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Creator | Title | Description | Subject | Date |
| 1 |
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Normann, Richard A.; Campbell, Patrick K.; Jones, Kelly E. | 100 electrode intracortical array: structural variability | A technique has been developed for fabricating three dimensional "hair brush" electrode arrays from monocrystalline silicon blocks. Arrays consist of a square pattern of 100 penetrating electrodes, with 400 microns interelectrode spacing. Each electrode is 1.5mm in length and tapers from about 100 m... | Microelectrode arrays; Stimulation; Micromachining | 1990 |
| 2 |
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Horch, Kenneth W.; Christensen, Douglas A. | Accelerated 4-year bachelors/masters degree program in biomedical engineering | In response to the need for providing advanced engineering education in a shorter time period than is currently possible by traditional curricula, we have created an Accelerated Dual Degree program in biomedical engineering. The purpose of this pilot program is to attract the brightest students, g... | Accelerated dual-degree program | 2002 |
| 3 |
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Horch, Kenneth W.; Christensen, Douglas A. | Accelerated 4-year bachelors/masters degree program in biomedical engineering | In response to the need for providing advanced engineering education in a shorter time period than is currently possible by traditional curricula, we have created an Accelerated Dual Degree program in biomedical engineering. The purpose of this pilot program is to attract the brightest students, g... | Accelerated; Dual-degrees; Education | 2002 |
| 4 |
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Christensen, Douglas A.; Horch, Kenneth W. | Accelerated dual-degree BS/MS program - experience with the first three years | We have initiated a pilot program that accelerates the studies of a small group of highly qualified students early in their college careers and allows them to earn both a bachelor's degree and a master's degree in about four years after starting college. It does this by introducing them early to res... | Accelerated dual-degree program | 2004 |
| 5 |
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Christensen, Douglas A. | Acoustic droplet vaporization, cavitation, and therapeutic properties of copolymer-stabilized perfluorocarbon nanoemulsions | Acoustic and therapeutic properties of Doxorubicin (DOX) and paclitaxel (PTX)-loaded perfluorocarbon nanoemulsions have been investigated in a mouse model of ovarian cancer. The nanoemulsions were stabilized by two biodegradable amphiphilic block copolymers that differed in the structure of the hydr... | Cancer therapy; Targeted drug delivery; Nanobubbles; Ultrasound; Perfluoropentane | 2009 |
| 6 |
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Horch, Kenneth W. | Acoustic interneurons of fiddler and ghost crabs | The properties of acoustic interneurons in fiddler (Uca pugilalor and U. minax) and ghost (Ocvpade qucldrula) crabs are described, as revealed bv tests with pure tones. Three types of interneurons were present in all species: tonic, which fired for the duration of the stimulus; phasic, which fire... | Acoustic crabs; Neural recording; Vibration reception | 1976 |
| 7 |
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Horch, Kenneth W. | Action potential classification with dual channel intrafascicular electrodes | Using recordings of peripheral nerve activity made with carbon fiber intrafascicular electrodes, we compared the performance of three different recording techniques (single channel, differential, and dual channel) and four different unit classification methods (linear discriminant analysis, temp... | Carbon fiber intrafascicular electrodes; Dual channel recording | 1994 |
| 8 |
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Horch, Kenneth W.; Lawrence, Steve M.; Dhillon, Gurpreet S. | Acute peripheral nerve recording characteristics of polymer-based longitudinal intrafascicular electrodes | We examined the recording characteristics of two different types of polymer-based longitudinal intrafascicular electrodes (LIFEs) in peripheral nerve: single-stranded (s-polyLIFEs) and multistranded (m-polyLIFEs). Recordings were also made from Pt-Ir wire-based electrodes (PtIrLIFEs) as a control. T... | Sciatic Nerve; Intrafascicular Electrodes, Peripheral Nerve Recording | 2004 |
| 9 |
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Normann, Richard A.; Jones, Kelly E. | Advanced demultiplexing system for physiological stimulation | A CMOS very large scale integration (VLSI) chip has been designed and built to implement a scheme developed for multiplexing/demultiplexing the signals required to operate an intracortical stimulating electrode array. Because the use of radio telemetry in a proposed system utilizing this chip may im... | Electrode Array; Stimulation; Telemetry; Microelectrodes; Transistors | 1997 |
| 10 |
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Horch, Kenneth W. | Are the extrinsic muscles better suited for signaling joint angles or finger tip location? | We used a biomechanical model of the human long finger to determine whether the extrinsic muscles are better suited for estimating the finger's joint angles or for estimating location of the finger tip. We found that two of the extrinsic muscles together could provide information sufficient to direc... | Extrinsic muscles; Metacarpophalangeal joint; Biomechanical models | 1997 |
| 11 |
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Gesteland, Raymond F.; Ives, Jeffrey T.; Stockham, Thomas G. | Automated film reader for DNA sequencing based on homomorphic deconvolution | An automated reader for electrophoresis based DNA sequencing methods is described that provides fast and accurate sequence determination. Digitized sequencing lanes are processed with homomorphic blind deconvolution in preparation for peak detection, interlane alignment, peak refinement and base cal... | Sequence Analysis; Electrophoresis; Automated Film Reader; Homomorphic Deconvolution | 1994 |
| 12 |
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Christensen, Douglas A. | Biosensor development at the University of Utah | Interest in biosensors has increased rapidly in the past few years due to the many potential advantages of these devices, such as small size, speed of response, and specificity 111. The term "biosensor" in the broad sense describes any device or apparatus which detects biological signals for the pu... | Silicon retina; Photosensing array; CHEMFET; Fluorescence lmmunosensor; Planar waveguide | 1994-07 |
| 13 |
