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Creator | Title | Description | Subject | Date |
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Martin, Isaac | A result concerning the F-Signature and the torsion divisors of strongly F-Regular singularities | Polstra showed that the cardinality of the torsion subgroup of the divisor class group of a local strongly F-regular ring is finite. In this thesis, we first provide an expository introduction to the field of F-singularities before improving upon Polstra's result by proving that the reciprocal of th... | | 2021 |
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Arnoholt, Alayna | An analysis on the influence of anxiety in post error slowing | Anxiety disorders are among the most common mental disorders and affect 15.7 million Americans each year (Lépine, 2002, p. 4). Anxiety is associated with reduced productivity, physical distress, and other diseases such as depression. Anxiety could also be influential in error response (Compton et a... | | 2021 |
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Rohaj, Aarushi | Apoptosis efficiency of the transfected elephant and human P35 vectors in P53 varying leiomyosarcoma cells | Comparative Oncology is an approach that integrates and connects commonly occurring cancers seen in animals, into studies focused on cancer biology, prevention, and treatment in humans. Studies show that natural mechanisms can suppress cancer 1,000 times more adequately in certain animals than in hu... | | 2021 |
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Narasipura, Eshan Amruth | Full synthesis of enzymatically cleavable linker between 929-designed ankyrin repeat protein and 17-dimethlyamino geldanamycin | Targeted cancer therapeutics are an important and promising field of cancer research due to their ability to reduce the off target effects produced in other therapies such as chemotherapy. Antibody Drug Conjugates (ADC) are one such therapeutic that specifically target cancer cells through antibody-... | | 2021 |
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Cowley, Jacob | Optimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynes | In order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the... | | 2021 |
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Steiner, William | Regulation of protein complexes during hedgehog signal transduction | The Hedgehog (Hh) pathway is an evolutionarily conserved signaling pathway essential in embryonic development and tissue homeostasis. Several cancers can form as a result of Hh pathway dysfunction. The G protein-coupled receptor (GPCR) Smoothened (SMO) is activated upon binding of the secreted Hh pr... | | 2021 |
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Wainer, Tobin | Star clusters in the triangulum galaxy: star cluster catalog and mass function fitting | We construct a catalog of star clusters in the Triangulum Galaxy (M33). The catalog is the result of the Local Group Cluster Search (LGCS) citizen science project through Zooniverse, where users classify images from the Hubble Space Telescope (HST). We base our star cluster catalog on the fraction o... | | 2021 |
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Aderibigbe, Justis | Trends in the usage of bidentate phosphines as ligands in nickel catalysis of hydrogenation reactions | A critically important process in catalysis is the formation of an active catalyst from the combination of a metal precursor and a ligand, as the efficacy of this reaction governs the amount of active catalyst. This review is a compacted but comprehensive review of reactions catalyzed by nickel and ... | | 2021 |
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Checketts, Cynthia | Why white mice? improving biological literacy through animal history | Throughout the undergraduate experience, biology students are introduced to hundreds of experiments, theories, and principles, many of which are rooted in animal experimentation. However, in required and information-heavy biology courses, the erasure of animals from the scientific story-which repres... | | 2021 |