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1 Hinchman, Colin4D flow characteristics of left atrial blood flow after atrial fibrillationAtrial fibrillation is the most prevalent cardiac arrhythmia and causes increased risk for stroke, yet accurate pathophysiological diagnosis remains a challenge. This study aimed to further investigate the physiologic biomarkers in the left atrium (LA) related to atrial fibrillation (AF) using 4D fl...2019
2 Sperber, Alexander M.A novel approach to differentiating cardiac fibroblasts from induced pluripotent stem cellsHeart disease remains the leading cause of death in the United States, and such disease is caused by electrical, chemical, or biomechanical imbalances in the heart. The two most abundant cells comprising the heart that are responsible for these functions are cardiomyocytes and cardiac fibroblasts. I...2022
3 Rohaj, AarushiApoptosis efficiency of the transfected elephant and human P35 vectors in P53 varying leiomyosarcoma cellsComparative Oncology is an approach that integrates and connects commonly occurring cancers seen in animals, into studies focused on cancer biology, prevention, and treatment in humans. Studies show that natural mechanisms can suppress cancer 1,000 times more adequately in certain animals than in hu...Doxorubicin; vectors2021
4 Estrada, JohannaBCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Philadelphia cromosome-positive leukemiaCML 1s caused by a random reciprocal translocation that joins the ABL1 gene on chromosome 9, with the BCR gene on chromosome 22. The result is the formation of the oncogenic BCR-ABL1 gene. This derivative chromosome is widely known as the Philadelphia Chromosome (Ph+), and it encodes a deregulated, ...Leukemia -- Genetic aspects -- Research Leukemia -- Treatment -- Research2014-04
5 Tazehabadi, TaraBioinformatics to detect functional interactions important for the DNA repair enzyme mutyhDNA is the blueprint of all biological life as it provides the means necessary for sharing of genetic information. DNA is formed and stabilized by interactions between four unique bases, Adenine (A), Cytosine (C), Guanine (G), and Thymine (T) which come together in predetermined patterns to create a...2022
6 Beseris, EthanBiological impact protection in human facial hairOur study investigated selective mechanisms that influenced the evolution of facial hair in human males (Homo sapiens). Beards are often perceived as an indicator of masculinity and social dominance in men, suggesting that they may play a role in male contest competition. Some authors propose that t...2018
7 Furrer, SummerCellular and subcellular localization patterns of hepatitis delta virus in sjogren's syndrome salivary gland tissuePrimary Sjogren's syndrome (pSS) is an autoimmune disorder, predominantly affecting women, that causes dry eyes, dry mouth, fatigue, and other extraglandular manifestations (Le Goff et al., 2017). It has been shown that chronic pathogen exposure can lead to development of autoimmune diseases such as...2022
8 Jensen, MadelineChanges in microbial diversity in storm-water green infrastructureIncreased urbanization has led to excess nutrients in urban ecosystems. Stormwater Green Infrastructure (SGI) is a method to capture these nutrients and prevent runoff. However, an increased understanding of ecosystem processes is needed to create more efficient SGIs. Past studies have shown that pl...2022
9 Barbeau, WilliamCharacterization of a New Ribosome Associated Quality Control PathwayProteins are life's double edged sword. Proteins are essential macromolecules of life, and the tasks that some proteins accomplish are quite marvelous. At the same time, if proteins misfold they have the potential to kill the cell that harbors them. It is becoming increasingly clear that proteins ha...Ribosomes - Research2016-12
10 Bell, MarisaCharacterization of Polyphenols in I. UmbelliferaSecondary metabolites in plants, including polyphenolics, may be responsible, in part, for diversity in the tropics. Variation in chemical defense among species of trees encourages specificity in herbivorous insects. Due to the short lifespan of insects compared to trees, diversity in chemical defen...2018
