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Bender, Austin | The role of ornithine, polyamines, and amino acid accumulation in the growth of melanoma | A frequent adaptation in the development of melanoma is the downregulation of argininosuccinate synthetase 1 (ASS1), the rate limiting enzyme in the production of the amino acid arginine from citrulline and aspartate. It is known that ASS1 is required for cells to proliferate in the absence of argin... | 2024 |
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