Filters: Department: "Bioengineering" Collection: "ir_uspace" School Or College: "College of Engineering"
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
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Macleod, Robert S. | Sensitivity and specificity of substrate mapping: An in silico framework for the evaluation of electroanatomical substrate mapping strategies | Background - Voltage mapping is an important tool for characterizing proarrhythmic electrophysiological substrate, yet it is subject to geometric factors that influence bipolar amplitudes and thus compromise performance. The aim of this study was to characterize the impact of catheter orientation on... | 2014-01-01 | |
| 2 |
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Christensen, Douglas A. | Ultrasound beam simulations in inhomogeneous tissue geometries using the hybrid angular spectrum method | The angular spectrum method is a fast, accurate and computationally efficient method for modeling wave propagation. However, the traditional angular spectrum method assumes that the region of propagation has homogenous properties. In this paper, the angular spectrum method is extended to calculate u... | 2012-01-01 | |
| 3 |
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Horch, Kenneth W.; Lawrence, Steve M.; Dhillon, Gurpreet S. | Acute peripheral nerve recording characteristics of polymer-based longitudinal intrafascicular electrodes | We examined the recording characteristics of two different types of polymer-based longitudinal intrafascicular electrodes (LIFEs) in peripheral nerve: single-stranded (s-polyLIFEs) and multistranded (m-polyLIFEs). Recordings were also made from Pt-Ir wire-based electrodes (PtIrLIFEs) as a control. T... | Sciatic Nerve; Intrafascicular Electrodes, Peripheral Nerve Recording | 2004 |
| 4 |
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Christensen, Douglas A. | Acoustic droplet vaporization, cavitation, and therapeutic properties of copolymer-stabilized perfluorocarbon nanoemulsions | Acoustic and therapeutic properties of Doxorubicin (DOX) and paclitaxel (PTX)-loaded perfluorocarbon nanoemulsions have been investigated in a mouse model of ovarian cancer. The nanoemulsions were stabilized by two biodegradable amphiphilic block copolymers that differed in the structure of the hydr... | Cancer therapy; Targeted drug delivery; Nanobubbles; Ultrasound; Perfluoropentane | 2009 |
| 5 |
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Christensen, Douglas A. | Ultrasound beam propagation using the hybrid angular spectrum method | We introduce a fast and accurate numerical method for simulating the propagation of an ultrasound beam inside inhomogeneous tissue for mapping beam absorption, refraction and diffraction in the body. The technique, called the hybrid angular spectrum method, is an extension of the angular spectrum m... | Ultrasound beam propagation; Medical ultrasound; Inhomogeneous tissue; Beam simulation | 2008-08 |
| 6 |
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Horch, Kenneth W. | Intraspinal microstimulation using cylindrical multielectrodes | A cylindrical multielectrode system specifically designed for intraspinal microstimulation was mechanically and electrically evaluated in the ventral horn of the feline lumbo-sacral spinal cord. Electrode insertions proved to be straight as evaluated from radiographs. Impedances were measured in s... | Cylindrical multielectrode; Microstimulation; Neural prosthesis; Current distance constants; Electrode array; Spinal cord stimulation | 2006-02 |
| 7 |
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Christensen, Douglas A.; Furse, Cynthia M. | Problem and treatment of DC offsets in FDTD simulations | This paper discusses the causes of and some solutions to the commonly observed problem of dc field offsets in finite-difference time-domain (FDTD) simulations. DC electric and magnetic field offsets are shown to be valid calculated responses of the modeled systems, resulting from interaction betwee... | Finite-difference time-domain method; Direct current offsets; Waveforms | 2000-08 |
| 8 |
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Horch, Kenneth W. | Muscle recruitment through electrical stimulation of the lumbo-sacral spinal cord | The goal of this study was to determine the feasibility of producing graded muscle contraction in individual muscles or muscle groups by electrically stimulating motor neurons in the lumbo-sacral spinal cord. Recruitment curves were obtained for quadriceps, tibialis anterior and triceps surae/pl... | Functional neuromuscular stimulation (FNS); Motor pools, Muscle recruitment, Spinal cord stimulation | 2000 |
| 9 |