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Christensen, Douglas A. | Bringing an integrative modeling experience to a freshman biomedical engineering course | As an integrating lab experience in our Fundamentals of Bioengineering freshman course, we have included a Major Project that ties together many of the principles of biomechanics and bioelectricity covered in the lecture. It uses the human systemic cardiovascular system as a model. During the first... | Matlab | 2004 |
| 14 |
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Gesteland, Raymond F. | Cell-free synthesis of herpes simplex virus proteins | Polyribosomes isolated from herpes simplex virus type I (HSV-1)-infected cells have been used to program a eucaryotic cell-free translation system. At least 10 HSV-specific polypeptides, with apparent molecular weights of 25,000 to 160,000, are synthesized by wild-type HSV-infected polyribosomes. Po... | Viral Proteins; Herpes Simplex; Peptide Biosynthesis; Thymidine Kinase | 1977 |
| 15 |
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Horch, Kenneth W. | Changes in primary afferent depolarization of sensory neurones during peripheral nerve regeneration in the cat | I. Micro-electrode recordings were made from normal and regenerating sural nerve fibres in cats. Increases in the excitability of the central terminals of these fibres after conditioning stimulation of other sural nerve fibres were taken as evidence for primary afferent depolarization. 2. At all... | Micro-electrode recording; Nerve regeneration; Primary afferent depolarization | 1981 |
| 16 |
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Collins, Zachary J.; Poelzing, Steven | Characterization of a four-camera ratiometric optical mapping system | Electrical activity precedes calcium mediated heart contractions. Optical mapping takes advantage of minimally invasive fluorescent molecular probes to image both electrical and calcium activity. These molecular probes allow for ratiometric imaging. We characterize a four camera system capable of... | Optical mapping; Ratiometric imaging; Di-4-ANEPPS; Indo-1; Trapeze Interactive Poster | 2010-03-15 |
| 17 |
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Gesteland, Raymond F. | Characterization of lysozyme messenger and lysozyme synthesized in vitro | In vitro systems for protein systhesis have been in wide use for about 10 years. In most of the early work protein synthesis was measured by following the incorporation of radioactive amino acids into acid precipitable material. This test cannot distinguish between the synthesis of complete, activ... | Lysozyme Messenger; Lysozyme Synthesized; Protein Synthesis | 1969 |
| 18 |
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Vardhan, Avantika | Characterizing growth patterns in longitudinal MRI using image contrast | Understanding the growth patterns of the early brain is crucial to the study of neuro-development. In the early stages of brain growth, a rapid sequence of biophysical and chemical processes take place. A crucial component of these processes, known as myelination, consists of the formation of a myel... | | 2014-01-01 |
| 19 |
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Angelucci, Alessandra; Lund, Jennifer S. | Circuits for local and global signal integration in primary visual cortex | Contrast-dependent changes in spatial summation and contextual modulation of primary visual cortex (V1) neuron responses to stimulation of their receptive field reveal long-distance integration of visual signals within V1, well beyond the classical receptive field (cRF) of single neurons. To identif... | Primary Visual Cortex; Extrastriate Cortex; Feed-back Connections; Lateral Connections; SUrround Modulation; Macaque | 2002-10-01 |
| 20 |
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Horch, Kenneth W. | Classification of action potentials in multi unit intrafascicular recordings using neural network pattern recognition techniques | Neural network pattern-recognition techniques were applied to the problem of identifying the sources of action potentials in multi-unit neural recordings made from intrafascicular electrodes implanted in cats. The network was a three-layer connectionist machine that used digitized action potenti... | Intrafascicular electrodes; Multi-unit neural activity; Artificial neural networks | 1994 |
| 21 |
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Horch, Kenneth W. | Closed loop control of ankle position using muscle afferent feedback with functional neuromuscular stimulation | This paper describes a closed-loop functional neuromuscular stimulation system that uses afferent neural activity from muscle spindle fibers as feedback for controlling position of the ankle joint. Ankle extension against a load was effected by neural stimulation through a dual channel intrafasc... | Neuromuscular stimulation; Functional neuromuscular stimulation (FNS); Neural electrodes | 1996 |
| 22 |
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Normann, Richard A.; Shoham, Shy | Coding of position by simultaneously recorded sensory neurones in the cat dorsal root ganglion | Muscle, cutaneous and joint afferents continuously signal information about the position and movement of individual joints. How does the nervous system extract more global information, for example about the position of the foot in space? To study this question we used microelectrode arrays to record... | Cats; Sensory Neurones; Movement; Limb Position | 2004 |
| 23 |
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Christensen, Douglas A.; Herron, James N. | Comparison of robust coupling techniques for planar waveguide immunosensors | We have analyzed and fabricated two different coupling schemes to meet the requirements for a convenient means of coupling into a planar waveguide immunosensor that is relatively insensitive to beam alignment. These are the "launch" coupler and the grating coupler. Each possesses advantages and dis... | Planar waveguide immunosensors; Fluorescence; Launch coupler; Grating coupler | 1993 |
| 24 |
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Christensen, Douglas A. | Computer-aided design of two-dimensional electric-type hyperthermia applicators using the finite-difference time-domain method | A hyperthermia applicator design tool consisting of a finite-difference time-domain (FDTD) technique in combination with a graphical display of electric fields and normalized linear temperature rise is described. This technique calculates, rather than assumes, antenna current distributions; it incl... | Finite-difference time-domain method; Hyperthermia applicator | 1991-09 |
| 25 |
