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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
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Christensen, Douglas A.; Herron, James N. | Evanescent coupling in a waveguide fluoroimmunosensor | A key factor in the analysis of evanescently-coupled optical sensors, such as the planar waveguide immunosensor analyzed here, is the efficiency of coupling between the optical waveguide modes and the fluorescent sources located on the surface of the waveguide. This is an important parameter in dete... | Evanescent coupling; Waveguide; Fluoroimmunosensor | 1992 |
| 2 |
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Christensen, Douglas A.; Vincent, G. Michael | Fiberoptic laser angioplasty probe with optical steerability | We have designed and bench tested an optically steerable fiberoptic probe for use in laser angioplasty. The unique feature of this design is the use of a gradient-index (GRIN) lens attached to the distal end of a seven-fiber bundle. By selecting which fiber of the bundle is illuminated by the source... | Fiberoptic probe; GRIN lens; Steerability | 1990 |
| 3 |
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Christensen, Douglas A. | Plasma-etched polymer waveguides for intrachip optical interconnects | Optical intrachip communication offers the potential advantages of high speed and lack of electrical interference. We report on progress made on an interconnect design using GaAs LEDs, polymer waveguides, and photodiodes in a silicon substrate. The polymer waveguides are fabricated in polyimide or p... | Polymer waveguides; Intrachip interconnects; LEDs | 1998 |
| 4 |
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Christensen, Douglas A.; Herron, James N. | Comparison of robust coupling techniques for planar waveguide immunosensors | We have analyzed and fabricated two different coupling schemes to meet the requirements for a convenient means of coupling into a planar waveguide immunosensor that is relatively insensitive to beam alignment. These are the "launch" coupler and the grating coupler. Each possesses advantages and dis... | Planar waveguide immunosensors; Fluorescence; Launch coupler; Grating coupler | 1993 |
| 5 |
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Christensen, Douglas A. | Laser diode coherence length variation with drive current: a tool for dispersion measurements | A visible light (670nm) laser diode was used as a variable coherence length source to measure dispersion characteristics in single-mode fibers. The diode's spectral width, measured against increasing drive current, was found to change from about 16 nanometers to less than 0.2 nanometer. The corresp... | Laser diode; Fiber interferometry | 1992 |
| 6 |
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Christensen, Douglas A.; Andrade, Joseph D. | Improved sensitivity in ellipsometry of thin biochemical films by employing sublayers | Ellipsometry is widely used for investigating the optical properties of thin films on planar substrates, including films of adsorbed proteins or polymers. The average thickness and effective refractive index of the adsorbed layer are calculated by measuring the A and ¥ ellipsometry parameters. Unfo... | Biochemical films; SiO2 sublayer | 1990 |
| 7 |
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Christensen, Douglas A. | Finite-difference time-domain modeling and experimental characterization of planar waveguide fluorescence sensors | The finite-difference time-domain method (FDTD) is a powerful numerical technique for solving Maxwell's equations in a discretized space and time grid. Its applications have up to now been in the analysis of electrically large structures in the microwave domain, and the scope of investigations has b... | Finite-difference time-domain method; Planar waveguide | 1992 |
| 8 |
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Christensen, Douglas A. | Planar waveguide biosensors for nucleic acid hybridization reactions | Oligonucleotide probes derived from (1) the T3 RNA polymerase promoter sequence (T3) and (2) prostate-specific antigen messenger RNA (PSA) were prepared and labeled with a red-emitting fluorescent dye (Cy5). The complimentary oligonucleotides (anti T3 and anti PSA) were prepared and labeled with bio... | Planar waveguides; Evanescence; Fluorescence; Glandular kallikrein; MDx; Molecular diagnostics; Nucleic acid; PSA; Oligonucleotide probes | 2000 |
| 9 |
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Christensen, Douglas A.; Herron, James N. | Optical immunoassay systems based upon evanescent wave interactions | Immunoassays based upon evanescent wave interactions are finding increased biosensing application. In these devices, the evanescent tail associated with total internal reflection of an incident beam at the substrate/solution interface provides sensitivity for surface-bound proteins over bulk molec... | Diagnostics; Evanescence; Planar waveguides; Human chorionic gonadotropin (hCG) | 1996 |
| 10 |
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Christensen, Douglas A. | Dispersion effects in fiber optic interferometry | An extended analysis of the effects of uncompensated fiber dispersion on the fringe visibility of a fiber optic interferometer is developed, with particular emphasis on stellar interferometry. Both material and waveguide dispersion for single-mode, polarization-preserving fibers are considered. It... | Stellar interferometry; Fiber optics; Statistical optics | 1997 |
| 11 |
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Christensen, Douglas A.; Herron, James N. | Rapid clinical diagnostics assays using injection-molded planar waveguides | The goal of our research program is to develop an evanescent wave immunoassay system that can be used in point-of-care and critical care settings. Several key attributes are required to accomplish this goal: (i) the assay system should be at least as sensitive as present day immunoassays; (ii) assay... | Planar waveguides; Creatine phosphokinase MB (CK-MB); Cardiac troponin I (cTnl); Diagnostics; Evanescence; Fluorescence; Human chorionic gonadotropin (hCG) | 1998 |
| 12 |
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Christensen, Douglas A.; Herron, James N. | Rapid single nucleotide polymorphism detection for personalized medicine applications using planar waveguide fluorescence sensors | Personalized medicine is an emerging field in which clinical diagnostics information about a patient's genotype or phenotype is used to optimize his/her pharmacotherapy. This article evaluates whether planar waveguide fluorescent sensors are suitable for determining such information from patient tes... | Personalized medicine; Planar waveguides; Fluorescence sensors; Evanescent excitation; Fluorescence; Hybridization; Molecular diagnostics; Peptide nucleic acid; Point of care; Single base extension; Single nucleotide polymorphism | 2006 |
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