions. Workers search for food either in groups or as individuals, and these feedin... | Ants; Arizona; California; Coexistence; Communities; Density specialization; Desert granivores; Foraging strategies; Insects; New Mexico; Resource partitioning | 1977 |
| 47 |
 |
Hansen, Mark S.; Healy, Lindsey J.; Johnson, Christopher R.; Capecchi, Mario R.; Keller, Charles; Jones, Greg M. | Virtual histology of transgenic mouse embryos for high-throughput phenotyping. | A bold new effort to disrupt every gene in the mouse genome necessitates systematic, interdisciplinary approaches to analyzing patterning defects in the mouse embryo. We present a novel, rapid, and inexpensive method for obtaining high-resolution virtual histology for phenotypic assessment of mouse ... | Forkhead Transcription Factors; Paired Box Transcription Factors | 2006 |
| 48 |
 |
Olivera, Baldomero M. | On a potential global role for vitamin K-dependent γ-carboxylation in animal systems | The vitamin K-dependent γ-carboxylation of glutamate to γ-carboxyglutamate was originally well characterized in the mammalian blood clotting cascade. γ-Carboxyglutamate has also been found in a number of other mammalian proteins and in neuropeptides from the venoms of marine snails belonging to... | Carboxylation; Glutamate; Carboxyglutamate; Carboxylase mRNA; Conantokin G | 2001 |
| 49 |
 |
Beckerle, Mary C. | ALP-enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans | Mutations that affect the Z-disk-associated ALP-Enigma proteins have been linked to human muscular and cardiac diseases. Despite their clear physiological significance for human health, the mechanism of action of ALP-Enigma proteins is largely unknown. In Caenorhabditis elegans, the ALP-Enigma prot... | Actin; Caenorhabditis elegans; Contractility; alp-1 mutants; Z-disks; Kettin | 2009 |
| 50 |
 |
Thomas, Kirk R.; Capecchi, Mario R. | Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian. cell nuclei | We have examined the mechanism of homologous recombination between plasmid molecules coinjected into cultured mammalian cells. Cell lines containing recombinant DNA molecules were obtained by selecting for the reconstruction of a functional Neor gene from two plasmids that bear different amber mutat... | Animals; Cells, Cultured; DNA Restriction Enzymes; Kinetics | 1985-01 |