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Horch, Kenneth W. | Control of ankle position using neural feedback | This paper describes a closed loop control system that uses afferent neural activity from muscle spindle fibers as feedback for controlling ankle position. The gastrocnemius muscle was stimulated through a dual channel intrafascicular electrode implanted in a fascicle of the tibial nerve. Dual cha... | Neuromuscular stimulation; Peripheral nerve; Joint angle | 1994 |
| 26 |
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Normann, Richard A. | Control of retinal sensitivity. I. Light and dark adaptation of vertebrate rods and cones | Rods and cones in Necturus respond with graded hyperpolarization to test flashes spanning about 3.5 log units of intensity. Steady background levels hyperpolarize the rods, and the rod responses become progressively smaller as background level is increased. In cones, higher background levels reduce... | Retina;Light and Dark Adaptation; Recepters; Bipolars; Ganglion Cells | 1974 |
| 27 |
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Gesteland, Raymond F.; Krapcho, Karen J.; Talbot, Phil; Thulin, Craig | Crystallization of the MS2 translational repressor alone and complexed to bromouridine | The coat protein from the MS2 bacteriophage plays a dual role by encapsidating viral RNA and also by binding RNA as a translational repressor. In order to study the isolated dimer in a conformation not influenced by capsid interactions, a mutant molecule was crystallized that is defective in capsid ... | Crystallization; RNA Bacteriophage; RNA Hairpin; Translational Repressor | 1995 |
| 28 |
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Horch, Kenneth W. | Differential activation of nerve fibers with magnetic stimulation in humans | Earlier observations in our lab had indicated that large, time-varying magnetic fields could elicit action potentials that travel in only one direction in at least some of the myelinated axons in peripheral nerves. The objective of this study was to collect quantitative evidence for magnetically in... | Magnetic stimulation; Peripheral nerve; Electromyographic potential; Somatosensory potential | 2006 |
| 29 |
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Horch, Kenneth W.; Dhillon, Gurpreet S. | Direct neural sensory feedback and control of a prosthetic arm | Evidence indicates that user acceptance of modern artificial limbs by amputees would be significantly enhanced by a system that provides appropriate, graded, distally referred sensations of touch and joint movement, and that the functionality of limb prostheses would be improved by a more natural co... | Peripheral Nerve Implant; Prosthetic Limb Control; Sensory Feedback | 2005-12 |
| 30 |
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Christensen, Douglas A. | Dispersion effects in fiber optic interferometry | An extended analysis of the effects of uncompensated fiber dispersion on the fringe visibility of a fiber optic interferometer is developed, with particular emphasis on stellar interferometry. Both material and waveguide dispersion for single-mode, polarization-preserving fibers are considered. It... | Stellar interferometry; Fiber optics; Statistical optics | 1997 |
| 31 |
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Gesteland, Raymond F.; Atkins, John F.; Ingram, Jennifer A.; Kelly, Paul J.; Grentzmann, Guido | Dual-luciferase reporter system for studying recoding signals | A new reporter system has been developed for measuring translation coupling efficiency of recoding mechanisms such as frameshifting or readthrough. A recoding test sequence is cloned in between the renilla and firefly luciferase reporter genes and the two luciferase activities are subsequently measu... | Amino Acid Sequence; Genes, Reporter; HIV; Antizyme; Translation | 1998 |
| 32 |
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Normann, Richard A. | Effects of background illumination on the photoresponses of red and green cones | 1. The photoresponses of light- and dark-adapted red and green cone photoreceptors were recorded intracellularly in the retina of the turtle, Pseduemys scripta elegans. Background illumination produced similar effects on both types of cones. 2. In response to the onset of a prolonged, steady backgro... | Turtles; Adaptation, Ocular; Retina; Signal Transmission | 1979 |
| 33 |
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Normann, Richard A.; Chandler, John P. | Effects of calcium ions on L-type horizontal cells in the isolated turtle retina | A technique by which the retina can be isolated from the turtle eye is described. Scanning electron microscopy revealed morphological variability between preparations and also between regions of the same one. Large areas were often totally free of any pigment epithelial cells, yet contained a high p... | Retina; Calcium; Horizontal Cell; Turtle | 1990 |
| 34 |
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Normann, Richard A. | Effects of GABA and related drugs on horizontal cells in the isolated turtle retina | The role of GABA in the outer plexiform layer of the turtle retina has been examined by intracellular recordings from L- and C-type horizontal cells in the isolated retina preparation. GABA (1-5 mM) slightly depolarized the L-type horizontal cells, reduced the amplitude of their photoresponses, and ... | Retina; Horizontal Cells; Synapse; Negative Feedback; GABA; Turtle | 1990 |
| 35 |
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Christensen, Douglas A. | Effects of increased energy prices on U.S. agriculture: an econometric approach | Although the contents of this manuscript remain the responsibility of the authors, we wish to thanks a group of reviewers for the time and conscientious effort they put forth to solidify this final draft. Andrew Morton, Brian Holding, Wesley Buchele, and Arnold Paulsen deserve much credit for their ... | Energy prices | 1981 |
| 36 |
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Hendee, Shonn P.; Faour, Fouad A.; Christensen, Douglas A.; Patrick, Baharah; Durney, Carl H.; Blumenthal, Donald K. | Effects of weak extremely low frequency magnetic fields on calcium/calmodulin interactions. | Mechanisms by which weak electromagnetic fields may affect biological systems are of current interest because of their potential health effects. Lednev has proposed an ion parametric resonance hypothesis (Lednev, 1991, Bioelectromagnetics, 12:71-75), which predicts that when the ac, frequency of a c... | Electromagnetic Fields; Calcium-binding Proteins; Lednev's Theory | 1996-06 |
| 37 |