11 Yamada, KayleneComparing Tollerance of Neotoma Lepida on Native Versus Novel Toxic DietsHerbivorous animals often ingest plants that protect themselves with chemicals, and these toxins typically differ in composition from plant to plant. For instance, juniper (Juniperus osteosperma) is dominated by terpenes, such as α-pinene, whereas creosote bush (Larrea tridentata) contains a cockta...2017
12 Neville, RoselynConstitutively activated AKT is not sufficient to keep cells alive following epithelial cell extrusionThe PI3 kinase (PI3K)/AKT signaling pathway regulates many fundamental behaviors of the cell. If any of the key members of this pathway are deregulated, it can lead to malignant changes in the cell. AKT enhances the survival of cells by inhibiting pro-apoptotic processes, and promoting pathways for ...PI3K/AKT - Chemistry; Cancer metastasis2014-05
13 Evans, Kathryn S.Defining the interaction between ETV4 and mediator subunit MED25Chromosomal rearrangements resulting in an overexpression of a subset of ETS transcription factors (ETV1, ETV4, ETV5, and ERG) are found in over 50% of prostate cancers (Tomlins et al., 2005). ERG and ETV1 have both shared and distinct gene targets, yet overexpression of ETV1 is often found to be as...Transcription factors; Prostate -- Cancer -- Genetic aspects; ETV42015-05
14 Gardner, JennaThe Disparity Between Student Science Writing and Professional Sciencetific WritingThere exists a disparity between student scientific writing and professional scientific writing. The audience, format, and intention of student papers as presented in the science classroom is different from those in the scientific field where the goal is to fully convince an unfamiliar audience and ...2017
15 Chen, Jason J.Dissecting the genetic and learned components of oscine birdsongThe interplay of genetically encoded and learned components in the development of the learned vocal signals of birdsong and human speech in not fully understood (Forstmeier et al, 2009). The fact that song is a learned vocal behavior does not imply the lack of a genetic basis in acquiring vocalizati...Birdsongs -- Research; Songbirds -- Genetics -- Research; Zebra finch -- Research; Nature and nurture -- Research; birdsong; Taeniopygia guttata2015-12
16 Dart, EmilyDiversity and metabolic potential of microbial communities in a site of continental serpentinizationThe geochemical process of serpentinization releases energy and organic carbon: two of the basic requirements need ed to support life. Sites of active serpentinization in the deep subsurface provide the intriguing possibility of a non-photosynthetically -supported biosphere. However, serpentinizatio...Microbial ecology - Research; Serpentine - Environmental aspects; Gros Morne National Park (N.L.); Syntrophomonadaceae; Serpentinizaiton; Tabeland Ophiolite2016-05
17 Prestgard-Duke, MichaelDynamin localization in Caenorhabditis ElegansDynamin is a 100-KDa GTPase that is essential for endocytosis. The classic model of endocytosis is a sequential mechanism: first, cell membrane is bent and internalized via the formation of a clathrin coat; next, dynamin facilitates GTP hydrolysis, resulting in membrane scission as the newly formed ...Caenorhabditis elegans; Guanosine triphosphatase; Endocytosis2014-05
18 Curtis, Kaili BreannThe Effect of Inflammatory Components on Influenza a Virulence EvolutionThe methodology for passaging influenza A virus in the mouse model has widely been established. However, traditional infection methods involving the inoculation of lung homogenates fail to account for the possible effects of host-associated factors on measures of virulence and in the virulence evolu...2020
19 Kasera, ShaliniEffect of IUGR and supplemental DHA on molecular mediators of hepatic lipid accumulation in the ratIntrauterine growth restriction (IUGR) refers to failure of the fetus to achieve its genetic growth potential in utero and is commonly caused by uteroplacental insufficiency secondary to maternal hypertensive disorders. A hallmark of IUGR is a decrease in circulating docosahexaenoic acid (DHA), an �...2022
20 Effects of Acute Hypoxia and High pCO2 on Total Protein Content and Metabolic Enzyme Activity in Rockfishes (Sebastes SPP.)Climate change is altering ocean chemistry and wind-driven upwelling regimes. In the California Current System (CCS), these changes are exposing nearshore fishes to increasing levels of high pCO2 and hypoxia. These stressors co-occur during upwelling events, lasting hours to days, and both have the ...2019