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Gesteland, Raymond F.; Weiss, Robert B. | Efficient shine- Dalgarno sequence but not translation is necessary for LacZ mRNA stability in Escherichia coli | The 5' ends of many bacterial transcripts are important in determining mRNA stability. A series of Shine-Dalgarno (SD) sequence changes showed that the complementarity of the SD sequence to the anti-SD sequence of 16S rRNA correlates with lacZ mRNA stability in Escherichia coli. Several initiation c... | Protein Biosynthesis; Ribosomes; Escherichia coli; Shine-Dalgarno Sequence | 1994 |
| 10 |
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Horch, Kenneth W. | Classification of action potentials in multi unit intrafascicular recordings using neural network pattern recognition techniques | Neural network pattern-recognition techniques were applied to the problem of identifying the sources of action potentials in multi-unit neural recordings made from intrafascicular electrodes implanted in cats. The network was a three-layer connectionist machine that used digitized action potenti... | Intrafascicular electrodes; Multi-unit neural activity; Artificial neural networks | 1994 |
| 11 |
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Horch, Kenneth W.; Christensen, Douglas A. | Accelerated 4-year bachelors/masters degree program in biomedical engineering | In response to the need for providing advanced engineering education in a shorter time period than is currently possible by traditional curricula, we have created an Accelerated Dual Degree program in biomedical engineering. The purpose of this pilot program is to attract the brightest students, g... | Accelerated dual-degree program | 2002 |
| 12 |
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Horch, Kenneth W. | Closed loop control of ankle position using muscle afferent feedback with functional neuromuscular stimulation | This paper describes a closed-loop functional neuromuscular stimulation system that uses afferent neural activity from muscle spindle fibers as feedback for controlling position of the ankle joint. Ankle extension against a load was effected by neural stimulation through a dual channel intrafasc... | Neuromuscular stimulation; Functional neuromuscular stimulation (FNS); Neural electrodes | 1996 |
| 13 |
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Christensen, Douglas A. | Resonant inductive applicator for neck hyperthermia | We have designed and phantom tested an inductive applicator especially suited for producing hyperthermia in cancerous regions in the neck. The applicator is tuned to resonate near 27 MHz; its inductive nature has the advantage of efficient coupling to the irregular neck anatomy. An inhomogeneou... | Hyperthermia applicator; Phantom tests | 1989 |
| 14 |
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Hansen, Mark S.; Healy, Lindsey J.; Johnson, Christopher R.; Capecchi, Mario R.; Keller, Charles; Jones, Greg M. | Virtual histology of transgenic mouse embryos for high-throughput phenotyping. | A bold new effort to disrupt every gene in the mouse genome necessitates systematic, interdisciplinary approaches to analyzing patterning defects in the mouse embryo. We present a novel, rapid, and inexpensive method for obtaining high-resolution virtual histology for phenotypic assessment of mouse ... | Forkhead Transcription Factors; Paired Box Transcription Factors | 2006 |
| 15 |
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Gesteland, Raymond F.; Atkins, John F.; Felden, Brice; McCutcheon, John P. | Probing the structure of the Escherichia coli 10Sa RNA (tmRNA) | The conformation of the Escherichia coli 10Sa RNA (tmRNA) in solution was investigated using chemical and enzymatic probes. Single- and double-stranded domains were identified by hydrolysis of tmRNA in imidazole buffer and by lead(II)-induced cleavages. Ribonucleases T1 and S1 were used to map unpai... | Covariation; Pseudoknot; Structural Probing; 10Sa RNA; tmRNA | 1997 |
| 16 |
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Normann, Richard A. | Functional reorganization of primary visual cortex induced by electrical stimulation in the cat. | Compared to the high degree of plasticity observed in a juvenile, mature sensory cortices have long been held to be immutable but, recently, researchers have suggested some plasticity persists in the mature cortex. Cortical reorganization has particular saliency to the development of a cortically ba... | Cat; Electrophysiology; Phosphene; Plasticity; Receptive Field; Striate Cortex | 2005 |
| 17 |