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Gesteland, Raymond F.; Weiss, Robert B. | Efficient shine- Dalgarno sequence but not translation is necessary for LacZ mRNA stability in Escherichia coli | The 5' ends of many bacterial transcripts are important in determining mRNA stability. A series of Shine-Dalgarno (SD) sequence changes showed that the complementarity of the SD sequence to the anti-SD sequence of 16S rRNA correlates with lacZ mRNA stability in Escherichia coli. Several initiation c... | Protein Biosynthesis; Ribosomes; Escherichia coli; Shine-Dalgarno Sequence | 1994 |
| 38 |
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Horch, Kenneth W. | Electrical stimulation of the ventral lumbo-sacral spinal cord results in mixed recruitment order of quadriceps and tibialis anterior motor units | Pulse width modulated, twitch recruitment curves for quadriceps and tibialis anterior were obtained by stimulating their respective motor activation pools in the ventral lumbo-sacral portion of the spinal cord. The duration of the twitch responses were analyzed as a function of stimulus strength ... | Quadriceps; Tibialis anterior; Ventral lumbo-sacral spinal cord; Reversed recruitment | 1997 |
| 39 |
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Normann, Richard A.; Shoham, Shy | Encoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglion | Recent advances in microelectrode array technology now permit a direct examination of the way populations of sensory neurons encode information about a limb's position in space. To address this issue, we recorded nerve impulses from about 100 single units simultaneously in the L6 and L7 dorsal root ... | Sensory; Encoding; Multielectrode; Dorsal Root Ganglion; Cutaneour; Muscle | 2004 |
| 40 |
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Christensen, Douglas A.; Herron, James N. | Evanescent coupling in a waveguide fluoroimmunosensor | A key factor in the analysis of evanescently-coupled optical sensors, such as the planar waveguide immunosensor analyzed here, is the efficiency of coupling between the optical waveguide modes and the fluorescent sources located on the surface of the waveguide. This is an important parameter in dete... | Evanescent coupling; Waveguide; Fluoroimmunosensor | 1992 |
| 41 |
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Gesteland, Raymond F.; Atkins, John F. | Evolutionary specialization of recoding: frameshifting in the expression of S. cerevisiae antizyme mRNA is via an atypical antizyme shift site but is still +1 | An autoregulatory translational shift to the +1 frame is required for the expression of ornithine decarboxylase antizyme from fungi to mammals. In most eukaryotes, including all vertebrates and a majority of the studied fungi/yeast, the site on antizyme mRNA where the shift occurs is UCC-UGA. The me... | Antizyme; ODC; Polyamines; Frameshifting | 2006 |
| 42 |
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Christensen, Douglas A.; Horch, Kenneth W. | Experience with the first three years of an accelerated dual-degree program in biomedical engineering | Our Department of Bioengineering has instituted a pilot program aimed at helping a select group of highly qualified students obtain both bachelor's and master's degrees in an accelerated timeframe-approximately four years from the beginning of their university studies. A key element of this progra... | Accelerated; Dual-degrees; Education | 2004 |
| 43 |
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Christensen, Douglas A. | Extending the two-dimensional FDTD method to hybrid electromagnetic systems with active and passive lumped elements | This paper extends the finite-difference time-domain (FDTD) method to include distributed electromagnetic systems with lumped elements (a hybrid system) and voltage and current sources. FDTD equations that include nonlinear elements like diodes and transistors are derived. Calculation of driving-p... | Finite-difference time-domain method; Lumped elements | 1992-04 |
| 44 |
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Christensen, Douglas A. | FDTD modeling in the design of optical chemical sensor structures | The finite-difference time-domain method (FDTD) is a numerical technique for solving Maxwell's equations in a discretized space and time frame. It has been used extensively in the analysis of electrically large structures in the microwave domain, but has only recently been applied to optical proble... | Finite-difference time-domain method; Immunochemical fluorosensors; Planar waveguides | 1991 |
| 45 |
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Christensen, Douglas A.; Vincent, G. Michael | Fiberoptic laser angioplasty probe with optical steerability | We have designed and bench tested an optically steerable fiberoptic probe for use in laser angioplasty. The unique feature of this design is the use of a gradient-index (GRIN) lens attached to the distal end of a seven-fiber bundle. By selecting which fiber of the bundle is illuminated by the source... | Fiberoptic probe; GRIN lens; Steerability | 1990 |
| 46 |
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Christensen, Douglas A. | Finite-difference time-domain modeling and experimental characterization of planar waveguide fluorescence sensors | The finite-difference time-domain method (FDTD) is a powerful numerical technique for solving Maxwell's equations in a discretized space and time grid. Its applications have up to now been in the analysis of electrically large structures in the microwave domain, and the scope of investigations has b... | Finite-difference time-domain method; Planar waveguide | 1992 |
| 47 |
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Gesteland, Raymond F.; Atkins, John F. | Frameshifting in gene 10 of bacteriophage T7 | Gene 10 of bacteriophage T7, which encodes the most abundant capsid protein, has two products: a major product, 10A (36 kDa), and a minor product, 10B (41 kDa). 10B is produced by frameshifting into the -1 frame near the end of the 10A coding frame and is incorporated into the capsid. The frameshift... | Frameshifting; Bacteriophage T7; RNA, Viral; Gene Expression | 1991 |
| 48 |
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Normann, Richard A. | Functional reorganization of primary visual cortex induced by electrical stimulation in the cat. | Compared to the high degree of plasticity observed in a juvenile, mature sensory cortices have long been held to be immutable but, recently, researchers have suggested some plasticity persists in the mature cortex. Cortical reorganization has particular saliency to the development of a cortically ba... | Cat; Electrophysiology; Phosphene; Plasticity; Receptive Field; Striate Cortex | 2005 |
| 49 |