21 Smith, SarahEffects of Mitochondrial Mobility on Astrocyte FunctionWithin the brain, astrocytes provide support and influence the excitability of neurons by regulating the extracellular levels of potassium (K+) and glutamate. These glial cells play a vital role in neural homeostasis by regulating the concentration of neurotransmitters at the synapse, therefore modu...2018
22 Lebrecht, MarandaEffects of ventilatory regimens on the prevalence of a common gastrointestinal disease in neonatesNecrotizing Enterocolitis, or NEC, is a common intestinal disease of preterm neonates. It is believed that bacterial colonization increases the risk of NEC. This study examines whether the type of ventilation of the neonate, either mechanical ventilation (MV) or non-invasive support (NIS), and the ...Enterocolitis, Neonatal necrotizing - Research; Newborn infants - Diseases; Sheep as laboratory animals - Research; Necrotizing enterocolitis; Lymphocytes2016-05
23 Muehlman, JayantiEffects of Wind-Generated Underwater Noise on Southern right Whale Group DynamicThe goal of this study was to investigate whether underwater noise affects the grouping behavior of southern right-whale (Eubalaena australis) mother-calf pairs at Península Valdés, Argentina. This area is a major calving ground for the population that occupies the western South Atlantic. Two larg...2020
24 Mercer, MarianneEstablishing a System for Structure-Function analysis of the Novel Role that NUP153 Plays in Nuclear AssemblyIn mitosis, equal partitioning of DNA between daughter cells requires an integrated series of events. At the start of anaphase the chromatin separates and forms two chromatin discs. This chromatin is then targeted by nuclear membrane proteins and membrane to form the nuclear envelope. These membrane...2018
25 Davis, Kacey A.Expression and Purification of Augertoxins: Searching for Novel Protein Folds in Venomous Marine SnailsThis study describes a method for bacterial expression and purification of previously uncharacterized proteins. The proteins chosen for this study come from auger snail toxins, which have evolved to help the snail hunt and kill their prey. Evolutionary pressure between predator and prey selects for ...2018
26 Borrowman, WilliamGas exchange of co-occurring plant species of the Great Basin Desert in an irrigated common gardenThe majority of plants in the Great Basin ecosystem have adapted to cope with drought during summer. While general characteristics of these plants have been studied in non-managed environments it is important to investigate the physiology of these plants when additional water is supplied. In this ...Urban heat island -- Prevention; Desert plants -- Ecology -- Great Basin -- Research; Plant ecophysiology -- Research; Irrigation -- Environmental aspects; Red Butte Garden (Salt Lake City, Utah)2014-04
27 Loret, AmyGenetic Modifiers of Severity in Collagen VI-Related Muscular DystrophyCollagen VI-related muscular dystrophies (COL6-RD) display phenotypic heterogeneity that includes mild Bethlem myopathy (BM), intermediate (INT), and severe Ullrich congenital muscular dystrophy (UCMD) phenotypes. COL6-RD are characterized by mutations within the collagen VI genes (COL6A1, COL6A2, a...heterogeneity; characterized; Resulting symptoms2019
28 Rahmati, KasraGenetically Modified Chemotaxis Signaling Protein Chey Binds to the Rotor Protein Flin to Control the Direction of Flagellar Rotation in Escherichia ColiBacterial chemotaxis is the directed movement of a bacterium in response to environmental chemical stimuli. Cells of E. coli, for example, swim by rotating their flagella and direct their movement by regulating reversals between counterclockwise (CCW) and clockwise (CW) rotation. The switch from CCW...2020
29 Acosta, LehiGenotype-dependent susceptibility to influenza and titer-virulence discordanceThe influenza a virus (IAV) is a major source of human mortality and both recent and anticipated pandemics make understanding this major human pathogen of paramount importance1,2. The use of mouse models allows us to experimentally manipulate critical variables to more fully understand the dynamics ...Influenza A virus - Research; Mice as laboratory animals - Research; Transmissibility; Virulence; Viral titers; Erythropoeintin2016-05
