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1 Bohs, Lynn A.Phylogeny of the carolinense clade of solanum (Solanaceae) inferred from nuclear and plastid DNA sequencesThe large and economically important genus Solanum contains ca. 1,400 species distributed worldwide. One of the 12-14 major clades identified in the genus is the Leptostemonum clade, or the "spiny solanums." Previous molecular phylogenetic studies have identified 14 major clades in the spiny solanum...2014-01-01
2 Adler, Frederick R.Reply:We appreciate the comments of Drs. Craig and Simpson and Drs. Mullins and Schwartz, and the challenge they raise to make MALD more believable, comprehensible, and usable. Acetaminophen (APAP) toxicity is indeed a complex process involving multiple steps. Although the underlying mathematics is more i...2012-01-01
3 Capecchi, Mario R.Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironmentAlveolar soft part sarcoma (ASPS), a deadly soft tissue malignancy with a predilection for adolescents and young adults, associates consistently with t(X;17) translocations that generate the fusion gene ASPSCR1-TFE3. We proved the oncogenic capacity of this fusion gene by driving sarcomagenesis in m...2014-01-01
4 Olivera, Baldomero M.Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snailsBackground: Conotoxins can be utilized to investigate enzyme-assisted folding of disulfide-rich peptides. Results: Various ER-resident cone snail enzymes act in concert to accelerate the oxidative folding of conotoxins and modulate their conformation by reconfiguring disulfide connectivities. Conclu...2012-01-01
5 Parkinson, John StansfieldMutational analysis of the P1 phosphorylation domain in E. coli CheA, the signaling kinase for chemotaxisThe histidine autokinase CheA functions as the central processing unit in the Escherichia coli chemotaxis signaling machinery. CheA receives autophosphorylation control inputs from chemoreceptors and in turn regulates the flux of signaling phosphates to the CheY and CheB response regulator proteins...2014-01-01
6 Jorgensen, ErikNano-fEM: Protein localization using photo-activated localization microscopy and electron microscopyMapping the distribution of proteins is essential for understanding the function of proteins in a cell. Fluorescence microscopy is extensively used for protein localization, but subcellular context is often absent in fluorescence images. Immuno-electron microscopy, on the other hand, can localize pr...2012-01-01
7 Capecchi, Mario R.Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1Mouse selenoprotein P (Sepp1) consists of an N-terminal domain (residues 1-239) that contains 1 selenocysteine (U) as residue 40 in a proposed redox-active motif (-UYLC-) and a Cterminal domain (residues 240-361) that contains 9 selenocysteines. Sepp1 transports selenium from the liver to other tiss...2014-01-01
8 Farmer, Colleen G.Unidirectional pulmonary airflow patterns in the savannah monitor lizardThe unidirectional airflow patterns in the lungs of birds have long been considered a unique and specialized trait associated with the oxygen demands of flying, their endothermic metabolism1 and unusual pulmonary architecture2,3. However, the discovery of similar flow patterns in the lungs of crocod...2014-02-20
9 Bohs, Lynn A.Two new species from the brevantherum clade of solanum (solanaceae) from eastern BrazilTwo new species of Solanum (Solanaceae) from eastern Brazil are described. Solanum anisocladum Giacomin & Stehmann is similar to S. megalochiton Mart., but differs by the indument of the adaxial leaf surface, which is composed of long porrect-stellate and unbranched trichomes. It also has a more rob...2013-01-01
10 Jorgensen, ErikUNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegansThe recycling of synaptic vesicles requires the recovery of vesicle proteins and membrane. Members of the stonin protein family (Drosophila Stoned B, mammalian stonin 2) have been shown to link the synaptic vesicle protein synaptotagmin to the endocytic machinery. Here we characterize the unc-41 gen...2012-01-01
11 Jorgensen, ErikInterferometric localization microscopyInterference of signal in Fourier space, emitted from single probes, is used to localize it by recording and computing the phase of the fringes. Such system has applications in super resolution localization microscopy.2014-01-01
12 Sekercioglu, CaganMapping functional traits: comparing bundance and presence-absence estimates at large spatial scalesEfforts to quantify the composition of biological communities increasingly focus on functional traits. The composition of communities in terms of traits can be summarized in several ways. Ecologists are beginning to map the geographic distribution of trait-based metrics from various sources of data,...2012-01-01
13 Beckerle, Mary C.Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibersActin stress fibers (SFs) in live cells consist of series of dynamic individual sarcomeric units. Within a group of consecutive SF sarcomeres, individual sarcomeres can spontaneously shorten or lengthen without changing the overall length of this group, but the underlying mechanism is unclear. We us...2014-01-01