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Christensen, Douglas A. | General formulation for connecting sources and passive lumped-circuit elements across multiple 3-D FDTD cells | A previous extension of the finite-difference time-domain (FDTD) method to include lumped-circuit elements is further extended to model lumped-element circuits connected across multiple FDTD cells. This formulation is needed to model many kinds of circuits, like those with a transistor or other ac... | Finite-difference time-domain method; Lumped-element circuit; Dielectric; Microstrip | 1996-02 |
| 50 |
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Horch, Kenneth W. | Identification of single units in multi-unit recordings from peripheral nerves | We are developing a computer-based method for identifying individual action potentials in multi-unit peripheral nerve recordings. Threshold level, sinusoidal stimuli are used to elicit phase-locked activity from single units. These action potentials are digitized, and a template is constructed usin... | Peripheral nerve; Neural recordings; Cutaneous mechanoreceptors | 1988 |
| 51 |
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Christensen, Douglas A.; Andrade, Joseph D. | Improved sensitivity in ellipsometry of thin biochemical films by employing sublayers | Ellipsometry is widely used for investigating the optical properties of thin films on planar substrates, including films of adsorbed proteins or polymers. The average thickness and effective refractive index of the adsorbed layer are calculated by measuring the A and ¥ ellipsometry parameters. Unfo... | Biochemical films; SiO2 sublayer | 1990 |
| 52 |
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Christensen, Douglas A. | Influence of temperature probe sheathing materials during ultrasonic heating | The influence of sheathing materials upon temperature probes used during the monitoring of ultrasonic heating was measured. The measurements show that the sheathing can be heated in a manner not representative of the temperature rise occurring in the surrounding material, altering the probe reading... | Ultrasonic hyperthermia; Sheathing; Phantom tests; Teflon | 1986-05 |
| 53 |
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Horch, Kenneth W. | Information contrained in sensory nerve recordings made with intrafascicular electrodes | Multiunit recordings were made in anesthetized cats with chronically implanted intrafascicular electrodes over a period of six months. Neural signals recorded with these electrodes consisted of activity in sensory fibers innervating a variety of cutaneous mechanoreceptors. Mechanical stimuli wer... | Intrafascicular electrodes; Functional electrical stimulation (FES); Closed-loop control | 1991 |
| 54 |
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Horch, Kenneth W. | Information extraction from peripheral nerves | This work is directed toward providing better rehabilitation for people suffering from somatosensory loss and paralysis due to spinal cord injury, head trauma, or stroke. The goal of this project is to demonstrate that information suitable for controlling prosthetic devices, modulating functional el... | Peripheral nerve; Neural recordings; Intrafascicular electrodes | 1991 |
| 55 |
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Christensen, Douglas A. | Interface of forest and agriculture in nonpoint pollution control | Management practices of agriculture, including conservation and tillage options, recently have received a great deal of attention with respect to their impact upon the environment. Research efforts have focused both on the direct impacts of reduced on-site productivity resulting from the erosion of ... | Suspended sediment; Channel erosion; Silviculture | 1983 |
| 56 |
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Horch, Kenneth W. | Intrafascicular electrodes for nerve stimulation | We have designed a new type of intrafascicular, implanted electrode for stimulating peripheral nerves to elicit muscle contraction. The electrode requires low current to stimulate the nerve fibers, provides a fine control of muscular force, and causes little or no tissue reaction. it is of potential... | Intrafascicular electrodes; Peripheral nerve; Neural recordings | 1988 |
| 57 |
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Horch, Kenneth W. | Intraspinal microstimulation using cylindrical multielectrodes | A cylindrical multielectrode system specifically designed for intraspinal microstimulation was mechanically and electrically evaluated in the ventral horn of the feline lumbo-sacral spinal cord. Electrode insertions proved to be straight as evaluated from radiographs. Impedances were measured in s... | Cylindrical multielectrode; Microstimulation; Neural prosthesis; Current distance constants; Electrode array; Spinal cord stimulation | 2006-02 |
| 58 |
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Christensen, Douglas A. | Introduction to biomedical engineering: biomechanics and bioelectricity - part I | Intended as an introduction to the field of biomedical engineering, this book covers the topics of biomechanics (Part I) and bioelectricity (Part II). Each chapter emphasizes a fundamental principle or law, such as Darcy's Law, Poiseuille's Law, Hooke's Law, Starling's law, levers and work in the a... | Biological membranes; Poiseuille's law; Hooke's law; Starling's law of the heart; Matlab | 2009 |
| 59 |
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Christensen, Douglas A. | Introduction to biomedical engineering: biomechanics and bioelectricity - part II | Intended as an introduction to the field of biomedical engineering, this book covers the topics of biomechanics (Part I) and bioelectricity (Part II). Each chapter emphasizes a fundamental principle or law, such as Darcy's Law, Poiseuille's Law, Hooke's Law, Starling's Law, levers and work in the... | Bioelectricity; Kirchhoff's voltage law; Kirchhoff's current law; Coulomb's law; Thevenin equivalent circuits; Nernst potential; Matlab | 2009 |
| 60 |
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Christensen, Douglas A. | Laser diode coherence length variation with drive current: a tool for dispersion measurements | A visible light (670nm) laser diode was used as a variable coherence length source to measure dispersion characteristics in single-mode fibers. The diode's spectral width, measured against increasing drive current, was found to change from about 16 nanometers to less than 0.2 nanometer. The corresp... | Laser diode; Fiber interferometry | 1992 |
| 61 |
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Normann, Richard A.; Branner, Almut | Long-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve | We studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions o... | Cats; Microelectrodes; Prosthesis Implantation; Sciatic Nerve | 2004 |
| 62 |
