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Creator | Title | Description | Subject | Date |
1 |
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Gesteland, Raymond F. | Translation of Rl7 RNA fragments | Examination of the events during infection of cells by RNA phages reveals phemonomena that are surprisingly complex for a virus that has only enough information to code for three to four proteins. The coat protein is synthesized at a rapid rate through most of the infectious cycle making it the pre... | Electrophoresis; RNA, Messenger; Peptide Biosynthesis; Kinetics | 1969 |
2 |
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Gesteland, Raymond F. | Characterization of lysozyme messenger and lysozyme synthesized in vitro | In vitro systems for protein systhesis have been in wide use for about 10 years. In most of the early work protein synthesis was measured by following the incorporation of radioactive amino acids into acid precipitable material. This test cannot distinguish between the synthesis of complete, activ... | Lysozyme Messenger; Lysozyme Synthesized; Protein Synthesis | 1969 |
3 |
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Gesteland, Raymond F. | Pattern of protein synthesis in monkey cells infected by simian virus 40 | After infection of several permanent monkey cell lines by simian virus 40 (SV40), four additional protein bands can be detected by simple sodium dodecyl sulfate-polyacrylamide gel electrophoresis of whole-cell extracts. These bands appear only after the onset of viral deoxyribonucleic acid (DNA) syn... | Monkeys; Simian virus 40; Peptides; DNA, Viral/biosynthesis | 1972 |
4 |
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Horch, Kenneth W. | Acoustic interneurons of fiddler and ghost crabs | The properties of acoustic interneurons in fiddler (Uca pugilalor and U. minax) and ghost (Ocvpade qucldrula) crabs are described, as revealed bv tests with pure tones. Three types of interneurons were present in all species: tonic, which fired for the duration of the stimulus; phasic, which fire... | Acoustic crabs; Neural recording; Vibration reception | 1976 |
5 |
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Gesteland, Raymond F. | Simian virus 40-specific polypeptides in Ad2+ND4- infected cells | A comparison of the proteins synthesized in human cells at late times after infection with adenovirus (Ad2) and with the adeno-simian virus 40 (SV40) hybrid viruses revealed polypeptides of 30,000 and 92,000 molecular weight specific for the hybrid viruses Ad2+ND1 and Ad2+ND4, respectively. Cell-fre... | Molecular Weight; Peptide Biosynthesis; RNA, Messenger; Viral Proteins | 1976 |
6 |
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Gesteland, Raymond F. | Cell-free synthesis of herpes simplex virus proteins | Polyribosomes isolated from herpes simplex virus type I (HSV-1)-infected cells have been used to program a eucaryotic cell-free translation system. At least 10 HSV-specific polypeptides, with apparent molecular weights of 25,000 to 160,000, are synthesized by wild-type HSV-infected polyribosomes. Po... | Viral Proteins; Herpes Simplex; Peptide Biosynthesis; Thymidine Kinase | 1977 |
7 |
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Horch, Kenneth W. | On the number and nature of regenerating myelinated axons after lesions of cutaneous nerves in the cat | 1. Electrophysiological and anatomical techniques were used to investigate normal and regenerating sural and posterior femoral cutaneous nerve fibres in the cat. 2. One and a half years after transection of these nerves it was found that the regenerating neurones supported multiple sprouts in the... | Nerve fibres; Transection; Nerve injury | 1981 |
8 |
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Horch, Kenneth W. | Changes in primary afferent depolarization of sensory neurones during peripheral nerve regeneration in the cat | I. Micro-electrode recordings were made from normal and regenerating sural nerve fibres in cats. Increases in the excitability of the central terminals of these fibres after conditioning stimulation of other sural nerve fibres were taken as evidence for primary afferent depolarization. 2. At all... | Micro-electrode recording; Nerve regeneration; Primary afferent depolarization | 1981 |
9 |
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Christensen, Douglas A. | Effects of increased energy prices on U.S. agriculture: an econometric approach | Although the contents of this manuscript remain the responsibility of the authors, we wish to thanks a group of reviewers for the time and conscientious effort they put forth to solidify this final draft. Andrew Morton, Brian Holding, Wesley Buchele, and Arnold Paulsen deserve much credit for their ... | Energy prices | 1981 |
10 |
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Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Neural signal for skin indentation depth. I. Changing indentations | Psychophysical tests on human subjects showed that judgments of skin indentation depth made when the fingertip was indented at rates from 0.2 to 16 mm/set were quite insensitive to changes in indentation velocity. Similar results were obtained on the forearm at indentation velocities of 0.4 to 16... | Skin; Indentation; Nerve impulses | 1983 |
11 |
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Christensen, Douglas A. | Interface of forest and agriculture in nonpoint pollution control | Management practices of agriculture, including conservation and tillage options, recently have received a great deal of attention with respect to their impact upon the environment. Research efforts have focused both on the direct impacts of reduced on-site productivity resulting from the erosion of ... | Suspended sediment; Channel erosion; Silviculture | 1983 |
12 |
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Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Neural signal for skin indentation depth. II. Steady indentations | The glabrous skin of the monkey's hand was stimulated with a waveform that indented the skin at a rate of 0.4 mm/set, held the skin steadily or nearly steadily indented for 12 set or longer, and then retracted back to the starting position. Recordings were made of activity in single afferent fibe... | Skin; Indentation; Nerve impulses | 1983 |
13 |
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Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Neural signal for the intensity of a tactile stimulus | The effect of indenting the skin at different rates on the perceived intensity of the stimulus was studied by indenting the skin of the fingertip with two triangular waveforms, given as a pair. The subjects were asked to judge which member of the pair was more intense. Perceived intensity was foun... | Skin; Indentation; Nerve impulses | 1984 |
