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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Wunderlich, Adam James | A nonparametric procedure for comparing the areas under correlated LROC curves | In contrast to the receiver operating characteristic (ROC) assessment paradigm, localization ROC (LROC) analysis provides a means to jointly assess the accuracy of localization and detection in an observer study. In a typical multireader, multicase (MRMC) evaluation, the data sets are paired so that... | 2012-01-01 | |
| 2 |
 | Gerig, Guido | A structural MRI study of human brain development from birth to two years | Brain development in the first 2 years after birth is extremely dynamic and likely plays an important role in neurodevelopmental disorders, including autism and schizophrenia. Knowledge regarding this period is currently quite limited. We studied structural brain development in healthy subjects from... | 2008-01-01 | |
| 3 |
 | Gerig, Guido | Abnormal vessel tortuosity as a marker of treatment response of malignant gliomas: preliminary report | Despite multiple advances in medical imaging, noninvasive monitoring of therapeutic efficacy for malignant gliomas remains problematic. An underutilized observation is that malignancy induces characteristic abnormalities of vessel shape. These characteristic shape abnormalities affect both capillari... | 2004-01-01 | |
| 4 |
 | Gerig, Guido | Analysis of longitudinal shape variability via subject specific growth modeling | Statistical analysis of longitudinal imaging data is crucial for understanding normal anatomical development as well as disease progression. This fundamental task is challenging due to the difficulty in modeling longitudinal changes, such as growth, and comparing changes across different populations... | 2012-01-01 | |
| 5 |
 | Gerig, Guido | Assessment of reliability of multi-site neuroimaging via traveling phantom study | This paper describes a framework for quantitative analysis of neuroimaging data of traveling human phantoms used for cross-site validation. We focus on the analysis of magnetic resonance image data including intra- and intersite comparison. Locations and magnitude of geometric deformation is studied... | 2008-01-01 | |
| 6 |
 | Gerig, Guido | Automatic corpus callosum segmentation using a deformable active Fourier contour model | The corpus callosum (CC) is a structure of interest in many neuroimaging studies of neuro-developmental pathology such as autism. It plays an integral role in relaying sensory, motor and cognitive information from homologous regions in both hemispheres. We have developed a framework that allows auto... | 2012-01-01 | |
| 7 |
 | Gerig, Guido | Brain maturation of newborns and infants | Recently, imaging studies of early human development have received more attention, as improved modeling methods might lead to a clearer understanding of the origin, timing, and nature of differences in neurodevelopmental disorders. Non-invasivemagnetic resonance imaging (MRI) can provide three-dimen... | 2011-01-01 | |
| 8 |
 | Gerig, Guido | Brain volumes in psychotic youth with schizophrenia and mood disorders | Background: We sought to test the hypothesis that deficits in grey matter volume are characteristic of psychotic youth with early-onset schizophrenia-spectrum disorders (EOSS) but not of psychotic youth with early-onset mood disorders (EOMD). Methods: We used magnetic resonance imaging to examine br... | 2010-01-01 | |
| 9 |
 | Gerig, Guido | Building spatiotemporal anatomical models using joint 4-D segmentation, registration, and subject-specific atlas estimation | Longitudinal analysis of anatomical changes is a vital component in many personalized-medicine applications for predicting disease onset, determining growth/atrophy patterns, evaluating disease progression, and monitoring recovery. Estimating anatomical changes in longitudinal studies, especially th... | 2012-01-01 | |
| 10 |
 | Gerig, Guido | Changes of MR and DTI appearance in early human brain development | Understanding myelination in early brain development is of clinical importance, as many neurological disorders have their origin in early cerebral organization and maturation. The goal of this work is to study a large neonate database acquired with standard MR imagery to illuminate effects of early ... | 2010-01-01 | |
| 11 |
 | Gerig, Guido | Closed and open source neuroimage analysis tools and libraries at UNC | The emergence of open-source libraries and development tools in the last decade has changed the process of academic software development in many ways. In medical image processing and visualization this change is especially evident, also because open source projects are actively furthered by grant fu... | 2006-01-01 | |
| 12 |
 | Gerig, Guido | Computational anatomy to assess longitudinal trajectory of brain growth | This paper addresses the challenging problem of statistics on images by describing average and variability. We describe computational anatomy tools for building 3-D and spatio-temporal 4-D atlases of volumetric image data. The method is based on the previously published concept of unbiased atlas bui... | 2006-01-01 | |
| 13 |