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Horch, Kenneth W. | Mechanical testing of metallic and polymeric intrafascicular electrodes | We are exploring alternatives to Pt/Ir wire for constructing ultra-flexible neural intrafascicular electrodes suitable for chronic implantation. In this study we measured the flexural properties of several kinds of fine metal wires and conducting polymer fibers. The fibers were made either of in... | Intrafascicular electrodes; Polymer fibers | 1994 |
| 63 |
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Horch, Kenneth W. | Microfabricated cylindrical multielectrodes for neural stimulation | The effects of spinal cord injuries are likely to be ameliorated with the help of functional electrical stimulation of the spinal cord, a technique that may benefit from a new style of electrode: the cylindrical multielectrode. This paper describes the specifications for, fabrication techniques for... | Cylindrical multielectrode; Depth electrodes; Impedance testing; Microelectromechanical systems (MEMS); Microstimulation; Impedance testing; Neural prosthesis | 2006-02 |
| 64 |
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Jenson, Justin Michael; Bock, Susan C. | Mitigating spinal cord injury | How would your life change if you became one of the 15,000 Americans to suffer a spinal cord injury this year? Trauma to the spinal cord causes immediate loss of function below the level of the injury. Then, in the hours and days after the accident, the body's secondary injury response may extend ... | Trapeze Interactive Poster | 2010-03-15 |
| 65 |
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Normann, Richard A.; Horch, Kenneth W.; Cha, Kichul | Mobility performance with a pixelized vision system | A visual prosthesis, based on electrical stimulation of the visual cortex, has been suggested as a means for partially restoring functional vision in the blind. The prosthesis would create a pixelized visual sense consisting of punctate spots of light (phosphenes). The present study investigated the... | Visual Prosthesis; Mobility; Phosphene Simulator | 1992 |
| 66 |
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Christensen, Douglas A. | Modeling sources in the FDTD formulation and their use in quantifying source and boundary condition errors | The modeling of voltage and current sources as either added or replaced sources in FDTD simulations is described and their differences discussed in terms of a transmission line analogy. An infinitesimal current element (ICE) is used to illustrate the validation of added source modeling and to study... | Finite-difference time-domain method; Infinitesimal current element | 1995-04 |
| 67 |
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Christensen, Douglas A. | Multiple sensor optical thermometry system for application in clinical hyperthermia | The thermometry system described is based upon the temperature dependence of the band edge absorption of infrared light in GaAs crystal. The design of the thermometry was completed, and the system was subjected to an extensive evaluation, including testing with tissue phantoms and microwave applic... | Thermometry; Hyperthermia applicator; Phantom tests | 1984-01 |
| 68 |
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Horch, Kenneth W. | Muscle recruitment through electrical stimulation of the lumbo-sacral spinal cord | The goal of this study was to determine the feasibility of producing graded muscle contraction in individual muscles or muscle groups by electrically stimulating motor neurons in the lumbo-sacral spinal cord. Recruitment curves were obtained for quadriceps, tibialis anterior and triceps surae/pl... | Functional neuromuscular stimulation (FNS); Motor pools, Muscle recruitment, Spinal cord stimulation | 2000 |
| 69 |
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Horch, Kenneth W. | Muscle recruitment with intrafascicular electrodes | We have studied muscle recruitment with Tefloninsulated, 25 pm diameter, Pt-Ir intrafasicular electrodes implanted in nerves innervating the gastrocnemius and soleus muscles of cats. The purpose of this study was to measure the performance of these bipolar electrodes, which had been designed to... | Functional neuromuscular stimulation (FNS); Intrafascicular electrode | 1991 |
| 70 |
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Normann, Richard A.; Maynard, Edwin M. | Neural interface for a cortical vision prosthesis | The development of a cortically based vision prosthesis has been hampered by a lack of basic experiments on phosphene psychophysics. This basic research has been hampered by the lack of a means to safely stimulate large numbers of cortical neurons. Recently, a number of laboratories have developed a... | Neuroprosthetics; Artificial Vision; Electrode Arrays; Multielectrode Recordings; Biocompatibility | 1999 |
| 71 |
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Normann, Richard A.; Kolb, Helga | Neural organization of the retina of the turtle Mauremys caspica: a light microscope and Golgi study | The organization of the retina of the turtle species Mauremys caspica, found in fresh water ponds of Israel, has been examined by light microscopical techniques including examination of fresh wholemount retina, one micron blue-stained vertical sections and Golgi-stained material. The anatomical find... | Turtle Retina; Photoreceptors; Golgi Technique; Amarcine Cells | 1988 |
| 72 |
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Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Neural signal for skin indentation depth. I. Changing indentations | Psychophysical tests on human subjects showed that judgments of skin indentation depth made when the fingertip was indented at rates from 0.2 to 16 mm/set were quite insensitive to changes in indentation velocity. Similar results were obtained on the forearm at indentation velocities of 0.4 to 16... | Skin; Indentation; Nerve impulses | 1983 |
| 73 |
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Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Neural signal for skin indentation depth. II. Steady indentations | The glabrous skin of the monkey's hand was stimulated with a waveform that indented the skin at a rate of 0.4 mm/set, held the skin steadily or nearly steadily indented for 12 set or longer, and then retracted back to the starting position. Recordings were made of activity in single afferent fibe... | Skin; Indentation; Nerve impulses | 1983 |
| 74 |
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Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Neural signal for the intensity of a tactile stimulus | The effect of indenting the skin at different rates on the perceived intensity of the stimulus was studied by indenting the skin of the fingertip with two triangular waveforms, given as a pair. The subjects were asked to judge which member of the pair was more intense. Perceived intensity was foun... | Skin; Indentation; Nerve impulses | 1984 |