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Horch, Kenneth W. | Microfabricated cylindrical multielectrodes for neural stimulation | The effects of spinal cord injuries are likely to be ameliorated with the help of functional electrical stimulation of the spinal cord, a technique that may benefit from a new style of electrode: the cylindrical multielectrode. This paper describes the specifications for, fabrication techniques for... | Cylindrical multielectrode; Depth electrodes; Impedance testing; Microelectromechanical systems (MEMS); Microstimulation; Impedance testing; Neural prosthesis | 2006-02 |
| 18 |
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Christensen, Douglas A. | Plasma-etched polymer waveguides for intrachip optical interconnects | Optical intrachip communication offers the potential advantages of high speed and lack of electrical interference. We report on progress made on an interconnect design using GaAs LEDs, polymer waveguides, and photodiodes in a silicon substrate. The polymer waveguides are fabricated in polyimide or p... | Polymer waveguides; Intrachip interconnects; LEDs | 1998 |
| 19 |
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Blumenthal, Donald K.; Underwood, Clayton J. | Adaptation of the protein kinase filter paper assay to a 96-well microtiter format. | The most widely used method for assaying protein kinase activities involves incorporation of radioactive phosphate into a protein or peptide substrate with subsequent binding or precipitaion of the radiolabeled substrate onto filter paper squares. We have adapted this assay for use with readily avai... | Protein Kinase Activities; Filter Papers; Radioactive Phosphate | 1999-02-01 |
| 20 |
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Horch, Kenneth W. | Muscle recruitment with intrafascicular electrodes | We have studied muscle recruitment with Tefloninsulated, 25 pm diameter, Pt-Ir intrafasicular electrodes implanted in nerves innervating the gastrocnemius and soleus muscles of cats. The purpose of this study was to measure the performance of these bipolar electrodes, which had been designed to... | Functional neuromuscular stimulation (FNS); Intrafascicular electrode | 1991 |
| 21 |
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Christensen, Douglas A. | Introduction to biomedical engineering: biomechanics and bioelectricity - part II | Intended as an introduction to the field of biomedical engineering, this book covers the topics of biomechanics (Part I) and bioelectricity (Part II). Each chapter emphasizes a fundamental principle or law, such as Darcy's Law, Poiseuille's Law, Hooke's Law, Starling's Law, levers and work in the... | Bioelectricity; Kirchhoff's voltage law; Kirchhoff's current law; Coulomb's law; Thevenin equivalent circuits; Nernst potential; Matlab | 2009 |
| 22 |
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Horch, Kenneth W. | Identification of single units in multi-unit recordings from peripheral nerves | We are developing a computer-based method for identifying individual action potentials in multi-unit peripheral nerve recordings. Threshold level, sinusoidal stimuli are used to elicit phase-locked activity from single units. These action potentials are digitized, and a template is constructed usin... | Peripheral nerve; Neural recordings; Cutaneous mechanoreceptors | 1988 |
| 23 |
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Gesteland, Raymond F.; Atkins, John F. | Frameshifting in gene 10 of bacteriophage T7 | Gene 10 of bacteriophage T7, which encodes the most abundant capsid protein, has two products: a major product, 10A (36 kDa), and a minor product, 10B (41 kDa). 10B is produced by frameshifting into the -1 frame near the end of the 10A coding frame and is incorporated into the capsid. The frameshift... | Frameshifting; Bacteriophage T7; RNA, Viral; Gene Expression | 1991 |
| 24 |
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Normann, Richard A.; Shoham, Shy | Encoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglion | Recent advances in microelectrode array technology now permit a direct examination of the way populations of sensory neurons encode information about a limb's position in space. To address this issue, we recorded nerve impulses from about 100 single units simultaneously in the L6 and L7 dorsal root ... | Sensory; Encoding; Multielectrode; Dorsal Root Ganglion; Cutaneour; Muscle | 2004 |
| 25 |
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Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Neural signal for skin indentation depth. I. Changing indentations | Psychophysical tests on human subjects showed that judgments of skin indentation depth made when the fingertip was indented at rates from 0.2 to 16 mm/set were quite insensitive to changes in indentation velocity. Similar results were obtained on the forearm at indentation velocities of 0.4 to 16... | Skin; Indentation; Nerve impulses | 1983 |