30 Kutschke, MichaelHip joint center differences between dual fluoroscopy, functional hip, and coda - establishing a reference standardMeasurements of joint angles, moments, and forces may be highly sensitive to positional changes in the center of a joint. Due to its deep location, the human hip joint center (HJC) can be difficult to determine. Previous studies have defined the HJC relative to external landmarks using infrared moti...Hip joint; Hip joint center2015-05
31 Thomas, NathanielThe HIV-protective bystander effect in macrophages is viral glycoprotein dependent and likely conferred via upregulation of ISG IFITM3During an immune response against a specific antigen, often during viral infections, T cells not specific to the antigen can be activated, a phenomenon known as bystander response. The "bystander response" has been studied extensively in T cells, but when examined for macrophages through the lens of...2022
32 Lan, Yung-ChiHYPO-osmolarity and glucose starvation localizes slm1 to mitochondria- A novel stress response pathwaySynthetic Lethal with Mss4 1 (Slm1) is a key protein found in the crossroad of the Membrane Compartment of Can1 (MCC) and the Membrane Compartment of TORC2 (MCT). The two compartments on the plasma membrane of budding yeast (Saccharomyces cerevisiae) are responsible for APC transporter regulation an...2022
33 Weaver, BradleyHypoxia and the mesenchymal transition in gliomaRecent advances in targeted therapy for cancer have had little influence on survival for patients diagnosed with Glioblastoma (GBM, WHO Grade IV tumors), and median survival time remains stagnant at 12-15 months post diagnosis. Genomic profiling of GBM indicates clear phenotypic subsets of these tum...Glioblastoma multiforme; Gliomas; Hypoxia; Mesenchymal transition2014-04
34 Fackler, Anderson N.Identification of Kin-20 and UNC-119 Knockout suppressors associated with neuronal development and maintenance in C. elegansNeurons comprise the nervous system-the essential signaling and communication system for nearly all multicellular organisms. To coordinate cells across an entire organism, they must grow to be relatively long. Therefore, neurons extend axons from the cell body. Immature neurons extend growth cones a...2018
35 Identification of potential causes for increased central line associated bloostream infection rates in the University of Utah NICUThe University of Utah Newborn Intensive Care Unit (UUNICU) has seen a recent increase in rate of Central Line Associated Bloodstream Infection (CLABSI) after an extended period of 965 days with no CLABSI's. Unfortunately, in the last three years, infection rate has been on average 2.6 CLABSI per ye...2023
36 Ong, ElaineIdentifying Natural Genetic Modifiers of Apoptosis and Retinal DegenerationApoptosis, or cell death, is an integral part of many diseases such as neurodegeneration, retinal degeneration, and cancer, yet it is unclear how apoptosis varies among individuals in a population. Retinitis pigmentosa (RP) is a retinal degeneration disease characterized by phenotypic heterogeneity ...2018
37 Pearson, CassidyMajor Urinary Protiens as a signal of genetic Quality and Infection statusThe Hamilton-Zuk hypothesis suggests that susceptibility to infectious disease is so important that many physical traits, particularly secondary sexual characters, will evolve to signal genetic quality for resistance to prospective mates. We expanded upon this theory using the house mouse (Mus muscu...2018
38 Shimko, TylerMapping suppressors of premature sperm activation in C. ElegansThe sperm of the roundworm Caenorhabditis elegans move by a crawling motion, in contrast to mammalian sperm, which exhibit a swimming motion. This method of locomotion makes the sperm of C. elegans an excellent model for examining cell motility. In order to become motile, the sperm must undergo the ...Caenorhabditis elegans -- Spermatozoa; Sperm activation2015-05
39 Astin, Holly M.Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish2016
40 Astin, M. HollyModulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in ZebrafishThe liver X receptors (LXRs) are important regulators of lipid and cholesterol metabolism and control diverse pathways in development, reproduction, metabolism, immunity and inflammation. Thus, LXRs have potential as therapeutic targets for diseases as diverse as lipid disorders, atherosclerosis...Liver X receptors - Research; Zebrafish - genetics2016-08