| 75 |
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Gerig, Guido | Neuro imaging research lab | | | 2012 |
| 76 |
 |
Normann, Richard A.; Maynard, Edwin M. | Neuronal interactions improve cortical population coding of movement direction | Interactions among groups of neurons in primary motor cortex (MI) may convey information about motor behavior. We investigated the information carried by interactions in MI of macaque monkeys using a novel multielectrode array to record simultaneously from 12-16 neurons during an arm-reaching task. ... | Motor Cortex; Monkey; Population Coding; Movement | 1999 |
| 77 |
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Horch, Kenneth W.; Normann, Richard A. | Noble metal penetrating cortical stimulating electrode array: preliminary results | Electrical stimulation of the visual cortex causes subjects to see spots of light (phosphenes) in their visual fields. We have developed arrays of penetrating electrodes which may from the basis of a visual prosthesis centered around electrical stimulation of the visual cortex. These arrays have bee... | Visual prosthesis | 1988 |
| 78 |
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Horch, Kenneth W. | On the number and nature of regenerating myelinated axons after lesions of cutaneous nerves in the cat | 1. Electrophysiological and anatomical techniques were used to investigate normal and regenerating sural and posterior femoral cutaneous nerve fibres in the cat. 2. One and a half years after transection of these nerves it was found that the regenerating neurones supported multiple sprouts in the... | Nerve fibres; Transection; Nerve injury | 1981 |
| 79 |
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Horch, Kenneth W. | Ontogeny of diving and feeding behavior in juvenile seaturtles: Leatherback Seaturtles (Dermochelys coriacea L) and Green Seaturtles (Chelonia mydas L) in the Florida Current | We compared activity, diving behavior and response to prey by Dermochelys coriacea and Chelonia mydas during their first 8-10 weeks of development.We reared juveniles in the laboratory and, at two-week intervals, released them in the ocean for a brief trial. Each turtle towed a device used to measur... | Hatchlings; Posthatchling; Habitats | 2004 |
| 80 |
 |
Christensen, Douglas A.; Herron, James N. | Optical immunoassay systems based upon evanescent wave interactions | Immunoassays based upon evanescent wave interactions are finding increased biosensing application. In these devices, the evanescent tail associated with total internal reflection of an incident beam at the substrate/solution interface provides sensitivity for surface-bound proteins over bulk molec... | Diagnostics; Evanescence; Planar waveguides; Human chorionic gonadotropin (hCG) | 1996 |
| 81 |
 |
Gesteland, Raymond F.; Atkins, John F. | Origin and destiny of adenovirus proteins | Lytic infection of human cells by adenovirus proceeds by a temporal expression of genes. Classically two phases have been defined: an early phase, which includes events occurring before the onset of DNA synthesis (8 hours), and a late phase, including events whose existence depends on the onset of... | Protein Biosynthesis; DNA, Viral; Adenoviridae; RNA, Viral; Time Factors | 1975 |
| 82 |
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Normann, Richard A. | Oscillations in rod and horizontal cell membrane potential: evidence for feed-back to rods in the vertebrate retina | 1. Rods and horizontal cells were studied with intracellular recordings in the retina of the toad, Bufo marinus; 161 cells were from the eyecup preparation and thirty were from the isolated perfused retina. 2. Of these cells, 39% exhibited either transient or sustained oscillations of membrane poten... | Retina; Photoreceptors; Toads; Adaptation, Ocular | 1976 |
| 83 |
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Gesteland, Raymond F.; Atkins, John F.; Baranov, Pavel V. | P-site tRNA is a crucial initiator of ribosomal frameshifting | The expression of some genes requires a high proportion of ribosomes to shift at a specific site into one of the two alternative frames. This utilized frameshifting provides a unique tool for studying reading frame control. Peptidyl-tRNA slippage has been invoked to explain many cases of programmed ... | Translation; Recoding; Kinetic Model; Frameshifting; Ribosome | 2004 |
| 84 |
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Gesteland, Raymond F. | Pattern of protein synthesis in monkey cells infected by simian virus 40 | After infection of several permanent monkey cell lines by simian virus 40 (SV40), four additional protein bands can be detected by simple sodium dodecyl sulfate-polyacrylamide gel electrophoresis of whole-cell extracts. These bands appear only after the onset of viral deoxyribonucleic acid (DNA) syn... | Monkeys; Simian virus 40; Peptides; DNA, Viral/biosynthesis | 1972 |
| 85 |
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Horch, Kenneth W. | Perspectives on new electrode technology for stimulating peripheral nerves with implantable motor prostheses | Abstract-The limits of present electrode technology are being reached in current motor prostheses for restoring functional movement in paralyzed people. Improved devices require electrodes and stimulation methods that will activate muscles selectively and independently with less implanted hardwa... | Paralysis; Prostheses; Electrodes | 1995 |
| 86 |
 |
Baehr, Wolfgang; Prestwich, Glenn D. | Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein | Bovine PDEdelta was originally copurified with rod cGMP phosphodiesterase (PDE) and shown to interact with prenylated, carboxymethylated C-terminal Cys residues. Other studies showed that PDEdelta can interact with several small GTPases including Rab13, Ras, Rap, and Rho6, all of which are prenylate... | Fluorescence Resonance Energy Transfer; GTP Phosphohydrolases; Immunohistochemistry | 2004 |
| 87 |
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Christensen, Douglas A. | Planar waveguide biosensors for nucleic acid hybridization reactions | Oligonucleotide probes derived from (1) the T3 RNA polymerase promoter sequence (T3) and (2) prostate-specific antigen messenger RNA (PSA) were prepared and labeled with a red-emitting fluorescent dye (Cy5). The complimentary oligonucleotides (anti T3 and anti PSA) were prepared and labeled with bio... | Planar waveguides; Evanescence; Fluorescence; Glandular kallikrein; MDx; Molecular diagnostics; Nucleic acid; PSA; Oligonucleotide probes | 2000 |