14 Adler, Frederick R.Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and deathAcetaminophen is the leading cause of acute liver injury in the developed world. Timely administration of N-Acetylcysteine (N-Ac) prevents the progression of serious liver injury and disease, while failure to administer N-Ac within a critical time frame allows disease progression and in the most sev...2012-01-01
15 Hughes, Kelly T.The effects of codon context on in vivo translation speedWe developed a bacterial genetic system based on translation of the his operon leader peptide gene to determine the relative speed at which the ribosome reads single or multiple codons in vivo. Low frequency effects of so-called ‘‘silent'' codon changes and codon neighbor (context) effects could...2014-01-01
16 Parkinson, John StansfieldHAMP domain structural determinants for signalling and sensory adaptation in Tsr, the E. coli serine chemoreceptorMotile Escherichia coli cells track chemical gradients with high sensitivity over wide concentration ranges [recently reviewed in (Hazelbauer et al., 2008; Hazelbauer & Lai, 2010)]. Stimulus detection, amplification, and integration occur in an arrayed network of signaling complexes that contain tra...2014-01-01
17 Sekercioglu, CaganKeystone species in seed dispersal networks are mainly determined by dietary specializationOne central issue in Ecology ecology has been the definition and identification of keystone species, i.e., species that are relatively more important than others for maintaining the structure of a community. Several keystone species concepts have been proposed, and network theory has been pointed o...2014-01-01
18 Hughes, Kelly T.FliT selectively enhances proteolysis of FlhC Subunit in FlhD4C2 complex by an ATP-dependent protease, ClpXPWe previously reported that the ClpXP ATP-dependent pro-tease specifically recognizes and degrades the flagellar master transcriptional activator complex, FlhD 4C2, to negatively control flagellar biogenesis. The flagellum-related protein, FliT, isalso a negative regulator of flagellar regulon by in...2014-01-01
19 Bowling, David R.Impacts of anthropogenic emissions and cold air pools on urban to montane gradients of snowpack ion concentrations in the Wasatch Mountains, UtahUrban montane valleys are often characterized by periodic wintertime temperature inversions (cold air pools) that increase atmospheric particulate matter concentrations, potentially stimulating the deposition of major ions to these snow-covered ecosystems. We assessed spatial and temporal patterns o...2014-01-01
20 Adler, Frederick R.Mathematical modeling the age dependence of Epstein-Barr virus associated infectious mononucleosisMost people get Epstein-Barr virus (EBV) infection at young age and are asymptomatic. Pri-mary EBV infection in adolescents and young adults however, often leads to infectious mononucleosis (IM) with symptoms including fever, fatigue, and sore throat that can persist for months. Expansion in the num...2012
21 Clayton, Dale H.Darwins finches combat introduced nest parasites with fumigated cottonIntroduced parasites are a threat to biodiversity when naïve hosts lack effective defenses against such parasites [1]. Several parasites have recently colonized the Galápagos Islands, threatening native bird populations [2]. For example, the introduced parasitic nest fly Philornis downsi (Diptera:...2014-01-01
22 Yamaguchi, AyakoDevelopment of an acute method to deliver transgenes into the brains of adult Xenopus laevisThe central vocal pathway of the African clawed frog, Xenopus laevis, is a powerful vertebrate model to understand mechanisms underlying central pattern generation. However, fast and efficient methods of introducing exogenous genes into the neurons of adult X. laevis are currently not available. Her...viral vector; vesicular stomatitis virus; Xenopus laevis; transgene; neurons; vocalizations; central pattern generator; electroporation2018
23 Adler, Frederick R.Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosisLung function, acute pulmonary exacerbations (APE), and weight are the best clinical predictors of survival in cystic fibrosis (CF); however, underlying mechanisms are incompletely understood. Biomarkers of current disease state predictive of future outcomes might identify mechanisms and provide tre...2012-01-01
24 Shapiro, Michael D.Divergence, convergence, and the ancestry of feral populations in the domestic rock pigeonStringham, Sydney A.; Mulroy, Elisabeth E.; Xing, Jinchuan; Record, David; Guernsey, Michael W.; Aldenhoven, Jaclyn T.; Osborne, Edward J.
25 Goller, FranzMotor control of sound frequency in birdsong involves the interaction between air sac pressure and labial tensionFrequency modulation is a salient acoustic feature of birdsong. Its control is usually attributed to the activity of syringeal muscles, which affect the tension of the labia responsible for sound production. We use experimental and theoretical tools to test the hypothesis that for birds producing to...2014-01-01
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