41 Watson, AndrePatterns of parasitism in a common Utah RodentMale-biased parasitism, where males are more commonly infected with and have higher parasite loads, is common across vertebrate taxa. Several factors could be driving this pattern. The immunocompetence handicap hypothesis suggests that higher testosterone levels in males suppress immune function whi...2022
42 Radhakrishnan, ParvathiPI3K inhibitors as potential new therapy against breast cancer progressionReceptor tyrosine kinases (RTKs) and their pleiotropic effectors play key roles in metastasis. Met and Ron are RTKs that have been shown to contribute to tumor growth and metastasis in both animal models and in patients. Recently, an alternative Ron isoform known as "short-form" Ron (sfRon) was asso...Breast - Cancer - Treatment - Research; Protein - tyrosine kinase - inhibitors - Therapeutic use; Enzyme inhibitors - Therapeutic use. - Research; Biology - Research2014-05
43 Lee, HaniPost-traumatic headache: an opportunity to develop new preclinical models for better understanding of pathology and treatmentPost-traumatic headache (PTH) is identified as one of the most frequent symptoms following traumatic brain injury (TBI) (Faux & Sheedy, 2008). Despite the high prevalence, there are currently no treatments which specifically target PTH. Instead of etiology-specific treatments, individuals suffering ...2022
44 Christensen, KianaQuantifying Patterns of Squamate Dental ComplexitySquamate reptiles are ideal subjects for investigating relationships between diet and dentition patterns because they exhibit wide dietary diversity and taxonomic abundance. Most previous research is qualitative and limited to a basic assessment of the influence diet has on dentition (Hotton, 1955; ...2020
45 Ellis, James H.Refractory status epilepticus and chronic kidney disease in a large pedigree due to a variant in the mitochondrial encoded trna phenylalanine (MT-TF) geneMitochondrial disorders present with a wide spectrum of neurological manifestations. Clinical syndromes are described largely by phenotypic indicators. Epilepsy is a common but not universal feature. Myoclonus epilepsy with ragged red fibers (MERRF) is a common clinical syndrome that presents with e...2018
46 Bader, CecilyThe Response of Arabidopsis Mutant BPS1-2 on Salt MediaHow would our world change if salt tolerance could be engineered in plants? The Arabidopsis mutant bps1-2 has been shown to respond differently on salt media than a nonmutated plant would. In normal conditions, the bps1-2 mutant will arrest development in the root and shoot shortly after germination...2017
47 Excell, KaterinaThe role of amyloid precursor protein in a model of alzheimer's diseaseAlzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ...2022
48 Nau, AdamThe role of heparan sulfate in maintaining stereotyped birdsongSong learning in Zebra Finches (Taeniopygia guttata) occurs during a critical period between 30-90 post hatch days, and involves acquisition of an acoustic model and a sensorimotor period of increasingly improving imitation of this model. Young birds sing highly variable songs early during this pe...Birdsongs - Research; Zebra finch - Research; Songbirds - Behavior; Heparan sulfate; Taeniopygia guttata; Neural circuitry2016-04
49 Russell, NicoleThe Role of Introns Within Alpha Conotoxin Genes in Cone SnailsCone snails, of which there are more than 600 species, have attracted a lot of attention. Cone snails, found in warm tropical waters across the world, are predators and produce venoms comprising diverse toxins. These toxins, termed conotoxins, have been the subject of a great amount of research. Whi...2016
50 Wang, ZhirongThe role of the autism-associated gene kirrel3 in synapse formationAlterations in the gene Kirrel3 are repeatedly associated with intellectual disability and autism. Kirrel3 regulates synapse formation in C. elegans but the role of Kirrel3 in synapse formation in the mammalian brain is unknown. In mice, Kirrel3 is expressed in specific cell types throughout the bra...Autism -- Genetic aspects; Synapses; Kirrel3 gene; Synapse formation2015-04
51 Wheeler, MayaRole of WNT-Dependent Neurogenesis in Functional Recovery Following Spinal Cord InjuryIn humans and other adult mammals, spinal cord injury leads to a permanent loss of motor and sensory function. The biggest obstacle to recovery is the inability of severed axons and neurons to regenerate. During embryogenesis, all vertebrates have a population of neural stem cells called radial glia...2019