| 88 |
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Christensen, Douglas A. | Plasma-etched polymer waveguides for intrachip optical interconnects | Optical intrachip communication offers the potential advantages of high speed and lack of electrical interference. We report on progress made on an interconnect design using GaAs LEDs, polymer waveguides, and photodiodes in a silicon substrate. The polymer waveguides are fabricated in polyimide or p... | Polymer waveguides; Intrachip interconnects; LEDs | 1998 |
| 89 |
 |
Lam, LeAnn | Pre-clinical animal model for ovarian cancer using live imaging system | Development of a live imaging animal model for orthotopic ovarian cancers in order to better understand disease mechanisms and response to potential anticancer drug treatments. | Ovarian cancer; Cancer; Animal model; Live imaging; Cell culture; ACCESS | 2015-04-14 |
| 90 |
 |
Gesteland, Raymond F.; Atkins, John F.; Felden, Brice; McCutcheon, John P. | Probing the structure of the Escherichia coli 10Sa RNA (tmRNA) | The conformation of the Escherichia coli 10Sa RNA (tmRNA) in solution was investigated using chemical and enzymatic probes. Single- and double-stranded domains were identified by hydrolysis of tmRNA in imidazole buffer and by lead(II)-induced cleavages. Ribonucleases T1 and S1 were used to map unpai... | Covariation; Pseudoknot; Structural Probing; 10Sa RNA; tmRNA | 1997 |
| 91 |
 |
Christensen, Douglas A.; Furse, Cynthia M. | Problem and treatment of DC offsets in FDTD simulations | This paper discusses the causes of and some solutions to the commonly observed problem of dc field offsets in finite-difference time-domain (FDTD) simulations. DC electric and magnetic field offsets are shown to be valid calculated responses of the modeled systems, resulting from interaction betwee... | Finite-difference time-domain method; Direct current offsets; Waveforms | 2000-08 |
| 92 |
 |
Gesteland, Raymond F. | Processing of adenovirus 2-induced proteins | Analysis of (35)S-methionine-labeled extracts of adenovirus 2-infected KB cells revealed 22 virus-induced polypeptide components. Most proteins of the virion were easily detected in extracts of whole cells labeled for short periods between 15 and 30 h after infection; however, several virion compone... | Adenoviridae; Viral Proteins; Protein Precursors; Methionine; Mouth Neoplasms | 1973 |
| 93 |
 |
Horch, Kenneth W. | Proposed specifications for a lumbar spinal cord electrode array for control of lower extremities in paraplegia | The goal of the study was to provide specifications for a stimulating electrode array to be implanted in the lumbosacral spinal cord as part of a functional neuromuscular stimulation (FNS) system for control of lower extremity muscles in paralyzed individuals. Dual channel stimulation of the qua... | Stimulating electrode array; FNS; Functional neuromuscular stimulation | 1997 |
| 94 |
 |
Christensen, Douglas A. | Pulsed Schlieren system for visualizing beams from phased-array HIFU applicators | We have assembled a Schlieren system for imaging the beam patterns from HIFU transducers in water to verify the desired beam focusing and direction. It consists of a high power (65 mW) short-pulse (as short as 2 ns) laser emitting at 658 nm, a beam expander/spatial filter, water tank, 400 Jim round ... | Ultrasound beam patterns; Pulsed laser; Wavefronts | 2007 |
| 95 |
 |
Christensen, Douglas A.; Herron, James N. | Rapid clinical diagnostics assays using injection-molded planar waveguides | The goal of our research program is to develop an evanescent wave immunoassay system that can be used in point-of-care and critical care settings. Several key attributes are required to accomplish this goal: (i) the assay system should be at least as sensitive as present day immunoassays; (ii) assay... | Planar waveguides; Creatine phosphokinase MB (CK-MB); Cardiac troponin I (cTnl); Diagnostics; Evanescence; Fluorescence; Human chorionic gonadotropin (hCG) | 1998 |
| 96 |
 |
Christensen, Douglas A.; Herron, James N. | Rapid single nucleotide polymorphism detection for personalized medicine applications using planar waveguide fluorescence sensors | Personalized medicine is an emerging field in which clinical diagnostics information about a patient's genotype or phenotype is used to optimize his/her pharmacotherapy. This article evaluates whether planar waveguide fluorescent sensors are suitable for determining such information from patient tes... | Personalized medicine; Planar waveguides; Fluorescence sensors; Evanescent excitation; Fluorescence; Hybridization; Molecular diagnostics; Peptide nucleic acid; Point of care; Single base extension; Single nucleotide polymorphism | 2006 |
| 97 |
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Christensen, Douglas A. | Resonant inductive applicator for neck hyperthermia | We have designed and phantom tested an inductive applicator especially suited for producing hyperthermia in cancerous regions in the neck. The applicator is tuned to resonate near 27 MHz; its inductive nature has the advantage of efficient coupling to the irregular neck anatomy. An inhomogeneou... | Hyperthermia applicator; Phantom tests | 1989 |
| 98 |
 |
Varner, Michael W.; Clark, Edward B.; Fernando, Kumari L.; Mathews, V. John | Robust estimation of fetal heart rate variability using Doppler ultrasound. | This paper presents a new measure of heart rate variability (HRV) that can be estimated using Doppler ultrasound techniques and is robust to variations in the angle of incidence of the ultrasound beam and the measurement noise. This measure employs the multiple signal characterization (MUSIC) algori... | Prenatal Ultrasonography; Fetal Heart Rate; Blood Flow Velocity; Algorithms | 2003-08 |
| 99 |
 |
Gesteland, Raymond F.; Atkins, John F.; Wills, Norma M. | rRNA-mRNA base pairing stimulates a programmed -1 ribosomal frameshift | Base pairing between the 3' end of 16S rRNA and mRNA is shown to be important for the programmed -1 frameshifting utilized in decoding the Escherichia coli dnaX gene. This pairing is the same as the Shine-Dalgarno pairing used by prokaryotic ribosomes in selection of translation initiators, but for ... | Frameshifting; Escherichia coli; Binding Sites; Base Composition | 1994 |
| 100 |
 |
Horch, Kenneth W. | Selective activation of functional muscle groups through stimulation of spinal motor pools | A microelectrode was used to stimulate motor neurons in the lumbo-sacral spinal cord of adult cats. Consistent with spinal cord anatomical studies, we found that the motor neurons responsible for activation of individual muscle groups are situated together in specific areas of the cord, forming mot... | Spinal motor pools | 1993 |