14 |
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Christensen, Douglas A. | Multiple sensor optical thermometry system for application in clinical hyperthermia | The thermometry system described is based upon the temperature dependence of the band edge absorption of infrared light in GaAs crystal. The design of the thermometry was completed, and the system was subjected to an extensive evaluation, including testing with tissue phantoms and microwave applic... | Thermometry; Hyperthermia applicator; Phantom tests | 1984-01 |
15 |
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Christensen, Douglas A. | Influence of temperature probe sheathing materials during ultrasonic heating | The influence of sheathing materials upon temperature probes used during the monitoring of ultrasonic heating was measured. The measurements show that the sheathing can be heated in a manner not representative of the temperature rise occurring in the surrounding material, altering the probe reading... | Ultrasonic hyperthermia; Sheathing; Phantom tests; Teflon | 1986-05 |
16 |
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Gesteland, Raymond F.; Atkins, John F.; Weiss, Robert B. | Slippery runs, shifty stops, backward steps and forward hops: -2, -1, +1, +2, +5 and +6 Ribosomal frameshifting | Frameshift mutations frequently express residual levels of gene activity; that is, they are often leaky. This leakiness can be used as a tool to define the functional components that affect the reading frame during gene expression. Recent technological advances in the capability to efficiently bu... | Molecular Sequence Data; Mutation; RNA, Transfer; Frameshifting | 1987 |
17 |
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Horch, Kenneth W. | Identification of single units in multi-unit recordings from peripheral nerves | We are developing a computer-based method for identifying individual action potentials in multi-unit peripheral nerve recordings. Threshold level, sinusoidal stimuli are used to elicit phase-locked activity from single units. These action potentials are digitized, and a template is constructed usin... | Peripheral nerve; Neural recordings; Cutaneous mechanoreceptors | 1988 |
18 |
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Horch, Kenneth W.; Normann, Richard A. | Noble metal penetrating cortical stimulating electrode array: preliminary results | Electrical stimulation of the visual cortex causes subjects to see spots of light (phosphenes) in their visual fields. We have developed arrays of penetrating electrodes which may from the basis of a visual prosthesis centered around electrical stimulation of the visual cortex. These arrays have bee... | Visual prosthesis | 1988 |
19 |
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Horch, Kenneth W. | Intrafascicular electrodes for nerve stimulation | We have designed a new type of intrafascicular, implanted electrode for stimulating peripheral nerves to elicit muscle contraction. The electrode requires low current to stimulate the nerve fibers, provides a fine control of muscular force, and causes little or no tissue reaction. it is of potential... | Intrafascicular electrodes; Peripheral nerve; Neural recordings | 1988 |
20 |
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Normann, Richard A.; Kolb, Helga; Lasater, Eric M. | Signal integration at the pedicle of turtle cone photoreceptors: an anatomical and electrophysiological study | The morphology of the axon which connects the cell body and pedicle of turtle cone photoreceptors was studied by light and electron microscopy. The axon which contains numerous synaptic vesicles, some endoplasmic reticulum, and a few cisternae is basically filled with cytoplasm. The length of the ax... | Cone Photoreceptor, Voltage Clamp; Isolated Cells; Input Resistance; Cell Body-Pedicle Coupling | 1989 |
21 |
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Christensen, Douglas A. | Resonant inductive applicator for neck hyperthermia | We have designed and phantom tested an inductive applicator especially suited for producing hyperthermia in cancerous regions in the neck. The applicator is tuned to resonate near 27 MHz; its inductive nature has the advantage of efficient coupling to the irregular neck anatomy. An inhomogeneou... | Hyperthermia applicator; Phantom tests | 1989 |
22 |
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Horch, Kenneth W. | Unit analysis in composite neural recordings | We have used threshold level, sinusoidal stimuli to selectively elicit phase-locked activity from cutaneous mechanoreceptors, for the purpose of evaluating single unit activity in multi-unit peripheral nerve recordings. Each receptor is characterized by its response to a range of mechanical stimuli ... | Neural recordings; Nerve fibers; Cutaneous mechanoreceptors | 1989 |
23 |
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Horch, Kenneth W. | Stability of chronic intrafascicular electrode recordings | We have implanted intrafascicular electrodes in peripheral nerves of cats and have recorded neural activity from a small population of nerve fibers for as long as six months, suggesting that these electrodes can be used on a chronic basis to acquire information about limb position, muscle force and ... | Intrafascicular electrodes; Electrode recordings | 1989 |
24 |
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Christensen, Douglas A.; Vincent, G. Michael | Fiberoptic laser angioplasty probe with optical steerability | We have designed and bench tested an optically steerable fiberoptic probe for use in laser angioplasty. The unique feature of this design is the use of a gradient-index (GRIN) lens attached to the distal end of a seven-fiber bundle. By selecting which fiber of the bundle is illuminated by the source... | Fiberoptic probe; GRIN lens; Steerability | 1990 |
25 |
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Horch, Kenneth W.; Normann, Richard A. | Simulation of a phosphene field based visual prosthesis | A visual prosthesis for the blind based upon electrical stimulation of the visual cortex requires the development of an array of electrodes. To establish design specifications for such an electrode array, we have conducted psychophysical experiments with normally sighted subjects wearing a portable... | Visual prosthesis; Phosphene simulator | 1990 |