52 Kannan, Sarmishta DiraviamThe Role that Lysosomes and Autophagy play in Alveolar soft parts Sarcoma, clear cell Sarcoma and Synovial SarcomaSarcomas are cancer of the connective tissue and are very deadly group of cancers. Two of the sarcoma types, alveolar soft parts sarcoma (ASPS) and clear cell sarcoma (CCS) have a unique vacuolar morphology. This unique morphology is absent in synovial sarcoma (SS). We believe that the unusual morph...2017
53 Nguyen, NamRoles of Transient Receptor Potenitial Ankyrin-1 and Vanilloid-3 in Endoplasmic Reticulum stress and Cytotoxicity in Lung Epithelial CellsAir pollution is a growing global health issue with considerable local relevance. In particular, exposure to wood smoke particulate matter (WSPM) is associated with the development and exacerbation of chronic inflammatory conditions and irreversible damage of the airways and alveoli. However, exact ...2020
54 Hunter, SamuelSignaling Role of the Hamp Domain in the Escherichia Coli Serine ChemoreceptorThe chemoreceptor Tsr enables Escherichia coli to track serine gradients in its environment. Binding of serine to the periplasmic domain propagates a signaling conformational change through other domains of the chemoreceptor molecule to modulate the activity of CheA, a kinase associated with t...Chemoreceptors - Research2016-07
55 Hahm, SuhyunStressors of varying properties induce differences in the modulation of behavior and biologyStress induces enduring behavioral and biological consequences. Despite its pervasiveness, the biological and neural processes underlying its effects remain largely unknown. The existing literature generally examines the repercussions of stress from the aspect of a single stressor; however, stressor...2022
56 Skedros, Gregory AthanasiosStructural and material changes in the sheep radius from newborn to adult: Functional adaptation versus developmental constraintBones that exhibit marked changes in structural and material characteristics during ontogeny are potentially useful for studying the mechanisms that produce functional adaptations. The diaphyseal region of the sheep radius was examined because it is relatively simply loaded in cranial-caudal bending...Functional adaptations - Sheep; Developmental constraint - Sheep; Ontogeny2015-08
57 Watkins, Ryan DavisSuppression of lymphangiogenesis using VEGF-C trapThe lymphatic system is responsible for controlling systemic fluid buildup. Lymphangiogenesis is a dynamic process involving sprouting, and maintaining new lymphatic vasculature. Vascular endothelial growth factor C (VEGF-C) is as a key growth factor that induces lymphangiogenesis by binding VEGF re...Lymphatics - Growth; Vascular endothelial growth factors - Antagonists; Lymphangiogenesis; VEGF-C trap2014-05
58 Domagala, DrueSynthesis of protacs to inhibit toll-like receptorsThe immune system is the body's defense against pathogens. Since it has to be able to withstand the fast-evolving nature of microscopic invaders, the immune system has a variety of mechanisms to recognize and destroy them. One way that pathogens are recognized is through toll-like receptor (TLR) sig...2022
59 Roestenburg, JessicaTesting the Perceptual Salience of Spectral Content in Zebra Finch SongBirds actively adjust the resonance properties of the upper vocal tract during singing, which results in specific harmonic structures of song elements. To what degree upper vocal tract filtering is relevant for the perceptual salience of song is poorly understood. This research utilizes (1) a biolog...2018
60 Woodruff, DerekUncovering Synaptic Defects resulting from loss of the intellectual disability and autism-associated gene Kirrel3Neurodevelopmental disorders severely impact an individual's life. Surprisingly, the genetic and cellular cause of over half of intellectual disability cases and more than 80% of autism spectrum disorders remain undiscovered1,2. It is likely that mutations in molecules regulating synapse development...2017
61 Checketts, CynthiaWhy white mice? improving biological literacy through animal historyThroughout the undergraduate experience, biology students are introduced to hundreds of experiments, theories, and principles, many of which are rooted in animal experimentation. However, in required and information-heavy biology courses, the erasure of animals from the scientific story-which repres...2021
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