 | Gerig, Guido | Constrained data decomposition and regression for analyzing healthy aging from fiber tract diffusion properties | It has been shown that brain structures in normal aging undergo significant changes attributed to neurodevelopmental and neurodegeneration processes as a lifelong, dynamic process. Modeling changes in healthy aging will be necessary to explain differences to neurodegenerative patterns observed in m... | 2009-01-01 | |
| 14 |
 | Gerig, Guido | Correspondence evaluation in local shape analysis and structural subdivision | Regional volumetric and local shape analysis has become of increasing interest to the neuroimaging community due to the potential to locate morphological changes. In this paper we compare three common correspondence methods applied to two studies of hippocampal shape in schizophrenia: correspondence... | 2007-01-01 | |
| 15 |
 | Gerig, Guido | Cortical enhanced tissue segmentation of neonatal brain MR images acquired by a dedicated phased array coil | The acquisition of high quality MR images of neonatal brains is largely hampered by their characteristically small head size and low tissue contrast. As a result, subsequent image processing and analysis, especially for brain tissue segmentation, are often hindered. To overcome this problem, a dedic... | 2009-01-01 | |
| 16 |
 | Gerig, Guido | Diffusion tensor imaging: application to the study of the developing brain | Objective: To provide an overview of diffusion tensor imaging (DTI) and its application to the study of white matter in the developing brain, in both healthy and clinical samples. Method: The development of DTI and its application to brain imaging of white matter tracts is discussed. 48 studies usi... | 2007-01-01 | |
| 17 |
 | Gerig, Guido | Discordance of prenatal and neonatal brain development in twins | Background: Discordance of birth weight has been observed in twin pairs, though little is known about prenatal and early neonatal discordance of head and brain size, and the role that zygosity and chorionicity play in discordances of early brain development in twins. Aims: To compare prenatal and ne... | 2009-01-01 | |
| 18 |
 | Gerig, Guido | Discrimination analysis using Multi-object statistics of shape and pose | A main focus of statistical shape analysis is the description of variability of a population of geometric objects. In this paper, we present work towards modeling the shape and pose variability of sets of multiple objects. Principal geodesic analysis (PGA) is the extension of the standard technique ... | 2007-01-01 | |
| 19 |
 | Gerig, Guido | Early postnatal development of corpus callosum and corticospinal white matter assessed with quantitative tractography | BACKGROUND AND PURPOSE: The early postnatal period is perhaps the most dynamic phase of white matter development. We hypothesized that the early postnatal development of the corpus callosum and corticospinal tracts could be studied in unsedated healthy neonates by using novel approaches to diffusion... | 2007-01-01 | |
| 20 |
 | Gerig, Guido | Efficient probabilistic and geometric anatomical mapping using particle mesh approximation on GPUs | Deformable image registration in the presence of considerable contrast differences and large size and shape changes presents significant research challenges. First, it requires a robust registration framework that does not depend on intensity measurements and can handle large nonlinear shape variati... | 2011-01-01 | |
| 21 |
 | Gerig, Guido | Estimation of smooth growth trajectories with controlled acceleration from time series shape data | Longitudinal shape analysis often relies on the estimation of a realistic continuous growth scenario from data sparsely distributed in time. In this paper, we propose a new type of growth model para-meterized by acceleration, whereas standard methods typically control the velocity. This mimics the b... | 2011-01-01 | |
| 22 |
 | Gerig, Guido | Evaluation of DTI property maps as basis of DTI atlas building | Compared to region of interest based DTI analysis, voxel-based analysis gives higher degree of localization and avoids the procedure of manual delineation with the resulting intra and inter-rater variability. One of the major challenges in voxel-wise DTI analysis is to get high quality voxel-level c... | 2010-01-01 | |
| 23 |
 | Gerig, Guido | Functional connectivity MR imaging reveals cortical functional connectivity in the developing brain | BACKGROUND AND PURPOSE: Unlike conventional functional MR imaging where external sensory/cognitive paradigms are needed to specifically activate different regions of the brain, resting functional connectivity MR imaging acquires images in the absence of cognitive demands (a resting condition) and de... | 2008-01-01 | |
| 24 |
 | Gerig, Guido | Group mean differences of voxel and surface objects via nonlinear averaging | Building of atlases representing average and variability of a population of images or of segmented objects is a key topic in application areas like brain mapping, deformable object segmentation and object classification. Recent developments in image averaging, i.e. constructing an image which is cen... | 2006-01-01 | |
| 25 |
 | Gerig, Guido | Group statistics of DTI fiber bundles using spatial functions of tensor measures | We present a framework for hypothesis testing of differences between groups of DTI ber tracts. An anatomical, tract-oriented coordinate system provides a basis for estimating the distribution of diffusion properties. The parametrization of sampled, smooth functions is normalized across a population ... | 2008-01-01 |